Trauma and Stressor Related Disorders: Clinical Trials

1699 completed, 426 recruiting, 337 unknown, 151 not yet recruiting. 1884 Not applicable, 346 Phase 2, 138 Phase 1, 138 Phase 3, 112 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	1884	Completed 1075, Recruiting 294, Unknown 195, Not yet recruiting 103, Active not recruiting 65, Terminated 64, Withdrawn 59, Enrolling by invitation 25, Suspended 4
Phase 2	346	Completed 177, Recruiting 54, Unknown 30, Terminated 28, Withdrawn 23, Not yet recruiting 18, Active not recruiting 7, Suspended 6, Enrolling by invitation 3
Phase 1	138	Completed 89, Recruiting 12, Unknown 11, Withdrawn 11, Terminated 8, Not yet recruiting 4, Active not recruiting 3
Phase 3	138	Completed 82, Recruiting 15, Unknown 13, Terminated 11, Withdrawn 7, Active not recruiting 5, Not yet recruiting 3, Enrolling by invitation 2
Phase 4	112	Completed 68, Terminated 13, Recruiting 10, Unknown 8, Withdrawn 7, Not yet recruiting 4, Active not recruiting 2
Early Phase 1	43	Completed 23, Recruiting 6, Not yet recruiting 5, Unknown 4, Terminated 2, Withdrawn 2, Suspended 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
RISE for PTSD and Substance Use Disorder in Veterans Written Exposure Therapy, Cognitive Behavioral Therapy for Substance Use Disorders (skill components), Cognitive Behavioral Therapy for Substance Use Disorders - Stress Disorders, Post-Traumatic, Substance-Related Disorders	Not applicable	Not yet recruiting	VA Office of Research and Development	30	2028-08-01	2026-10-29
The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veterans Acceptance and Commitment Therapy for Social Health, Achievement, and Relationship Effectiveness (ACT-SHARE) - Alcohol Problems, Post-Traumatic Stress Disorder	Not applicable	Not yet recruiting	VA Office of Research and Development	29	2028-07-03	2025-11-19
Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002 Intervention D SLS-002, Intervention D Placebo - Post Traumatic Stress Disorder	Phase 2	Suspended	Global Coalition for Adaptive Research	200	2028-05-01	2026-05-20
ACT for Veterans With IBD and Mental Health Challenges Acceptance and Commitment Therapy - Inflammatory Bowel Diseases, Crohn's Disease	Not applicable	Not yet recruiting	VA Office of Research and Development	50	2028-01-01	2026-02-09
Department of Defense PTSD Adaptive Platform Trial - Intervention B - Vilazodone Intervention B Vilazodone Hydrochloride (HCl), Intervention B Placebo - Post Traumatic Stress Disorder	Phase 2	Not yet recruiting	Global Coalition for Adaptive Research	200	2027-08-01	2026-05-20
Identification of Physiological Sleep Indices That Reflect Clinical Improvement and Reduction in Stress Biomarkers After Stellate Ganglion Block in Patients With Posttraumatic Stress Disorder (PTSD) Stellate ganglion block - Post Traumatic Stress Disorder	Not applicable	Not yet recruiting	sara dichtwald	60	2027-08-01	2026-10-07
Cognitive Training for Functioning in PTSD COGENT (Cognitive ENhancement Training), ST (Sham Training) - Posttraumatic Stress Disorder	Not applicable	Not yet recruiting	VA Office of Research and Development	176	2027-07-01	2026-07-16
Salience Network Informed rTMS for PTSD Active MRI-Guided intermittent theta burst stimulation (iTBS), Sham MRI-Guided intermittent theta burst stimulation (iTBS) - Stress Disorders, Post-Traumatic	Not applicable	Not yet recruiting	VA Office of Research and Development	84	2027-07-01	2026-10-27
Written Exposure Therapy Plus Adjunctive Methylphenidate Treatment for Veterans With PTSD Written Exposure Therapy (WET), methylphenidate (MPH), placebo (PBO) - PTSD - Post Traumatic Stress Disorder	Phase 2	Not yet recruiting	VA Office of Research and Development	138	2027-07-01	2026-10-29
Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries	Phase 2	Not yet recruiting	VA Office of Research and Development	46	2027-05-24	2026-02-17
A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression Symptoms Self-Guided STAIR Coach with Real-Time Assessment, Real-Time Assessment - Psychosocial Functioning, Stress Disorders, Post-Traumatic	Not applicable	Not yet recruiting	VA Office of Research and Development	40	2027-04-01	2026-10-06
Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain Mantram Repetition Program for PTSD + Pain, Health Education while Living with Pain - Stress Disorders, Post-Traumatic, Pain, Chronic	Not applicable	Not yet recruiting	VA Office of Research and Development	170	2027-04-01	2026-07-27
Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation - PTSD - Post Traumatic Stress Disorder	Early Phase 1	Not yet recruiting	Wayne State University	60	2027-04-01	2026-07-13
Assessing Trauma-related Links Between Affective and Metabolic Systems prazosin - Posttraumatic Stress Disorder, Metabolic Syndrome	Phase 4	Not yet recruiting	VA Office of Research and Development	70	2027-03-01	2026-10-15
PTSD and Alcohol Couples Treatment for Veterans COPE + BFIT - PTSD, AUD	Early Phase 1	Not yet recruiting	VA Office of Research and Development	80	2027-03-01	2026-02-10
Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms Resilience Training for Veterans (REST-V), Usual resources - Depression, Stress Disorders, Post-Traumatic	Not applicable	Not yet recruiting	VA Office of Research and Development	200	2027-03-01	2026-09-01
Inhaled Cannabis for Treatment of PTSD High THC Cannabis, Placebo cannabis - Post Traumatic Stress Disorder PTSD	Phase 2	Not yet recruiting	Multidisciplinary Association for Psychedelic Studies	320	2027-02-01	2026-08-11
Pregnenolone to Target Concurrent PTSD and Stress Induced Alcohol Use in Veterans: A Dose Finding Study Brexanolone - Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)	Phase 2	Not yet recruiting	Pharmacotherapies for Alcohol and Substance Use Disorders Alliance	40	2027-01-15	2026-09-21
Improving Mental Healthcare Outcomes for Minoritized Veterans Through a Peer-led, Patient Navigation Program (PARTNER-MH 2.0) PARTNER-MH, Educational Brochure - Diagnoses of Depression, Anxiety	Not applicable	Not yet recruiting	VA Office of Research and Development	268	2027-01-04	2026-06-16
An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma Cognitive Processing Therapy - Post-Traumatic Stress Disorder, Chronic, Depressed Mood	Not applicable	Not yet recruiting	University of Alabama at Birmingham	25	2027-01-01	2026-10-15

Showing 20 of 3014. Sign in to see all of them.

Narrower conditions

Stress Disorders, Post-Traumatic (2650)  ·  Depression (520)  ·  Anxiety Disorders (494)  ·  Wounds and Injuries (226)  ·  Combat Disorders (196)  ·  Psychological Trauma (138)  ·  Substance-Related Disorders (136)  ·  Stress Disorders, Traumatic (119)  ·  Psychological Well-Being (115)  ·  Alcoholism (105)  ·  Depressive Disorder, Major (94)  ·  Brain Injuries, Traumatic (93)  ·  Sleep Initiation and Maintenance Disorders (82)  ·  Mental Disorders (74)  ·  Adjustment Disorders (61)

Broader conditions

Mental Disorders (2940)  ·  Stress Disorders, Traumatic (2797)  ·  Behavior (837)  ·  Behavioral Symptoms (631)  ·  Nervous System Diseases (348)  ·  Pathological Conditions, Signs and Symptoms (302)  ·  Chemically-Induced Disorders (261)  ·  Signs and Symptoms (214)  ·  Mood Disorders (173)  ·  Neurologic Manifestations (170)  ·  Central Nervous System Diseases (166)  ·  Brain Diseases (159)  ·  Wounds and Injuries (154)  ·  Trauma, Nervous System (134)

Interventions

Therapeutics (112)  ·  Cognitive Behavioral Therapy (89)  ·  Eye Movement Desensitization Reprocessing (47)  ·  N-Methyl-3,4-methylenedioxyamphetamine (39)  ·  2-cyclohexylidenhydrazo-4-phenyl-thiazole (32)  ·  Ketamine (32)  ·  Transcranial Magnetic Stimulation (32)  ·  Sertraline (29)  ·  Propranolol (28)  ·  Psilocybin (26)  ·  Prazosin (24)  ·  Psychotherapy (23)  ·  Exercise (21)  ·  Implosive Therapy (21)  ·  Paroxetine (18)

Sponsors

VA Office of Research and Development (269)  ·  US Department of Veterans Affairs (56)  ·  Medical University of South Carolina (47)  ·  Karolinska Institutet (39)  ·  University of Washington (37)  ·  Yale University (35)  ·  Emory University (33)  ·  Stanford University (31)  ·  Duke University (30)  ·  The University of Texas Health Science Center at San Antonio (30)  ·  Massachusetts General Hospital (29)  ·  University of Konstanz (28)  ·  Assistance Publique - Hôpitaux de Paris (24)  ·  NYU Langone Health (21)  ·  University of California, Los Angeles (21)

Countries

United States (1800)  ·  France (165)  ·  Canada (140)  ·  Israel (106)  ·  Sweden (67)  ·  Germany (61)  ·  United Kingdom (52)  ·  Switzerland (49)  ·  Norway (47)  ·  Turkey (Türkiye) (43)  ·  Denmark (34)  ·  Netherlands (34)  ·  Spain (34)  ·  China (28)  ·  Italy (21)

Top investigators

Joseph Zohar, MD (9)  ·  Yuval Neria, PhD (7)  ·  Charles Marmar, MD (6)  ·  JoAnn Difede, PhD (6)  ·  Yair Bar-Haim, PhD (6)  ·  Douglas Zatzick, MD (5)  ·  James S Gordon, MD (5)  ·  Lori L Davis, MD (5)  ·  Thomas Elbert, Prof. Dr. (5)  ·  Zev Schuman-Olivier, MD (5)  ·  Adriana Feder, MD (4)  ·  Alan L Peterson, PhD (4)  ·  Casey Straud, PsyD (4)  ·  Christine E Marx, MD, MA (4)

Results publications

PMID 37795783, PMID 38767196, PMID 35141873, PMID 31065731, PMID 31572236, PMID 32500209, PMID 32368793, PMID 26606250, PMID 33972795, PMID 34480016, PMID 12182270, PMID 17503104, PMID 18279507, PMID 19101777, PMID 21946660, PMID 24506079, PMID 24740528, PMID 24893322, PMID 25441015, PMID 25706090, PMID 28239485, PMID 28453969, PMID 28569390, PMID 29746232, PMID 29793970, PMID 31092670, PMID 31343205, PMID 32034416, PMID 32077948, PMID 32608505, PMID 33431807, PMID 33587394, PMID 33947471, PMID 34015141, PMID 34672659, PMID 34941354, PMID 35395811, PMID 35833254, PMID 35901423, PMID 36938380, PMID 36987703, PMID 37146219, PMID 37709999, PMID 37833734, PMID 38805199, PMID 38907784, PMID 40387497, PMID 40811121, PMID 41460640, PMID 41464305

NIH funding

2023 (8), 2019 (7), 2025 (5), P30AG064198 (5), 2016 (4), 2017 (3), K23DA016574 (2), P20AA017839 (2), P50MH058911 (2), P50MH115837 (2), R01AA028776 (2), R01MH051509 (2), R01MH064662 (2), R01MH066348 (2), R01MH122867 (2)