123 completed, 29 recruiting, 11 terminated, 10 unknown. 95 Not applicable, 35 Phase 2, 33 Phase 4, 18 Phase 3, 10 Phase 1.
Follow Nicotine Replacement Therapy: new trials by email Literature Review of Nicotine Replacement Therapy trials Research Report on Nicotine Replacement Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion - Tobacco Use Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 120 | 2027-03-01 | 2026-07-20 |
| DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy Text- and web-based support, Nicotine Replacement Therapy (NRT, nicotine patch), Nicotine replacement therapy lozenge - Dual Use of Cigarettes and E-cigarettes | Phase 2 | Not yet recruiting | Medical University of South Carolina | 321 | 2026-11-01 | 2026-10-15 |
| Evaluation of the Efficacy of QUITOXIL® in Smoking Cessation Quitoxil®, Nicotine Replacement Therapies - Tobacco Use Disorder | Not applicable | Not yet recruiting | KLAVA Innovation | 606 | 2026-10-01 | 2026-07-24 |
| Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use Nicotine Replacement Therapies, Brief Behavioral Counseling - E Cigarette Use, Cessation, Tobacco | Phase 4 | Not yet recruiting | West Virginia University | 100 | 2026-09-01 | 2026-08-26 |
| Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT) - Tobacco Use Cessation, Tobacco Use Disorder | Not applicable | Not yet recruiting | University of Virginia | 120 | 2026-09-01 | 2026-07-10 |
| Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation Varenicline (VAR), Nicotine lozenge (NRT), Smartphone intervention with adherence components (COMBO-A) - Smoking Cessation | Phase 2 | Recruiting | University of Oklahoma | 496 | 2026-07-21 | 2026-08-19 |
| Enhancing Smoking Cessation for African American People Everywhere ESCAPE app + NRT, quiSTART app + NRT, Control (CTRL) - ESCAPE Intervention+NRT, quitSTART Intervention+NRT | Phase 2 | Recruiting | University of Houston | 300 | 2026-06-30 | 2026-07-13 |
| Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment transdermal nicotine replacement therapy - Smoking | Phase 4 | Recruiting | Duke University | 600 | 2026-05-06 | 2026-07-23 |
| Smart Olfaction App to Reduce Relapse Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition - Nicotine Dependence | Early Phase 1 | Recruiting | University of Houston | 132 | 2026-04-22 | 2026-07-08 |
| Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients Auricular acupressure, Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge), Sham Auricular Acupressure - Nicotine Dependence, Nicotine Withdrawal | Not applicable | Recruiting | Chiao-Chiao Liao | 60 | 2026-03-23 | 2026-04-13 |
| The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit. Nicotine Replacement Therapy (NRT, nicotine patch), Music intervention, Biological collection - Nicotine Replacement Therapy, Healthcare Professionals | Not applicable | Not yet recruiting | Poitiers University Hospital | 80 | 2026-03-01 | 2026-02-17 |
| Semaglutide for Smoking Cessation in Patients With Diabetes Semaglutide, Nicotine replacement - Diabetes Mellitus, Type 2, Nicotine Addiction | Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 100 | 2026-02-13 | 2026-09-08 |
| Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness Nicotine Replacement Therapy (NRT), Wellness Coaching - Tobacco Cessation, Tobacco Abstinence | Phase 4 | Recruiting | University of California, San Francisco | 150 | 2025-11-14 | 2025-11-21 |
| Cytisine vs Nicotine Replacement Therapy Cytisine, Nicotine replacement therapy (NRT) - Tobacco Dependence, COPD Asthma | Not applicable | Enrolling by invitation | Ottawa Hospital Research Institute | 200 | 2025-11-04 | 2026-03-17 |
| Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers. E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms - Cigarette Smoking Behavior, E-Cigarette Use | Not applicable | Completed | Thomas Jefferson University | 44 | 2025-08-05 | 2026-10-27 |
| Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia Carbon Monoxide Measurement, Nicotine Lozenge, Oral Nicotine Pouch - Cigarette Smoking-Related Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 1000 | 2025-06-13 | 2026-06-30 |
| Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation Acupuncture, Nicotine Replacement therapy, Smoking cessation counseling - Smoking | Not applicable | Recruiting | The University of Hong Kong | 270 | 2025-05-05 | 2025-05-11 |
| Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge), Cytisine, Varenicline (Champix) - Tobacco | Phase 4 | Recruiting | Ottawa Heart Institute Research Corporation | 150 | 2025-04-30 | 2026-03-05 |
| E-cigarette Harm Reduction Among PLWHA in South Africa Nicotine Replacement Therapy (NRT), E-Cigarette (EC), Counseling - Tobacco Smoking | Phase 1 | Completed | NYU Langone Health | 106 | 2025-04-15 | 2026-06-09 |
| Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy Electronic Cigarettes (EC), Nicotine replacement therapy (NRT) - Smoking Cessation, Obesity and Obesity-related Medical Conditions | Not applicable | Recruiting | Brown University | 60 | 2025-04-01 | 2026-05-18 |
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Smoking Cessation (102) · Smoking (50) · Tobacco Use Disorder (46) · Cigarette Smoking (18) · Tobacco Use Cessation (18) · Tobacco Smoking (13) · Tobacco Use (13) · Vaping (12) · Cardiovascular Diseases (6) · Carcinoma, Non-Small-Cell Lung (4) · Lung Neoplasms (4) · Mental Disorders (4) · Pulmonary Disease, Chronic Obstructive (4) · Substance-Related Disorders (4) · HIV Infections (3)
NYU Langone Health (9) · M.D. Anderson Cancer Center (8) · Duke University (7) · The University of Hong Kong (7) · Centre for Addiction and Mental Health (6) · University of California, San Francisco (6) · University of Oklahoma (6) · Medical University of South Carolina (5) · Ohio State University Comprehensive Cancer Center (5) · VA Office of Research and Development (5) · Brown University (4) · National Institute on Drug Abuse (NIDA) (4) · Rutgers, The State University of New Jersey (4) · University of Houston (4) · University of Kansas Medical Center (4)
United States (135) · Canada (10) · Hong Kong (5) · France (4) · Brazil (2) · Germany (2) · India (2) · South Africa (2) · Taiwan (2) · United Kingdom (2) · Australia (1) · China (1) · Greece (1) · Israel (1) · Kenya (1)
Scott Sherman, MD (3) · Anne Joseph, MD (2) · Elisabeth Kruse, PhD (2) · Hilary A Tindle, MD, MPH (2) · Jamie Ostroff, PhD (2) · Jason Robinson (2) · Jean C. Beckham, Ph.D. (2) · Jon O Ebbert, MD (2) · Joseph Ladapo, MD, PhD (2) · Monica Webb Hooper, PhD (2) · Nancy A Rigotti, MD (2) · Omar El-Shahawy (2) · Peter Selby, MD, MHSc (2) · Rosemarie Martin, Ph.D. (2) · S. Rob Vorel, MD, PhD (2)
PMID 37230961, PMID 34611902, PMID 22123796, PMID 32269028, PMID 37142273, PMID 39868569, PMID 10606193, PMID 11784452, PMID 15266423, PMID 15846610, PMID 16157462, PMID 16203030, PMID 16801293, PMID 17632223, PMID 17888856, PMID 18065851, PMID 18236294, PMID 18397444, PMID 18420774, PMID 18544464, PMID 18852395, PMID 19129277, PMID 19349629, PMID 19664750, PMID 19901150, PMID 20060229, PMID 20430565, PMID 21215528, PMID 21233256, PMID 21928117, PMID 21955930, PMID 22417200, PMID 22761006, PMID 22770436, PMID 22852832, PMID 22949583, PMID 23074432, PMID 23873976, PMID 24075893, PMID 24716466, PMID 24794687, PMID 24813547, PMID 25138333, PMID 25323093, PMID 25361769, PMID 25699616, PMID 26116584, PMID 26336372, PMID 26498173, PMID 26612457
R01DA021619 (2), R01DA032243 (2), R34DA043751 (2), 1RC1HL099668 (1), 2008 (1), K01MD014165 (1), K01MD015295 (1), K07CA215546 (1), K23DA025735 (1), K23DA041616 (1), P20GM130414 (1), P30CA012197 (1), P30CA016056 (1), P30CA044579 (1), P30CA225520 (1)