2784 completed, 1065 recruiting, 1052 unknown, 929 terminated. 3126 Phase 2, 1969 Phase 1, 813 Phase 3, 669 Not applicable, 91 Phase 4.
Follow Carcinoma, Non-Small-Cell Lung: new trials by email Literature Review of Carcinoma, Non-Small-Cell Lung trials Research Report on Carcinoma, Non-Small-Cell Lung
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of RC48-ADC Combined With Pyrotinib For Treatment of Local Advanced or Metastasis NSCLC With HER2 Mutation RC48-ADC, Pyrotinib - Non-small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | RemeGen Co., Ltd. | 26 | 2027-12-01 | 2026-09-22 |
| Multinational Observational Study to Describe Diagnostic Stage Shift in Patients With Lung Cancer Using Medical Records Lung Cancer | Not yet recruiting | AstraZeneca | 3000 | 2027-04-01 | 2026-06-02 | |
| Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial Atezolizumab, Atezolizumab and Recombinant Human Hyaluronidase, Biospecimen Collection - Lung Non-Small Cell Carcinoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 336 | 2027-03-02 | 2026-10-26 |
| Lung Functional Avoidance Radiotherapy Using Hyperpolarized Xenon MRI Hyperpolarized xenon MRI - Carcinoma, Non-Small-Cell Lung | Phase 1 / Phase 2 | Not yet recruiting | Xemed LLC | 10 | 2027-03-01 | 2026-09-01 |
| Using an Artificial Intelligence Software Tool (iSeg) During Radiation Treatment Planning for Patients With Lung Tumors Artificial Intelligence-based Intervention, Best Practice, Computed Tomography - Lung Carcinoma, Lung Non-Small Cell Carcinoma | Not applicable | Not yet recruiting | Northwestern University | 34 | 2027-02-13 | 2026-10-27 |
| OLE Study Subsequent to Parent Study of Rilogrotug for the Treatment of Weight Loss and Anorexia in Patients With Cancer Cachexia and mCRC or mNSCLC Rilogrotug - Cachexia; Cancer, Cachexia | Phase 2 / Phase 3 | Not yet recruiting | AVEO Pharmaceuticals, Inc. | 400 | 2027-02-01 | 2026-10-22 |
| DK222 Study at Hopkins [18F]DK222 radiotracer - Non-Small Cell Lung Cancer, Urothelial Cancer | Phase 1 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 6 | 2027-01-31 | 2026-09-29 |
| Study Using a Drug-device Combination Product to Determine Safety, Tolerability and Antitumor Activity for Patients With Advanced, Non-small Cell Lung Cancer NHT102, DryNeb - NSCLC (Advanced Non-small Cell Lung Cancer) | Phase 1 / Phase 2 | Not yet recruiting | Nob Hill Therapeutics, Inc. | 100 | 2027-01-11 | 2026-10-08 |
| A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan Compared to Standard of Care in Adult Participants Previously Treated, EGFR Wildtype, Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer Telisotuzumab Adizutecan, Docetaxel, Ramucirumab - Non-Squamous Non-Small Cell Lung Cancer | Phase 3 | Not yet recruiting | AbbVie | 660 | 2027-01-06 | 2026-10-05 |
| Effects of Supervised Aerobic Exercise on Biomarkers in Patients With nSCLC Receiving Immunotherapy Exercise - Non-Small Cell Lung Cancer, Aerobic Exercise | Not applicable | Not yet recruiting | Izmir Bakircay University | 78 | 2027-01-04 | 2026-10-21 |
| Perioperative Cemiplimab for Resectable Non-Small Cell Lung Cancer With High PD-L1 Cemiplimab, Adjuvant chemotherapy - Lung Cancer (NSCLC) | Phase 2 | Not yet recruiting | Henry Ford Health System | 33 | 2027-01-01 | 2026-07-15 |
| ctDNA-Guided Intraventricular Therapy for CNS Malignancies CSF ctDNA-Guided Clinical Management - Leptomeningeal Disease, Glioblastoma | Not applicable | Not yet recruiting | Alireza Mansouri | 77 | 2027-01-01 | 2026-07-08 |
| A Multicenter Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced / Metastatic Solid Tumors. Signatera Genome ultra-sensitive ctDNA blood test - NSCLC (Advanced Non-small Cell Lung Cancer), NSCLC (Non-small Cell Lung Cancer) | Not applicable | Not yet recruiting | Natera, Inc. | 920 | 2027-01-01 | 2026-10-27 |
| Immune Checkpoint Blockade and Chemotherapy With or Without Fecal Microbiota Transplant in Advanced Non-Small Cell Lung Cancer LND101, Carboplatin, Pemetrexed - Non Small Cell Lung Cancer | Phase 2 | Not yet recruiting | Canadian Cancer Trials Group | 160 | 2026-12-31 | 2026-10-27 |
| The APRIL Trial Evaluating Upfront Stereotactic Body Radiotherapy in Stage III Advanced Non-small Cell Lung Cancer SBRT in stage III NSCLC - Non Small Cell Lung Cancer | Not applicable | Not yet recruiting | All India Institute of Medical Sciences | 20 | 2026-12-19 | 2026-09-24 |
| A Study Evaluating The Combination of Immunotherapy With Radiotherapy in Non-Small Cell Lung Cancer Investigator Choice Immunotherapy (for example: pembrolizumab, cemiplimab, durvalumab, ipilimumab plus nivolumab), Investigator Choice Chemotherapy (for example docetaxel with or without ramucirumab, gemcitabine, or other National Comprehensive Cancer Network (NCCN)-recommended treatments), Ablative Hypofractionated Radiotherapy - Non-Small Cell Lung Cancer, Metastatic Lung Cancer | Phase 2 | Recruiting | University of Chicago | 39 | 2026-12-12 | 2026-06-16 |
| 3-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary Segmental Resection Trial 3-Dimensional VR Modelling (Elucis) with Intravascular Indocyanine Green Fluorescence Mapping, 3-Dimensional Modelling (Synapse 3D) with Intravascular Indocyanine Green Fluorescence Mapping - Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | St. Joseph's Healthcare Hamilton | 89 | 2026-12-01 | 2026-02-02 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Docetaxel Plus Plinabulin vs Docetaxel Plus Placebo in Advanced/Metastatic Non-Squamous NSCLC After PD-1/PD-L1 Therapy and Platinum Chemotherapy (DUBLIN-4) Plinabulin, Docetaxel, Placebo (matching plinabulin placebo) - Non-Small Cell Lung Cancer, Non-squamous Non-Small Cell Lung Cance | Phase 3 | Not yet recruiting | BeyondSpring Pharmaceuticals Inc. | 442 | 2026-12-01 | 2026-09-29 |
| TCR1188-ABC Cells in KRAS-mutated Cancers TCR1188-ABC cells, Fludarabine + Cyclophosphamide combination, Tocilizumab - Cholangiocarcinoma, Colorectal Cancer | Phase 1 | Recruiting | University of Pennsylvania | 30 | 2026-12-01 | 2026-10-14 |
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Lung Neoplasms (1775) · Colorectal Neoplasms (444) · Neoplasms (436) · Melanoma (404) · Breast Neoplasms (387) · Neoplasm Metastasis (344) · Small Cell Lung Carcinoma (344) · Squamous Cell Carcinoma of Head and Neck (295) · Ovarian Neoplasms (294) · Carcinoma, Renal Cell (285) · Pancreatic Neoplasms (269) · Adenocarcinoma of Lung (235) · Stomach Neoplasms (231) · Triple Negative Breast Neoplasms (197)
Respiratory Tract Diseases (7033) · Carcinoma, Bronchogenic (7032) · Neoplasms by Site (7030) · Bronchial Neoplasms (7028) · Respiratory Tract Neoplasms (7025) · Thoracic Neoplasms (7017) · Lung Diseases (7006) · Neoplasms (6636) · Lung Neoplasms (5297) · Neoplasms by Histologic Type (1375) · Neoplasms, Glandular and Epithelial (1188) · Carcinoma (966) · Digestive System Diseases (827) · Skin and Connective Tissue Diseases (816) · Digestive System Neoplasms (814)
Carboplatin (813) · Pemetrexed (632) · Cisplatin (565) · Paclitaxel (502) · pembrolizumab (484) · Docetaxel (447) · Gemcitabine (331) · Erlotinib Hydrochloride (307) · Radiotherapy (262) · Nivolumab (248) · Bevacizumab (233) · osimertinib (185) · Drug Therapy (167) · durvalumab (160) · Radiosurgery (138)
AstraZeneca (181) · National Cancer Institute (NCI) (173) · Eli Lilly and Company (141) · Pfizer (121) · M.D. Anderson Cancer Center (105) · Sun Yat-sen University (96) · Novartis Pharmaceuticals (91) · Hoffmann-La Roche (90) · Bristol-Myers Squibb (86) · Merck Sharp & Dohme LLC (81) · Boehringer Ingelheim (66) · Memorial Sloan Kettering Cancer Center (66) · Alliance for Clinical Trials in Oncology (65) · Fudan University (50) · Hunan Province Tumor Hospital (48)
United States (3218) · China (1685) · France (797) · Spain (784) · Italy (645) · South Korea (634) · Canada (624) · Germany (560) · United Kingdom (529) · Taiwan (477) · Australia (469) · Japan (417) · Belgium (391) · Netherlands (391) · Poland (364)
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