651 completed, 98 recruiting, 79 unknown, 36 not yet recruiting. 621 Not applicable, 92 Phase 2, 54 Phase 1, 46 Phase 4, 30 Phase 3.
Follow Tobacco Use: new trials by email Literature Review of Tobacco Use trials Research Report on Tobacco Use
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Episodic Future Thinking, Loss Aversion and Cigarette Smoking Episodic Future Thinking, Control Episodic Thinking - Tobacco Smoking | Not applicable | Withdrawn | University of Vermont | 2050-01-01 | 2026-05-04 | |
| A Mindfulness-based Intervention for Sexual Assault Survivors mindfulness-based intervention, comparison intervention - Alcohol Misuse, Tobacco Use | Not applicable | Not yet recruiting | Georgia State University | 120 | 2027-10-04 | 2026-07-16 |
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling - Cigarette Smoking, Veterans | Phase 4 | Not yet recruiting | VA Office of Research and Development | 112 | 2027-04-01 | 2026-09-14 |
| Impacto 2.0: Mobile Smoking Cessation Across Texas Impacto 2.0, quitSTART - Cigarette Smoking, Smoking Cessation | Not applicable | Not yet recruiting | Michael J. Zvolensky, Ph.D. | 100 | 2027-02-01 | 2026-11-06 |
| Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information - Smoking Cessation, Cigarette Smoking | Not applicable | Not yet recruiting | University of Minnesota | 30 | 2027-01-11 | 2026-11-12 |
| Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder Deep TMS System With H4 Coil - Opioid Use Disorder, Tobacco Use Disorder | Not applicable | Not yet recruiting | Payel Roy | 12 | 2027-01-01 | 2026-08-27 |
| Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea SPECTRUM cigarettes - Cigarette Smoking, Nicotine Dependence | Not applicable | Not yet recruiting | Sung-il Cho | 300 | 2027-01-01 | 2026-08-10 |
| A Web-Based Text Messaging for Tobacco Cessation in Rural Mississippi Motivational text messaging for tobacco cessation, Non-specific text messaging - Tobacco Cessation | Not applicable | Not yet recruiting | University of Mississippi Medical Center | 150 | 2026-12-01 | 2026-02-24 |
| Remote Interventions for Menthol Cigarette Use Quitline (QL), Mobile incentive-based intervention - Cigarette Smoking | Not applicable | Not yet recruiting | University of Michigan | 1200 | 2026-12-01 | 2026-11-09 |
| A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product Menthol 5%, Combustible cigarette - Smoking Behaviors, Smoking ( Cigarette) | Not applicable | Not yet recruiting | RAI Services Company | 28 | 2026-11-15 | 2026-10-20 |
| EFFECTS OF PHASE I PERIODONTAL THERAPY IN CIGARETTE SMOKERS, HEATED TOBACCO PRODUCT USERS, DUAL USERS, AND NON-SMOKERS Phase I Periodontal Therapy - Generalized Gingivitis, Tobacco Use, Cigarette Use | Not applicable | Not yet recruiting | Cyprus Health and Social Sciences University | 140 | 2026-11-09 | 2026-11-12 |
| Adaptation and Testing of a Novel Text-based Tobacco Cessation and Education Intervention in Kenyan Emergency Department Patients Text2Quit-Kenya - Tobacco Use, Tobacco Use Cessation | Not applicable | Recruiting | Yale University | 285 | 2026-11-01 | 2026-10-27 |
| Smoking Cessation in Patients With Cancer Standardized Brief Smoking-Cessation Counseling, Add-on One-Session Structured CBT-Based Smoking-Cessation Counseling - Cancer, Tobacco Use | Not applicable | Recruiting | Nguyen Duc Khoa, MD, PhD | 446 | 2026-10-20 | 2026-10-26 |
| Smoking Relapse Prevention in Patients With Cancer Standardized Brief Relapse-Prevention Counseling, Add-on One-Session Structured CBT-Based Relapse-Prevention Counseling - Cancer, Tobacco Use | Not applicable | Recruiting | Vietnam National Cancer Hospital | 498 | 2026-10-20 | 2026-10-21 |
| Impact of Electronic Cigarette Temperature and Solvent on Biomarkers High temperature wattage setting on electronic cigarette, Low temperature wattage setting on electronic cigarette, High concentration of Propylene Glycol - Oxidative Stress, Tobacco Use | Not applicable | Not yet recruiting | Milton S. Hershey Medical Center | 50 | 2026-10-15 | 2026-09-15 |
| A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products Golden Tobacco Chill 5% (4) 6.5W, Glacier Menthol 5% (4) 6.5W, Fresh Mint 5% (4) 6.5W - Smoking Behaviors, Smoking ( Cigarette) | Not applicable | Not yet recruiting | RAI Services Company | 50 | 2026-10-01 | 2026-07-31 |
| THCV Treatment for Smokers Δ9-Tetrahydrocannabivarin (oral gummy), Matched Placebo (oral gummy) - Tobacco Use Disorder, Smoking Cessation | Phase 2 | Not yet recruiting | University of California, Los Angeles | 32 | 2026-10-01 | 2026-08-04 |
| The ICEC Cluster Trial: Integrated Community Engagement Collaborative for Youth Substance Use Prevention in Rural America Integrated Community Engagement Collaborative, School-Based Data Collection and Reporting without Network Coordinator Support - Substance Use (Drugs, Alcohol), Tobacco Use | Not applicable | Not yet recruiting | West Virginia University | 25000 | 2026-10-01 | 2026-09-28 |
| Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers Salivary IL-8 and Serum IL-6 Measurement - Oral Potentially Malignant Disorders, Oral Lichen Planus | Recruiting | British University In Egypt | 250 | 2026-10-01 | 2026-11-04 |
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Cigarette Smoking (433) · Smoking (275) · Tobacco Smoking (259) · Smoking Cessation (226) · Tobacco Use Disorder (169) · Vaping (96) · Tobacco Use Cessation (65) · Substance-Related Disorders (36) · Alcohol Drinking (32) · Behavior, Addictive (24) · Pulmonary Disease, Chronic Obstructive (21) · Schizophrenia (21) · Smoking Reduction (20) · Lung Neoplasms (18)
Behavior (961) · Smoking (465) · Tobacco Smoking (395) · Health Behavior (278) · Mental Disorders (239) · Chemically-Induced Disorders (212) · Substance-Related Disorders (176) · Pathological Conditions, Signs and Symptoms (90) · Respiratory Tract Diseases (56) · Pathologic Processes (54) · Lung Diseases (50) · Signs and Symptoms (41) · Disease Attributes (36) · Drinking Behavior (33)
Tobacco Use Cessation Devices (67) · Varenicline (44) · Nicotine Replacement Therapy (40) · Nicotine (34) · Electronic Nicotine Delivery Systems (27) · Bupropion (22) · Tobacco Products (22) · Nicotine Chewing Gum (18) · Standard of Care (18) · HTR3D protein, human (17) · Smoking Devices (16) · Counseling (12) · Surveys and Questionnaires (11) · Behavior Therapy (10) · Cognitive Behavioral Therapy (10)
RAI Services Company (44) · Duke University (35) · Medical University of South Carolina (23) · University of California, San Francisco (23) · Yale University (20) · University of Oklahoma (19) · Massachusetts General Hospital (18) · Johns Hopkins University (16) · University of Minnesota (16) · Virginia Polytechnic Institute and State University (16) · Mayo Clinic (14) · Abramson Cancer Center at Penn Medicine (13) · Philip Morris Products S.A. (12) · Altria Client Services LLC (10) · Brown University (10)
United States (700) · Turkey (Türkiye) (22) · Canada (18) · France (18) · United Kingdom (14) · Germany (10) · China (8) · Hong Kong (8) · India (7) · Italy (7) · Sweden (7) · Brazil (6) · Romania (6) · Egypt (5) · Pakistan (5)
Jason Hong, MD (7) · Jed E Rose, Ph.D. (7) · Andrew Strasser, Ph.D. (5) · Christelle Haziza, PhD (5) · Gary Dull, PhD (5) · Brian Keyser (4) · Debra Kelsh, MD (4) · Devon Noonan, PhD (4) · Dorothy Hatsukami, PhD (4) · Lisa Fucito, PhD (4) · Milly Kanobe (4) · Milly Kanobe, PhD (4) · Neal L Benowitz, MD (4) · Adam Bisaga, M.D. (3) · Adam M Leventhal, PhD (3)
PMID 33605440, PMID 37142273, PMID 39868569, PMID 34611902, PMID 40183092, PMID 26336372, PMID 27401980, PMID 28616847, PMID 31687769, PMID 35420700, PMID 42523979, PMID 10165099, PMID 10191796, PMID 10417762, PMID 10493090, PMID 10510989, PMID 10581887, PMID 10740940, PMID 10748642, PMID 10761958, PMID 10773438, PMID 10791509, PMID 10812284, PMID 10885042, PMID 10901493, PMID 10946439, PMID 11176814, PMID 11236847, PMID 11260806, PMID 11420814, PMID 11516593, PMID 11717401, PMID 12010856, PMID 1202204, PMID 12028847, PMID 12047734, PMID 12235470, PMID 12438835, PMID 12472994, PMID 12492263, PMID 12814497, PMID 1453243, PMID 15010446, PMID 1511534, PMID 15370156, PMID 15370939, PMID 15564614, PMID 15700921, PMID 15796782, PMID 15820329
P50DA027840 (9), U54DA031659 (5), P01CA200512 (4), P50CA180908 (4), P01CA217806 (3), R01DA017572 (3), U54DA036105 (3), U54DA058256 (3), 2017 (2), 271201400069C-0-0-1 (2), K23HD102560 (2), P01CA180945 (2), P50CA180907 (2), P50DA036151 (2), R01CA141531 (2)