53 completed, 17 unknown, 10 recruiting, 4 active not recruiting. 25 Not applicable, 19 Phase 3, 14 Phase 4, 11 Phase 2, 4 Phase 1.
Follow Antidepressive Agents: new trials by email Literature Review of Antidepressive Agents trials Research Report on Antidepressive Agents
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Biomarkers and Pharmacogenomics for Precision Depression Therapy Pharmacogenomic Testing, Antidepressant Agents - Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 220 | 2026-07-01 | 2026-07-31 |
| Psychoactive Drug Use and Acute Care Use After Trauma and Out-of-Hospital Cardiac Arrest Opioids (ATC N02A), Antiepileptics (ATC N03A), Antipsychotics (ATC N05A) - Wounds and Injuries, Out-of-Hospital Cardiac Arrest | Active not recruiting | Azienda Usl di Bologna | 52720 | 2026-06-10 | 2026-10-20 | |
| Efficacy and Mechanisms of Escitalopram in Drug-Naïve First-Episode Major Depressive Disorder Escitalopram (Oral antidepressant) - Depression - Major Depressive Disorder | Not applicable | Recruiting | Peking University | 200 | 2026-03-20 | 2026-08-20 |
| Dorsal Penile Nerve Cryoneurolysis for Lifelong PE Percutaneous Dorsal Penile Nerve Cryoneurolysis, Sertraline (Oral Antidepressant), Tadalafil 5 mg - Premature Ejaculation | Not applicable | Completed | Biruni University | 117 | 2026-02-04 | 2026-10-16 |
| Clinical Effect and Mechanism Study of Five Elements Music Therapy(FEMT) on Depression Disorder Five-Element Music 1 combined with antidepressant medication, Five-Element Music 2 combined with antidepressant medication, No Intervention: Observational Cohort - Depression Disorder, Depression Disorders | Not applicable | Not yet recruiting | Shanghai Mental Health Center | 120 | 2025-07-01 | 2025-07-03 |
| Moving on After Breast Cancer Trial for Depressed Breast Cancer Survivors in Pakistan Non-specialist delivered Low intensity guided self-help (Khushi and Khatoon), Moving on After Breast Cancer (ABC) plus, Standardised pharmacological treatment (antidepressants) - Major Depressive Disorder (MDD), Breast Cancer Survivor | Not applicable | Recruiting | Pakistan Institute of Living and Learning | 26376 | 2025-06-13 | 2026-03-18 |
| Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. Group A: (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol,anxiolytics: clonazepam, stedon, tavor antidepressants: seropram),, Group B (Pharmacotherapy and TAU) (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, antidepressants,, Group C (Pharmacotherapy and Psychotherapy) Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, lithium, depakine - Treatment Resistant Schizophrenia, Treatment Resistant Bipolar Disorder | Phase 4 | Active not recruiting | Dr. Stavroula Rakitzi | 84 | 2025-06-04 | 2026-05-01 |
| Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders Physical Exercise, Antidepressant medication (ADM) - Major Depressive Disorder, Inflammatory Response | Not applicable | Recruiting | Fundación de Investigación Biomédica - Hospital Universitario de La Princesa | 124 | 2025-04-21 | 2026-09-02 |
| Effective of Transcranial Magnetic Stimulation (TMS) vs Treatment as Usual for First-Episode Depression in Adults Transcranial magnetic stimulation, Antidepressant - Major Depressive Disorder | Phase 4 | Not yet recruiting | Sultan Qaboos University | 120 | 2025-01-01 | 2024-10-28 |
| Pharmacogenomics of Mood Disorder in Chronic Kidney Disease Patients Antidepressants - Chronic Kidney Disease(CKD), Depression | Not yet recruiting | Wonju Severance Christian Hospital | 300 | 2024-12-01 | 2024-11-05 | |
| Comparison of the Effectiveness Level of Virtual Reality Exposure Therapy With Sertraline Treatment in Social Anxiety Disorder Virtual Reality Exposure Therapy, Sertraline (Oral Antidepressant) - Social Anxiety Disorder | Phase 4 | Recruiting | Emine Kanmaz | 56 | 2024-11-15 | 2025-09-25 |
| Effect of Sertraline on Inflammation in Hemodialysis Patients with Depression: a Randomized Controlled Trial Sertraline (Oral Antidepressant), Placebo - Inflamation, Hemodialysis | Not applicable | Active not recruiting | Nishtar Medical University | 62 | 2024-10-15 | 2025-03-04 |
| Improving Outcomes in Depression in Primary Care in a Low Resource Setting Healthy Activity Program (HAP), Antidepressant medication (fluoxetine) - Depression, Depressive Disorder | Phase 3 | Active not recruiting | Harvard Medical School (HMS and HSDM) | 1500 | 2024-03-18 | 2026-05-22 |
| Chemotherapy Induced Peripheral Neuropathy by Taxanes and Capsaicin 8%. Capsaicin 8% Patch, antidepressants (tricyclics and serotonin reuptake inhibitor SRIs), antiepiletics, lidocaine patches, and neurostimulation - Patients With Taxane-induced Chronic Neuropathic Pain | Not applicable | Recruiting | Hospital Ambroise Paré Paris | 50 | 2024-03-12 | 2026-05-22 |
| Maternal And Infant Antipsychotic Study Antipsychotics, Non-antipsychotic medication, No Medication - Antipsychotics, Pregnancy | Recruiting | Icahn School of Medicine at Mount Sinai | 74 | 2023-09-29 | 2026-06-22 | |
| OptimizeD Pilot Study Healthy Activity Program (HAP), Antidepressant medication (ADM) - Depression, Depressive Disorder | Phase 3 | Completed | Harvard Medical School (HMS and HSDM) | 76 | 2023-08-01 | 2024-04-09 |
| Neuronavigation Guided iTBS With Personalized Target for Depression sham iTBS combined with antidepressants, iTBS combined with antidepressants - Depression | Phase 2 | Completed | Xijing Hospital | 68 | 2023-07-10 | 2026-04-27 |
| The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. Pregabalin, Tianeptine - Post-mastectomy Pain Syndrome | Not applicable | Completed | National Cancer Institute, Egypt | 90 | 2023-06-21 | 2025-03-10 |
| Side Effects of Psychiatric Medications - a Nested Case Control Cohort Historical Prospective Study Psychiatric Drugs - Psychotic Disorders | Unknown | Mark Weiser, MD, Principal Investigator | 22777 | 2023-03-26 | 2024-03-04 | |
| Study of Virtual Reality-based Medical Device for Patients with Depressive Disorder OMNIFIT DTx-MDD, standard treatment - Depressive Disorder, Major Depressive Disorder | Not applicable | Completed | Omni C&S | 162 | 2023-03-09 | 2024-11-04 |
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Depression (42) · Depressive Disorder, Major (32) · Depressive Disorder, Treatment-Resistant (8) · Anxiety Disorders (6) · Depressive Disorder (6) · Bipolar Disorder (3) · Breast Neoplasms (3) · Inflammation (3) · Mental Disorders (3) · Mood Disorders (3) · Motor Activity (3) · Psychotic Disorders (3) · Schizophrenia (3) · Acute Coronary Syndrome (2) · Autism Spectrum Disorder (2)
Janssen Research & Development, LLC (7) · Shire (4) · Centre for Addiction and Mental Health (3) · Otsuka Pharmaceutical Development & Commercialization, Inc. (3) · University Hospital, Caen (3) · El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez (2) · Harvard Medical School (HMS and HSDM) (2) · New York State Psychiatric Institute (2) · Ajay Wasan, MD, Msc (1) · Alliance for Clinical Trials in Oncology (1) · Azienda Usl di Bologna (1) · Baker Heart and Diabetes Institute (1) · Biruni University (1) · Butler Hospital (1) · Centre Hospitalier Universitaire de Saint Etienne (1)
United States (30) · China (12) · France (9) · Germany (9) · Spain (9) · Brazil (8) · Canada (8) · Mexico (6) · Poland (6) · Belgium (5) · Chile (4) · Czechia (4) · Estonia (4) · Finland (4) · Hungary (4)
Abdul Khalid (1) · Ajay Wasan, MD, MSc (1) · Anna R. Brandon, PhD, MSCS (1) · Antoni Serrano, PhD (1) · Antonio R Cano-Vindel, Professor (1) · Bernhard T. Baune, Professor (1) · Bill J Duke, M.A., Ph.D. (1) · Boadie W Dunlop, MD/MS (1) · Carlos A Zarate, M.D. (1)
PMID 32860422, PMID 34235612, PMID 33128208, PMID 35022754, PMID 38557430, PMID 18832427, PMID 20816039, PMID 21731833, PMID 23106023, PMID 23585997, PMID 23585999, PMID 24766999, PMID 32367114, PMID 34288609, PMID 34510411, PMID 34973081, PMID 36149841, PMID 36273682, PMID 37019044, PMID 39428602, PMID 10990547, PMID 11063978, PMID 11723286, PMID 12244081, PMID 12949224, PMID 14677403, PMID 15147306, PMID 15351385, PMID 15987799, PMID 16002441, PMID 16794566, PMID 17146104, PMID 17591596, PMID 17592907, PMID 17657327, PMID 19192475, PMID 19254516, PMID 19287552, PMID 19332318, PMID 19403329, PMID 19470987, PMID 19671217, PMID 19853048, PMID 20098527, PMID 20633386, PMID 21068312, PMID 21167786, PMID 21494337, PMID 21511342, PMID 21631313
2014 (5), R01MH121632 (2), 2015 (1), K23MH099097 (1), R01HD111117 (1), R01HL114924 (1), R01MH062719 (1), R01MH066992 (1), R01MH071268 (1), R01MH073719 (1), R34MH070642 (1), R37MH051247 (1), UG3AR076568 (1)