1275 completed, 297 unknown, 138 terminated, 114 recruiting. 456 Phase 2, 438 Phase 3, 434 Phase 4, 419 Phase 1, 250 Not applicable.
Follow this drug Literature Review of Metformin trials Research Report on Metformin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients Metformin, Val, Cel and Met XR Low, Val, Cel and Met XR High - Type 2 Diabetes, High Blood Pressure | Phase 1 / Phase 2 | Withdrawn | ARKAY Therapeutics | 2026-12-10 | 2026-07-16 | |
| Metformin and ACLR Muscle Recovery Metformin, Placebo - Atrophy, Inflammation | Early Phase 1 | Not yet recruiting | University of Utah | 40 | 2026-11-01 | 2026-07-13 |
| DDI Study of ECC0509 With Metformin, Midazolam, and Caffeine ECC0509, Metformin, Caffeine - Steatohepatitis, Nonalcoholic, Osteo Arthritis | Phase 1 | Not yet recruiting | Eccogene | 40 | 2026-11-01 | 2026-10-14 |
| Cardioprotective Effect of Empagliflozin in Breast Cancer Patients Empagliflozin (EMPA), Metformin - Empgliflozin Cardioprotective Effect | Phase 3 | Not yet recruiting | Tanta University | 150 | 2026-10-01 | 2026-09-24 |
| Metformin-Dapagliflozin Effects on IGF-1 in Male T2DM With MASLD Metformin + Dapagliflozin, Metformin - Type 2 Diabetes, Metabolic Dysfunction-Associated Steatotic Liver Disease | Not applicable | Not yet recruiting | The 95th Hospital of Putian，Putian, Fujian, China | 84 | 2026-10-01 | 2026-08-21 |
| Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis Metformin, Matching Placebo - Idiopathic Pulmonary Fibrosis | Phase 3 | Not yet recruiting | University of Massachusetts, Worcester | 800 | 2026-09-28 | 2026-09-08 |
| Drug-drug Interactions Studies of VC005 Tablets in Healthy Adult Subjects VC005 and verapamil, VC005 and probenecid, VC005 and metformin - Healthy Adult Participants | Phase 1 | Not yet recruiting | Jiangsu vcare pharmaceutical technology co., LTD | 84 | 2026-09-20 | 2026-09-01 |
| Efficacy of Vildagliptin Versus Metformin in Patients With Polycystic Ovary Syndrome Metformin, Vildagliptin (Galvus) - Poly Cystic Ovary Syndrome | Phase 2 / Phase 3 | Not yet recruiting | Tanta University | 70 | 2026-09-20 | 2026-09-21 |
| A Phase I Study of the Interaction of D-2570 With Other Drugs in Healthy Adults Itraconazole, Rifampicin, Omeprazole - Healthy Subjects | Phase 1 | Not yet recruiting | InventisBio Co., Ltd | 60 | 2026-09-16 | 2026-10-15 |
| Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome Metformin, Dapagliflozin (10mg Tab) - Poly Cystic Ovary Syndrome | Phase 2 / Phase 3 | Not yet recruiting | Tanta University | 60 | 2026-09-10 | 2026-09-09 |
| Efficacy and Safety of Hebenrun in Patients With Type 2 Diabetes Metformin, Hebenrun - Type 2 Diabetes Mellitus | Not applicable | Not yet recruiting | Jiangxi University of Traditional Chinese Medicine | 110 | 2026-09-01 | 2026-08-17 |
| Phase III Trial of SGLT2 Inhibitor and Thiazolidinedione Fixed-Dose Combination vs. Monotherapy in Type 2 Diabetes Patients on Metformin Fixed-dose combination of SGLT2 inhibitor and thiazolidinedione, Control Group 1 Intervention - SGLT2 inhibitor monotherapy, Control Group 2 Intervention - Thiazolidinedione monotherapy - Type 2 Diabetes Mellitus (T2DM) | Phase 3 | Withdrawn | Eurofarma Laboratorios S.A. | 2026-09-01 | 2025-12-18 | |
| Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations Metformin - Chronic Obstructive Pulmonary Disease (COPD) | Phase 1 | Not yet recruiting | Duke University | 45 | 2026-09-01 | 2026-04-29 |
| Dapagliflozin Versus Metformin for the Management of Antipsychotic-Induced Weight Gain: A Pragmatic Pilot Randomized Controlled Trial Dapagliflozin, Metformin, Common Lifestyle Program - Antipsychotic-induced Weight Gain (AIWG), Antipsychotic-induced Weight Gain | Phase 4 | Not yet recruiting | Sultan Qaboos University | 110 | 2026-09-01 | 2026-06-10 |
| Metformin Inhibits DNMT3A Clonal Hematopoiesis in Acute Leukemia Metformin - DNMT3A Gene Mutation | Phase 1 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 32 | 2026-08-30 | 2026-08-10 |
| Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity Metformin, Placebo - Osteoarthritis (OA) of the Knee | Early Phase 1 | Recruiting | The University of Hong Kong | 100 | 2026-08-30 | 2026-08-18 |
| Metformin in Parkinson's Disease: Safety and Efficacy Metformin 500mg - Parkinsons Disease (PD) | Phase 4 | Not yet recruiting | Jinnah Medical & Dental College | 70 | 2026-08-28 | 2026-09-09 |
| Phase 1 Study in Healthy Adults to See How Sevabertinib Changes Metformin Levels in the Body Metformin, Sevabertinib (BAY 2927088) - Healthy Participants | Phase 1 | Not yet recruiting | Bayer | 40 | 2026-08-21 | 2026-08-07 |
| Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOS Metformin, İnositol, Folic Acid - PCOS (Polycystic Ovary Syndrome), Insulin Resistance | Not applicable | Recruiting | Dicle University | 90 | 2026-08-13 | 2026-10-16 |
| Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans Topical metformin - Acanthosis Nigricans | Phase 1 | Not yet recruiting | Al-Azhar University | 34 | 2026-08-10 | 2026-08-12 |
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