296 completed, 25 recruiting, 22 unknown, 20 terminated. 140 Not applicable, 92 Phase 4, 76 Phase 2, 42 Phase 3, 39 Phase 1.
Follow this drug Literature Review of Tobacco Use Cessation Devices trials Research Report on Tobacco Use Cessation Devices
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion - Tobacco Use Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 120 | 2027-03-01 | 2026-07-20 |
| DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy Text- and web-based support, Nicotine Replacement Therapy (NRT, nicotine patch), Nicotine replacement therapy lozenge - Dual Use of Cigarettes and E-cigarettes | Phase 2 | Not yet recruiting | Medical University of South Carolina | 321 | 2026-11-01 | 2026-10-15 |
| iCanQuit Smoking Cessation Among Hispanic Adults iCanQuit Smartphone App Smoking Cessation Program, Nicotine Gum, Nicotine Patch - Cigarette Smoking-Related Carcinoma | Phase 3 | Not yet recruiting | Fred Hutchinson Cancer Center | 854 | 2026-10-15 | 2026-09-21 |
| Position-Directed Budesonide Nasal Drops for CRS-associated Olfactory Dysfunction Nasal Drops, Nasal Spray - Chronic Rhinosinusitis (CRS), Olfactory Dysfunction | Not applicable | Not yet recruiting | Peking University Third Hospital | 78 | 2026-09-25 | 2026-09-16 |
| Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use Nicotine Replacement Therapies, Brief Behavioral Counseling - E Cigarette Use, Cessation, Tobacco | Phase 4 | Not yet recruiting | West Virginia University | 100 | 2026-09-01 | 2026-08-26 |
| Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation Varenicline (VAR), Nicotine lozenge (NRT), Smartphone intervention with adherence components (COMBO-A) - Smoking Cessation | Phase 2 | Recruiting | University of Oklahoma | 496 | 2026-07-21 | 2026-08-19 |
| My Path to Quit Tobacco Nicotine patch, Quitline Counseling Phone Calls, Counseling Sessions - Smoking Cessation | Phase 4 | Recruiting | University of Wisconsin, Madison | 1550 | 2026-07-06 | 2026-07-23 |
| A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches - Smoking Cessation | Phase 2 / Phase 3 | Recruiting | Mayo Clinic | 150 | 2026-06-04 | 2026-09-25 |
| Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment transdermal nicotine replacement therapy - Smoking | Phase 4 | Recruiting | Duke University | 600 | 2026-05-06 | 2026-07-23 |
| Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients Auricular acupressure, Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge), Sham Auricular Acupressure - Nicotine Dependence, Nicotine Withdrawal | Not applicable | Recruiting | Chiao-Chiao Liao | 60 | 2026-03-23 | 2026-04-13 |
| The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit. Nicotine Replacement Therapy (NRT, nicotine patch), Music intervention, Biological collection - Nicotine Replacement Therapy, Healthcare Professionals | Not applicable | Not yet recruiting | Poitiers University Hospital | 80 | 2026-03-01 | 2026-02-17 |
| C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker - Tobacco Dependence | Phase 4 | Active not recruiting | Johns Hopkins University | 30 | 2025-12-10 | 2026-07-06 |
| Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Undergoing Thoracic Surgery: A Randomized Controlled Pilot Study Nicotine patch - Nicotine Dependence, Thoracic Diseases | Not applicable | Recruiting | Henan Provincial People's Hospital | 80 | 2025-11-30 | 2026-01-22 |
| THRIVE in Sedated Gastrointestinal Endoscopy High-Flow Nasal Oxygen (THRIVE), Standard Nasal Cannula Oxygen - Hypoxemia, Gastrointestinal Endoscopy | Completed | Fatih Sultan Mehmet Training and Research Hospital | 222 | 2025-07-01 | 2026-03-23 | |
| Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia Carbon Monoxide Measurement, Nicotine Lozenge, Oral Nicotine Pouch - Cigarette Smoking-Related Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 1000 | 2025-06-13 | 2026-06-30 |
| Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge), Cytisine, Varenicline (Champix) - Tobacco | Phase 4 | Recruiting | Ottawa Heart Institute Research Corporation | 150 | 2025-04-30 | 2026-03-05 |
| Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation Nicotine patches plus nicotine mouth spray, Nicotine Tapering Plan - Vaping Cessation | Phase 3 | Recruiting | University of Auckland, New Zealand | 774 | 2025-03-25 | 2025-04-03 |
| Beta-Adrenergic Modulation of Drug Cue Reactivity Propranolol, Nicotine Patch, Placebo Propranolol - Tobacco Use Disorder, Nicotine Dependence | Phase 4 | Recruiting | University of Oklahoma | 80 | 2024-11-26 | 2026-04-28 |
| C-Raven, a Virtual Tobacco Cessation Intervention in the Community C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker - Tobacco Dependence | Phase 4 | Completed | Johns Hopkins University | 10 | 2024-10-30 | 2026-02-02 |
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Smoking Cessation (157) · Tobacco Use Disorder (124) · Smoking (83) · Cigarette Smoking (41) · Tobacco Use Cessation (36) · Schizophrenia (20) · Vaping (20) · Tobacco Smoking (15) · Tobacco Use (15) · Psychotic Disorders (10) · Depression (9) · Acquired Immunodeficiency Syndrome (6) · Harm Reduction (6) · Alcoholism (5) · COVID-19 (5)
Duke University (25) · University of Wisconsin, Madison (17) · M.D. Anderson Cancer Center (14) · National Institute on Drug Abuse (NIDA) (12) · Centre for Addiction and Mental Health (10) · Yale University (10) · Johns Hopkins University (9) · University of California, San Francisco (9) · University of Oklahoma (9) · University of Minnesota (8) · Vanderbilt University Medical Center (8) · H. Lee Moffitt Cancer Center and Research Institute (7) · Mayo Clinic (7) · McNeil AB (7) · The University of Texas Health Science Center, Houston (7)
United States (284) · Canada (18) · France (13) · Germany (7) · Italy (7) · China (6) · South Africa (4) · Sweden (4) · Austria (3) · United Kingdom (3) · Belgium (2) · Denmark (2) · Laos (2) · Mexico (2) · Netherlands (2)
Jed E Rose, Ph.D. (9) · Elisabeth Kruse, PhD (6) · Shu-Hong Zhu, Ph.D. (5) · A Eden Evins, MD, MPH (3) · Dorothy Hatsukami, PhD (3) · Jon O Ebbert, MD (3) · Laura MacPherson, PhD (3) · Luba Yammine, PhD (3) · Stephen I Rennard, MD (3) · Vladimir Nekhendzy, MD (3) · Alan S Lewis, MD, PhD (2) · Alejandra Ellison-Barnes, MD (2) · Andrew Pipe, MD (2) · Anton Chau, MD MMSc (2) · Caryn Lerman, Ph.D. (2)
PMID 37142273, PMID 37335995, PMID 34611902, PMID 39868569, PMID 37230961, PMID 17874878, PMID 17941858, PMID 20124230, PMID 23669629, PMID 25192771, PMID 25388828, PMID 10191796, PMID 10417762, PMID 10493090, PMID 10510989, PMID 10581887, PMID 10740940, PMID 10748642, PMID 10791509, PMID 10812284, PMID 10885042, PMID 10901493, PMID 11027360, PMID 11176814, PMID 11236847, PMID 11260806, PMID 11516593, PMID 11681767, PMID 11717401, PMID 12010856, PMID 1202204, PMID 12028847, PMID 12047734, PMID 12165190, PMID 12377405, PMID 12438835, PMID 12478880, PMID 12492263, PMID 12509650, PMID 12745503, PMID 12814497, PMID 12832959, PMID 12946238, PMID 13630833, PMID 1453243, PMID 14636967, PMID 15007373, PMID 15010446, PMID 15023708, PMID 1511534
P50DA027840 (8), R01HL109031 (3), 2005 (2), 2008 (2), P50CA084718 (2), P50CA143188 (2), P50DA019706 (2), R01DA038442 (2), R33MH122464 (2), R34DA043751 (2), 1RC1CA144382-01 (1), 2014 (1), K01CA160670 (1), K01DA029645 (1), K02DA034767 (1)