11 completed, 1 terminated. 12 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Completed 11, Terminated 1 |
| Phase 2 | 3 | Completed 2, Terminated 1 |
Follow Unipolar Depression: new trials by email Literature Review of Unipolar Depression trials Research Report on Unipolar Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine As an Adjunctive Therapy for Major Depression (2) Ketamine, Midazolam - Major Depressive Episode, Unipolar Depression | Phase 3 | Completed | University of Dublin, Trinity College | 63 | 2021-09-13 | 2025-02-13 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) electroconvulsive therapy (ECT), Ketamine - Treatment Resistant Depression, Electroconvulsive Therapy | Phase 2 / Phase 3 | Completed | Bo Hu | 403 | 2017-04-07 | 2023-09-28 |
| Investigating tDCS as a Treatment for Unipolar and Bipolar Depression Sham tDCS device, Soterix tDCS device - Unipolar Depression, Bipolar Depression | Phase 2 / Phase 3 | Completed | The University of New South Wales | 120 | 2012-06-01 | 2015-12-02 |
| A Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior IPT-A - Unipolar Depression, Dysthymia | Phase 3 | Completed | New York State Psychiatric Institute | 10 | 2011-09-01 | 2014-09-04 |
| EScitalopram PIndolol ONset of Action escitalopram, pindolol, escitalopram - Unipolar Depression | Phase 2 / Phase 3 | Terminated | Markus KOSEL | 18 | 2010-10-01 | 2015-05-27 |
| Berlin Magnetic Seizure Therapy Depression Trial 01 magnetic seizure therapy - Unipolar Depression, Bipolar Depression | Phase 3 | Completed | Charite University, Berlin, Germany | 32 | 2009-06-01 | 2018-07-13 |
| Repetitive Transcranial Magnetic Stimulation and Venlafaxine in Depression active venlafaxine and active rTMS-repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed, active rTMS -repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed and sham venlafaxine, sham rTMS- repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed and active venlafaxine - Unipolar Depression | Phase 3 | Completed | Club rTMS et Psychiatrie | 170 | 2008-05-01 | 2013-07-19 |
| The Effects of Quetiapine XR on Cognition, Mood and Anxiety Symptoms in SSRI-Resistant Unipolar Depression Quetiapine XR - Unipolar Depression | Phase 3 | Completed | University of British Columbia | 64 | 2007-09-01 | 2010-11-16 |
| The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated Depression Wellbutrin, Placebo - Depression, Major Depressive Disorder | Phase 3 | Completed | Mclean Hospital | 32 | 2005-08-01 | 2014-08-06 |
| Risperidone vs. Bupropion ER Augmentation of SSRIs in Treatment-Resistant Depression Rispridone (drug) and Bupropion ER (drug) - Unipolar Depression | Phase 3 | Completed | Vanderbilt University | 30 | 2004-07-01 | 2015-06-02 |
| Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression. triiodothyronine, sertraline - Major Depression, Bipolar Disorder | Phase 3 | Completed | Hadassah Medical Organization | 220 | 2002-10-01 | 2007-01-04 |
| Amitriptyline and Paroxetine Treatment of Major Depression amitriptyline, paroxetine - Unipolar Depression | Phase 3 | Completed | Central Institute of Mental Health, Mannheim | 127 | 1997-10-01 | 2024-01-31 |
Depressive Disorder (12) · Depression (5) · Depressive Disorder, Major (5) · Bipolar Disorder (4) · Depressive Disorder, Treatment-Resistant (2) · Dysthymic Disorder (1) · Mental Disorders (1)
Mood Disorders (12) · Mental Disorders (11) · Behavior (5) · Behavioral Symptoms (5) · Bipolar and Related Disorders (4)
Ketamine (2) · Amitriptyline (1) · Bupropion (1) · Dexetimide (1) · Electroconvulsive Therapy (1) · Escitalopram (1) · Midazolam (1) · Paroxetine (1) · Pharmaceutical Preparations (1) · Pindolol (1) · Sertraline (1) · Triiodothyronine (1) · Venlafaxine Hydrochloride (1)
Bo Hu (1) · Central Institute of Mental Health, Mannheim (1) · Charite University, Berlin, Germany (1) · Club rTMS et Psychiatrie (1) · Hadassah Medical Organization (1) · Markus KOSEL (1) · Mclean Hospital (1) · New York State Psychiatric Institute (1) · The University of New South Wales (1) · University of British Columbia (1) · University of Dublin, Trinity College (1) · Vanderbilt University (1)
United States (6) · Germany (2) · Australia (1) · Canada (1) · France (1) · Ireland (1) · Israel (1) · Monaco (1) · Switzerland (1)
Allan Young, MD (1) · Amit Anand, MD (1) · Bernard Lerer, MD (1) · Beth L Murphy, MD, PhD (1) · Declan M McLoughlin, PhD (1) · Laura Mufson, PhD (1) · Markus Kosel, MD-PhD (1) · Michael Deuschle, MD (1) · Richard C Shelton, MD (1)
PMID 17548749, PMID 20952454, PMID 23277262, PMID 25192980, PMID 29111077, PMID 30172724, PMID 30572160, PMID 37224232, PMID 37361338, PMID 37974160, PMID 40900112, PMID 41123905
2019 (1)