44 completed, 8 not yet recruiting, 4 recruiting, 1 terminated. 54 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 54 | Completed 41, Not yet recruiting 8, Recruiting 4, Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product Menthol 5%, Combustible cigarette - Smoking Behaviors, Smoking ( Cigarette) | Not applicable | Not yet recruiting | RAI Services Company | 28 | 2026-11-15 | 2026-10-20 |
| A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products Golden Tobacco Chill 5% (4) 6.5W, Glacier Menthol 5% (4) 6.5W, Fresh Mint 5% (4) 6.5W - Smoking Behaviors, Smoking ( Cigarette) | Not applicable | Not yet recruiting | RAI Services Company | 50 | 2026-10-01 | 2026-07-31 |
| A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System FT25614, FT25615, FT25616 - Smoking, Tobacco | Not applicable | Recruiting | RAI Services Company | 480 | 2026-09-30 | 2026-10-22 |
| Abuse Liability of Four Modern Oral Nicotine Products Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Wintergreen (fleece A), 12 mg nicotine, Wintergreen (fleece A), 9 mg nicotine - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 50 | 2026-07-15 | 2026-07-06 |
| A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers 31237616, 31237617, 31237571 - Smoking, Tobacco | Not applicable | Recruiting | RAI Services Company | 1060 | 2026-07-01 | 2026-07-17 |
| Abuse Liability of Two Modern Oral Nicotine Pouched Products Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Modern Oral Pouch Wintergreen-A 9 mg Nicotine, Modern Oral Pouch Wintergreen-B 9 mg Nicotine - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 40 | 2026-06-15 | 2026-05-19 |
| A Consumer Use Behavior Study to Measure the Puffing Topography of Heated Tobacco Products P2515910, P2512610 - Cigarette Smokers | Not applicable | Not yet recruiting | RAI Services Company | 200 | 2026-06-01 | 2026-06-30 |
| A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers P2613422, P2611222, P2615522 - Smoking, Tobacco | Not applicable | Recruiting | RAI Services Company | 1280 | 2026-05-14 | 2026-06-03 |
| A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems Product A, Product B, Product C - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 40 | 2026-03-15 | 2026-01-07 |
| Abuse Liability for Eight Electronic Nicotine Products Product A, Product B, Product C - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 70 | 2026-02-15 | 2026-01-07 |
| Abuse Liability for Four Heated Tobacco Product (HTP) Consumables and Two HTP Devices Product A, Product N, Product B - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 40 | 2026-01-01 | 2025-12-16 |
| Abuse Liability for Five Modern Oral Nicotine Products Product A, Product B, Product C - Smoking, Smoking Behaviors | Not applicable | Recruiting | RAI Services Company | 40 | 2025-12-15 | 2025-12-30 |
| A RCT to Determine the Effect of ENDS Flavor Availability on Abstinence Within Smokers P2611222, P2615022, P2615122 - Smoking, Tobacco | Not applicable | Terminated | RAI Services Company | 668 | 2025-09-17 | 2026-02-27 |
| A Consumer Use Behavior Study to Evaluate Puffing Topography and Average Daily Consumption of Heated Tobacco Products RDTH002581, RDTH002580, RDTH002582 - Smoking Cigarette | Not applicable | Completed | RAI Services Company | 212 | 2025-09-01 | 2025-12-23 |
| Modern Nicotine Oral Product Abuse Liability Product A, Product B, Product C - Smoking, Tobacco Use | Not applicable | Completed | RAI Services Company | 40 | 2025-02-03 | 2025-12-23 |
| CSD231005 Nicotine Pouch Biomarkers of Exposure Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine - Tobacco Use, Smoking | Not applicable | Completed | RAI Services Company | 200 | 2024-08-22 | 2025-04-11 |
| CSD201204 An Actual Use Study of P12 Electronic Nicotine Delivery System Among U.S. Adult Smokers P1213416, P1213422, P1213716 - Smoking, Tobacco | Not applicable | Completed | RAI Services Company | 1845 | 2023-09-15 | 2024-02-23 |
| CSD200902: Assessment of Indoor Air Quality for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Environmental Testing Chamber Marlboro Gold Box, Newport Box, Non-combusted cigarette variant 42001401 - Tobacco Use, Smoking | Not applicable | Completed | RAI Services Company | 120 | 2022-05-23 | 2024-04-30 |
| CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches Product A, Product B, Product C - Smoking, Tobacco Use | Not applicable | Completed | RAI Services Company | 42 | 2022-05-01 | 2022-06-29 |
| CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting Non-combusted cigarette variant 42001401, Non-combusted cigarette variant 42001399, Non-combusted cigarette variant 40007386 - Smoking, Smoking Behaviors | Not applicable | Completed | RAI Services Company | 194 | 2022-04-21 | 2023-03-27 |
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Smoking (49) · Tobacco Use (42) · Tobacco Smoking (29) · Vaping (5) · Cigarette Smoking (3) · Smoking Cessation (1)
HTR3D protein, human (15) · Nicotine (5) · Menthol (4) · Tobacco Products (1)
United States (48) · United Kingdom (2)
Jason Hong, MD (7) · Gary Dull, PhD (5) · Brian Keyser (4) · Melissa Tapia, Ph.D. (4) · Milly Kanobe (4) · Milly Kanobe, PhD (4) · Bobbette Jones, DrPH (3) · Brian Keyser, PhD (2) · Charles Tomek, MD (2) · Elizabeth Yoon, FNP-C (2) · Elizabeth Yoon, MSN, FNP-C (2) · Michael Gartner, MD (2) · Nathan Segall, MD (2) · Patrudu Makena, PhD (2) · Christine Campbell (1)
PMID 40183092, PMID 42523979, PMID 28634710, PMID 29725702, PMID 37902830, PMID 39453550