301 completed, 44 recruiting, 29 unknown, 19 terminated. 255 Not applicable, 59 Phase 2, 26 Phase 1, 25 Phase 4, 11 Phase 3.
Follow Cigarette Smoking: new trials by email Literature Review of Cigarette Smoking trials Research Report on Cigarette Smoking
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling - Cigarette Smoking, Veterans | Phase 4 | Not yet recruiting | VA Office of Research and Development | 112 | 2027-04-01 | 2026-09-14 |
| Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder Deep TMS System With H4 Coil - Opioid Use Disorder, Tobacco Use Disorder | Not applicable | Not yet recruiting | Payel Roy | 12 | 2027-01-01 | 2026-08-27 |
| Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea SPECTRUM cigarettes - Cigarette Smoking, Nicotine Dependence | Not applicable | Not yet recruiting | Sung-il Cho | 300 | 2027-01-01 | 2026-08-10 |
| A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product Menthol 5%, Combustible cigarette - Smoking Behaviors, Smoking ( Cigarette) | Not applicable | Not yet recruiting | RAI Services Company | 28 | 2026-11-15 | 2026-10-20 |
| Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information - Smoking Cessation, Cigarette Smoking | Not applicable | Not yet recruiting | University of Minnesota | 30 | 2026-11-10 | 2026-10-13 |
| Remote Interventions for Menthol Cigarette Use Quitline (QL), Mobile incentive-based intervention - Cigarette Smoking | Not applicable | Not yet recruiting | University of Michigan | 1200 | 2026-11-01 | 2026-09-14 |
| A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products Golden Tobacco Chill 5% (4) 6.5W, Glacier Menthol 5% (4) 6.5W, Fresh Mint 5% (4) 6.5W - Smoking Behaviors, Smoking ( Cigarette) | Not applicable | Not yet recruiting | RAI Services Company | 50 | 2026-10-01 | 2026-07-31 |
| THCV Treatment for Smokers Δ9-Tetrahydrocannabivarin (oral gummy), Matched Placebo (oral gummy) - Tobacco Use Disorder, Smoking Cessation | Phase 2 | Not yet recruiting | University of California, Los Angeles | 32 | 2026-10-01 | 2026-08-04 |
| Generalized and Domain-Specific Episodic Thinking for Smoking Cessation Episodic Future Thinking (EFT), Episodic Recent Thinking (ERT), Domain-specific episodic thinking - Cigarette Smoking Behavior | Not applicable | Recruiting | Virginia Polytechnic Institute and State University | 134 | 2026-09-25 | 2026-10-13 |
| Ecological Momentary Assessment of Smoking Triggers, Needs, and Cigarette Forgoing Non-Adaptive Motivational EMI, Adaptive Motivational EMI - Smoking ( Cigarette) | Not applicable | Not yet recruiting | University of South Carolina | 45 | 2026-09-20 | 2026-10-01 |
| Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+) Empower LCS, Call+ Telephone Navigation, Usual Care - Lung Cancer Screening, Lung Neoplasms | Not applicable | Recruiting | University of California, Irvine | 80 | 2026-09-16 | 2026-09-21 |
| Impact of Sweeteners on the Addictive Threshold of Nicotine Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose - Smoking ( Cigarette) | Phase 1 | Not yet recruiting | Yale University | 36 | 2026-09-01 | 2026-08-31 |
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| Effects of Tobacco Abuse Liability-dependent Taxes in the ETM Control, Product Category Score, Product Category Rank - Cigarette Smoking Behavior | Not applicable | Withdrawn | Virginia Polytechnic Institute and State University | 2026-07-31 | 2026-09-15 | |
| Piloting Novel Interventional Strategies to Improve Nicotine Pouches as a Substitute for Smoking Nicotine replacement therapy patches, Oral nicotine pouches - Smoking ( Cigarette) | Phase 4 | Enrolling by invitation | Medical University of South Carolina | 10 | 2026-06-26 | 2026-07-06 |
| THE EFFECT OF A TRANSTHEORETICAL MODEL-BASED CHATBOT SUPPORT INTERVENTION ON SMOKING BEHAVIOR IN UNIVERSITY STUDENTS Dumansız (Transtheoretical Model-Based Chatbot Support Intervention) - Smoking ( Cigarette), Smoking (Tobacco) Addiction | Not applicable | Active not recruiting | Seher DÖNER | 100 | 2026-06-25 | 2026-10-21 |
| PASCAL Feasibility Study chatbot, no chatbot - Smoking Cessation, Smoking (Tobacco) Addiction | Not applicable | Recruiting | University of Minnesota | 120 | 2026-06-11 | 2026-06-24 |
| Smoking Cessation With Wearables to Improve General, Oral Health and Quality of Life Telemedicine-Based Smoking Cessation Program, Conventional Smoking Cessation Behavioral Program - Smoking ( Cigarette), Smoking (Tobacco) Addiction | Not applicable | Not yet recruiting | University of Salerno | 102 | 2026-06-01 | 2026-05-18 |
| Smoking, Pain Threshold, and Hand Strength in Women observational study - Smoking ( Cigarette), Women | Completed | Karabuk University | 132 | 2026-05-25 | 2026-06-12 |
Showing 20 of 430. Sign in to see all of them.
Smoking (134) · Smoking Cessation (121) · Tobacco Use Disorder (88) · Tobacco Use (47) · Vaping (44) · Tobacco Smoking (43) · Behavior, Addictive (19) · Tobacco Use Cessation (16) · Schizophrenia (15) · Smoking Reduction (11) · Harm Reduction (9) · Pulmonary Disease, Chronic Obstructive (9) · Alcohol Drinking (8) · Lung Neoplasms (8)
Behavior (429) · Tobacco Smoking (387) · Tobacco Use (383) · Smoking (296) · Health Behavior (127) · Mental Disorders (118) · Chemically-Induced Disorders (98) · Substance-Related Disorders (92) · Pathological Conditions, Signs and Symptoms (42) · Pathologic Processes (25) · Lung Diseases (21) · Respiratory Tract Diseases (21) · Compulsive Behavior (19) · Impulsive Behavior (19) · Signs and Symptoms (18)
Tobacco Use Cessation Devices (41) · Varenicline (31) · Nicotine (24) · Nicotine Replacement Therapy (17) · Electronic Nicotine Delivery Systems (15) · Bupropion (14) · Nicotine Chewing Gum (9) · Smoking Devices (9) · Standard of Care (8) · Tobacco Products (8) · Behavior Therapy (5) · Therapeutics (5) · Counseling (4) · Ethanol (4) · Methods (4)
Duke University (27) · Medical University of South Carolina (15) · Virginia Polytechnic Institute and State University (15) · Yale University (13) · University of California, San Francisco (11) · Abramson Cancer Center at Penn Medicine (10) · University of Oklahoma (10) · Brown University (7) · UConn Health (7) · University of Southern California (7) · Massachusetts General Hospital (6) · University of Minnesota (6) · Masonic Cancer Center, University of Minnesota (5) · University of California, Los Angeles (5) · University of North Carolina, Chapel Hill (5)
United States (330) · Turkey (Türkiye) (13) · Canada (8) · China (6) · Italy (5) · United Kingdom (5) · Germany (4) · Brazil (3) · Egypt (3) · France (3) · Pakistan (3) · Poland (3) · South Korea (3) · Belgium (2) · Hong Kong (2)
Jed E Rose, Ph.D. (7) · Andrew Strasser, Ph.D. (5) · F. Joseph McClernon, Ph.D. (3) · James M Davis, MD (3) · Jason A Oliver, PhD (3) · Lisa Fucito, PhD (3) · Neal L Benowitz, MD (3) · Warren K Bickel, Ph.D. (3) · Adam M Leventhal, PhD (2) · Amy Cohn, PhD (2) · Christelle Haziza, PhD (2) · Christine E Sheffer, Ph.D. (2) · Colleen A Hanlon, PhD (2) · Cynthia Conklin, PhD (2) · Darla E. Kendzor, PhD (2)
PMID 37142273, PMID 34611902, PMID 26336372, PMID 28616847, PMID 31687769, PMID 35420700, PMID 39868569, PMID 10165099, PMID 10191796, PMID 10417762, PMID 10493090, PMID 10510989, PMID 10581887, PMID 10740940, PMID 10748642, PMID 10791509, PMID 10812284, PMID 10885042, PMID 10901493, PMID 11176814, PMID 11236847, PMID 11260806, PMID 11420814, PMID 11516593, PMID 11717401, PMID 12010856, PMID 1202204, PMID 12028847, PMID 12047734, PMID 12235470, PMID 12438835, PMID 12492263, PMID 12814497, PMID 1453243, PMID 15010446, PMID 1511534, PMID 15370156, PMID 15370939, PMID 15564614, PMID 15700921, PMID 15796782, PMID 15820329, PMID 15941943, PMID 1613610, PMID 16499517, PMID 16504277, PMID 1668228, PMID 16720082, PMID 16756420, PMID 17008196
P50DA027840 (9), P01CA200512 (4), P50CA180908 (4), P01CA217806 (3), U54DA031659 (3), 271201400069C-0-0-1 (2), P01CA180945 (2), P50CA180907 (2), R01CA237670 (2), R01CA266966 (2), R01DA038442 (2), U54CA229973 (2), 1RC1HL099668 (1), 2017 (1), 271201500019C-0-0-1 (1)