63 completed, 10 recruiting, 6 withdrawn, 5 terminated. 67 Not applicable, 10 Phase 2, 5 Phase 1, 5 Phase 3, 2 Phase 4.
Follow Electronic Nicotine Delivery Systems: new trials by email Literature Review of Electronic Nicotine Delivery Systems trials Research Report on Electronic Nicotine Delivery Systems
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Understanding Oral Nicotine Pouch Use in Healthy Volunteers 0 mg oral nicotine pouches, 3 mg oral nicotine pouches, 6 mg oral nicotine pouches - Healthy Adult Participants | Phase 1 | Not yet recruiting | University of California, San Francisco | 24 | 2026-10-01 | 2026-09-21 |
| The Villainous Vape: Advancing Vaping Prevention Among Adolescents Through a Comic Book Health Impacts of E-cigarettes, Mind Matters: The Body's Response to Nicotine, Tobacco, and Vaping, The Villainous Vape - Vaping Behaviors | Not applicable | Not yet recruiting | University of Rochester | 90 | 2026-09-01 | 2026-07-30 |
| Evaluating the Effect of Nicotine on Eye Movements and Related Behaviors in Electronic Cigarette Users, NICS-EYES Trial Avoidance, Biospecimen Collection, Cigarette Smoking - Cigarette Smoking-Related Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 25 | 2026-08-17 | 2026-10-05 |
| Persistence of Oral DNA Adducts in Smokers and Vapers Abstain from smoking/vaping - Smokers, Vaping | Not applicable | Withdrawn | University of Minnesota | 2026-03-01 | 2026-02-13 | |
| Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers. E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms - Cigarette Smoking Behavior, E-Cigarette Use | Not applicable | Completed | Thomas Jefferson University | 44 | 2025-08-05 | 2026-10-27 |
| Effects of E-Cigarette Use on Oxidative Stress and Matrix Degradation E-Cigarette Use - Smoking Behaviors, Periodontal Health | Completed | Ankara Medipol University | 60 | 2025-04-30 | 2026-01-13 | |
| E-cigarette Harm Reduction Among PLWHA in South Africa Nicotine Replacement Therapy (NRT), E-Cigarette (EC), Counseling - Tobacco Smoking | Phase 1 | Completed | NYU Langone Health | 106 | 2025-04-15 | 2026-06-09 |
| Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy Electronic Cigarettes (EC), Nicotine replacement therapy (NRT) - Smoking Cessation, Obesity and Obesity-related Medical Conditions | Not applicable | Recruiting | Brown University | 60 | 2025-04-01 | 2026-05-18 |
| Perceptions of Vaping Products Biospecimen Collection, Survey Administration, Vaping Topography - Abuse Tobacco, Exposure | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 53 | 2025-03-03 | 2026-09-08 |
| Vaping and Smoking Project in People With Schizophrenia Acute (24-hour) abstinence, Ad libitum smoking/vaping - Acute Abstinence From Cigarettes vs E-cigarettes (ENDS) | Not applicable | Recruiting | State University of New York at Buffalo | 64 | 2025-02-15 | 2026-03-09 |
| E-cigarette Switching Older Adults E-cigarette, Control/Standard Advice - Tobacco Use, Opioid Use Disorder | Not applicable | Completed | University of Maryland, Baltimore | 36 | 2024-11-25 | 2026-07-10 |
| Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers E-cigarettes, Oral nicotine pouches - E-cigarette Use, Cigarette Smoking | Not applicable | Recruiting | Abramson Cancer Center at Penn Medicine | 200 | 2024-10-02 | 2026-03-12 |
| The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers E-cigarettes - Smoking, Tobacco Use | Not applicable | Recruiting | Abramson Cancer Center at Penn Medicine | 210 | 2024-08-26 | 2026-02-19 |
| Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors - Smoking, Smoking Behaviors | Not applicable | Recruiting | Yale University | 256 | 2024-08-20 | 2026-03-19 |
| E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling - Cigarette Smoking | Not applicable | Recruiting | NYU Langone Health | 60 | 2023-11-13 | 2026-09-29 |
| Trial for Harm Reduction With Incentives & Vaping E-cigarettes ENDS, CI, No ENDS - Obesity, Smoking Cessation | Not applicable | Completed | Brown University | 39 | 2023-11-01 | 2024-11-18 |
| The Effectiveness of Using E-Cigarettes for Smoking Cessation and Decreasing Risk of Diseases Among Heavy Smokers Electronic cigarettes + Health Counselling, Health Counselling - Smoking Cessation | Not applicable | Withdrawn | Shenzhen Smoore Technology Limited | 2023-11-01 | 2023-02-13 | |
| Vaping-Related Seizures - A Prospective Study Vaping - Evaluate the Association of Vaping With Seizures | Withdrawn | Dartmouth-Hitchcock Medical Center | 2023-09-01 | 2023-10-10 | ||
| Effects of Tobacco Flavoring and Liquid Composition on Vaping Topography Vaping, Biospecimen Collection, Questionnaire Administration - Tobacco-Related Carcinoma | Not applicable | Terminated | Roswell Park Cancer Institute | 21 | 2023-08-30 | 2025-12-22 |
| Adolescent Inpatient Tobacco and ENDS Intervention E-cigarette & Tobacco Use Treatment Intervention - Vaping, Smoking | Not applicable | Completed | Children's Mercy Hospital Kansas City | 144 | 2023-08-01 | 2026-02-09 |
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Vaping (56) · Tobacco Use Disorder (26) · Cigarette Smoking (16) · Smoking (16) · Smoking Cessation (15) · Tobacco Use (9) · Harm Reduction (6) · Tobacco Smoking (6) · Pulmonary Disease, Chronic Obstructive (3) · Cardiovascular Diseases (2) · Lung Diseases (2) · Mood Disorders (2) · Obesity (2) · Schizophrenia (2) · Alcoholism (1)
Brown University (5) · NYU Langone Health (4) · Ohio State University Comprehensive Cancer Center (4) · Rose Research Center, LLC (4) · University of California, San Francisco (4) · Duke University (3) · Medical University of South Carolina (3) · Roswell Park Cancer Institute (3) · University of Minnesota (3) · University of Southern California (3) · University of Vermont (3) · Virginia Commonwealth University (3) · Abramson Cancer Center at Penn Medicine (2) · Dartmouth-Hitchcock Medical Center (2) · Queen Mary University of London (2)
United States (75) · United Kingdom (4) · Canada (2) · Sweden (2) · France (1) · Germany (1) · Greece (1) · South Africa (1) · Turkey (Türkiye) (1)
Gideon St. Helen, PhD (2) · Jed E Rose, Ph.D. (2) · Larry Hawk, PhD (2) · Omar El-Shahawy (2) · Peter Shields, MD (2) · Abbey Masonbrink, MD, MPH (1) · Adam M Leventhal, PhD (1) · Alayna P Tackett, PhD (1) · Alexandra R Hershberger (1) · Alison Breland, PhD (1) · Amy C Janes, PhD (1) · Amy J Arouni, MD (1) · Andreas Kyriakou, MD (1) · Barney Vaughan, MD (1) · Cara M Murphy, Ph.D. (1)
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U54DA036114 (4), P20GM130414 (3), P50DA027840 (2), R01DA054276 (2), U54HL147127 (2), 2017 (1), F31AA024682 (1), K23DA055736 (1), P30CA016056 (1), P50CA180890 (1), P50DA009236 (1), P50DA036105 (1), R01CA210625 (1), R01CA287474 (1), R01CA290541 (1)