109 completed, 28 unknown, 9 not yet recruiting, 4 active not recruiting. 157 Phase 2, 49 Phase 3, 27 Phase 1.
Follow Periodontitis: new trials by email Literature Review of Periodontitis trials Research Report on Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adjunctive Melatonin Gel With MINST on GCF Galectin-3 and IL-1 in Stage III-IV Periodontitis Melatonin gel, Minimally Invasive Non-Surgical Therapy (MINST) - Periodontitis, Periodontitis (Stage 3) | Phase 2 | Not yet recruiting | Badr University | 40 | 2026-11-30 | 2026-11-09 |
| Effect of Gingival Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Management of Infra-bony Periodontal Defect Gingival mesenchymal stem cell derived small extracellular vesicles, β-calcium triphosphate (β-TCP) + collagen membrane - Infra-bony Periodontal Defect | Phase 2 | Not yet recruiting | Ain Shams University | 22 | 2026-10-01 | 2026-10-15 |
| The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration - Post Operative Pain, Acute, Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 40 | 2026-10-01 | 2026-09-21 |
| Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients Minimally Invasive Nonsurgical Therapy, Injectable Platelet-Rich Fibrin, Chlorhexidine 2% - Bony Defects, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Cairo University | 63 | 2026-09-30 | 2026-08-27 |
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded nanoparticles, Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded macroparticles, Non- surgical periodontal therapy only - Stage III Periodontitis | Phase 2 | Completed | Nada Mahmoud Soliman | 27 | 2026-06-01 | 2026-10-21 |
| Efficacy and Safety of LP-005 Injection in Patients With Moderate-to-Severe Periodontitis LP-005 Injection, Placebo Injection - Periodontitis | Phase 2 | Not yet recruiting | Longbio Pharma (Suzhou) Co., Ltd. | 100 | 2026-05-01 | 2026-05-22 |
| Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial Xylitol Chewing gum, Sorbitol chewing gum - Preterm Birth, Low Birthweight Neonate | Phase 2 / Phase 3 | Recruiting | University of Washington | 6000 | 2026-03-26 | 2026-09-10 |
| Injectable Platelet-Rich Fibrin (i-PRF) and Oxygen-Releasing Gel in the Treatment of Stage II Periodontitis. Injectable Platelet-Rich Fibrin (i-PRF, Peroxoborate Oxygen-Releasing Oral Gel, Scaling and Root Planing (SRP) - Stage III Periodontitis | Phase 1 / Phase 2 | Completed | Assiut University | 24 | 2026-01-20 | 2026-11-12 |
| N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC) - Apical Periodontitis | Phase 2 | Active not recruiting | Alexandria University | 40 | 2025-11-15 | 2025-12-30 |
| The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament Diclofenac Sodium, Calcium hydroxide - Endodontic Disease, Pulp Disease, Dental | Phase 2 / Phase 3 | Recruiting | British University In Egypt | 48 | 2025-11-01 | 2025-05-30 |
| Effect of Nano-Hyaluronic Acid in Intrabony Defects Treated With Minimally Invasive Non-Surgical Technique Minimally invasive non-surgical technique (MINST), nano-hyaluronic acid - Periodontal Disease, Periodontitis | Phase 1 / Phase 2 | Active not recruiting | Cairo University | 28 | 2025-07-15 | 2026-05-19 |
| Micro-Needling Technique Using Ozonated Olive Oil in Periodontal Diseases microneedling, scaling, Ozonated olive oil - Periodontal Diseases, Periodontitis and Treatment Need | Phase 2 | Not yet recruiting | Fayoum University | 30 | 2025-07-01 | 2025-05-25 |
| Treatment of Periodontitis by Tulsi Gel Tulsi gel, Chlorhexidine gel - Advanced Periodontitis, Stage III Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Al-Azhar University | 24 | 2025-07-01 | 2025-07-01 |
| Evaluation of Locally Applied Ferulic Acid as Adjunct to Mechanical Debridement in Treatment of Periodontitis Ferulic Acid, Placebo, mechanical debridement only - Periodontitis | Phase 1 / Phase 2 | Active not recruiting | Salah Awad Alanazi | 80 | 2025-05-16 | 2026-02-13 |
| To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis Calcium Hydroxide Intracanal medication, triple antibiotic paste (TAP) - Apical Periodontitis, Irreversible Pulpitis with Apical Periodontitis | Phase 2 / Phase 3 | Unknown | Komal Ashraf Khan | 180 | 2025-05-01 | 2025-02-12 |
| The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study Stem Cell Product, Bleeding and clots - Apical Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | TC Erciyes University | 45 | 2025-01-01 | 2025-01-08 |
| Efficacy of Locally Delivered Rosemary Extract Gel in Management of Periodontitis Herbal therapy, Placebo Drug - Periodontitis (Stage 3), Periodontal Pocket | Phase 2 | Completed | Ain Shams University | 48 | 2024-10-20 | 2026-04-13 |
| Evaluation of iPRF With Vit.D As an Adjunct to Non-Surgical Therapy in the Treatment of Stage III Periodontitis PMPR+iPRF, PMPR+iPRF+Vit.D, PMPR only - Periodontal Pocket | Phase 2 | Unknown | Cairo University | 45 | 2024-10-01 | 2024-08-26 |
| The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis NSP and chitosan nanoparticles gel loaded by quercetin, NSP and chitosan nanoparticles gel, scaling and root planning - Periodontal Pocket | Phase 2 | Active not recruiting | Mansoura University | 60 | 2024-08-15 | 2025-05-21 |
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Chronic Periodontitis (61) · Periapical Periodontitis (12) · Periodontal Diseases (12) · Periodontal Pocket (12) · Aggressive Periodontitis (7) · Alveolar Bone Loss (4) · Diabetes Mellitus, Type 2 (4) · Gingivitis (4) · Dental Caries (3) · Inflammation (3) · Pain, Postoperative (3) · Periapical Abscess (3) · Dental Pulp Diseases (2) · Dental Pulp Necrosis (2)
Mouth Diseases (157) · Stomatognathic Diseases (157) · Periodontal Diseases (145) · Pathological Conditions, Signs and Symptoms (70) · Pathologic Processes (68) · Chronic Disease (61) · Disease Attributes (61) · Jaw Diseases (16) · Periapical Diseases (16) · Infections (8) · Tooth Diseases (8) · Endocrine System Diseases (6) · Glucose Metabolism Disorders (6) · Metabolic Diseases (6)
Tooth Exfoliation (18) · Root Planing (15) · Metronidazole (8) · Amoxicillin (6) · Metformin (6) · Chlorhexidine (5) · Atorvastatin (4) · Docosahexaenoic Acids (4) · Doxycycline (4) · Periodontal Debridement (4) · Rosuvastatin Calcium (4) · Alendronate (3) · Aspirin (3) · Carticaine (3) · Control Groups (3)
Government Dental College and Research Institute, Bangalore (25) · Ain Shams University (6) · SVS Institute of Dental Sciences (6) · Universidade Estadual Paulista Júlio de Mesquita Filho (5) · Alexandria University (4) · Cairo University (4) · Tanta University (4) · Islamic Azad University, Sanandaj (3) · Postgraduate Institute of Dental Sciences Rohtak (3) · Tatyasaheb Kore Dental College (3) · Virginia Commonwealth University (3) · Al-Azhar University (2) · Dexcel Pharma Technologies Ltd. (2) · Dr. D. Y. Patil Dental College & Hospital (2) · Geistlich Pharma AG (2)
Egypt (31) · India (21) · Brazil (10) · United States (10) · China (4) · Pakistan (4) · Chile (3) · Iran (3) · South Korea (3) · Turkey (Türkiye) (3) · Israel (2) · Japan (2) · Malaysia (2) · Saudi Arabia (2) · Venezuela (2)
Parthasarathy Madurantakam, DDS, PhD (3) · A R Pradeep, MDS (2) · Avani R Pradeep, MDS (2) · Dilip Khambete, MDS (2) · Maha R. Taalab, PhD (2) · Makoto Tamura, Ph.D (2) · Mauro P Santamaria, PhD (2) · Mauro Santamaria, Professor (2) · Michael McGuire, DDS (2) · Rampalli V Chandra, MDS;DNB (2) · Ahmed Fattouh, Bachelor (1) · Ahmed Y Gamal, PhD (1) · Aliaa G Aboulela, PhD (1) · Angela Paliaologou-Gallis, DDS (1) · Ann Haffajee (1)
PMID 33197289, PMID 15016256, PMID 18596969, PMID 21238793, PMID 22028505, PMID 22093005, PMID 24970858, PMID 25523604, PMID 27715376, PMID 28731373, PMID 29859084, PMID 30076613, PMID 30611255, PMID 30624092, PMID 31102044, PMID 31257591, PMID 32383274, PMID 32794485, PMID 32960889, PMID 33413320, PMID 33899259, PMID 33952216, PMID 34087466, PMID 3425152, PMID 36635764, PMID 37148266, PMID 3793432, PMID 38395824, PMID 38847929, PMID 39364843, PMID 39709402, PMID 40739139, PMID 8910821
P50AT000076 (1), R01DE012108 (1), R01DE014242 (1), R01HD119029 (1), UL1RR025758-02 (1)