158 completed, 23 recruiting, 12 terminated, 10 unknown. 217 Phase 2, 31 Phase 1, 27 Phase 3.
Follow Smoking: new trials by email Literature Review of Smoking trials Research Report on Smoking
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy Text- and web-based support, Nicotine Replacement Therapy (NRT, nicotine patch), Nicotine replacement therapy lozenge - Dual Use of Cigarettes and E-cigarettes | Phase 2 | Not yet recruiting | Medical University of South Carolina | 321 | 2026-11-01 | 2026-10-15 |
| THCV Treatment for Smokers Δ9-Tetrahydrocannabivarin (oral gummy), Matched Placebo (oral gummy) - Tobacco Use Disorder, Smoking Cessation | Phase 2 | Not yet recruiting | University of California, Los Angeles | 32 | 2026-10-01 | 2026-08-04 |
| Enhancing Smoking Cessation for African American People Everywhere ESCAPE app + NRT, quiSTART app + NRT, Control (CTRL) - ESCAPE Intervention+NRT, quitSTART Intervention+NRT | Phase 2 | Recruiting | University of Houston | 300 | 2026-06-30 | 2026-07-13 |
| Ongoing Lung Decline With Age Intensified Response Fisetin, Placebo - Age-Related Lung Function Decline | Phase 2 | Recruiting | Cedars-Sinai Medical Center | 40 | 2026-06-17 | 2026-10-15 |
| Multi-Site Trial of Tirzepatide for Smoking Cessation Tirzepatide, Placebo - Smoking Cessation, Smoking Behaviors | Phase 2 | Recruiting | University of Southern California | 300 | 2026-06-05 | 2026-07-17 |
| A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches - Smoking Cessation | Phase 2 / Phase 3 | Recruiting | Mayo Clinic | 150 | 2026-06-04 | 2026-09-25 |
| GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV Semaglutide (Rybelsus®), Placebo - HIV, Alcohol | Phase 2 | Recruiting | Vanderbilt University Medical Center | 200 | 2026-04-17 | 2026-05-26 |
| The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction VapeAway filter system - Addiction Nicotine | Phase 2 | Recruiting | VapeAway | 70 | 2025-12-24 | 2026-01-07 |
| Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis Standard Varenicline Dosing (1 mg BID), Bupropion 150 mg twice daily, Increased Varenicline Dosing (1mg TID) - Pancreatitis, Chronic, Pancreatitis, Acute | Phase 2 | Withdrawn | Mayo Clinic | 2025-11-06 | 2026-07-07 | |
| A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse Brenipatide, Placebo - Smoking | Phase 2 | Recruiting | Eli Lilly and Company | 222 | 2025-11-03 | 2026-09-22 |
| A Trial of Varenicline for E-cigarette Cessation Varenicline 1mg BID, Placebo - E-cigarette Use, Vaping | Phase 2 | Recruiting | Yale University | 326 | 2025-10-14 | 2025-12-17 |
| Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration Cannabis, Nicotine, Pax Loose Leaf Vaporizer - THC, Cannabis | Phase 2 | Recruiting | University of California, San Francisco | 48 | 2025-07-01 | 2026-01-07 |
| Kick-Nic! Youth Quit Vaping App Kick-Nic! mobile phone application, NCI Quit Vaping website - Nicotine Vaping | Phase 2 | Recruiting | Yale University | 306 | 2025-01-07 | 2026-07-31 |
| Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test - Electronic Cigarette Related Lung Damage | Phase 2 / Phase 3 | Recruiting | Y. Michael Shim, MD | 80 | 2024-12-19 | 2026-03-17 |
| Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity Cytisinicline, Placebo Oral Capsule - Smoking Cessation, Tobacco Use Disorder | Phase 2 | Recruiting | University of California, Los Angeles | 64 | 2024-12-05 | 2025-12-03 |
| Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes - Tobacco Use Disorder | Phase 2 | Recruiting | University of Vermont | 308 | 2024-11-01 | 2025-06-27 |
| Cannabidiol for Reducing Cigarette Use Cannabidiol (CBD) 800 mg, Placebo - Tobacco Use Disorder, Tobacco Smoking | Phase 2 | Recruiting | University of California, Los Angeles | 120 | 2024-10-31 | 2026-04-13 |
| E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC). - Opioid Use Disorder, Cigarette Smoking | Phase 2 | Recruiting | NYU Langone Health | 302 | 2024-08-08 | 2026-11-09 |
| App for Reducing Cravings to Smoke Updating Existing Smartphone App, Quitline Services, Quitline Services and Smartphone App - Smoking | Phase 2 | Active not recruiting | H. Lee Moffitt Cancer Center and Research Institute | 1051 | 2024-06-11 | 2026-09-11 |
| The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence Placebo, AB-free kava - Smoking | Phase 2 | Recruiting | University of Florida | 76 | 2024-06-06 | 2026-01-27 |
Showing 20 of 217. Sign in to see all of them.
Tobacco Use Disorder (74) · Smoking Cessation (71) · Cigarette Smoking (59) · Vaping (21) · Tobacco Smoking (13) · Marijuana Smoking (11) · Alcoholism (9) · Schizophrenia (9) · Behavior, Addictive (8) · Tobacco Use (7) · Tobacco Use Cessation (7) · Alcohol Drinking (6) · Substance-Related Disorders (6) · Marijuana Abuse (5)
Behavior (217) · Mental Disorders (106) · Chemically-Induced Disorders (90) · Substance-Related Disorders (86) · Health Behavior (78) · Tobacco Use (68) · Tobacco Smoking (56) · Pathological Conditions, Signs and Symptoms (21) · Smoking, Non-Tobacco Products (12) · Lung Diseases (11) · Pathologic Processes (11) · Respiratory Tract Diseases (11) · Signs and Symptoms (11) · Marijuana Use (9)
Tobacco Use Cessation Devices (29) · Varenicline (29) · Nicotine (19) · Nicotine Replacement Therapy (18) · Bupropion (15) · Electronic Nicotine Delivery Systems (8) · Naltrexone (8) · Behavior Therapy (5) · Cognitive Behavioral Therapy (5) · Counseling (5) · Nicotine Chewing Gum (5) · Sugars (4) · nabiximols (4) · Atomoxetine Hydrochloride (3) · Dronabinol (3)
Yale University (23) · Mayo Clinic (11) · Duke University (8) · Brown University (7) · Medical University of South Carolina (6) · National Institute on Drug Abuse (NIDA) (5) · University of Pennsylvania (5) · University of Vermont (5) · Johns Hopkins University (4) · The University of Texas Health Science Center, Houston (4) · University of Minnesota (4) · University of Oklahoma (4) · VA Office of Research and Development (4) · Centre for Addiction and Mental Health (3) · GlaxoSmithKline (3)
United States (183) · Canada (4) · Brazil (2) · Denmark (2) · France (2) · Israel (2) · Japan (2) · Laos (2) · Netherlands (2) · United Kingdom (2) · Argentina (1) · Australia (1) · China (1) · Czechia (1) · Egypt (1)
Jed E Rose, Ph.D. (5) · Sherry A McKee, PhD (4) · Luba Yammine, PhD (3) · Suchitra Krishnan-Sarin, Ph.D. (3) · Caryn Lerman, PhD (2) · Christian Hendershot, Ph.D. (2) · Christian Meyer, Dr. (2) · James M Davis, M.D. (2) · Jed E. Rose, Ph.D. (2) · Laura MacPherson, PhD (2) · Marc E Mooney, Ph.D. (2) · Ramzi Salloum, PhD (2) · Stephanie O'Malley, PhD (2) · Ulrich John, Prof. Dr. (2)
PMID 37142273, PMID 37230961, PMID 29663982, PMID 34611902, PMID 39240566, PMID 42560883, PMID 15534159, PMID 16240558, PMID 17587504, PMID 18480694, PMID 18686184, PMID 19196814, PMID 19483180, PMID 19524389, PMID 19786427, PMID 20056957, PMID 20078491, PMID 20081039, PMID 20093899, PMID 20191360, PMID 20211945, PMID 20334673, PMID 20434863, PMID 20466951, PMID 20542391, PMID 20590478, PMID 20719253, PMID 20947286, PMID 21163939, PMID 21221531, PMID 21270788, PMID 21276244, PMID 21356232, PMID 21473764, PMID 21565525, PMID 21652735, PMID 21656058, PMID 21785892, PMID 21928117, PMID 21939867, PMID 22007015, PMID 22097928, PMID 22157229, PMID 22229310, PMID 22352784, PMID 22464727, PMID 22592966, PMID 22741619, PMID 22761006, PMID 22898118
P50AA015632 (5), P50DA027840 (5), P50DA033945 (3), U54DA036114 (3), K01DA019446 (2), P50DA013333 (2), R34DA043751 (2), 2004 (1), 2014 (1), I01CX002357 (1), I01CX002543 (1), K01MD015295 (1), K23DA022471 (1), K23DA039294 (1), N01CN35159 (1)