242 completed, 22 recruiting, 19 terminated, 16 unknown. 96 Phase 2, 90 Phase 4, 66 Phase 3, 49 Not applicable, 31 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion - Tobacco Use Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 120 | 2027-03-01 | 2026-07-20 |
| Varenicline as a Treatment for Cannabis Use Disorder Varenicline (Chantix), Placebo - Cannabis Abuse | Phase 2 | Not yet recruiting | Medical University of South Carolina | 224 | 2026-12-01 | 2026-08-25 |
| Varenicline for Smoking Cessation in Pancreatitis Varenicline (VAR) - Pancreatitis, Chronic Pancreatitis | Phase 4 | Not yet recruiting | Mayo Clinic | 45 | 2026-11-13 | 2026-10-19 |
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia RP-008, Varenicline tartrate - Trigeminal Neuralgia | Phase 1 / Phase 2 | Recruiting | Kriya Therapeutics, Inc. | 24 | 2026-08-01 | 2026-06-08 |
| Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation Varenicline (VAR), Nicotine lozenge (NRT), Smartphone intervention with adherence components (COMBO-A) - Smoking Cessation | Phase 2 | Recruiting | University of Oklahoma | 496 | 2026-07-21 | 2026-08-19 |
| Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study) Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham - Nicotine Dependence, Transcranial Magnetic Stimulation | Phase 4 | Recruiting | Massachusetts General Hospital | 30 | 2026-07-02 | 2026-09-15 |
| Ocular Surface Health and Tear Film Stability With a Nasal Spray Dry Eye Treatment Varenicline 0.03Mg/Spray Nasal Soln - Dry Eye, Meibomian Gland Dysfunction | Phase 4 | Recruiting | University of California, Berkeley | 65 | 2026-03-06 | 2026-05-27 |
| A Trial of Varenicline for E-cigarette Cessation Varenicline 1mg BID, Placebo - E-cigarette Use, Vaping | Phase 2 | Recruiting | Yale University | 326 | 2025-10-14 | 2025-12-17 |
| Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2 Varenicline - Alcohol Use Disorder, Hiv | Phase 2 | Active not recruiting | Yale University | 30 | 2025-06-16 | 2026-04-16 |
| A Study of Varenicline in the Treatment of Visceral Sensation Varenicline - Irritable Bowel Syndrome | Phase 1 | Completed | Mayo Clinic | 8 | 2025-06-01 | 2026-01-06 |
| Cannabis-Tobacco Co-Use Treatment Study Varenicline, Counseling, Psychosocial modules - Tobacco Use Disorder, Tobacco Use Cessation | Phase 3 | Recruiting | Medical University of South Carolina | 200 | 2025-05-06 | 2026-04-03 |
| Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge), Cytisine, Varenicline (Champix) - Tobacco | Phase 4 | Recruiting | Ottawa Heart Institute Research Corporation | 150 | 2025-04-30 | 2026-03-05 |
| Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse Experimental health intervention, Varenicline - Tobacco Use, Tobacco Cessation | Phase 2 | Recruiting | Yale University | 114 | 2025-04-21 | 2026-06-05 |
| Reducing Falls With Varenicline in Hypocholinergic Parkinson Disease Placebo, Varenicline - Parkinson Disease | Phase 2 | Recruiting | Vikas Kotagal | 102 | 2025-04-09 | 2026-03-31 |
| tDCS Plus Varenicline for Smoking Cessation Active Transcranial Direct Current Stimulation (tDCS), Varenicline 1mg BID, Sham Transcranial Direct Current Stimulation (tDCS) - Nicotine Dependence, Tobacco Smoking | Phase 4 | Recruiting | Centre for Addiction and Mental Health | 160 | 2025-03-10 | 2025-08-12 |
| E-cigarette Cessation in Adults Who Co-use Cannabis Varenicline Pill, Contingency management, Counseling - Nicotine Dependence, Tobacco Use Disorder | Phase 4 | Recruiting | Medical University of South Carolina | 105 | 2025-02-19 | 2026-06-12 |
| Efficacy of Varenicline Tartrate in Treating Frequent Premature Ventricular Contractions Varenicline Tartrate Tablets, Placebo - Premature Ventricular Contraction (PVC) | Phase 2 | Completed | Yihan Chen | 116 | 2025-02-17 | 2025-11-19 |
| Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder Varenicline Tartrate, Placebo - Nicotine Addiction, Craving | Early Phase 1 | Recruiting | University of California, San Diego | 200 | 2024-11-19 | 2026-03-16 |
Showing 20 of 326. Sign in to see all of them.
Smoking Cessation (159) · Tobacco Use Disorder (96) · Smoking (76) · Cigarette Smoking (31) · Alcoholism (17) · Schizophrenia (17) · Substance-Related Disorders (14) · Tobacco Use Cessation (14) · Tobacco Smoking (11) · Vaping (11) · Alcohol Drinking (10) · Dry Eye Syndromes (9) · Acquired Immunodeficiency Syndrome (8) · Behavior, Addictive (7) · Depression (7)
Pfizer (42) · Yale University (22) · Mayo Clinic (14) · University of Pennsylvania (14) · Centre for Addiction and Mental Health (12) · Medical University of South Carolina (12) · Duke University (10) · Massachusetts General Hospital (8) · Oyster Point Pharma, Inc. (7) · University of California, Los Angeles (7) · University of Wisconsin, Madison (7) · M.D. Anderson Cancer Center (6) · Albert Einstein College of Medicine (4) · Ottawa Heart Institute Research Corporation (4) · University of Maryland, Baltimore (4)
United States (222) · Canada (34) · South Korea (11) · United Kingdom (10) · France (9) · Germany (9) · Australia (7) · China (7) · Mexico (7) · Brazil (6) · Spain (6) · Taiwan (6) · Czechia (5) · Denmark (5) · Russia (5)
Jed E Rose, Ph.D. (4) · Lisa Fucito, PhD (4) · Sherry A McKee, PhD (4) · Andrew Pipe, MD (3) · E. Jennifer Edelman, MD, MHS (3) · Nicole Nollen, PhD (3) · Robert A Schnoll, PhD (3) · A. Eden Evins, MD, MPH (2) · Aimee McRae-Clark, PharmD (2) · Caryn Lerman, PhD (2) · F. Joseph McClernon, Ph.D. (2) · Jason Robinson (2) · Jennifer G Plebani, PhD (2)
PMID 37142273, PMID 34611902, PMID 37230961, PMID 39868569, PMID 37096956, PMID 18084743, PMID 18442345, PMID 20457644, PMID 20819082, PMID 20884658, PMID 30946162, PMID 31502736, PMID 33300144, PMID 34062053, PMID 36401081, PMID 38369951, PMID 38770804, PMID 39101506, PMID 10494779, PMID 12748199, PMID 12800127, PMID 12837716, PMID 1456527, PMID 15634270, PMID 16221753, PMID 16820546, PMID 16820547, PMID 16820548, PMID 17407636, PMID 17692719, PMID 17692720, PMID 17962429, PMID 18263663, PMID 18513462, PMID 18687246, PMID 18842256, PMID 19004600, PMID 19192221, PMID 19238488, PMID 19243716, PMID 19251401, PMID 19323966, PMID 19686530, PMID 19693492, PMID 19733449, PMID 19874586, PMID 20048210, PMID 20207347, PMID 20363092, PMID 20395358
P50AA015632 (4), P50DA018185 (3), P50DA027840 (3), 2009 (2), K01DA019446 (2), K01DA025073 (2), K23DA025736 (2), P01CA180945 (2), P60DA005186 (2), R01HL109031 (2), R37CA237245 (2), 1RC1HL099668 (1), 1UG3NS133515-01A1 (1), 2008 (1), 2017 (1)