129 completed, 34 recruiting, 23 terminated, 18 withdrawn. 104 Not applicable, 43 Phase 2, 25 Phase 1, 15 Phase 4, 10 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Digital Coach to Support Exposure Therapy Homework for Anxious Youth BraveBot, Self-Guided Exposure Therapy Homework - Anxiety Disorders, OCD | Not applicable | Not yet recruiting | Massachusetts General Hospital | 50 | 2027-02-01 | 2026-10-07 |
| Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis Smartphone-based Mindfulness Exercise, Smartphone-based Psychoeducation, Neutral Control Message - Psychosis, Anxiety | Not applicable | Not yet recruiting | Mclean Hospital | 10 | 2027-01-15 | 2026-10-05 |
| EEG and Actigraphy Biomarkers of Written Exposure Therapy for Posttraumatic Stress Disorder Written Exposure Therapy, Neutral Writing Condition - Posttraumatic Stress Disorder (PTSD) | Not applicable | Not yet recruiting | Mclean Hospital | 200 | 2027-01-01 | 2026-10-14 |
| Gamma Light and Sound Stimulation in Schizophrenia GENUS, Sham Stimulation - Schizophrenia Spectrum Disorders | Not applicable | Not yet recruiting | Massachusetts Institute of Technology | 20 | 2026-12-01 | 2026-10-07 |
| Single Session Intervention for Postpartum Intrusive Thoughts Postpartum Intrusive Thoughts and Anxiety (PITA) Program - Postpartum Intrusive Thoughts | Not applicable | Not yet recruiting | Mclean Hospital | 30 | 2026-10-01 | 2026-07-27 |
| Recovery Inspired Support Engagement (RISE) Pilot ITC - Support Persons, Family Members | Not applicable | Recruiting | Mclean Hospital | 18 | 2026-09-14 | 2026-09-15 |
| One-Day cTBS Over the Precuneus Precuneus-targeted continuous theta-burst stimulation, Left dorsolateral prefrontal cortex intermittent theta-burst stimulation, Sham transcranial magnetic stimulation - Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD) | Not applicable | Recruiting | Mclean Hospital | 69 | 2026-09-08 | 2026-09-11 |
| Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101 TMS, NRX-101 - Major Depression | Early Phase 1 | Not yet recruiting | Mclean Hospital | 30 | 2026-09-01 | 2026-09-22 |
| Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder Sham iTBS, TMS, D-cycloserine - Major Depression, Healthy Participants | Phase 1 / Phase 2 | Not yet recruiting | Mclean Hospital | 100 | 2026-09-01 | 2026-08-14 |
| A Pilot Trial of One-Day Accelerated TMS and D-cycloserine in Suicidal Patients With Borderline Personality Disorder TMS, D-Cycloserine (DCS) - Borderline Personality Disorder (BPD) | Phase 1 / Phase 2 | Recruiting | Mclean Hospital | 20 | 2026-06-10 | 2026-08-05 |
| Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism Niagen® - Healthy Adult | Not applicable | Recruiting | Massachusetts General Hospital | 50 | 2026-06-01 | 2026-06-17 |
| Mechanisms of Written Exposure Therapy in Residential SUD Treatment Written Exposure Therapy, Neutral Writing - PTSD - Post Traumatic Stress Disorder, Substance Use Disorder (SUD) | Not applicable | Not yet recruiting | Mclean Hospital | 108 | 2026-06-01 | 2026-02-09 |
| An Intervention to Reduce Discrepancy in Everyday Preferences Templated, clinician-facilitated intervention to align everyday living preferences assessment - Dementia, Mild Cognitive Impairment | Not applicable | Withdrawn | Mclean Hospital | 2026-04-01 | 2026-06-30 | |
| Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression D-Cycloserine (DCS), Continuous theta-burst stimulation (cTBS), Transcranial Magnetic Stimulation Sham - Major Depression | Early Phase 1 | Recruiting | Mclean Hospital | 80 | 2026-03-11 | 2026-05-13 |
| BXCL501 After Stress to Increase Recovery Success BXCL501 (dexmedetomidine HCl), Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 100 | 2026-02-23 | 2026-04-14 |
| Identifying Substance Use Consequences none, there is no intervention in this study - Substance Use Disorder (SUD) | Recruiting | Mclean Hospital | 50 | 2026-02-10 | 2026-03-31 | |
| Stress Dynamics and Familial Risk for Depression in Female Adolescents Computer Task Manipulation - Major Depressive Disorder | Not applicable | Recruiting | Mclean Hospital | 148 | 2025-10-15 | 2025-10-23 |
| Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans Nociceptin Receptor Antagonist (LY-2940094), DS8R Biphasic Constant Current Stimulator - Depression - Major Depressive Disorder, Anxiety | Phase 2 | Withdrawn | Mclean Hospital | 2025-06-01 | 2025-09-25 | |
| Novel and Conventional Interventions for Cognitive and Emotional Flexibility in Patient Trauma D-Cycloserine (DCS), Transcranial Magnetic Stimulation, Unified Protocol - Depression, Anxiety | Phase 2 | Active not recruiting | Mclean Hospital | 75 | 2025-06-01 | 2026-10-09 |
| Pharmacologic Augmentation of TMS for Depression With D-serine TMS, D-serine, Placebo - Depression | Phase 1 | Recruiting | Mclean Hospital | 60 | 2025-04-01 | 2026-05-15 |
Showing 20 of 238. Sign in to see all of them.
Depression (45) · Depressive Disorder, Major (37) · Bipolar Disorder (36) · Anxiety Disorders (24) · Psychotic Disorders (23) · Schizophrenia (23) · Opioid-Related Disorders (15) · Tobacco Use Disorder (15) · Stress Disorders, Post-Traumatic (11) · Substance-Related Disorders (10) · Alcoholism (9) · Obsessive-Compulsive Disorder (9) · Mania (8) · Cognitive Dysfunction (7) · Marijuana Abuse (7)
Nicotine (8) · Transcranial Magnetic Stimulation (7) · Cycloserine (6) · Memantine (5) · Cannabidiol (4) · Therapeutics (4) · Buprenorphine (3) · Cognitive Behavioral Therapy (3) · Glycine (3) · Progesterone (3) · Sertraline (3) · Sugars (3) · nicotinamide-beta-riboside (3) · Alprazolam (2) · Amisulpride (2)
United States (221) · Canada (2) · Denmark (1) · Ecuador (1) · Israel (1) · Pakistan (1) · Russia (1) · Switzerland (1)
Diego Pizzagalli, PhD (8) · Beth L Murphy, MD, PhD (5) · Brent P Forester, MD (4) · Brian P Brennan, MD (4) · Dost Ongur, MD PhD (4) · Nancy K Mello, PhD (4) · Brian P Brennan, M.D. (3) · Courtney Beard, PhD (3) · David Borsook, MD, PhD (3) · Diego A Pizzagalli, Ph.D. (3) · Diego A Pizzagalli, PhD (3) · Diego A. Pizzagalli, PhD (3) · Jack Mendelson, M.D. (3) · James I Hudson, M.D., Sc.D. (3) · Kevin P Hill, MD, MHS (3)
PMID 14702256, PMID 24331545, PMID 31279534, PMID 31784354, PMID 32368793, PMID 36375174, PMID 10689661, PMID 15474895, PMID 15780843, PMID 16677714, PMID 17446014, PMID 17897484, PMID 18821452, PMID 19411368, PMID 19434621, PMID 19548294, PMID 19956089, PMID 20427731, PMID 20520285, PMID 20625473, PMID 20958851, PMID 21132846, PMID 21308886, PMID 21397626, PMID 21753920, PMID 22065255, PMID 22143072, PMID 22926607, PMID 23117126, PMID 23607675, PMID 23750742, PMID 24219166, PMID 24294145, PMID 24699040, PMID 25042759, PMID 25189089, PMID 25562462, PMID 26048637, PMID 26356811, PMID 26364274, PMID 26871943, PMID 26891040, PMID 26969299, PMID 27647710, PMID 27929004, PMID 28009467, PMID 28703950, PMID 28942738, PMID 29045770, PMID 29486867
R01MH068376 (3), K23DA050808 (2), P50MH119467 (2), R34MH097820 (2), U01DA019378 (2), 3UG1DA015831-21S4 (1), F32MH115530 (1), K01DA023659 (1), K01DA029645 (1), K23DA050780 (1), K23DA051406 (1), K23DK120517 (1), K23MH077287 (1), K23MH091210 (1), K23MH097786 (1)