140 completed, 15 terminated, 15 unknown, 6 recruiting. 44 Phase 1, 44 Phase 3, 41 Phase 4, 24 Phase 2, 15 Not applicable.
Follow Lamotrigine: new trials by email Literature Review of Lamotrigine trials Research Report on Lamotrigine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3) KarXT, Lithium, Valproate - Bipolar Disorder Type I With Mania | Phase 3 | Recruiting | Bristol-Myers Squibb | 450 | 2025-07-18 | 2026-09-14 |
| A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants Xanomeline/Trospium Chloride, Lithium, Valproic Acid - Healthy Volunteers | Phase 1 | Completed | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 133 | 2024-12-26 | 2026-02-24 |
| Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study Sodium Valproate 500 Mg Prolonged-Release Oral Tablet, Lamotrigine, E.E.G - Epilepsy, Lamotrigine | Phase 4 | Unknown | Assiut University | 50 | 2024-07-29 | 2024-07-30 |
| Lithium Versus Lamotrigine in Bipolar Disorder, Type II Lithium Carbonate, Lamotrigine - Bipolar II Disorder | Phase 4 | Recruiting | University Hospital Bispebjerg and Frederiksberg | 200 | 2024-05-08 | 2026-03-20 |
| Single-dose, Two-way Crossover Bioequivalence of Lamotrigine in Healthy Male Volunteers Under Fasting Conditions Lamotrigine 100 MG - Fasting | Phase 1 | Completed | Desitin Arzneimittel GmbH | 24 | 2023-04-03 | 2024-01-10 |
| The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children Valproic acid, Carbamazepin, Phenytoin - Drug Resistant Epilepsy | Phase 4 | Unknown | Dr Cipto Mangunkusumo General Hospital | 100 | 2023-03-01 | 2023-01-26 |
| Treatment of Myotonia - Lamotrigine Versus Namuscla Lamotrigine, Namuscla - Non-Dystrophic Myotonia | Not applicable | Unknown | Grete Andersen, MD | 32 | 2022-12-05 | 2022-12-06 |
| The Efficacy and Safety of Lamotrigine Versus Carbamazepine in Focal Epilepsy Lamotrigine tablet, Carbamazepine-Containing Product in Oral Dose Form - Focal Epilepsy | Phase 4 | Unknown | Dhaka Medical College | 70 | 2022-11-01 | 2023-10-10 |
| Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding Lamotrigine, Levetiracetam, Oxcarbazepine - Epilepsy, Pregnancy Related | Recruiting | University of Pittsburgh | 60 | 2022-07-20 | 2026-05-06 | |
| Drug Concentrations in Breast Milk and Prediction of Blood Levels of the Breastfed Infants either of Atenolol, Bupropion, Brivaracetam, Escitalopram, Fluconazole, Lacosamide, Lamotrigine, Levetiracetam, Methotrexate or Ezetimibe - Breast Feeding | Completed | The Hospital for Sick Children | 39 | 2022-03-09 | 2024-04-10 | |
| Precision Medicine in the Treatment of Epilepsy Levetiracetam, Levetiracetam Tablets, Lamotrigine tablet - Epilepsy | Recruiting | Gitte Moos Knudsen | 550 | 2022-02-18 | 2024-04-11 | |
| Enhancing the Effects of Alcohol Treatment With Lamotrigine Lamotrigine, Placebo - Alcohol Use Disorder | Phase 2 | Completed | Brown University | 44 | 2022-01-24 | 2025-06-13 |
| MExiletine Versus Lamotrigine in Non-Dystrophic Myotonias Mexiletine, Lamotrigine 25Mg Oral Tablet, Extended Release - Non-Dystrophic Myotonia | Phase 3 | Unknown | University College, London | 60 | 2021-08-12 | 2022-11-02 |
| Modification of Epilepsy Screen Questionnaire and Treatment Feasibility Evaluation Zonisamide 100mg, Levetiracetam 500mg, LamoTRIgine 50mg - Epilepsy | Not applicable | Unknown | National Taiwan University Hospital | 40 | 2021-07-01 | 2021-06-25 |
| Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy(STANDLOW) Low dose carbamazepine, Standard dose carbamazepine, Low dose levetiracetam - Epilepsies, Partial | Phase 4 | Completed | Mario Negri Institute for Pharmacological Research | 58 | 2021-05-10 | 2025-07-08 |
| Lamotrigine and Bupropion for Meniere's Disease Lamotrigine and Bupropion, Placebo - Meniere Disease, Ménière's Vertigo | Phase 2 | Unknown | Dent Neuroscience Research Center | 34 | 2020-12-16 | 2022-06-21 |
| A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine Lamotrigine, BI 409306, Placebo - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 40 | 2020-12-01 | 2024-03-12 |
| Bioequivalence of Lamnet (Lamotrigine)100mg Tablet With the Reference Product Lamictal 100mg (Lamotrigine) Tablet Under Fasting Conditions Lamotrigine tablet - Bioequivalence | Phase 1 | Completed | University of Karachi | 26 | 2020-09-04 | 2022-09-08 |
| Ketogenic Diet for New-Onset Absence Epilepsy Modified Atkins Diet, Absence epilepsy medications - Absence Epilepsy, Ketogenic Dieting | Phase 3 | Recruiting | Johns Hopkins University | 40 | 2020-08-10 | 2026-05-07 |
| Ketamine-Induced Brain Changes and Their Modulation by Lamotrigine Lamotrigine, Ketamine, Placebo Pretreatment - Emotions | Not applicable | Completed | Charite University, Berlin, Germany | 75 | 2020-03-10 | 2021-03-29 |
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Bipolar Disorder (49) · Epilepsy (47) · Depression (14) · Seizures (9) · Epilepsies, Partial (7) · Psychotic Disorders (6) · Mania (5) · Depressive Disorder, Major (4) · Mood Disorders (4) · Pain (4) · Schizophrenia (4) · Alcoholism (3) · Anxiety Disorders (3) · Depressive Disorder (3) · Mental Disorders (3)
GlaxoSmithKline (40) · Dr. Reddy's Laboratories Limited (8) · Teva Pharmaceuticals USA (4) · The University of Texas Health Science Center at San Antonio (3) · University Hospitals Cleveland Medical Center (3) · University of Texas Southwestern Medical Center (3) · Yale University (3) · Assiut University (2) · Dent Neuroscience Research Center (2) · Emory University (2) · Grete Andersen, MD (2) · IPCA Laboratories Ltd. (2) · Johns Hopkins University (2) · MaineHealth (2) · Massachusetts General Hospital (2)
United States (87) · Canada (12) · India (11) · South Korea (10) · Germany (9) · Denmark (8) · Netherlands (8) · China (7) · Japan (7) · United Kingdom (7) · France (6) · Italy (6) · Spain (6) · Argentina (5) · Australia (4)
Srinivas Yadav K, Dr. (3) · Benoit Girard, MD (2) · Dorian Williams, M.D. (2) · Dr. Manish Singhal, MBBS (2) · Dr. Ralph Scallion, MD (2) · E. Sherwood Brown, M.D., Ph.D. (2) · Eric Bicrell, M.D. (2) · Keming Gao, MD, PhD (2) · Lixin Zhang, MD, PhD (2) · Ralph Scallion E.E, M.D. (2) · Alexander Khokhlov (1) · Andrew G Herzog, MD (1)
PMID 34523118, PMID 11765093, PMID 15005752, PMID 15110730, PMID 15330403, PMID 15349007, PMID 15465989, PMID 15541061, PMID 15569893, PMID 15652736, PMID 15677618, PMID 15723025, PMID 15898966, PMID 15950022, PMID 15960566, PMID 16023735, PMID 16168792, PMID 16176440, PMID 16197928, PMID 16338761, PMID 16339615, PMID 16339616, PMID 16344515, PMID 16426088, PMID 16448626, PMID 16449473, PMID 16449474, PMID 16552982, PMID 16566627, PMID 16595351, PMID 16635643, PMID 16675760, PMID 16677228, PMID 16816280, PMID 16816301, PMID 16928441, PMID 17007487, PMID 17042830, PMID 17392295, PMID 17404119, PMID 17728418, PMID 17915977, PMID 18227782, PMID 18358540, PMID 18399724, PMID 18428211, PMID 18588360, PMID 18615166, PMID 18681768, PMID 18778916
2005 (1), 2016 (1), 2018 (1), 2023 (1), K20DA000191 (1), K23AA017666 (1), M01RR000071 (1), P20MH068662 (1), P30MH086045 (1), R01AG058671 (1), R01HD105305 (1), R01MH078060 (1), R01MH079261 (1), R01MH082845 (1), R01MH090276 (1)