227 completed, 13 terminated, 12 recruiting, 12 withdrawn. 127 Not applicable, 43 Phase 2, 41 Phase 1, 39 Phase 4, 30 Phase 3.
Follow Nicotine: new trials by email Literature Review of Nicotine trials Research Report on Nicotine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pre-Clinic Visit Online Education for Thyroid Cancer THRIVE, ACS "After a Thyroid Cancer Diagnosis" Flyer - Thyroid Cancer | Not applicable | Not yet recruiting | Cedars-Sinai Medical Center | 60 | 2027-08-01 | 2026-09-01 |
| Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling - Cigarette Smoking, Veterans | Phase 4 | Not yet recruiting | VA Office of Research and Development | 112 | 2027-04-01 | 2026-09-14 |
| Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion - Tobacco Use Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 120 | 2027-03-01 | 2026-07-20 |
| THRIVE: A Recovery-Focused Suicide Prevention Intervention in Crisis Stabilization Centers Toward Hope, Recovery, Interpersonal Growth, Values, and Engagement (THRIVE), Center Care as Usual - Suicide | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 552 | 2026-12-15 | 2026-10-20 |
| iCanQuit Smoking Cessation Among Hispanic Adults iCanQuit Smartphone App Smoking Cessation Program, Nicotine Gum, Nicotine Patch - Cigarette Smoking-Related Carcinoma | Phase 3 | Not yet recruiting | Fred Hutchinson Cancer Center | 854 | 2026-12-01 | 2026-10-29 |
| Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream Biospecimen Collection, Cannabis sativa Extract, Nicotine - Cannabis Dependence | Early Phase 1 | Not yet recruiting | Roswell Park Cancer Institute | 60 | 2026-10-15 | 2026-09-25 |
| Impact of Sweeteners on the Addictive Threshold of Nicotine Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose - Smoking ( Cigarette) | Phase 1 | Not yet recruiting | Yale University | 36 | 2026-09-01 | 2026-08-31 |
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| Abuse Liability of Four Modern Oral Nicotine Products Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Wintergreen (fleece A), 12 mg nicotine, Wintergreen (fleece A), 9 mg nicotine - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 50 | 2026-07-15 | 2026-07-06 |
| My Path to Quit Tobacco Nicotine patch, Quitline Counseling Phone Calls, Counseling Sessions - Smoking Cessation | Phase 4 | Recruiting | University of Wisconsin, Madison | 1550 | 2026-07-06 | 2026-11-10 |
| Abuse Liability of Two Modern Oral Nicotine Pouched Products Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Modern Oral Pouch Wintergreen-A 9 mg Nicotine, Modern Oral Pouch Wintergreen-B 9 mg Nicotine - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 40 | 2026-06-15 | 2026-05-19 |
| Teen motHers' ReproductIve and behaVioral Health intErvention in Barbados THRIVE Integrated Care Program - Pregnancy in Adolescence | Not applicable | Not yet recruiting | Hada Fongha Ieong, PhD | 50 | 2026-06-01 | 2026-01-06 |
| Comparative Evaluation of Nicotine Analogs Biospecimen Collection, Nicotine, 6-Methyl Nicotine - Tobacco-Related Carcinoma, Addiction | Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 70 | 2026-05-29 | 2026-06-26 |
| Preliminary Testing and Development of a Short Digital Intervention for Patients on Waiting Lists for Psychological Treatment Digital therapy program (short), Digital therapy program (long), Mental health advice - Depression, Anxiety | Not applicable | Enrolling by invitation | University of Oslo | 80 | 2026-03-24 | 2026-05-01 |
| Clinical Trial to Reduce Perinatal Intimate Partner Violence Doulas, Thrive - Domestic Violence, Perinatal Problems | Not applicable | Recruiting | University of Pittsburgh | 250 | 2025-11-01 | 2026-04-16 |
| Transition Health and Resilience Through Valued Experiences (THRiVE) Pilot for Newly Separated Veterans Transition Health and Resilience through Valued Experiences (THRiVE) Program - Military Transition, Community Reintegration | Not applicable | Recruiting | RTI International | 40 | 2025-07-30 | 2026-06-10 |
| Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration Cannabis, Nicotine, Pax Loose Leaf Vaporizer - THC, Cannabis | Phase 2 | Recruiting | University of California, San Francisco | 48 | 2025-07-01 | 2026-01-07 |
| Parenting Intervention for Mothers With Substance Use Disorder THRIVE - Substance Use Disorders, Children of Mothers With Substance Use Disorders | Not applicable | Completed | Boston Medical Center | 9 | 2025-01-17 | 2026-04-07 |
| Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine (S)-Nicotine, (R)- nicotine, Racemic nicotine - Nicotine Dependence, Nicotine Vaping | Phase 1 | Recruiting | University of California, San Francisco | 18 | 2024-12-06 | 2026-05-14 |
| Study About Group and Phone Follow-Up After a Crisis THRIVE (Toward Hope, Recovery, Interpersonal Growth, Values, and Engagement), Discharge / Safety Planning - Suicide, Crisis; Emotional | Not applicable | Completed | University of Rochester | 59 | 2024-09-23 | 2026-07-17 |
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Tobacco Use Disorder (104) · Smoking Cessation (92) · Smoking (63) · Vaping (34) · Cigarette Smoking (24) · Depression (10) · Tobacco Use Cessation (10) · Tobacco Use (8) · Harm Reduction (7) · Lung Neoplasms (6) · Schizophrenia (6) · Substance-Related Disorders (6) · Carcinoma, Non-Small-Cell Lung (5) · Marijuana Abuse (5) · Anxiety Disorders (4)
Yale University (28) · McNeil AB (13) · Duke University (12) · GlaxoSmithKline (12) · Centre for Addiction and Mental Health (9) · Mclean Hospital (8) · M.D. Anderson Cancer Center (7) · National Institute on Drug Abuse (NIDA) (7) · Johns Hopkins University (6) · University of California, Los Angeles (6) · University of California, San Francisco (6) · University of Pennsylvania (6) · Columbia University (5) · University of Minnesota (5) · University of Wisconsin, Madison (5)
United States (220) · Canada (19) · Sweden (14) · United Kingdom (4) · Spain (3) · Denmark (2) · France (2) · Israel (2) · Italy (2) · Norway (2) · Switzerland (2) · Barbados (1) · Czechia (1) · Egypt (1) · Finland (1)
Elisabeth Kruse, PhD (14) · Jed E Rose, Ph.D. (5) · Mehmet Sofuoglu, M.D.,Ph.D. (4) · Nancy K Mello, PhD (4) · Laura MacPherson, PhD (3) · Laurie Zawertailo, PhD (3) · Mehmet Sofuoglu, M.D., Ph.D. (3) · Pamela Flood, MD (3) · Shu-Hong Zhu, Ph.D. (3) · Alison Breland, PhD (2) · Andrew Barnes, PhD (2) · Andrew Pipe, MD (2) · Brian Keyser (2) · Caryn Lerman, PhD (2)
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P50DA027840 (7), U54DA036151 (7), 2008 (5), U54DA036105 (5), P50DA036107 (3), P01CA180945 (2), P50DA013333 (2), P50DA036151 (2), R33MH122464 (2), 2005 (1), 2009 (1), 2017 (1), F31DA047018 (1), K01AA019694 (1), K01MD014165 (1)