55 completed, 7 terminated, 4 active not recruiting, 3 unknown. 50 Not applicable, 8 Phase 2, 7 Phase 1, 3 Phase 3, 2 Early Phase 1.
Follow Tobacco Products: new trials by email Literature Review of Tobacco Products trials Research Report on Tobacco Products
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Villainous Vape: Advancing Vaping Prevention Among Adolescents Through a Comic Book Health Impacts of E-cigarettes, Mind Matters: The Body's Response to Nicotine, Tobacco, and Vaping, The Villainous Vape - Vaping Behaviors | Not applicable | Not yet recruiting | University of Rochester | 90 | 2026-09-01 | 2026-07-30 |
| Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants THS1 (TP18 variant 1), THS2 (TP18 variant 2), THS3 (TP18 variant 3) - Smoking | Not applicable | Active not recruiting | Philip Morris Products S.A. | 108 | 2026-02-19 | 2026-07-30 |
| Pharmacokinetics and Pharmacodynamics of THS With LEVIA Compared to THS With TEREA and to Cigarettes THS with LEVIA (ad libitum), THS with TEREA (ad libitum), THS with LEVIA - Nicotine | Not applicable | Completed | Philip Morris Products S.A. | 24 | 2026-02-01 | 2026-05-05 |
| Nicotine Pharmacokinetics and Pharmacodynamics of Two Variants of VM 1.0 Compared to Cigarettes in Adult Current Smokers VM16, VM32, Cigarette (CC) - Nicotine | Not applicable | Active not recruiting | Philip Morris Products S.A. | 16 | 2025-07-17 | 2025-08-22 |
| Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS Cigarette, THS - COPD, Smoking | Not applicable | Active not recruiting | Philip Morris Products S.A. | 290 | 2025-04-02 | 2026-08-31 |
| Informing Oral Nicotine Pouch Regulations to Promote Public Health Biospecimen Collection, Cigarette, Nicotine Oral Pouch - Tobacco-Related Carcinoma | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 160 | 2025-01-13 | 2026-08-17 |
| Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures Cigarettes - Tobacco Use, Cigarette Smoking | Not applicable | Active not recruiting | Masonic Cancer Center, University of Minnesota | 26 | 2024-10-12 | 2026-07-13 |
| Combined and Separate Effects of Cannabis and Tobacco: Psychomotor, Subjective and Physiological Outcomes Cannabis, Tobacco, Cannabis tobacco - Driving Under the Influence | Not applicable | Recruiting | Centre for Addiction and Mental Health | 60 | 2024-10-07 | 2026-03-17 |
| Remote Trial - Tobacco Product Standard (VLNC) Tobacco and non-tobacco e-cigarettes, Tobacco only e-cigarettes - Tobacco Use | Not applicable | Terminated | Masonic Cancer Center, University of Minnesota | 11 | 2024-09-11 | 2025-04-10 |
| Snus and Home Blood Pressure Snus with or without tobacco - Blood Pressure, Dyslipidemias | Not applicable | Unknown | University Hospital, Linkoeping | 28 | 2023-10-09 | 2024-04-09 |
| Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease Cigarette, THS, Smoking Abstinence - Cardiovascular Diseases, Smoking | Not applicable | Withdrawn | Philip Morris Products S.A. | 2023-03-15 | 2024-11-18 | |
| Study Assessing Efficacy and Safety of NFL-101 on Reduction of Reinforcing Properties of Cigarettes (PRECESTO) NFL-101, Placebo - Smoking Cessation, Nicotine Dependence | Phase 2 | Completed | NFL Biosciences SAS | 34 | 2023-02-21 | 2023-10-19 |
| Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms. THS use, Cigarette, Smoking Abstinence - COPD, Smoking | Not applicable | Terminated | Philip Morris Products S.A. | 715 | 2022-12-16 | 2024-09-26 |
| Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS THS Blade device, THS Induction Mono device, THS Induction Mid device - Smoking, Tobacco Smoking | Not applicable | Completed | Philip Morris Products S.A. | 91 | 2022-11-04 | 2024-09-20 |
| Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers Nicotine, Cigarette - Nicotine Withdrawal, Nicotine Addiction | Phase 1 | Completed | Johns Hopkins University | 71 | 2022-07-27 | 2026-07-23 |
| Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence P4M3 CA35, P4M3 CM35, CIG - Nicotine, Vaping | Not applicable | Completed | Philip Morris Products S.A. | 74 | 2022-07-15 | 2024-03-13 |
| Sugars in Cigarettes Cigarettes with added sucrose - Tobacco Use | Not applicable | Completed | Masonic Cancer Center, University of Minnesota | 30 | 2022-02-24 | 2026-02-27 |
| Changes in Oral Health in Tobacco Cigarettes Smokers After Switching to Combustion-Free Nicotine Delivery Systems TOBACCO CIGARETTES, COMBUSTION-FREE NICOTINE DELIVERY SYSTEMS (C-F NDS), NOT SMOKING - Gingivitis, Periodontal Diseases | Not applicable | Completed | Eclat Srl. | 460 | 2021-10-18 | 2025-09-08 |
| Construal Level as a Novel Pathway for Affect Regulation and Cancer Control High-level construal, Down-regulation of craving for cigarettes, Up-regulation of goal energization - Smoking Cessation, Smoking Reduction | Not applicable | Completed | University of Oregon | 300 | 2021-10-11 | 2026-07-21 |
| Metabolic Syndrome in Diabetic Smokers Using Cigarettes & Combustion-Free Nicotine Delivery Systems TOBACCO CIGARETTES, COMBUSTION-FREE NICOTINE DELIVERY SYSTEMS (C-F NDS) - Cardiovascular Risk Factor, Diabetes Mellitus, Type 2 | Not applicable | Unknown | Eclat Srl. | 576 | 2021-09-27 | 2022-10-27 |
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Smoking (27) · Vaping (15) · Tobacco Use (14) · Tobacco Use Disorder (14) · Smoking Cessation (9) · Cigarette Smoking (8) · Tobacco Smoking (8) · Cardiovascular Diseases (4) · Pulmonary Disease, Chronic Obstructive (3) · Coronary Artery Disease (2) · Lung Diseases (2) · Motor Activity (2) · Periodontal Diseases (2) · Acute Coronary Syndrome (1) · Alcoholism (1)
Philip Morris Products S.A. (11) · University of California, San Francisco (5) · Masonic Cancer Center, University of Minnesota (3) · All India Institute of Medical Sciences (2) · Cedars-Sinai Medical Center (2) · Centre for Addiction and Mental Health (2) · Duke University (2) · Eclat Srl. (2) · H. Lee Moffitt Cancer Center and Research Institute (2) · NFL Biosciences SAS (2) · Ohio State University Comprehensive Cancer Center (2) · UConn Health (2) · University of Minnesota (2) · University of Vermont (2) · Abramson Cancer Center at Penn Medicine (1)
United States (44) · United Kingdom (8) · France (5) · Japan (5) · Canada (3) · Poland (3) · Bulgaria (2) · Czechia (2) · Germany (2) · India (2) · Romania (2) · Slovakia (2) · Sweden (2) · Austria (1) · Denmark (1)
Christelle Haziza, PhD (6) · Neal L Benowitz, MD (3) · Xavier Jaumont, MD (3) · Shalini Gupta, MDS,FDSRCS (2) · Yves Donazzolo, MD (2) · Andrew Barnes, PhD (1) · Andrew Strasser, Ph.D. (1) · Anna O Popko, MD (1) · Antonio Pacino, D.D.S. (1) · Bernard Le Foll, MD, PHD (1) · Bobbette A Jones, DrPH, CCRP (1) · Bobbette Jones, DrPH (1) · Brittney L Keller-Hamilton, PhD, MPH (1) · Buddy G Brown, MS (1)
PMID 18686184, PMID 23154216, PMID 25762758, PMID 25787701, PMID 25787702, PMID 25787703, PMID 26542471, PMID 28461283, PMID 29864548, PMID 31106492, PMID 31867643, PMID 32658536, PMID 33598954, PMID 33605440, PMID 33813637, PMID 33906842, PMID 34647773, PMID 35266059, PMID 35655314, PMID 35974320, PMID 36480388, PMID 37044158, PMID 37443061, PMID 37988256, PMID 38393754, PMID 39240566, PMID 40241094, PMID 42560883
R01DA039264 (2), P50CA180890 (1), R01CA141596 (1), R01CA260831 (1), R01DA020752 (1), R01DA042526 (1), R01DA042532 (1), R01DA051005 (1), R01DA055962 (1), R01HD083404 (1), R01HL117736 (1), R01HL139331 (1), R21DA041596 (1), U01DA045530 (1), U19CA157345 (1)