452 completed, 67 recruiting, 52 unknown, 24 not yet recruiting. 409 Not applicable, 69 Phase 2, 39 Phase 4, 34 Phase 1, 18 Phase 3.
Follow Tobacco Smoking: new trials by email Literature Review of Tobacco Smoking trials Research Report on Tobacco Smoking
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Episodic Future Thinking, Loss Aversion and Cigarette Smoking Episodic Future Thinking, Control Episodic Thinking - Tobacco Smoking | Not applicable | Withdrawn | University of Vermont | 2050-01-01 | 2026-05-04 | |
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling - Cigarette Smoking, Veterans | Phase 4 | Not yet recruiting | VA Office of Research and Development | 112 | 2027-04-01 | 2026-09-14 |
| Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder Deep TMS System With H4 Coil - Opioid Use Disorder, Tobacco Use Disorder | Not applicable | Not yet recruiting | Payel Roy | 12 | 2027-01-01 | 2026-08-27 |
| Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea SPECTRUM cigarettes - Cigarette Smoking, Nicotine Dependence | Not applicable | Not yet recruiting | Sung-il Cho | 300 | 2027-01-01 | 2026-08-10 |
| A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product Menthol 5%, Combustible cigarette - Smoking Behaviors, Smoking ( Cigarette) | Not applicable | Not yet recruiting | RAI Services Company | 28 | 2026-11-15 | 2026-10-20 |
| Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information - Smoking Cessation, Cigarette Smoking | Not applicable | Not yet recruiting | University of Minnesota | 30 | 2026-11-10 | 2026-10-13 |
| Remote Interventions for Menthol Cigarette Use Quitline (QL), Mobile incentive-based intervention - Cigarette Smoking | Not applicable | Not yet recruiting | University of Michigan | 1200 | 2026-11-01 | 2026-09-14 |
| A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products Golden Tobacco Chill 5% (4) 6.5W, Glacier Menthol 5% (4) 6.5W, Fresh Mint 5% (4) 6.5W - Smoking Behaviors, Smoking ( Cigarette) | Not applicable | Not yet recruiting | RAI Services Company | 50 | 2026-10-01 | 2026-07-31 |
| THCV Treatment for Smokers Δ9-Tetrahydrocannabivarin (oral gummy), Matched Placebo (oral gummy) - Tobacco Use Disorder, Smoking Cessation | Phase 2 | Not yet recruiting | University of California, Los Angeles | 32 | 2026-10-01 | 2026-08-04 |
| A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System FT25614, FT25615, FT25616 - Smoking, Tobacco | Not applicable | Recruiting | RAI Services Company | 480 | 2026-09-30 | 2026-10-22 |
| Generalized and Domain-Specific Episodic Thinking for Smoking Cessation Episodic Future Thinking (EFT), Episodic Recent Thinking (ERT), Domain-specific episodic thinking - Cigarette Smoking Behavior | Not applicable | Recruiting | Virginia Polytechnic Institute and State University | 134 | 2026-09-25 | 2026-10-13 |
| Ecological Momentary Assessment of Smoking Triggers, Needs, and Cigarette Forgoing Non-Adaptive Motivational EMI, Adaptive Motivational EMI - Smoking ( Cigarette) | Not applicable | Not yet recruiting | University of South Carolina | 45 | 2026-09-20 | 2026-10-01 |
| Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+) Empower LCS, Call+ Telephone Navigation, Usual Care - Lung Cancer Screening, Lung Neoplasms | Not applicable | Recruiting | University of California, Irvine | 80 | 2026-09-16 | 2026-09-21 |
| The SMOKE Telehealth Study Smoking and Health Telehealth Intervention 1, Smoking and Health Telehealth Intervention 2 - Tobacco Smoking | Not applicable | Recruiting | Binghamton University | 78 | 2026-09-01 | 2026-08-12 |
| Impact of Sweeteners on the Addictive Threshold of Nicotine Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose - Smoking ( Cigarette) | Phase 1 | Not yet recruiting | Yale University | 36 | 2026-09-01 | 2026-08-31 |
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| Effects of Tobacco Abuse Liability-dependent Taxes in the ETM Control, Product Category Score, Product Category Rank - Cigarette Smoking Behavior | Not applicable | Withdrawn | Virginia Polytechnic Institute and State University | 2026-07-31 | 2026-09-15 | |
| Abuse Liability of Four Modern Oral Nicotine Products Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Wintergreen (fleece A), 12 mg nicotine, Wintergreen (fleece A), 9 mg nicotine - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 50 | 2026-07-15 | 2026-07-06 |
| A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers 31237616, 31237617, 31237571 - Smoking, Tobacco | Not applicable | Recruiting | RAI Services Company | 1060 | 2026-07-01 | 2026-07-17 |
Showing 20 of 651. Sign in to see all of them.
Cigarette Smoking (430) · Smoking (209) · Smoking Cessation (173) · Tobacco Use Disorder (125) · Tobacco Use (105) · Vaping (67) · Tobacco Use Cessation (32) · Behavior, Addictive (23) · Smoking Reduction (20) · Schizophrenia (19) · Substance-Related Disorders (15) · Alcohol Drinking (13) · Pulmonary Disease, Chronic Obstructive (13) · Lung Neoplasms (11)
Behavior (647) · Tobacco Use (546) · Smoking (442) · Health Behavior (191) · Mental Disorders (166) · Chemically-Induced Disorders (142) · Substance-Related Disorders (127) · Pathological Conditions, Signs and Symptoms (58) · Pathologic Processes (37) · Respiratory Tract Diseases (33) · Lung Diseases (29) · Signs and Symptoms (24) · Compulsive Behavior (23) · Disease Attributes (22)
Tobacco Use Cessation Devices (53) · Varenicline (38) · Nicotine (28) · Nicotine Replacement Therapy (27) · Electronic Nicotine Delivery Systems (20) · Bupropion (17) · HTR3D protein, human (14) · Standard of Care (14) · Nicotine Chewing Gum (13) · Smoking Devices (13) · Tobacco Products (13) · Counseling (8) · Behavior Therapy (7) · Cognitive Behavioral Therapy (7) · Therapeutics (6)
RAI Services Company (32) · Duke University (27) · Medical University of South Carolina (15) · University of California, San Francisco (15) · Virginia Polytechnic Institute and State University (15) · Johns Hopkins University (14) · Yale University (14) · University of Oklahoma (13) · Massachusetts General Hospital (12) · Abramson Cancer Center at Penn Medicine (10) · Brown University (10) · University of Minnesota (9) · University of Southern California (9) · Juul Labs, Inc. (8) · NYU Langone Health (8)
United States (479) · Turkey (Türkiye) (19) · Canada (14) · United Kingdom (12) · France (8) · Germany (7) · Brazil (6) · China (6) · Italy (6) · Hong Kong (5) · Egypt (4) · Pakistan (4) · Poland (4) · Romania (4) · Belgium (3)
Jed E Rose, Ph.D. (7) · Andrew Strasser, Ph.D. (5) · Brian Keyser (4) · Gary Dull, PhD (4) · Milly Kanobe (4) · Neal L Benowitz, MD (4) · Adam M Leventhal, PhD (3) · F. Joseph McClernon, Ph.D. (3) · James M Davis, MD (3) · Jason A Oliver, PhD (3) · Jason Hong, MD (3) · Laurie A Zawertailo, PhD (3) · Lisa Fucito, PhD (3) · Marc L Steinberg, Ph.D. (3) · Melissa Tapia, Ph.D. (3)
PMID 37142273, PMID 34611902, PMID 39868569, PMID 26336372, PMID 27401980, PMID 28616847, PMID 31687769, PMID 35420700, PMID 40183092, PMID 10165099, PMID 10191796, PMID 10417762, PMID 10493090, PMID 10510989, PMID 10581887, PMID 10740940, PMID 10748642, PMID 10773438, PMID 10791509, PMID 10812284, PMID 10885042, PMID 10901493, PMID 10946439, PMID 11176814, PMID 11236847, PMID 11260806, PMID 11420814, PMID 11516593, PMID 11717401, PMID 12010856, PMID 1202204, PMID 12028847, PMID 12047734, PMID 12235470, PMID 12438835, PMID 12472994, PMID 12492263, PMID 12814497, PMID 1453243, PMID 15010446, PMID 1511534, PMID 15370156, PMID 15370939, PMID 15564614, PMID 15700921, PMID 15796782, PMID 15820329, PMID 15941943, PMID 1613610, PMID 16499517
P50DA027840 (9), P01CA200512 (4), P50CA180908 (4), U54DA031659 (4), P01CA217806 (3), 271201400069C-0-0-1 (2), P01CA180945 (2), P50CA180907 (2), R01CA237670 (2), R01CA260460 (2), R01CA266966 (2), R01DA038442 (2), R34DA043751 (2), U54CA229973 (2), 1RC1HL099668 (1)