82 completed, 10 unknown, 9 recruiting, 6 terminated. 111 Phase 3, 27 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 111 | Completed 82, Unknown 10, Recruiting 9, Terminated 6, Active not recruiting 3, Withdrawn 1 |
| Phase 2 | 27 | Completed 21, Recruiting 2, Terminated 2, Unknown 2 |
Follow Smoking: new trials by email Literature Review of Smoking trials Research Report on Smoking
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT) AXS-05 (dextromethorphan-bupropion), Bupropion, Placebo - Smoking Cessation | Phase 3 | Recruiting | Axsome Therapeutics, Inc. | 705 | 2026-08-27 | 2026-11-06 |
| A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches - Smoking Cessation | Phase 2 / Phase 3 | Recruiting | Mayo Clinic | 150 | 2026-06-04 | 2026-09-25 |
| Intervention to Increase Intention to Change Alcohol/Tobacco Use in Veterans With Chronic Disease MINDSET, Usual Care - Tobacco Smoking, Alcohol-Related Disorders | Phase 3 | Recruiting | VA Office of Research and Development | 270 | 2025-10-01 | 2025-12-31 |
| Impact of Aversive Warnings on E-Cigarette Cessation Graphic Warning Labels - E Cigarette Use | Phase 3 | Unknown | University of California, San Diego | 1000 | 2025-05-01 | 2024-06-05 |
| Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation Nicotine patches plus nicotine mouth spray, Nicotine Tapering Plan - Vaping Cessation | Phase 3 | Recruiting | University of Auckland, New Zealand | 774 | 2025-03-25 | 2025-04-03 |
| Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test - Electronic Cigarette Related Lung Damage | Phase 2 / Phase 3 | Recruiting | Y. Michael Shim, MD | 80 | 2024-12-19 | 2026-03-17 |
| Effectiveness of Different THR Products in Adult Population E-Cigarette, Nicotine patch - Smoking Cessation | Phase 3 | Unknown | Foundation for a Smoke Free World INC | 258 | 2024-06-01 | 2023-11-21 |
| PeRiopEratiVE SmokiNg CessaTion Trial Cytisine, Video Messaging - Smoking (Tobacco) Addiction, Smoking Cessation | Phase 3 | Active not recruiting | Population Health Research Institute | 1720 | 2024-01-15 | 2024-10-03 |
| V+PSF-M for Tobacco Cessation in HIV Care in India Varenicline, Positively Smoke Free Mobile (PSF-M), Standard Care - Human Immunodeficiency Virus, Smoking Cessation | Phase 3 | Recruiting | University of Colorado, Denver | 400 | 2024-01-02 | 2025-06-15 |
| Switching to E-cigarettes in Smokers Not Interested in Quitting Varenicline Tartrate, Placebo, Electronic cigarette - Smoking Reduction | Phase 3 | Recruiting | University of Kansas Medical Center | 500 | 2023-07-17 | 2026-10-13 |
| Aggressive Smoking Cessation Trial (ASAP) Combination Therapy Arm (Varenicline and Nicotine E-Cigarettes Plus Counseling), Varenicline Plus Counseling - Acute Coronary Syndrome, Cardiovascular Diseases | Phase 3 | Recruiting | Sir Mortimer B. Davis - Jewish General Hospital | 798 | 2023-02-02 | 2025-04-29 |
| Integrating Financial Coaching and Smoking Cessation Coaching Financial counseling, Nicotine Replacement Therapy Agent - Patches, Nicotine Replacement Therapy Agent - Lozenges - Smoking | Phase 3 | Recruiting | NYU Langone Health | 602 | 2022-12-08 | 2026-05-04 |
| Characterization of the Pharmacodynamic Response to Vaped THC THC or Placebo - Vaping, THC | Phase 3 | Withdrawn | Massachusetts General Hospital | 2022-11-01 | 2022-02-11 | |
| Cytisine and E-cigarettes With Supportive Text-messaging for Smoking Cessation (Cess@Tion) Cytisine, Nicotine delivered via an e-cigarette, Cytisine plus nicotine delivered via an e-cigarette - Smoking Cessation | Phase 3 | Completed | University of Auckland, New Zealand | 807 | 2022-05-05 | 2024-12-19 |
| The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette Bupropion, Zonisamide, Placebo bupropion - Smoking Cessation | Phase 3 | Completed | Rose Research Center, LLC | 180 | 2021-12-14 | 2026-02-06 |
| Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts Nicoderm CQ 21Mg/24Hr Transdermal System - Tobacco Use Cessation | Phase 2 / Phase 3 | Completed | Brown University | 49 | 2021-09-01 | 2025-04-06 |
| Metabolism Informed Smoking Treatment: The MIST RCT Post-discharge automated phone calls (IVR) with option to connect with a tobacco coach., Nicotine Replacement Therapy, Varenicline - Smoking | Phase 3 | Completed | Vanderbilt-Ingram Cancer Center | 606 | 2020-11-17 | 2025-12-05 |
| Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes Zonisamide, Bupropion, Halo G6 e-cigarette - Smoking Cessation | Phase 3 | Completed | Rose Research Center, LLC | 26 | 2020-05-27 | 2022-04-13 |
| Optimizing Tobacco Use Treatment for PLWHA Varenicline, Nicotine patch, Standard treatment - HIV/AIDS, Nicotine Dependence | Phase 3 | Active not recruiting | Abramson Cancer Center at Penn Medicine | 340 | 2020-02-17 | 2026-09-04 |
| Vaping THC From Electronic Cigarettes Nicotine, Cannabis, PAX Loose Leaf Vaporizer - Marijuana Dependence | Phase 3 | Completed | University of California, San Francisco | 8 | 2019-03-20 | 2023-06-29 |
Showing 20 of 111. Sign in to see all of them.
Smoking Cessation (52) · Tobacco Use Disorder (28) · Vaping (13) · Cigarette Smoking (11) · Tobacco Use Cessation (9) · Tobacco Smoking (7) · Pulmonary Disease, Chronic Obstructive (6) · Acquired Immunodeficiency Syndrome (4) · Alcohol Drinking (4) · HIV Infections (4) · Tobacco Use (4) · Asthma (3) · Inflammation (3) · Marijuana Abuse (3)
Behavior (110) · Health Behavior (55) · Mental Disorders (39) · Chemically-Induced Disorders (34) · Substance-Related Disorders (32) · Tobacco Use (16) · Pathological Conditions, Signs and Symptoms (15) · Pathologic Processes (12) · Tobacco Smoking (11) · Lung Diseases (10) · Respiratory Tract Diseases (10) · Immune System Diseases (9) · Disease Attributes (8) · Lung Diseases, Obstructive (8)
Varenicline (25) · Bupropion (15) · Nicotine (14) · Tobacco Use Cessation Devices (14) · Nicotine Replacement Therapy (6) · Counseling (5) · Standard of Care (5) · Sugars (5) · Electronic Nicotine Delivery Systems (4) · Motivational Interviewing (3) · Nicotine Chewing Gum (3) · cytisine (3) · Tobacco Products (2) · Transdermal Patch (2) · Zonisamide (2)
Mayo Clinic (7) · University of California, San Francisco (5) · University of Minnesota (5) · Duke University (4) · M.D. Anderson Cancer Center (4) · Nabi Biopharmaceuticals (4) · The Miriam Hospital (4) · University of Auckland, New Zealand (3) · Assistance Publique - Hôpitaux de Paris (2) · Georgetown University (2) · Kaiser Permanente (2) · National Institute on Drug Abuse (NIDA) (2) · Rose Research Center, LLC (2) · Sanofi (2) · US Department of Veterans Affairs (2)
United States (81) · Canada (10) · Denmark (4) · France (4) · New Zealand (3) · Pakistan (3) · India (2) · Sweden (2) · Australia (1) · Bangladesh (1) · Belgium (1) · Brazil (1) · Finland (1) · Iran (1) · Israel (1)
Jed E Rose, Ph.D. (3) · Belinda Borrelli, PhD (2) · Marc E Mooney, Ph.D. (2) · Mark Dransfield, MD (2) · Natalie Walker, PhD (2) · Paul Cinciripini, PhD (2) · Arthur V. Peterson, Jr., PhD (1) · Asgeir R Helgason, PhD (1) · B M Smith, MD (1) · Bess H Marcus, PhD (1) · Beth C Bock, PhD (1) · Bonnie Spring, PhD (1) · Brian J Smith, MBBS; FRACP;PhD;Dip Clin Epid (1) · Caryn Lerman, PhD (1)
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K01DA019446 (2), P50DA027840 (2), 2004 (1), 2017 (1), K24AA013736 (1), M01RR006192 (1), P50CA180908 (1), R01CA082569 (1), R01CA086242 (1), R01CA133068 (1), R01CA138417 (1), R01CA206193 (1), R01CA207228 (1), R01CA232516 (1), R01CA243914 (1)