1108 completed, 139 unknown, 118 recruiting, 66 terminated. 930 Not applicable, 182 Phase 2, 146 Phase 4, 126 Phase 3, 91 Phase 1.
Follow Smoking Cessation: new trials by email Literature Review of Smoking Cessation trials Research Report on Smoking Cessation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VergeRx for Smokers Not Ready to Quit VergeRx, SmokefreeTXT, NRT Lozenge (Combination) - Tobacco Use Cessation | Not applicable | Not yet recruiting | University of Virginia | 592 | 2027-12-01 | 2026-07-09 |
| Impacto 2.0: Mobile Smoking Cessation Across Texas Impacto 2.0, quitSTART - Cigarette Smoking, Smoking Cessation | Not applicable | Not yet recruiting | Michael J. Zvolensky, Ph.D. | 100 | 2027-02-01 | 2026-11-06 |
| Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Primary Care CEASE+ - Smoking, Smoking Cessation | Phase 1 | Not yet recruiting | University of Minnesota | 50 | 2027-01-01 | 2026-02-27 |
| Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder Deep TMS System With H4 Coil - Opioid Use Disorder, Tobacco Use Disorder | Not applicable | Not yet recruiting | Payel Roy | 12 | 2027-01-01 | 2026-08-27 |
| Impact of Lung Cancer Screening With Chest Scans Combined With Coaching on Smoking Cessation in Heavy Smokers Image-Based Counseling, Smoking Cessation Coaching, Low-Dose Chest Computed Tomography (LDCT) - Lung Cancer (Diagnosis), Smoking Cessation | Not applicable | Not yet recruiting | Hôpital Fribourgeois | 116 | 2027-01-01 | 2026-10-21 |
| New Smoking Cessation Intervention in Primary Care - a Randomized Controlled Trial WillQuit App, Smoking cessation standard treatment, - Smoking Cessation, Smoking Cessation Counselling | Not applicable | Not yet recruiting | Helse Nord-Trøndelag HF | 620 | 2027-01-01 | 2026-10-28 |
| PROMETHEE: A Shared Interregional Tele-Tobacco Cessation Platform Embedded Within the IMPULSION Lung Cancer Screening Program PROMETHEE Cohort, Control Cohort - Smoking Cessation, Lung Cancer Screening | Not yet recruiting | Hospices Civils de Lyon | 5400 | 2027-01-01 | 2026-11-06 | |
| Smoking Cessation Program for Lao People With HIV Smoking Cessation Self Help Guide, Smartphone-delivered Automated Messaging - Smoking Cessation, HIV | Not applicable | Not yet recruiting | University of Oklahoma | 1200 | 2027-01-01 | 2026-11-06 |
| Comparing the Efficacy of a Conversational Agent (QuitBot) Versus Standard Health Education on Smoking Cessation Among Medical Students in Cairo University Conversational agent, Standard health education - Conversational Agent, Smoking Cessation | Not applicable | Not yet recruiting | Cairo University | 180 | 2026-12-10 | 2026-11-02 |
| Varenicline for Smoking Cessation in Pancreatitis Varenicline (VAR) - Pancreatitis, Chronic Pancreatitis | Phase 4 | Not yet recruiting | Mayo Clinic | 45 | 2026-11-13 | 2026-10-19 |
| Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information - Smoking Cessation, Cigarette Smoking | Not applicable | Not yet recruiting | University of Minnesota | 30 | 2026-11-10 | 2026-10-13 |
| Contingency Management to Promote Smoking Cessation Study Health Rewards, Control - Smoking Cessation | Not applicable | Not yet recruiting | University of Kansas Medical Center | 40 | 2026-11-06 | 2026-10-27 |
| LLM Intervention for Tobacco in Underserved Populations (LIFT-UP) LIFT-UP Chatbot - Smoking Cessation | Not applicable | Not yet recruiting | University of Utah | 22 | 2026-11-01 | 2026-10-01 |
| Smoking Cessation in Patients With Cancer Standardized Brief Smoking-Cessation Counseling, Add-on One-Session Structured CBT-Based Smoking-Cessation Counseling - Cancer, Tobacco Use | Not applicable | Recruiting | Nguyen Duc Khoa, MD, PhD | 446 | 2026-10-20 | 2026-10-26 |
| Smoking Relapse Prevention in Patients With Cancer Standardized Brief Relapse-Prevention Counseling, Add-on One-Session Structured CBT-Based Relapse-Prevention Counseling - Cancer, Tobacco Use | Not applicable | Recruiting | Vietnam National Cancer Hospital | 498 | 2026-10-20 | 2026-10-21 |
| A Study of Nicotine Orodispersible Tablet on Craving Relief of Male and Female Smoker Volunteers Nicotine Mint Oro Dispersible Tablet (Nic ODT), Placebo Oro Dispersible Tablet (Placebo ODT) - Smoking Cessation, Nicotine Replacements Therapy | Phase 2 | Recruiting | McNeil AB | 280 | 2026-10-05 | 2026-10-23 |
| Multi-Theory Model-Based AI Agent Intervention for Smoking Cessation in Early-Stage Cancer Patients MTM-Based AI Agent for smoking cessation, Counseling - Smoking Cessation, Early-Stage Cancer | Not applicable | Not yet recruiting | Sun Yat-sen University | 156 | 2026-10-01 | 2026-09-18 |
| TORCH - Transdiagnostic Observation of Risk Factors, Craving and Health Behaviours in Psychiatric Patients person-centred interventions - Psychiatric Disorders | Not yet recruiting | Jacobs University Bremen gGmbH | 250 | 2026-10-01 | 2026-09-28 | |
| THCV Treatment for Smokers Δ9-Tetrahydrocannabivarin (oral gummy), Matched Placebo (oral gummy) - Tobacco Use Disorder, Smoking Cessation | Phase 2 | Not yet recruiting | University of California, Los Angeles | 32 | 2026-10-01 | 2026-08-04 |
| ChatGPT-Supported Text Messaging Program for Smoking Cessation BeFree+Bot, BeFree - Smoking Cessation | Not applicable | Not yet recruiting | George Washington University | 180 | 2026-10-01 | 2026-10-14 |
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Smoking (401) · Tobacco Use Disorder (318) · Cigarette Smoking (123) · Tobacco Use Cessation (91) · Tobacco Smoking (76) · Tobacco Use (75) · Vaping (55) · Behavior, Addictive (36) · Lung Neoplasms (36) · Smoking Reduction (36) · Pulmonary Disease, Chronic Obstructive (33) · Neoplasms (30) · Schizophrenia (28) · Motor Activity (26)
Behavior (1563) · Health Behavior (1551) · Mental Disorders (371) · Chemically-Induced Disorders (339) · Substance-Related Disorders (318) · Smoking (167) · Tobacco Use (151) · Pathological Conditions, Signs and Symptoms (129) · Tobacco Smoking (99) · Respiratory Tract Diseases (87) · Pathologic Processes (79) · Lung Diseases (77) · Disease Attributes (59) · Signs and Symptoms (56) · Neoplasms by Site (55)
Varenicline (159) · Tobacco Use Cessation Devices (157) · Nicotine Replacement Therapy (102) · Nicotine (92) · Bupropion (68) · Nicotine Chewing Gum (55) · Counseling (36) · Motivational Interviewing (28) · Standard of Care (27) · Surveys and Questionnaires (24) · cytisine (23) · Cognitive Behavioral Therapy (22) · Crisis Intervention (21) · Behavior Therapy (20) · Methods (18)
The University of Hong Kong (68) · Pfizer (43) · University of California, San Francisco (38) · University of Wisconsin, Madison (33) · Yale University (31) · Medical University of South Carolina (29) · Massachusetts General Hospital (27) · University of Oklahoma (26) · Centre for Addiction and Mental Health (25) · Duke University (25) · M.D. Anderson Cancer Center (23) · McNeil AB (23) · H. Lee Moffitt Cancer Center and Research Institute (19) · US Department of Veterans Affairs (19) · National Institute on Drug Abuse (NIDA) (18)
United States (917) · Canada (76) · Hong Kong (58) · France (48) · China (47) · United Kingdom (46) · Spain (36) · Germany (32) · Sweden (31) · Switzerland (23) · Turkey (Türkiye) (23) · Denmark (19) · Italy (15) · Netherlands (15) · South Korea (13)
Elisabeth Kruse, PhD (22) · Man Ping Wang, PhD (12) · Ho Cheung William Li, PhD (11) · Reto Auer, Prof.Dr.med (10) · Jed E Rose, Ph.D. (8) · Janice Tsoh, PhD (7) · Shu-Hong Zhu, Ph.D. (7) · Andrew Pipe, MD (6) · Sherry A McKee, PhD (6) · Thomas Brandon, Ph.D. (6) · Belinda Borrelli, PhD (5) · John R Hughes, MD (5) · Ramzi Salloum, PhD (5)
PMID 37142273, PMID 34611902, PMID 37230961, PMID 39868569, PMID 35420700, PMID 37335995, PMID 33605440, PMID 41546550, PMID 26336372, PMID 20884658, PMID 32269028, PMID 32813276, PMID 33323188, PMID 39101506, PMID 18084743, PMID 18442345, PMID 20457644, PMID 20819082, PMID 21621992, PMID 22123796, PMID 22229310, PMID 22882805, PMID 24139766, PMID 26116584, PMID 26711164, PMID 27462120, PMID 27613910, PMID 28340108, PMID 28655173, PMID 31522134, PMID 31687769, PMID 32534252, PMID 34062053, PMID 39799985, PMID 40962497, PMID 41869372, PMID 10165099, PMID 10191796, PMID 10417762, PMID 10493090, PMID 10510989, PMID 10581887, PMID 10606193, PMID 10740940, PMID 10748642, PMID 10761958, PMID 10773438, PMID 10791509, PMID 10812284, PMID 10885042
2017 (18), 2008 (9), P50DA027840 (7), P01CA180945 (5), P50CA143188 (4), P50CA180908 (4), 2005 (3), P50AA015632 (3), 2009 (2), 271201400069C-0-0-1 (2), K01MD015295 (2), K22CA237639 (2), K23AG067929 (2), K23DA022471 (2), K23DA035288 (2)