2355 completed, 779 unknown, 286 not yet recruiting, 271 recruiting. 2702 Not applicable, 228 Phase 2, 208 Phase 3, 187 Phase 4, 112 Phase 1.
Follow Tooth Diseases: new trials by email Literature Review of Tooth Diseases trials Research Report on Tooth Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash Moringa Oleifera, Chlorhexidine mouthwash, Base formula - Plaque, Dental, Antimicrobial | Phase 2 / Phase 3 | Not yet recruiting | Misr International University | 90 | 2027-12-01 | 2026-10-08 |
| Bacterial Colonization, Gingival Health, and Surface Roughness of Three Crown Types in Children's Teeth Bioflx crown, Group Z, Group S - Carious Lesion, Ready-made Crowns | Not applicable | Not yet recruiting | Al-Azhar University | 75 | 2027-07-01 | 2026-11-10 |
| Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected Molars Nano Silver Fluoride, Photobiomodulation Therapy, Pre-appointment analgesics - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Ain Shams University | 45 | 2027-05-01 | 2026-09-17 |
| Treatment of Skeletal Class II Malocclusion With Modified Twin-Block Appliance With Clear Plates Modified Twin-Block Appliance with Clear Plates., Traditional Twin-Block appliance - Malocclusion, Angle Class II | Not applicable | Recruiting | Hama University | 32 | 2027-03-15 | 2026-09-16 |
| The Effect of Bitewing Radiography on Outcomes and Costs of Treating Caries in Permanent Teeth Visual-tactile caries examination, Visual-tactile caries examination and bilateral bitewing radiography - Dental Caries, Teeth Loss | Not applicable | Not yet recruiting | Jukka Leinonen | 250 | 2027-03-01 | 2026-10-20 |
| Timing, Trajectories and Prediction in Severe Dental Crowding: The Create SPACE (cSPACE) Early first premolar extraction with observation, Early first premolar extraction with planned fixed orthodontic treatment - Crowding of Teeth, Malocclusion; Displaced Teeth | Not applicable | Not yet recruiting | Vastra Gotaland Region | 300 | 2027-03-01 | 2026-11-02 |
| S-TiUltra Implant Study NobelReplace S-TiUltra, NobelReplace TiUnite - Missing Tooth/Teeth | Phase 4 | Not yet recruiting | University of Maryland, Baltimore | 30 | 2027-02-01 | 2026-11-02 |
| Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection Sodium hypochlorite 3%, Frankincense-based irrigant - Pulp Necrosis, Root Canal Infection | Early Phase 1 | Not yet recruiting | Oman Dental College | 30 | 2027-01-19 | 2026-09-22 |
| Clinical Performance of High Viscous Glass Ionomer Cervical Restorations With Silver-Modified Atraumatic Restorative Technique (SMART) Versus Conventional Treatment in Elderly Cancer Patients. (A 12-month Randomized Clinical Trial) Silver Diamine Fluoride (SDF, 38%), Conventional Tooth Preparation, High-Viscosity Glass Ionomer Cement - Dental Caries, Cervical Caries | Not applicable | Not yet recruiting | Cairo University | 30 | 2027-01-15 | 2026-10-19 |
| AI-Based Caries and Plaque Detection and Caries Risk Prediction in Children individualized preventive recommendations - Dental Caries, Caries Risk | Not yet recruiting | Marmara University | 250 | 2027-01-10 | 2026-11-10 | |
| Multicenter Clinical Study on the Efficacy and Esthetic Outcomes of Immediate Implant Placement Using the Socket-Shield Technique Versus Conventional Immediate Implantation in the Anterior Maxillary Esthetic Zone the Socket Shield Technique (SST) immediate implant placement, Conventional immediate implant placement - Teeth Absent, Teeth Missing | Not applicable | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 48 | 2027-01-01 | 2026-09-16 |
| Effect of Hemostatic Agents on TheraCal PT Pulpotomy Success in Primary Molars 2.5% Sodium Hypochlorite applied to pulpal tissue/stumps for 3 minutes to achieve hemostasis prior to TheraCal PT placement during primary molar pulpotomy and 15% Ferric Sulfate (Astringedent™ 15.5%) - Reversible Pulpitis, Dental Caries | Not applicable | Not yet recruiting | Reem Mohamed Gaber | 75 | 2027-01-01 | 2026-10-15 |
| Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children Calcium Hydroxide, Iodoform, paste, modified triple antibiotic paste - Dental Pulp Necrosis, Periapical Diseases | Not applicable | Not yet recruiting | Cairo University | 50 | 2027-01-01 | 2026-08-19 |
| Evaluation of Corrective Surgery Versus Dental Implants in Compromised Mandibular Molars hemi sectioning - Root Caries, Vertical Root Fracture | Not applicable | Not yet recruiting | Ain Shams University | 28 | 2027-01-01 | 2026-06-08 |
| Evaluation of Corrective Surgery Versus Dental Implants in Compromised Upper Molars root amputation - Root Caries | Not applicable | Not yet recruiting | Ain Shams University | 28 | 2027-01-01 | 2026-05-27 |
| Applying Navigation and Care to Help Ongoing Retention Family Navigation, Usual Care - Child Obesity | Not applicable | Not yet recruiting | University of Alberta | 252 | 2027-01-01 | 2026-09-22 |
| Comparison of Orthodontic Molar Protraction With and Without Adjunctive Surgery Orthodontic Molar Protraction and PAOO, Orthodontic Molar Protraction - Malocclusion | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 40 | 2027-01-01 | 2026-10-15 |
| Children Acceptance of AgNP Mouthwash Against Chlorhexidine 0.12% and Chlorhexidine .2% Mouthwashs nano silver mouthwash, Chlorhexidine mouthwash (0.12%), Chlorhexidine mouthwash (0.2%) - Teeth Staining, Numbness of the Tongue and Soft Tissue | Not applicable | Not yet recruiting | Cairo University | 93 | 2027-01-01 | 2026-10-21 |
| Safety of Intraosseous Anaesthesia in Children With Haemophilia Intraosseous Anaesthesia - Haemophilia A, Haemophilia B | Not applicable | Not yet recruiting | Ankara Yildirim Beyazıt University | 20 | 2027-01-01 | 2026-11-04 |
| PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic Teeth PRP-Assisted Regenerative Endodontic Treatment, Conventional Root Canal Treatment - Pulp Necrosis, Apical Periodontitis | Not applicable | Not yet recruiting | TC Erciyes University | 10 | 2027-01-01 | 2026-11-05 |
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Dental Caries (1015) · Dental Plaque (342) · Dentin Sensitivity (288) · Malocclusion (278) · Gingivitis (167) · Dental Pulp Necrosis (157) · Tooth Loss (156) · Bruxism (151) · Toothache (141) · Molar Hypomineralization (133) · Dental Pulp Diseases (130) · Mouth, Edentulous (124) · Malocclusion, Angle Class II (123) · Jaw, Edentulous (118) · Tooth, Impacted (118)
Stomatognathic Diseases (4008) · Tooth Demineralization (1077) · Mouth Diseases (810) · Pathological Conditions, Signs and Symptoms (630) · Periodontal Diseases (445) · Dental Pulp Diseases (368) · Signs and Symptoms (361) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (357) · Dental Deposits (356) · Congenital Abnormalities (350) · Stomatognathic System Abnormalities (342) · Jaw Diseases (332) · Pathologic Processes (327) · Musculoskeletal Diseases (324)
Low-Level Light Therapy (48) · Sodium Fluoride (44) · Dental Implants (32) · silver diamine fluoride (32) · Fluorides (27) · Calcium Hydroxide (26) · Chlorhexidine (24) · Control Groups (24) · mineral trioxide aggregate (24) · Ibuprofen (23) · Toothpastes (23) · Orthodontic Appliances, Fixed (22) · Pemetrexed (22) · Sodium Hypochlorite (21) · Pulpotomy (20)
Cairo University (355) · Damascus University (88) · Al-Azhar University (70) · University of Sao Paulo (58) · GlaxoSmithKline (56) · Colgate Palmolive (53) · Hacettepe University (51) · Ain Shams University (49) · Mansoura University (49) · Marmara University (44) · HALEON (33) · University of Nove de Julho (29) · The University of Hong Kong (28) · Dentsply Sirona Implants and Consumables (25) · Postgraduate Institute of Dental Sciences Rohtak (25)
United States (590) · Egypt (576) · Turkey (Türkiye) (444) · Brazil (249) · Italy (136) · Syria (103) · Spain (100) · China (98) · France (98) · United Kingdom (90) · Pakistan (79) · Canada (61) · Germany (58) · Switzerland (56) · India (51)
Mohammad Y Hajeer, DDS MSc PhD (17) · Andrea Scribante, DDS, PhD (9) · Mohammad Y Hajeer, DDS,MSc,PhD (9) · Andrea Scribante, Associate Professor (8) · Mathilde C Peters, DMD, PhD (6) · Bennett T Amaechi, BDS, MS, PhD (5) · Daniela P Raggio, Professor (5) · Gregg H Gilbert, DDS, MBA (5) · Henry Greenwell, DMD (5) · Jeffery L Milleman, DDS, MPA (5) · Nehal Amir, BDS (5) · Peter Milgrom, DDS (5)
PMID 20932395, PMID 24158342, PMID 26964798, PMID 31164116, PMID 5264376, PMID 10343087, PMID 11132515, PMID 12218274, PMID 14489483, PMID 1452871, PMID 1592970, PMID 16211157, PMID 17518963, PMID 18341239, PMID 18434577, PMID 19365118, PMID 19696851, PMID 20723019, PMID 21055598, PMID 22128671, PMID 22211303, PMID 22257664, PMID 23190278, PMID 23640952, PMID 23972577, PMID 24182579, PMID 24843394, PMID 25045768, PMID 25443280, PMID 25634162, PMID 25677244, PMID 25905656, PMID 26588111, PMID 27009835, PMID 27093773, PMID 28410008, PMID 30264270, PMID 30500094, PMID 30883951, PMID 31640741, PMID 31839988, PMID 33514787, PMID 33653326, PMID 34083157, PMID 3457698, PMID 34676918, PMID 34743243, PMID 35656656, PMID 37138297, PMID 37266982
U01DE016747 (7), 2019 (5), 2014 (4), 2009 (2), 2015 (2), 2017 (2), 2023 (2), 2025 (2), D43TW007768 (2), K23DE023579 (2), U54DE014254 (2), 1UG3DE029443-01 (1), 1UL1RR024148 (1), 2005 (1), 2008 (1)