72 completed, 8 terminated, 7 unknown, 6 not yet recruiting. 41 Not applicable, 26 Phase 4, 15 Phase 2, 13 Phase 3, 7 Phase 1.
Follow Nicotine Chewing Gum: new trials by email Literature Review of Nicotine Chewing Gum trials Research Report on Nicotine Chewing Gum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling - Cigarette Smoking, Veterans | Phase 4 | Not yet recruiting | VA Office of Research and Development | 112 | 2027-04-01 | 2026-09-14 |
| Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion - Tobacco Use Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 120 | 2027-03-01 | 2026-07-20 |
| Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Not yet recruiting | Xianhui Wang | 20 | 2026-11-01 | 2026-10-21 |
| iCanQuit Smoking Cessation Among Hispanic Adults iCanQuit Smartphone App Smoking Cessation Program, Nicotine Gum, Nicotine Patch - Cigarette Smoking-Related Carcinoma | Phase 3 | Not yet recruiting | Fred Hutchinson Cancer Center | 854 | 2026-10-15 | 2026-09-21 |
| Varenicline for Smoking Reduction in Veterans Not Ready To Quit Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT) - Veterans, Tobacco Use Disorder | Phase 4 | Recruiting | VA Office of Research and Development | 400 | 2026-08-17 | 2026-08-31 |
| Gen AI Powered Behavioral Support Plus Chewing Gum Intervention for Construction Workers Who Smoke AWARD advice, Brief leaflet on health warning and smoking cessation, Referral card - Smoking Cessation | Not applicable | Not yet recruiting | The University of Hong Kong | 200 | 2026-06-20 | 2026-06-17 |
| Acute Nicotine Gum and Tinnitus Loudness in Non-Smoking Adults Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Completed | San Diego State University | 29 | 2026-03-25 | 2026-10-16 |
| Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product - Smoking Cessation, Harm Reduction | Phase 3 | Completed | Rose Research Center, LLC | 150 | 2024-08-29 | 2026-02-06 |
| Smoking Cessation Program in the Construction Sector Nicorette, Tobacco Quit-line, Brief Behavioral Counseling - Smoking Cessation, Tobacco Use Cessation | Phase 4 | Active not recruiting | University of Miami | 608 | 2024-04-10 | 2026-08-21 |
| Pharmacokinetic and Subjective Effects of Heated Tobacco Products Product A, Product B, Product C - Tobacco Use | Not applicable | Completed | Altria Client Services LLC | 80 | 2024-02-06 | 2026-03-27 |
| Effects of Caffeine and Nicotine Gum on Balance Performance in Athletes Caffeine Gum 3mg/kg, Nicotine Gum (4 mg), Placebo Gum (Xylitol) - Athletic Performance, Postural Stability | Not applicable | Completed | Gülbin Rudarlı | 20 | 2024-01-08 | 2025-12-04 |
| Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product - Smoking Cessation, Harm Reduction | Phase 3 | Terminated | Rose Research Center, LLC | 4 | 2023-12-27 | 2025-03-30 |
| Evaluating Smoking Cessation Interventions for PWH in South Africa Varenicline, Nicotine patch, Nicotine gum - Smoking Cessation, HIV | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 660 | 2023-11-27 | 2026-10-19 |
| Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation - Tobacco Use Disorder | Phase 2 | Recruiting | VA Office of Research and Development | 50 | 2023-10-31 | 2026-02-18 |
| BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study Text message smoking treatment, Nicotine replacement therapy sampling, Wisconsin Tobacco QuitLine Referral - Quitting Smoking, Smoking Cessation | Phase 4 | Completed | University of Wisconsin, Madison | 12376 | 2023-07-24 | 2026-06-26 |
| Smoking Cessation and Menstrual Cycle Phase Timing of nicotine replacement therapy start date, Nicotine Replacement Therapy Agent - Nicotine Dependence, Tobacco Smoking | Phase 4 | Recruiting | Centre for Addiction and Mental Health | 1200 | 2022-11-30 | 2026-03-19 |
| Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex Nicotine gum, Placebo gum - Aging | Early Phase 1 | Completed | University of California, Berkeley | 44 | 2022-06-06 | 2026-07-24 |
| Easy Access to Smoking Cessation for People Receiving Opioid Agonist Therapy Who Are Smoking Tobacco Nicotine patch, Nicotine gum, Nicotine lozenge - Smoking Cessation, Substance-Related Disorders | Not applicable | Active not recruiting | Haukeland University Hospital | 266 | 2022-04-07 | 2024-06-28 |
| WeChat Quit Coach Pilot Study WeChat Quit Coach, Leaflet, Optional Nicotine Replacement Therapy (NRT) Patches or Lozenges - Smoking Cessation | Not applicable | Completed | NYU Langone Health | 150 | 2022-02-10 | 2026-07-31 |
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Smoking Cessation (55) · Tobacco Use Disorder (33) · Smoking (21) · Cigarette Smoking (9) · Tobacco Use Cessation (7) · Tobacco Use (6) · Harm Reduction (5) · Schizophrenia (5) · Tobacco Smoking (4) · Vaping (4) · Alcohol Drinking (3) · Psychotic Disorders (3) · Substance-Related Disorders (3) · Body Weight (2) · Depression (2)
McNeil AB (9) · Duke University (8) · VA Office of Research and Development (6) · University of Minnesota (4) · University of Wisconsin, Madison (4) · Centre for Addiction and Mental Health (3) · Johns Hopkins University (3) · National Institute on Drug Abuse (NIDA) (3) · Yale University (3) · 22nd Century Group, Inc. (2) · Mark Vander Weg (2) · Rose Research Center, LLC (2) · The University of Hong Kong (2) · University of Kansas Medical Center (2) · University of Miami (2)
United States (68) · Sweden (8) · Canada (4) · South Africa (3) · China (2) · Czechia (1) · Denmark (1) · Finland (1) · France (1) · Greece (1) · Hong Kong (1) · Japan (1) · Jordan (1) · Norway (1) · Spain (1)
Elisabeth Kruse, PhD (8) · A Eden Evins, MD, MPH (2) · Debra Kelsh, MD (2) · Dorothy Hatsukami, Ph.D. (2) · E. Jennifer Edelman, MD, MHS (2) · Jean C Beckham, Ph.D. (2) · Jean C Beckham, PhD (2) · Jean C. Beckham, Ph.D. (2) · Stephen I Rennard, MD (2) · Taghrid Asfar, MD (2) · Xianhui Wang (2) · Amanda L Graham, PhD (1) · Amy J Arouni, MD (1) · Claudio M Pannuti, PhD (1)
PMID 37142273, PMID 37335995, PMID 37230961, PMID 17632223, PMID 17763111, PMID 17888856, PMID 19392908, PMID 19664750, PMID 21561497, PMID 21605389, PMID 22992296, PMID 24329972, PMID 24794687, PMID 25005652, PMID 25699616, PMID 27535024, PMID 27918881, PMID 28288601, PMID 28549278, PMID 28806908, PMID 29454141, PMID 29878062, PMID 30646142, PMID 30664539, PMID 31426671, PMID 31619205, PMID 31832719, PMID 33063570, PMID 33794354, PMID 34255698, PMID 34611902, PMID 35196033, PMID 35435813, PMID 35978355, PMID 36848129, PMID 37005655, PMID 37285107, PMID 37639601, PMID 37889541, PMID 38184633, PMID 38409089, PMID 39037756, PMID 39665734, PMID 39868569, PMID 39937506, PMID 40489501, PMID 40543725, PMID 41758512
2008 (4), R01AG067073 (2), 1RC1CA144382-01 (1), 2009 (1), K01MD014165 (1), P01CA180945 (1), P50CA143188 (1), P50DA013333 (1), R01AA011197 (1), R01CA135884 (1), R01CA155489 (1), R01CA174481 (1), R01CA243910 (1), R01CA298383 (1), R01DA002538 (1)