35 completed, 13 recruiting, 4 terminated, 3 unknown. 34 Not applicable, 5 Phase 4, 4 Phase 2, 3 Phase 3, 1 Early Phase 1.
Follow Smoking Reduction: new trials by email Literature Review of Smoking Reduction trials Research Report on Smoking Reduction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| Trauma-Informed Care for Smoking Cessation for Pregnancy Expired carbon monoxide (CO), Interviews, Questionnaires - Smoking Cessation, Tobacco Smoking | Not applicable | Recruiting | University of California, San Francisco | 20 | 2025-11-19 | 2026-09-10 |
| A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g) - Thromboangiitis Obliterans (Buerger's Disease) | Phase 1 | Recruiting | Antidote Therapeutics, Inc | 15 | 2025-10-01 | 2025-10-15 |
| Interventional Study on Smoking Reduction in Psychiatry TABAPSY, Usual Care - Tobacco Addiction | Not applicable | Recruiting | GCS-CCOMS | 6500 | 2025-01-15 | 2026-10-08 |
| A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home Indoor Air Quality Monitor AirGradient ONE - Smoking, Smoking Cessation | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 10 | 2024-11-14 | 2026-08-27 |
| E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC). - Opioid Use Disorder, Cigarette Smoking | Phase 2 | Recruiting | NYU Langone Health | 302 | 2024-08-08 | 2026-03-11 |
| Detour: a Smartphone Game to Help Youth Quit Smoking Detour, Self-help brochure - Smoking Cessation, Smoking Reduction | Not applicable | Recruiting | Behavioural Science Institute | 604 | 2024-07-05 | 2024-11-08 |
| Impact of Multi-Component Interventions on High-Risk COPD Smokers Multi-component intervention for smokers - Multimorbidity, Tobacco Use Cessation | Not applicable | Completed | Peking Union Medical College | 4247 | 2024-06-17 | 2026-06-04 |
| Early Life Intervention in Pediatrics Supported by E-health - SMOKE Life-Style app, Sham Comparator - Smoking Reduction, Asthma in Children | Not applicable | Recruiting | Insel Gruppe AG, University Hospital Bern | 160 | 2024-05-07 | 2026-05-06 |
| rTMS-concurrent Behavioral Priming for Reducing Smoking Cravings Repetitive transcranial magnetic stimulation (rTMS) - Smoking Reduction, Smoking Behaviors | Not applicable | Recruiting | West Virginia University | 20 | 2024-04-16 | 2025-04-09 |
| Tobacco Cessation in Public Housing Cessation Intervention - Smoking Cessation, Smoking Reduction | Not applicable | Completed | Johns Hopkins University | 18 | 2024-04-03 | 2026-01-22 |
| Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia 4 weeks of Nicotine lozenge, 8 weeks of Nicotine Replacement Therapy Patch, QuitAid - Smoking Cessation, Smoking, Cigarette | Not applicable | Recruiting | University of Virginia | 768 | 2024-03-06 | 2026-04-20 |
| Switching to E-cigarettes in Smokers Not Interested in Quitting Varenicline Tartrate, Placebo, Electronic cigarette - Smoking Reduction | Phase 3 | Recruiting | University of Kansas Medical Center | 500 | 2023-07-17 | 2026-10-13 |
| Feasibility of a Virtual Smoking Cessation Program Virtual Smoking Cessation Program - Smoking, Smoking Cessation | Not applicable | Completed | University Health Network, Toronto | 54 | 2022-12-01 | 2025-03-30 |
| The Impact of Menthol Flavoring on Switching in Adult Menthol Smokers Menthol-flavored electronic cigarette, Tobacco-flavored electronic cigarette - Smoking Reduction | Not applicable | Recruiting | Nikki Nollen, PhD, MA | 800 | 2022-11-08 | 2026-10-13 |
| The Next Step in Smoking Prevention: the Reduction of Tobacco Retail Outlets, a Comprehensive Policy Evaluation Supermarket tobacco sales ban - Smoking, Tobacco, Smoking Behaviors | Completed | Maastricht University Medical Center | 1530 | 2022-10-26 | 2026-10-22 | |
| Preoperative Smoking Cessation in Patients Undergoing Surgery Intensive preoperative smoking cessation counselling - Smoking Cessation, Smoking Reduction | Not applicable | Terminated | Luzerner Kantonsspital | 251 | 2022-09-02 | 2026-02-27 |
| Testing the Efficacy of A Scalable, Telephone-Delivered, Guided Imagery Tobacco Cessation Intervention Guided Imagery Intervention, Standard Behavioral Control - Smoking Cessation, Smoking | Not applicable | Completed | University of Arizona | 1209 | 2022-08-01 | 2026-10-16 |
| Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children Progesterone 200 MG Oral Capsule - Smoking, Smoking Cessation | Phase 4 | Recruiting | University of Minnesota | 171 | 2022-04-14 | 2026-07-13 |
| Supporting Smoke-Free Policy Compliance in Public Housing Reduction (relocation and reduction of personal smoking) and cessation, Resident Endorsement - Smoking, Smoking Cessation | Not applicable | Completed | Columbia University | 405 | 2022-02-03 | 2026-01-07 |
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Smoking Cessation (36) · Smoking (22) · Tobacco Smoking (13) · Cigarette Smoking (11) · Tobacco Use Disorder (8) · Vaping (5) · Tobacco Use (3) · Behavior, Addictive (2) · Neoplasms (2) · Postoperative Complications (2) · Tobacco Use Cessation (2) · Acquired Immunodeficiency Syndrome (1) · Adolescent Behavior (1) · Body Weight (1)
Behavior (56) · Health Behavior (56) · Smoking (34) · Tobacco Use (17) · Mental Disorders (13) · Chemically-Induced Disorders (10) · Substance-Related Disorders (9) · Pathological Conditions, Signs and Symptoms (7) · Tobacco Smoking (7) · Pathologic Processes (6) · Cardiovascular Diseases (3) · Disease Attributes (3) · Signs and Symptoms (3) · Compulsive Behavior (2) · Impulsive Behavior (2)
Tobacco Use Cessation Devices (5) · Varenicline (4) · Behavior Therapy (2) · Nicotine (2) · Nicotine Replacement Therapy (2) · Acetylcysteine (1) · Bupropion (1) · Counseling (1) · Electronic Nicotine Delivery Systems (1) · Exercise (1) · Interviews as Topic (1) · Isradipine (1) · Medication Therapy Management (1) · Methods (1) · Nebulizers and Vaporizers (1)
University of Catania (4) · University of California, San Francisco (3) · Columbia University (2) · National Institutes of Health (NIH) (2) · VA Office of Research and Development (2) · Antidote Therapeutics, Inc (1) · Behavioural Science Institute (1) · Cairo University (1) · Chelsea and Westminster NHS Foundation Trust (1) · Chinese University of Hong Kong (1) · Click Therapeutics, Inc. (1) · Dr. Julian Reyes López (1) · Duke University (1) · GCS-CCOMS (1) · Ghana Health Services (1)
United States (33) · Italy (4) · Canada (3) · United Kingdom (3) · Egypt (2) · Mexico (2) · Netherlands (2) · Switzerland (2) · Australia (1) · China (1) · Czechia (1) · Denmark (1) · France (1) · Germany (1) · Guadeloupe (1)
Riccardo Polosa, MD, PhD (3) · Nicole Nollen, PhD (2) · Anita Hargrave-Bouagnon, MD, MAS (1) · Anne Joseph, MD (1) · Anne Joseph, MD, MPH (1) · Anne M Joseph, MD, MPH (1) · Arturo Lerner, MD (1) · Avi Bleich, MD, MPH (1) · Cara C Young, Ph.D. (1) · Ching Ching Chan, FHKAM (1) · Christian Fankhauser, PD Dr. med. (1) · Christian Meyer, Dr. (1) · D. Brad Rindal, DDS (1) · Darrell Gray, MD (1) · Deby Peres, MD (1)
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P50DA013333 (2), 2023 (1), P50DA015369 (1), R01AT011500 (1), R01CA166149 (1), R01CA240555 (1), R01DA024709 (1), R01DA039678 (1), R01HD100418 (1), R21DA049539 (1), U01DA058547 (1), U01DE026135 (1), UL1TR003098 (1)