3375 completed, 815 unknown, 417 recruiting, 292 terminated. 2046 Not applicable, 559 Phase 2, 556 Phase 3, 439 Phase 4, 354 Phase 1.
Follow Pulmonary Disease, Chronic Obstructive: new trials by email Literature Review of Pulmonary Disease, Chronic Obstructive trials Research Report on Pulmonary Disease, Chronic Obstructive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Developing an Intervention to Optimize Virtual Care Adoption for COPD Management VC-OPTIONS - Chronic Obstructive Pulmonary Disease | Not applicable | Not yet recruiting | VA Office of Research and Development | 40 | 2027-09-02 | 2026-09-29 |
| Remote Intervention Versus Routine Monitoring in COPD Patients With Chronic Hypercapnia Receiving Home Non-invasive Respiratory Support Remote Management, Remote Monitoring Only - COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD | Not applicable | Not yet recruiting | Sir Run Run Shaw Hospital | 236 | 2027-08-01 | 2026-08-06 |
| RSV Vaccination to Reduce Recurrent AECOPD RSV vaccination (Arexvy, GlaxoSmithKline) - COPD, RSV | Phase 4 | Not yet recruiting | Chinese University of Hong Kong | 320 | 2027-07-01 | 2026-04-13 |
| cfMSC Stem Cell Therapy Targeting COPD clonal fetal MSCs - Chronic Obstructive Pulmonary Disease (COPD) | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-08-27 |
| Comparative Effectiveness of Roflumilast and Azithromycin in Reducing Exacerbations in Severe Chronic Obstructive Pulmonary Disease ( COPD ) Patients With Chronic Bronchitis Phenotype Roflumilast Oral Tablet, Azithromycin 250 mg - Chronic Obstructive Pulmonary Disease With Exacerbation | Phase 4 | Not yet recruiting | Sidra Aziz | 70 | 2027-02-01 | 2026-08-31 |
| Study of Fluticasone/Formoterol/Glycopyrronium for the Treatment Chronic Obstructive Pulmonary Disease (TRIPLAR) Fluticasone 250mcg/Formoterol 12mcg/Glycopyrronium 25mcg, Comparator - Trimbow® - Chronic Obstructive Pulmonary Disease | Phase 3 | Not yet recruiting | Eurofarma Laboratorios S.A. | 1252 | 2027-01-30 | 2026-10-26 |
| Repeat Treatment With Metered Cryospray in Patients With Chronic Obstructive Pulmonary Disease With Chronic Bronchitis Metered cryospray (MCS) - COPD (Chronic Obstructive Pulmonary Disease), Chronic Bronchitis | Not applicable | Not yet recruiting | CSA Medical, Inc. | 10 | 2027-01-02 | 2026-10-05 |
| Pulmonary Rehabilitation Frequency in COPD Patients Pulmonary Rehabilitation - COPD, COPD (Chronic Obstructive Pulmonary Disease) | Not applicable | Not yet recruiting | Hospital Universitario Fundación Alcorcón | 158 | 2027-01-01 | 2026-05-08 |
| A Study of the Effect of a Nurse Navigator Program on High Risk Patients Nurse Navigator Program - Patient Readmission, Arthroplasty, Replacement, Knee | Not applicable | Not yet recruiting | Mayo Clinic | 300 | 2027-01-01 | 2026-03-19 |
| The Effect of Inhaled Nitric Oxide on Pulmonary Gas-exchange in COPD Inhaled Nitric Oxide, Placebo - Chronic Obstructive Pulmonary Disease | Phase 1 / Phase 2 | Not yet recruiting | University of Alberta | 80 | 2026-12-01 | 2026-07-08 |
| Effect of add-on Doxofylline on Lung Function in Stable COPD Doxofylline - Chronic Obstructive Pulmonary Disease | Phase 4 | Not yet recruiting | University of Milan | 78 | 2026-12-01 | 2026-04-29 |
| Portable Positive Pressure Therapy Device BREATHE, BiPAP, COPD Inhaler - COPD | Not applicable | Not yet recruiting | Koronis Biomedical Technologies | 20 | 2026-12-01 | 2025-03-25 |
| A Clinical Trial Comparing TQC3927 Inhaled Powder With Glycopyrronium Bromide and Formoterol Inhaled Aerosol (Biovoping® Lingchang®) for the Treatment of Chronic Obstructive Pulmonary Disease TQC3927 inhalation aerosol, Glyceryl bromide/formoterol inhalation aerosol - Chronic Obstructive Pulmonary Disease | Phase 2 | Suspended | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 90 | 2026-12-01 | 2026-09-03 |
| Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD Inhalation of bronchodilation therapy at FRC, Inhalation of bronchodilation therapy at RV - COPD, Lung Injury | Not yet recruiting | University of Milan | 30 | 2026-12-01 | 2026-05-04 | |
| Effectiveness and Efficiency of Home Telemonitoring and Non-invasive Ventilation in Patients With COPD and Hypercapnia (EVALECO) Home Non-Invasive Ventilation and Telemonitoring - Pulmonary Disease, Chronic Obstructive (COPD), Hypercapnia | Not yet recruiting | Air Liquide Healthcare Spain | 92 | 2026-12-01 | 2026-10-28 | |
| Firefighter's Longitudinal Airway and Respiratory Exposome/Multiome Study (FLARES) Anosmia, Chronic Obstructive Pulmonary Disease | Enrolling by invitation | National Institute of Allergy and Infectious Diseases (NIAID) | 350 | 2026-11-02 | 2026-10-28 | |
| Validation of 1 Minute Sit-to Stand Test for Assessment of Breathlessness at Exertion in Individuals With Chronic Lung Disease 1MSTS - COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis) | Not yet recruiting | Jacob Sandberg | 120 | 2026-11-01 | 2026-09-23 | |
| Effect of Dietary Fiber Supplementation on Systemic Inflammation and Clinical Parameters in COPD Dietary Fiber Supplementation, Placebo Control - Pulmonary Disease, Chronic Obstructive (COPD), Pulmonary Diseases | Not applicable | Not yet recruiting | Júnea Regina Pires Drews | 100 | 2026-11-01 | 2026-10-14 |
| Urolithin A Supplementation During Pulmonary Rehabilitation in Patients With COPD Urolithin A, Placebo - Chronic Obstructive Pulmonary Disease (COPD) | Phase 2 | Not yet recruiting | Bryan A. Ross | 198 | 2026-11-01 | 2026-10-13 |
| Acute Muscular and Vascular Responses to a Single Session of Exercise With BFR in COPD Blood Flow Restriction, Standard exercise session - Control Condition, Pulmonary Disease (COPD), Chronic Obstructive | Not applicable | Not yet recruiting | University Hospital, Grenoble | 40 | 2026-11-01 | 2026-06-30 |
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Asthma (437) · Emphysema (299) · Dyspnea (233) · Motor Activity (226) · Bronchitis, Chronic (201) · Heart Failure (201) · Lung Diseases (195) · Lung Diseases, Obstructive (104) · Diabetes Mellitus (100) · Lung Diseases, Interstitial (89) · Respiratory Insufficiency (85) · Lung Neoplasms (81) · Anxiety Disorders (70) · Pneumonia (70)
Disease Attributes (5395) · Pathological Conditions, Signs and Symptoms (5395) · Pathologic Processes (5388) · Chronic Disease (5358) · Respiratory Tract Diseases (5347) · Lung Diseases, Obstructive (5291) · Lung Diseases (5200) · Bronchial Diseases (701) · Immune System Diseases (498) · Signs and Symptoms (483) · Respiration Disorders (473) · Behavior (459) · Hypersensitivity (448) · Respiratory Hypersensitivity (446) · Hypersensitivity, Immediate (439)
Tiotropium Bromide (242) · Formoterol Fumarate (135) · Salmeterol Xinafoate (99) · Glycopyrrolate (81) · Albuterol (77) · indacaterol (73) · Exercise (72) · Fluticasone (71) · Budesonide (64) · olodaterol (55) · Fluticasone-Salmeterol Drug Combination (48) · Noninvasive Ventilation (47) · Ipratropium (46) · GSK573719 (41) · Roflumilast (40)
GlaxoSmithKline (275) · AstraZeneca (236) · Boehringer Ingelheim (235) · Novartis Pharmaceuticals (88) · Chiesi Farmaceutici S.p.A. (61) · Riphah International University (61) · Imperial College London (49) · University of Zurich (38) · Pearl Therapeutics, Inc. (37) · VA Office of Research and Development (36) · Assiut University (35) · Schön Klinik Berchtesgadener Land (35) · Laval University (33) · Brigham and Women's Hospital (28) · National Heart, Lung, and Blood Institute (NHLBI) (28)
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Esther Garcia, MD (18) · Konrad E Bloch, MD (14) · Talant M Sooronbaev, MD (13) · Colin Reisner, MD (11) · Dave Singh, MD (11) · Ronald G Crystal, MD (11)
PMID 33511633, PMID 34495549, PMID 32943047, PMID 35815359, PMID 37542951, PMID 42149813, PMID 42551404, PMID 17507545, PMID 35514131, PMID 39423760, PMID 12091180, PMID 19720809, PMID 24127811, PMID 33124005, PMID 10377201, PMID 1759018, PMID 17951621, PMID 20102307, PMID 23497334, PMID 24314123, PMID 25066329, PMID 25359355, PMID 25496316, PMID 25918120, PMID 28419462, PMID 30077810, PMID 32462607, PMID 32671684, PMID 32848381, PMID 33152467, PMID 38616018, PMID 42476723, PMID 11282762, PMID 15764761, PMID 16055882, PMID 16310554, PMID 16565429, PMID 16936234, PMID 17197484, PMID 18786894, PMID 19179484, PMID 19729666, PMID 20071991, PMID 20427767, PMID 20843247, PMID 21103404, PMID 21227674, PMID 21397482, PMID 22206353, PMID 22793945
2017 (25), 2009 (23), 2015 (22), 2018 (16), 2023 (16), 2008 (15), 2025 (15), 2014 (14), 2019 (13), 2016 (9), R01HL082480 (5), U10HL074424 (5), 2005 (3), R01HL136682 (3), P50CA090440 (2)