737 completed, 84 recruiting, 61 unknown, 50 terminated. 493 Not applicable, 204 Phase 2, 96 Phase 1, 95 Phase 4, 77 Phase 3.
Follow Tobacco Use Disorder: new trials by email Literature Review of Tobacco Use Disorder trials Research Report on Tobacco Use Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion - Tobacco Use Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 120 | 2027-03-01 | 2026-07-20 |
| Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder Deep TMS System With H4 Coil - Opioid Use Disorder, Tobacco Use Disorder | Not applicable | Not yet recruiting | Payel Roy | 12 | 2027-01-01 | 2026-08-27 |
| Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea SPECTRUM cigarettes - Cigarette Smoking, Nicotine Dependence | Not applicable | Not yet recruiting | Sung-il Cho | 300 | 2027-01-01 | 2026-08-10 |
| Effects of Psilocybin on Craving in Nicotine Dependence Psilocybin (drug) - Nicotine Dependence | Phase 2 | Not yet recruiting | University of British Columbia | 3 | 2027-01-01 | 2026-10-01 |
| Chatbot for Online Support Groups to Treat Tobacco Addiction online quit-smoking support group with intelligent chatbot, online quit-smoking support group with unintelligent bot - Tobacco Dependence, Tobacco Use Disorder | Not applicable | Not yet recruiting | University of California, Irvine | 120 | 2026-12-01 | 2026-05-22 |
| Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information - Smoking Cessation, Cigarette Smoking | Not applicable | Not yet recruiting | University of Minnesota | 30 | 2026-11-10 | 2026-10-13 |
| Neurostructural and Biochemical Signatures of Tobacco Smoking in Mood Disorders Major Depressive Disorder, Bipolar Disorder | Not yet recruiting | Assiut University | 240 | 2026-11-01 | 2026-11-02 | |
| Developing an E-Cigarette Cessation Intervention for Hispanic/Latina(o) Youth in Florida: The BReATHE Study E-cigarette Cessation Manual - Vaping Teens, Vaping Behaviors | Not applicable | Recruiting | Florida International University | 120 | 2026-10-26 | 2026-10-28 |
| TORCH - Transdiagnostic Observation of Risk Factors, Craving and Health Behaviours in Psychiatric Patients person-centred interventions - Psychiatric Disorders | Not yet recruiting | Jacobs University Bremen gGmbH | 250 | 2026-10-01 | 2026-09-28 | |
| THCV Treatment for Smokers Δ9-Tetrahydrocannabivarin (oral gummy), Matched Placebo (oral gummy) - Tobacco Use Disorder, Smoking Cessation | Phase 2 | Not yet recruiting | University of California, Los Angeles | 32 | 2026-10-01 | 2026-08-04 |
| Evaluation of the Efficacy of QUITOXIL® in Smoking Cessation Quitoxil®, Nicotine Replacement Therapies - Tobacco Use Disorder | Not applicable | Not yet recruiting | KLAVA Innovation | 606 | 2026-10-01 | 2026-07-24 |
| Evaluation of Community Health Worker Support to Help People With Serious Mental Illness to Quit Smoking Integrated CHW Support intervention, Enhanced usual care (EUC) - Nicotine Dependance, Serious Mental Illness | Not applicable | Not yet recruiting | Massachusetts General Hospital | 937 | 2026-10-01 | 2026-08-27 |
| Prevalence and Association of Dysfunctional Breathing With Nicotine Dependence and Physical Activity Among Young Smokers Observational evaluation. - Dysfunctional Breathing, Physical Activity | Not yet recruiting | Istinye University | 420 | 2026-09-30 | 2026-09-28 | |
| §SMOKE Nicotine and Tobacco Youth Cohort Tobacco Use Behavior, Nicotine Dependence Tobacco Product | Recruiting | University of Southern Denmark | 10000 | 2026-09-23 | 2026-11-02 | |
| LaunchPad: Supporting Healthy Decisions and Preventing Drug Use After High School Introduction, Norms re: Protective Behavior Strategies (PBS), Life Skills - Substance-related Disorders, Alcohol-Related Disorders | Not applicable | Not yet recruiting | Prevention Strategies, LLC | 5000 | 2026-09-01 | 2026-06-25 |
| Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT) - Tobacco Use Cessation, Tobacco Use Disorder | Not applicable | Not yet recruiting | University of Virginia | 120 | 2026-09-01 | 2026-07-10 |
| AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access - Nicotine Dependence, Cigarettes | Not applicable | Not yet recruiting | State University of New York at Buffalo | 100 | 2026-08-24 | 2026-08-06 |
| Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability Biospecimen Collection, Questionnaire Administration, Cigarette Purchase Task - Cigarette Addiction, Tobacco Use Disorder | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 48 | 2026-08-18 | 2026-10-14 |
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
Showing 20 of 1025. Sign in to see all of them.
Smoking Cessation (318) · Smoking (246) · Cigarette Smoking (89) · Vaping (78) · Tobacco Use (69) · Tobacco Use Cessation (66) · Substance-Related Disorders (52) · Tobacco Smoking (51) · Alcoholism (35) · Behavior, Addictive (33) · Schizophrenia (33) · Lung Neoplasms (28) · Mental Disorders (19) · Carcinoma, Non-Small-Cell Lung (18)
Chemically-Induced Disorders (1025) · Mental Disorders (1006) · Substance-Related Disorders (973) · Behavior (641) · Health Behavior (353) · Smoking (148) · Tobacco Use (100) · Tobacco Smoking (75) · Pathological Conditions, Signs and Symptoms (44) · Respiratory Tract Diseases (43) · Neoplasms (41) · Neoplasms by Site (39) · Lung Diseases (38) · Alcohol-Related Disorders (34) · Compulsive Behavior (33)
Tobacco Use Cessation Devices (124) · Nicotine (104) · Varenicline (96) · Bupropion (54) · Nicotine Replacement Therapy (46) · Nicotine Chewing Gum (33) · Electronic Nicotine Delivery Systems (26) · Counseling (25) · Behavior Therapy (23) · Sugars (19) · Cognitive Behavioral Therapy (16) · Transcranial Magnetic Stimulation (15) · Tobacco Products (14) · Exercise (12) · Progesterone (10)
National Institute on Drug Abuse (NIDA) (68) · Yale University (58) · University of Pennsylvania (39) · University of California, San Francisco (32) · University of Minnesota (30) · Centre for Addiction and Mental Health (29) · Medical University of South Carolina (28) · University of Wisconsin, Madison (27) · Duke University (26) · Mayo Clinic (24) · Massachusetts General Hospital (22) · McNeil AB (18) · University of Vermont (18) · VA Office of Research and Development (17) · Brown University (15)
United States (798) · Canada (43) · Sweden (18) · France (17) · Germany (14) · Turkey (Türkiye) (12) · China (8) · Spain (8) · United Kingdom (7) · Brazil (6) · Czechia (4) · Denmark (4) · Israel (4) · Norway (4) · Cyprus (3)
Elisabeth Kruse, PhD (16) · Dorothy Hatsukami, Ph.D. (11) · Caryn Lerman, PhD (8) · Elliot Stein, Ph.D. (8) · Dorothy Hatsukami, PhD (7) · Jed E Rose, Ph.D. (7) · James M Davis, MD (6) · John R Hughes, MD (6) · Timothy B Baker, PhD (6) · Maria Varga, MD (5) · Mehmet Sofuoglu, M.D.,Ph.D. (5) · Robert A Schnoll, PhD (5) · Shu-Hong Zhu, Ph.D. (5) · Bernard Le Foll, MD, PhD (4) · Caryn Lerman, Ph.D. (4)
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P50DA027840 (10), 2008 (7), U54DA036151 (7), P50DA009253 (5), P30CA016672 (4), P50AA015632 (4), P50CA143188 (4), P50DA019706 (4), R01DA017572 (4), U54DA036114 (4), K01DA019446 (3), P50DA009241 (3), P50DA013333 (3), P50DA036114 (3), R01HL109031 (3)