95 completed, 12 recruiting, 9 terminated, 8 unknown. 137 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 137 | Completed 95, Recruiting 12, Terminated 9, Unknown 8, Not yet recruiting 5, Withdrawn 5, Active not recruiting 2, Enrolling by invitation 1 |
Follow Smoking: new trials by email Literature Review of Smoking trials Research Report on Smoking
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling - Cigarette Smoking, Veterans | Phase 4 | Not yet recruiting | VA Office of Research and Development | 112 | 2027-04-01 | 2026-09-14 |
| Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use Nicotine Replacement Therapies, Brief Behavioral Counseling - E Cigarette Use, Cessation, Tobacco | Phase 4 | Not yet recruiting | West Virginia University | 100 | 2026-09-01 | 2026-08-26 |
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study) Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham - Nicotine Dependence, Transcranial Magnetic Stimulation | Phase 4 | Recruiting | Massachusetts General Hospital | 30 | 2026-07-02 | 2026-09-15 |
| Piloting Novel Interventional Strategies to Improve Nicotine Pouches as a Substitute for Smoking Nicotine replacement therapy patches, Oral nicotine pouches - Smoking ( Cigarette) | Phase 4 | Enrolling by invitation | Medical University of South Carolina | 10 | 2026-06-26 | 2026-07-06 |
| Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment transdermal nicotine replacement therapy - Smoking | Phase 4 | Recruiting | Duke University | 600 | 2026-05-06 | 2026-07-23 |
| Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking Daridorexant 50 mg, Placebo - Smoking, Nicotine | Phase 4 | Not yet recruiting | Legacy Health System | 44 | 2026-02-10 | 2026-01-09 |
| tDCS Plus Varenicline for Smoking Cessation Active Transcranial Direct Current Stimulation (tDCS), Varenicline 1mg BID, Sham Transcranial Direct Current Stimulation (tDCS) - Nicotine Dependence, Tobacco Smoking | Phase 4 | Recruiting | Centre for Addiction and Mental Health | 160 | 2025-03-10 | 2025-08-12 |
| E-cigarette Cessation in Adults Who Co-use Cannabis Varenicline Pill, Contingency management, Counseling - Nicotine Dependence, Tobacco Use Disorder | Phase 4 | Recruiting | Medical University of South Carolina | 105 | 2025-02-19 | 2026-06-12 |
| Addiction Potential of Very Low Nicotine Filtered Little Cigars Reduced Nicotine Content Cigars, Normal nicotine content cigar, Usual brand cigar - Smoking (Tobacco) Addiction | Phase 4 | Recruiting | Ohio State University Comprehensive Cancer Center | 50 | 2025-02-13 | 2026-10-29 |
| Beta-Adrenergic Modulation of Drug Cue Reactivity Propranolol, Nicotine Patch, Placebo Propranolol - Tobacco Use Disorder, Nicotine Dependence | Phase 4 | Recruiting | University of Oklahoma | 80 | 2024-11-26 | 2026-04-28 |
| The Avenues Study: Dual Use Cessation Varenicline, Nicotine patch, Dual Focused Cessation Counseling - Smoking Cessation, Electronic Cigarette Use | Phase 4 | Recruiting | University of Wisconsin, Madison | 500 | 2024-09-24 | 2026-10-07 |
| Tobacco Cessation at FDNY opt out enrollment, tailored counseling, varenicline started prior to target quit date, opt in enrollment, non-tailored counseling, varenicline started prior to target quit date - Tobacco Use, Tobacco Smoking | Phase 4 | Completed | Albert Einstein College of Medicine | 23 | 2024-05-31 | 2026-11-05 |
| Smoking Cessation Program in the Construction Sector Nicorette, Tobacco Quit-line, Brief Behavioral Counseling - Smoking Cessation, Tobacco Use Cessation | Phase 4 | Active not recruiting | University of Miami | 608 | 2024-04-10 | 2026-08-21 |
| Implementation of Transcranial Magnetic Stimulation for Smoking Cessation Brainsway H4 deep rTMS coil and Brainsway stimulator system - Smoking | Phase 4 | Recruiting | Centre for Addiction and Mental Health | 40 | 2024-03-30 | 2026-03-27 |
| Treating Caregivers Who Smoke at AFCH Nicotine Replacement Product - Smoking, Smoking Cessation | Phase 4 | Completed | University of Wisconsin, Madison | 23 | 2024-03-05 | 2026-04-16 |
| Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects Bupropion, Nicotine replacement therapy (Nicotine patches) - Tobacco Smoking, Tobacco Withdrawal | Phase 4 | Unknown | National Institute of Respiratory Diseases, Mexico | 134 | 2024-01-15 | 2024-02-23 |
| Effects and Safety of Clonidine Patch on Young and Middle-aged Smokers With Mild Hypertension Clonidine controlled-release patch, Amlodipine - Hypertension | Phase 4 | Not yet recruiting | Jing Liu | 92 | 2024-01-01 | 2024-01-17 |
| BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study Text message smoking treatment, Nicotine replacement therapy sampling, Wisconsin Tobacco QuitLine Referral - Quitting Smoking, Smoking Cessation | Phase 4 | Completed | University of Wisconsin, Madison | 12376 | 2023-07-24 | 2026-06-26 |
Showing 20 of 137. Sign in to see all of them.
Smoking Cessation (54) · Tobacco Use Disorder (39) · Cigarette Smoking (25) · Tobacco Smoking (15) · Vaping (14) · Schizophrenia (9) · Alcoholism (8) · Pulmonary Disease, Chronic Obstructive (5) · Smoking Reduction (5) · Tobacco Use (5) · Substance-Related Disorders (4) · Tobacco Use Cessation (4) · Asthma (3) · Behavior, Addictive (3)
Behavior (137) · Mental Disorders (60) · Health Behavior (57) · Chemically-Induced Disorders (50) · Substance-Related Disorders (46) · Tobacco Use (35) · Tobacco Smoking (24) · Pathological Conditions, Signs and Symptoms (14) · Pathologic Processes (11) · Schizophrenia Spectrum and Other Psychotic Disorders (9) · Alcohol-Related Disorders (8) · Disease Attributes (8) · Respiratory Tract Diseases (8) · Vascular Diseases (8)
Tobacco Use Cessation Devices (38) · Varenicline (37) · Nicotine Replacement Therapy (15) · Nicotine Chewing Gum (14) · Bupropion (13) · Nicotine (11) · Counseling (7) · Motivational Interviewing (5) · Ethanol (4) · Sugars (4) · Behavior Therapy (3) · Cognitive Behavioral Therapy (3) · Naltrexone (3) · Transdermal Patch (3) · Chewing Gum (2)
University of Wisconsin, Madison (18) · Centre for Addiction and Mental Health (8) · Massachusetts General Hospital (8) · Duke University (7) · VA Office of Research and Development (5) · University of Miami (4) · Yale University (4) · Johns Hopkins University (3) · Mayo Clinic (3) · University of California, San Francisco (3) · University of Pennsylvania (3) · Medical University of South Carolina (2) · Nathan Kline Institute for Psychiatric Research (2) · Pfizer (2) · Swedish Match AB (2)
United States (99) · Canada (12) · China (4) · France (4) · Germany (4) · Brazil (3) · Mexico (3) · Spain (3) · Switzerland (3) · United Kingdom (3) · Australia (2) · Croatia (2) · Czechia (2) · Hong Kong (2) · Italy (2)
Taghrid Asfar, MD (3) · Timothy B Baker, PhD (3) · Anne M. Joseph, MD MPH (2) · Eden Evins, MD (2) · Jason A Oliver, PhD (2) · Jessica Cook, PhD (2) · Laurie A Zawertailo, PhD (2) · Megan E Piper, PhD (2) · Michael C Fiore, MD, MPH, MBA (2) · Nancy A Rigotti, MD (2) · Peter Selby, MD, MHSc (2) · Randi Schuster, PhD (2) · Robin Mermelstein, PhD (2) · Sarah M. Wilson, PhD (2)
PMID 37142273, PMID 37230961, PMID 39868569, PMID 17874878, PMID 34611902, PMID 37335995, PMID 10191796, PMID 10417762, PMID 10493090, PMID 10510989, PMID 10581887, PMID 10740940, PMID 10748642, PMID 10791509, PMID 10812284, PMID 10885042, PMID 10901493, PMID 11176814, PMID 11236847, PMID 11260806, PMID 11390919, PMID 11516593, PMID 12010856, PMID 1202204, PMID 12028847, PMID 12047734, PMID 12438835, PMID 12492263, PMID 12814497, PMID 14525940, PMID 1453243, PMID 14636967, PMID 15007373, PMID 15010446, PMID 15023708, PMID 1511534, PMID 15364185, PMID 15370156, PMID 15370939, PMID 15533910, PMID 15541431, PMID 15561445, PMID 15586837, PMID 15820329, PMID 15900212, PMID 15925263, PMID 16123753, PMID 1613610, PMID 16402081, PMID 16402128
P01CA180945 (3), P50CA143188 (3), R01AA011197 (2), R01DA052583 (2), 1RC1CA144382-01 (1), 2023 (1), K01DA043413 (1), K24DA030301 (1), P50CA084718 (1), P50CA084724 (1), P50DA019706 (1), P50HL084945 (1), R01AA011124 (1), R01AA011210 (1), R01AA011216 (1)