Smoking: Clinical Trials

1567 completed, 211 recruiting, 191 unknown, 89 terminated. 1274 Not applicable, 217 Phase 2, 137 Phase 4, 127 Phase 1, 111 Phase 3.

By phase and status

Phase	Trials	Status
Not applicable	1274	Completed 898, Recruiting 120, Unknown 97, Not yet recruiting 48, Terminated 45, Withdrawn 31, Active not recruiting 27, Enrolling by invitation 7, Suspended 1
Phase 2	217	Completed 158, Recruiting 23, Terminated 12, Unknown 10, Withdrawn 9, Active not recruiting 3, Not yet recruiting 2
Phase 4	137	Completed 95, Recruiting 12, Terminated 9, Unknown 8, Not yet recruiting 5, Withdrawn 5, Active not recruiting 2, Enrolling by invitation 1
Phase 1	127	Completed 96, Recruiting 10, Terminated 7, Withdrawn 5, Unknown 4, Active not recruiting 3, Not yet recruiting 2
Phase 3	111	Completed 82, Unknown 10, Recruiting 9, Terminated 6, Active not recruiting 3, Withdrawn 1
Early Phase 1	35	Completed 22, Recruiting 5, Unknown 4, Active not recruiting 2, Not yet recruiting 1, Withdrawn 1

Follow Smoking: new trials by email Literature Review of Smoking trials Research Report on Smoking

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Episodic Future Thinking, Loss Aversion and Cigarette Smoking Episodic Future Thinking, Control Episodic Thinking - Tobacco Smoking	Not applicable	Withdrawn	University of Vermont		2050-01-01	2026-05-04
Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV	Phase 4	Not yet recruiting	Yale University	794	2027-09-30	2026-09-23
Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling - Cigarette Smoking, Veterans	Phase 4	Not yet recruiting	VA Office of Research and Development	112	2027-04-01	2026-09-14
Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion - Tobacco Use Disorder	Not applicable	Not yet recruiting	VA Office of Research and Development	120	2027-03-01	2026-07-20
Increasing Lung Cancer Screening Among Emergency Department Patients - LCS R01 Basic Referral, Facilitated Referral, Text Messaging - Smoking History, Current Smoker	Not applicable	Not yet recruiting	University of Rochester	1036	2027-03-01	2026-05-05
Impacto 2.0: Mobile Smoking Cessation Across Texas Impacto 2.0, quitSTART - Cigarette Smoking, Smoking Cessation	Not applicable	Not yet recruiting	Michael J. Zvolensky, Ph.D.	100	2027-02-01	2026-11-06
E-cigarette Social Media Marketing and Its Perceptions by Youth Exposure to Influencer Age and Context Variations in E-Cigarette Marketing - Vaping	Not applicable	Not yet recruiting	University of Southern California	6000	2027-01-01	2026-07-20
Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Primary Care CEASE+ - Smoking, Smoking Cessation	Phase 1	Not yet recruiting	University of Minnesota	50	2027-01-01	2026-02-27
Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder Deep TMS System With H4 Coil - Opioid Use Disorder, Tobacco Use Disorder	Not applicable	Not yet recruiting	Payel Roy	12	2027-01-01	2026-08-27
Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea SPECTRUM cigarettes - Cigarette Smoking, Nicotine Dependence	Not applicable	Not yet recruiting	Sung-il Cho	300	2027-01-01	2026-08-10
Impact of Lung Cancer Screening With Chest Scans Combined With Coaching on Smoking Cessation in Heavy Smokers Image-Based Counseling, Smoking Cessation Coaching, Low-Dose Chest Computed Tomography (LDCT) - Lung Cancer (Diagnosis), Smoking Cessation	Not applicable	Not yet recruiting	Hôpital Fribourgeois	116	2027-01-01	2026-10-21
Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis Cannabis (THC), Tobacco Cigarette - Cannabis Use, Tobacco	Early Phase 1	Not yet recruiting	Hannah Harris	12	2026-12-01	2026-11-04
C-Raven LDCT: Lung Cancer Screening Intervention Video/Brochure, Video/Brochure/Follow-up Call - Lung Cancer Screening	Not applicable	Not yet recruiting	Johns Hopkins University	300	2026-12-01	2026-11-02
Remote Interventions for Menthol Cigarette Use Quitline (QL), Mobile incentive-based intervention - Cigarette Smoking	Not applicable	Not yet recruiting	University of Michigan	1200	2026-12-01	2026-11-09
Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT Trial Vaping - Fruit flavored ENDS, Biospecimen Collection, Vaping - tobacco flavored ENDS - Tobacco Cessation, Electronic Nicotine Delivery Systems	Not applicable	Not yet recruiting	Roswell Park Cancer Institute	286	2026-11-30	2026-10-27
A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product Menthol 5%, Combustible cigarette - Smoking Behaviors, Smoking ( Cigarette)	Not applicable	Not yet recruiting	RAI Services Company	28	2026-11-15	2026-10-20
Using Smartwatches to Monitor Smoking in Real-life Situations Smoking		Enrolling by invitation	National Institute on Minority Health and Health Disparities (NIMHD)	30	2026-11-15	2026-11-10
Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information - Smoking Cessation, Cigarette Smoking	Not applicable	Not yet recruiting	University of Minnesota	30	2026-11-10	2026-10-13
Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty NP Seal, PICO, Prevena - Wound Surgical, Diabetes	Not applicable	Not yet recruiting	The Cleveland Clinic	300	2026-11-09	2026-11-04
Cardiovascular Impacts of E-cigarettes Among Older Adults Nicotine E-cigarette, Tobacco Cigarette - Hypertension, Tobacco Cigarette Smoking	Not applicable	Not yet recruiting	University of Maryland, Baltimore	40	2026-11-01	2026-10-19

Showing 20 of 2249. Sign in to see all of them.

Narrower conditions

Smoking Cessation (568)  ·  Cigarette Smoking (433)  ·  Tobacco Use Disorder (394)  ·  Vaping (392)  ·  Tobacco Smoking (259)  ·  Tobacco Use (192)  ·  Pulmonary Disease, Chronic Obstructive (84)  ·  Tobacco Use Cessation (79)  ·  Motor Activity (61)  ·  Behavior, Addictive (60)  ·  Smoking Reduction (56)  ·  Hypertension (55)  ·  Cardiovascular Diseases (52)  ·  Alcohol Drinking (51)

Broader conditions

Behavior (2239)  ·  Health Behavior (627)  ·  Mental Disorders (554)  ·  Tobacco Use (548)  ·  Chemically-Induced Disorders (472)  ·  Substance-Related Disorders (431)  ·  Tobacco Smoking (395)  ·  Pathological Conditions, Signs and Symptoms (279)  ·  Pathologic Processes (187)  ·  Respiratory Tract Diseases (182)  ·  Lung Diseases (146)  ·  Disease Attributes (133)  ·  Signs and Symptoms (114)  ·  Chronic Disease (102)

Interventions

Tobacco Use Cessation Devices (138)  ·  Varenicline (119)  ·  Nicotine (110)  ·  Nicotine Replacement Therapy (78)  ·  Electronic Nicotine Delivery Systems (65)  ·  Bupropion (51)  ·  Tobacco Products (41)  ·  Nicotine Chewing Gum (35)  ·  Counseling (28)  ·  Exercise (26)  ·  Smoking Devices (26)  ·  Motivational Interviewing (25)  ·  Standard of Care (21)  ·  Surveys and Questionnaires (21)  ·  Cognitive Behavioral Therapy (20)

Sponsors

Yale University (73)  ·  Duke University (56)  ·  University of California, San Francisco (47)  ·  RAI Services Company (46)  ·  Medical University of South Carolina (43)  ·  University of Wisconsin, Madison (39)  ·  Philip Morris Products S.A. (38)  ·  Massachusetts General Hospital (33)  ·  The University of Hong Kong (30)  ·  University of Minnesota (30)  ·  Mayo Clinic (28)  ·  University of Pennsylvania (28)  ·  Johns Hopkins University (26)  ·  University of Southern California (26)  ·  VA Office of Research and Development (25)

Countries

United States (1449)  ·  Turkey (Türkiye) (78)  ·  Canada (77)  ·  United Kingdom (50)  ·  France (46)  ·  Germany (34)  ·  China (32)  ·  Spain (29)  ·  Italy (26)  ·  Hong Kong (25)  ·  Egypt (21)  ·  Brazil (20)  ·  Denmark (20)  ·  Switzerland (18)  ·  Japan (17)

Top investigators

Christelle Haziza, PhD (23)  ·  Alison Breland, PhD (9)  ·  Ronald G Crystal, MD (9)  ·  Neal L Benowitz, MD (8)  ·  James M Davis, MD (7)  ·  Jed E Rose, Ph.D. (7)  ·  Andrew Strasser, Ph.D. (6)  ·  Caryn Lerman, PhD (5)  ·  Gary Dull, PhD (5)  ·  Ho Cheung William Li, PhD (5)  ·  Lisa Fucito, PhD (5)  ·  Maria Varga, MD (5)

Results publications

PMID 37142273, PMID 39868569, PMID 34611902, PMID 35420700, PMID 37230961, PMID 33605440, PMID 39101506, PMID 26336372, PMID 37335995, PMID 39240566, PMID 40183092, PMID 42560883, PMID 17874878, PMID 22123796, PMID 22229310, PMID 23377993, PMID 23485014, PMID 24006963, PMID 24158379, PMID 24622644, PMID 24739452, PMID 26160457, PMID 26711164, PMID 27117828, PMID 27401980, PMID 27462120, PMID 28616847, PMID 28720080, PMID 29486960, PMID 29663982, PMID 29754582, PMID 29940292, PMID 31687769, PMID 33687070, PMID 35818122, PMID 37733666, PMID 39742855, PMID 41869372, PMID 42288659, PMID 42523979, PMID 10165099, PMID 10191796, PMID 10417762, PMID 10480701, PMID 10493090, PMID 10510989, PMID 10581887, PMID 10740940, PMID 10748642, PMID 10773438

NIH funding

P50DA027840 (9), U54DA036105 (9), P50AA015632 (5), U54DA031659 (5), U54DA036114 (5), P01CA200512 (4), P01CA217806 (4), P50CA143188 (4), P50CA180908 (4), U54DA036151 (4), 2023 (3), K01DA019446 (3), K23DA022471 (3), P01CA180945 (3), P20GM130414 (3)