69 completed, 36 recruiting, 10 unknown, 5 terminated. 77 Not applicable, 15 Phase 2, 8 Phase 1, 7 Phase 3, 6 Phase 4.
Follow Anhedonia: new trials by email Literature Review of Anhedonia trials Research Report on Anhedonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multimodal Differences in Effort-based Decision-Making in Depression Effort-based Decision-Making Task - Depression, Anhedonia | Not applicable | Not yet recruiting | Georgia Institute of Technology | 90 | 2027-01-01 | 2026-08-27 |
| Clinical and Neurocomputational Effects of Behavioral Activation in Veterans With Impaired Social Functioning Behavioral Activation (BA), Supportive Care Therapy (SCT) - Social Anhedonia, Social Function Impairment | Not applicable | Not yet recruiting | VA Office of Research and Development | 136 | 2027-01-01 | 2026-07-16 |
| Positive Events Training to Enhance Positive Emotions in Adolescents With Elevated Depressive Symptoms: An N=1 Trial Positive Events Training (PET) - Emotional Distress, Anhedonia | Not applicable | Enrolling by invitation | KU Leuven | 1 | 2026-10-01 | 2026-09-17 |
| Promoting Positive Emotions in Adolescents Using Positive Events Training: An Indicated Approach Positive Events Training (PET) - Emotional Distress, Anhedonia | Not applicable | Recruiting | KU Leuven | 36 | 2026-10-01 | 2026-10-22 |
| Pramipexole vs Placebo Treatment in Bipolar Disorder With Anhedonic Depression Pramipexole, Placebo - Bipolar Disorder (BD) | Phase 3 | Recruiting | Daniel Lindqvist | 126 | 2026-10-01 | 2026-10-22 |
| Psilocybin as a Novel Therapy for Residual Anhedonia Psilocybin, Placebo - Anhedonia, Emotional Blunting | Phase 1 | Recruiting | NYU Langone Health | 90 | 2026-09-01 | 2026-09-15 |
| Reward Sensitivity Digital Intervention for Suicide Risk Suicide prevention treatment - Suicidal Ideation, Suicidal | Not applicable | Recruiting | University of Pennsylvania | 20 | 2026-08-21 | 2026-08-26 |
| Efficacy of kTMP, a Novel Non-invasive Brain Stimulation Method, for the Treatment of Anhedonia A new non-invasive brain stimulation tool, A new non-invasive brain stimulation tool with sham setting selected - Anhedonia, Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | Magnetic Tides | 104 | 2026-07-15 | 2026-07-08 |
| A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents ViraSafe: Treatment pushes, BRITE - Suicide, Mental Health Disorder | Not applicable | Recruiting | Ksana Health | 100 | 2026-06-18 | 2026-08-12 |
| French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments - Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP) | Not applicable | Recruiting | Fondation FondaMental | 3000 | 2026-06-11 | 2026-10-19 |
| Evaluation of Anhedonia and Emotional Eating in Individuals Using GLP-1 Receptor Agonists Obesity, Emotional Eating | Recruiting | TC Erciyes University | 60 | 2026-06-01 | 2026-09-03 | |
| Study on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in Depression Left DLPFC + OFC iTBS, Left DLPFC iTBS - Major Depression, Anhedonia | Not applicable | Recruiting | Guo Wenbin | 60 | 2026-05-19 | 2026-09-10 |
| Neutralizing Interleukin (IL)-6 Tocilizumab - Major Depressive Disorder | Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 60 | 2026-03-26 | 2026-04-29 |
| Causal Role of Rostromedial Prefrontal Cortex for Positive Savoring in Depression Accelerated Intermittent Theta Burst Transcranial Magnetic Stimulation - Left Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta Burst | Not applicable | Enrolling by invitation | Florida State University | 48 | 2026-03-23 | 2026-05-20 |
| tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety tVNS, Sham - Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms) | Not applicable | Recruiting | Dr. Nils B. Kroemer | 104 | 2026-03-23 | 2026-04-23 |
| Investigating the Efficacy and Mechanisms of Individualized tACS Targeting Anhedonia in Late-Life Depression Transcranial Alternating Current Stimulation (tACS), shame tACS - Late-Life Depression, Anhedonia | Not applicable | Recruiting | Jie Li | 80 | 2026-03-16 | 2026-06-10 |
| Positive Affect Treatment for Spanish-Speaking Individuals Positive Affect Treatment - Anhedonia, Depression in Adults | Not applicable | Active not recruiting | Southern Methodist University | 12 | 2026-01-20 | 2026-03-25 |
| The Effect of Transcranial Direct Current Stimulation (tDCS) in Improving Emotion Health Transcranial Direct Current Stimulation, Sham tDCS - Subthreshold Depression, Positive Emotions | Not applicable | Recruiting | The University of Hong Kong | 90 | 2026-01-08 | 2026-05-04 |
| Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects Psilocybin (Usona Institute), Risperidone 1 MG, MRI - Depression - Major Depressive Disorder, Anhedonia | Phase 1 | Recruiting | Medical University of Vienna | 85 | 2025-11-01 | 2026-03-24 |
| Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents ViraBrite nudges - Suicide, Mental Health Disorder | Not applicable | Completed | Ksana Health | 24 | 2025-07-16 | 2026-08-12 |
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Depression (65) · Depressive Disorder, Major (33) · Anxiety Disorders (15) · Depressive Disorder (14) · Bipolar Disorder (9) · Mood Disorders (8) · Psychotic Disorders (6) · Schizophrenia (6) · Suicidal Ideation (6) · Suicide (6) · Depressive Disorder, Treatment-Resistant (5) · Mental Disorders (5) · Inflammation (4) · Lethargy (4)
Nervous System Diseases (131) · Neurobehavioral Manifestations (131) · Neurologic Manifestations (131) · Pathological Conditions, Signs and Symptoms (131) · Signs and Symptoms (131) · Mental Disorders (71) · Behavior (70) · Behavioral Symptoms (65) · Mood Disorders (44) · Depressive Disorder (33) · Bipolar and Related Disorders (9) · Schizophrenia Spectrum and Other Psychotic Disorders (8) · Self-Injurious Behavior (8) · Pathologic Processes (5) · Body Weight (4)
Aticaprant (6) · Pramipexole (4) · Psilocybin (4) · Therapeutics (4) · Transcranial Direct Current Stimulation (3) · carbidopa, levodopa drug combination (3) · Cognitive Behavioral Therapy (2) · Dextroamphetamine (2) · Endotoxins (2) · Levodopa (2) · Magnetic Resonance Spectroscopy (2) · Transcranial Magnetic Stimulation (2) · 2-cyclohexylidenhydrazo-4-phenyl-thiazole (1) · Bupropion (1) · Buspirone (1)
Mclean Hospital (5) · University of California, Los Angeles (5) · University of North Carolina, Chapel Hill (5) · Emory University (4) · Janssen Research & Development, LLC (4) · Region Skane (4) · University of Oxford (4) · Florida State University (3) · Istituto Auxologico Italiano (3) · Ksana Health (3) · Ruhr University of Bochum (3) · Anhui Medical University (2) · GrayMatters Health Ltd. (2) · James Murrough (2) · KU Leuven (2)
United States (74) · Germany (11) · United Kingdom (9) · Sweden (8) · Belgium (7) · China (7) · Canada (6) · Poland (6) · France (5) · Italy (5) · Brazil (4) · Bulgaria (4) · Spain (4) · Argentina (3) · Czechia (3)
Diego Pizzagalli, PhD (4) · Jennifer Felger, PhD (4) · Catherine Harmer, DPhil (2) · Filip Raes (2) · Gabriel S Dichter, PhD (2) · Simon E Blackwell, Dr. phil. (2) · Aaron S Heller, PhD (1) · Adam J Woods, Ph.D. (1) · Alicia E Meuret, Ph.D. (1) · Andrew D Krystal, MD, MS (1) · Andrew H Miller, MD (1) · Andrew M Goldfine, MD (1) · Andrew M Novick, MD, PhD (1)
PMID 36907457, PMID 37148652, PMID 38035737, PMID 38815760, PMID 39213738, PMID 42286321, PMID 19323966, PMID 19411368, PMID 26142081, PMID 30123524, PMID 30783071, PMID 32819321, PMID 33250788, PMID 33653118, PMID 33933667, PMID 35894246, PMID 35927580, PMID 36055535, PMID 36307561, PMID 36330836, PMID 36855177, PMID 37131247, PMID 37276084, PMID 37591042, PMID 38074707, PMID 38300292, PMID 38653177, PMID 39069372, PMID 39744036, PMID 39824379, PMID 40751860, PMID 41001561, PMID 41098338, PMID 41192236, PMID 41298372, PMID 41902663
R01MH068376 (2), R44MH135605 (2), R61MH110027 (2), 2018 (1), 2019 (1), K01AG072049 (1), K23MH108752 (1), K23MH133971 (1), K99MH126161 (1), P50MH115838 (1), R00MH126161 (1), R01AA031013 (1), R01DA031687 (1), R01MH109637 (1), R01MH119382 (1)