96 completed, 10 recruiting, 7 terminated, 5 withdrawn. 127 Phase 1, 31 Phase 2.
Follow Smoking: new trials by email Literature Review of Smoking trials Research Report on Smoking
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Primary Care CEASE+ - Smoking, Smoking Cessation | Phase 1 | Not yet recruiting | University of Minnesota | 50 | 2027-01-01 | 2026-02-27 |
| Impact of Sweeteners on the Addictive Threshold of Nicotine Nicotine 0.05 mg/pulse and 0.1 mg/pulse, Saline Placebo (0.5mL injection), sucralose - Smoking ( Cigarette) | Phase 1 | Not yet recruiting | Yale University | 36 | 2026-09-01 | 2026-08-31 |
| Nicotine Pouch Pharmacokinetics Abuse Liability Participants will place the pouch between their top lip and their gum for 30 minutes as per use instructions. - Smoking Behaviors | Phase 1 | Active not recruiting | JT International SA | 55 | 2026-01-08 | 2026-08-19 |
| A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g) - Thromboangiitis Obliterans (Buerger's Disease) | Phase 1 | Recruiting | Antidote Therapeutics, Inc | 15 | 2025-10-01 | 2025-10-15 |
| Effects of Cannabidiol on Stress and Nicotine Withdrawal Epidiolex - CBD, Stress | Phase 1 | Recruiting | Johns Hopkins University | 90 | 2025-08-25 | 2026-08-10 |
| Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors quitSTART Mobile Application, Chatbot Feature in quitSTART Mobile Application - Nicotine Vaping, Nicotine Use Disorder | Phase 1 | Terminated | Washington University School of Medicine | 26 | 2025-06-04 | 2026-10-26 |
| E-cigarette Harm Reduction Among PLWHA in South Africa Nicotine Replacement Therapy (NRT), E-Cigarette (EC), Counseling - Tobacco Smoking | Phase 1 | Completed | NYU Langone Health | 106 | 2025-04-15 | 2026-06-09 |
| Effect of Cannabis on E-Cigarette Use Behavior THC High Dose, THC Low Dose, THC 0mg - Cannabis Use, Tobacco Use | Phase 1 | Recruiting | Johns Hopkins University | 100 | 2025-03-19 | 2026-04-09 |
| Effect of Cannabis on Cigarette Use Behavior THC 30mg, THC 5mg, THC 0mg - Cannabis Use, Tobacco Use | Phase 1 | Recruiting | Johns Hopkins University | 100 | 2025-01-22 | 2026-01-16 |
| Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine (S)-Nicotine, (R)- nicotine, Racemic nicotine - Nicotine Dependence, Nicotine Vaping | Phase 1 | Recruiting | University of California, San Francisco | 18 | 2024-12-06 | 2026-05-14 |
| Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use Varenicline, Counseling, Guided Self-Change Booklets - Cigarette Smoking, E-Cigarette Use | Phase 1 | Completed | Yale University | 19 | 2024-04-01 | 2026-11-05 |
| Overcoming Nicotine Dependence to Enable Quitting Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling - Tobacco Use, Smoking Cessation | Phase 1 / Phase 2 | Recruiting | Rush University Medical Center | 780 | 2023-03-24 | 2026-09-09 |
| Oral Cannabidiol for Tobacco Cessation 300 mg Cannabidiol, 600 mg Cannabidiol, Placebo - Tobacco Use, Tobacco Smoking | Phase 1 | Recruiting | Johns Hopkins University | 50 | 2022-11-01 | 2026-01-07 |
| Biomarkers of Exposure and Effect in Standardized Research E-cigarette (SREC) Users Standardized Research E-cigarette (SREC) - Smoking, Cigarette | Phase 1 | Completed | Masonic Cancer Center, University of Minnesota | 47 | 2022-05-11 | 2026-10-15 |
| Study of EMB-001 as a Potential Smoking Cessation Treatment EMB-001 - Tobacco Use Disorder | Phase 1 / Phase 2 | Terminated | Embera NeuroTherapeutics, Inc. | 13 | 2021-06-10 | 2026-11-05 |
| The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence E-cigarettes - Nicotine Dependence | Phase 1 / Phase 2 | Completed | Duke University | 20 | 2021-05-21 | 2024-02-21 |
| STARS (Smoking Treatment And Remote Sampling) Study Varenicline 0.5 MG, Nicotine Replacement Therapy (NRT) - Smoking, Smoking Cessation | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 652 | 2021-02-08 | 2026-02-17 |
| Development of a mHealth Intervention for Ambivalent Smokers Control mHealth program, Experimental mHealth program, Nicotine patch - Tobacco Use Disorder, Smoking Cessation | Phase 1 | Completed | Kaiser Permanente | 57 | 2020-12-16 | 2023-01-23 |
| Alcohol and Cigarette Craving During Oxytocin Treatment Oxytocin nasal spray, Placebo - Alcohol Use Disorder, Smoking | Phase 1 | Completed | Brown University | 19 | 2020-11-09 | 2024-05-14 |
| Hyperpolarized Xenon-129 MR Imaging of the Lung Hyperpolarized Xenon -129 MRI - E-Cig Use | Phase 1 / Phase 2 | Recruiting | University of Virginia | 24 | 2020-11-05 | 2020-12-10 |
Showing 20 of 127. Sign in to see all of them.
Tobacco Use Disorder (35) · Smoking Cessation (28) · Cigarette Smoking (26) · Tobacco Smoking (10) · Vaping (10) · Tobacco Use (6) · Behavior, Addictive (4) · Marijuana Abuse (4) · Alcohol Drinking (3) · Substance-Related Disorders (3) · Water Pipe Smoking (3) · Alcoholism (2) · Anxiety Disorders (2) · Attention Deficit Disorder with Hyperactivity (2)
Behavior (127) · Mental Disorders (52) · Chemically-Induced Disorders (43) · Substance-Related Disorders (40) · Tobacco Use (32) · Health Behavior (30) · Tobacco Smoking (24) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (5) · Compulsive Behavior (4) · Impulsive Behavior (4) · Drinking Behavior (3) · Nutritional and Metabolic Diseases (3) · Pipe Smoking (3)
Nicotine (14) · Tobacco Use Cessation Devices (13) · Varenicline (10) · Nicotine Replacement Therapy (6) · Counseling (5) · Bupropion (4) · Dronabinol (4) · Motivational Interviewing (3) · Tobacco Products (3) · Atomoxetine Hydrochloride (2) · Cannabidiol (2) · Cotinine (2) · Electronic Nicotine Delivery Systems (2) · Ethanol (2) · Naltrexone (2)
Yale University (13) · Johns Hopkins University (7) · Duke University (6) · National Institute on Drug Abuse (NIDA) (4) · University of California, San Francisco (4) · Masonic Cancer Center, University of Minnesota (3) · Star Scientific, Inc (3) · University of Minnesota (3) · Battelle Memorial Institute (2) · Cedars-Sinai Medical Center (2) · Emory University (2) · GlaxoSmithKline (2) · Mayo Clinic (2) · Pfizer (2) · Rock Creek Pharmaceuticals, Inc. (2)
United States (103) · Canada (3) · France (2) · Germany (2) · Australia (1) · Brazil (1) · China (1) · Egypt (1) · Netherlands (1) · New Zealand (1) · South Africa (1) · South Korea (1) · Spain (1) · Syria (1) · United Kingdom (1)
Maria Varga, MD (5) · Neal L Benowitz, MD (3) · Dustin Lee, PhD (2) · Lisa Fucito, PhD (2) · Mehmet Sofuoglu, M.D., Ph.D. (2) · Michael J Zvolensky, Ph.D. (2) · Naomi Fujioka, MD (2) · Stephen J Heishman, Ph.D. (2) · Adam M Leventhal, PhD (1) · Albert Arias, MD (1) · Alison Breland, PhD (1) · Amanda Mathew, PhD (1) · Andrea H. Weinberger, Ph.D. (1)
PMID 37142273, PMID 17587504, PMID 20056957, PMID 21270788, PMID 21356232, PMID 22229310, PMID 23811612, PMID 24020450, PMID 24894701, PMID 25419583, PMID 25671683, PMID 27896797, PMID 28725452, PMID 29034576, PMID 29139311, PMID 30286396, PMID 30526213, PMID 32075695, PMID 33792551, PMID 33831213, PMID 33852730, PMID 34347865, PMID 34375409, PMID 35718119, PMID 37379059, PMID 42101840
P50AA015632 (2), R01DA058624 (2), 271201400069C-0-0-1 (1), 271201500019C-0-0-1 (1), F31DA040369 (1), K01AA026874 (1), K23AA020000 (1), K23DA039294 (1), K24DA023464 (1), N01CN35159 (1), P50CA196530 (1), R00DA037276 (1), R01CA103827 (1), R01CA120142 (1), R01CA140256 (1)