69 completed, 15 unknown, 5 not yet recruiting, 4 recruiting. 94 Phase 3, 49 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 94 | Completed 69, Unknown 15, Not yet recruiting 5, Recruiting 4, Terminated 1 |
| Phase 2 | 49 | Completed 38, Unknown 7, Not yet recruiting 2, Recruiting 2 |
Follow Periodontitis: new trials by email Literature Review of Periodontitis trials Research Report on Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment Active Oral Hygiene Regimen, Placebo Oral Hygiene Regimen - Periodontal Disease, Gingival Inflammation and Bleeding | Phase 3 | Not yet recruiting | Colgate Palmolive | 100 | 2026-09-01 | 2026-09-03 |
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial Xylitol Chewing gum, Sorbitol chewing gum - Preterm Birth, Low Birthweight Neonate | Phase 2 / Phase 3 | Recruiting | University of Washington | 6000 | 2026-03-26 | 2026-09-10 |
| Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth. Allium Sativum as an intracanal medicament - Apical Periodontitis, Periapical Radiolucency | Phase 3 | Not yet recruiting | University of Health Sciences Lahore | 96 | 2026-01-20 | 2026-01-06 |
| A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis Bimekizumab, Placebo - Palmoplantar Pustulosis | Phase 3 | Recruiting | UCB Biopharma SRL | 320 | 2025-11-14 | 2026-08-27 |
| The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament Diclofenac Sodium, Calcium hydroxide - Endodontic Disease, Pulp Disease, Dental | Phase 2 / Phase 3 | Recruiting | British University In Egypt | 48 | 2025-11-01 | 2025-05-30 |
| Evaluation of The Periodontal Parameters Following Non-Surgical Periodontal Therapy With and Without Adjunctive Use of Injectable Platelet Rich Fibrin: A Randomized Controlled Clinical Trial non-surgical periodontal therapy, non-surgical periodontal therapy + I-PRF - Periodontitis (Stage 3) | Phase 3 | Not yet recruiting | Cairo University | 30 | 2025-07-01 | 2025-07-29 |
| Treatment of Periodontitis by Tulsi Gel Tulsi gel, Chlorhexidine gel - Advanced Periodontitis, Stage III Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Al-Azhar University | 24 | 2025-07-01 | 2025-07-01 |
| To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis Calcium Hydroxide Intracanal medication, triple antibiotic paste (TAP) - Apical Periodontitis, Irreversible Pulpitis with Apical Periodontitis | Phase 2 / Phase 3 | Unknown | Komal Ashraf Khan | 180 | 2025-05-01 | 2025-02-12 |
| Therapeutic Effect of Manuka Honey Oral Rinse in Periodontitis Patients Undergoing Hemodialysis Manuka honey oral rinse., Normal saline rinses. - Periodontitis, Hemodialysis | Phase 3 | Recruiting | Ain Shams University | 150 | 2024-10-01 | 2025-12-31 |
| Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice Amoxicillin, Metronidazole, Placebo - Periodontitis, Periodontal Diseases | Phase 3 | Completed | Rutgers, The State University of New Jersey | 236 | 2024-04-25 | 2026-04-14 |
| Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel Minocycline hydrochloride with noisome carrier, Minocycline Hydrochloride only - Periodontitis | Phase 2 / Phase 3 | Unknown | Ain Shams University | 30 | 2024-02-25 | 2024-02-12 |
| Effect of Use of Calcium Hydroxide and Metformin Intracanal Medicament After NSRCT Metformin - Apical Periodontitis | Phase 2 / Phase 3 | Completed | Postgraduate Institute of Dental Sciences Rohtak | 120 | 2023-08-01 | 2025-05-28 |
| Efficacy of Herbal Dentifrice in Treatment of Chronic Periodontitis Dentifrice Paste - Chronic Periodontitis | Phase 3 | Completed | Dr. D. Y. Patil Dental College & Hospital | 75 | 2023-08-01 | 2024-10-08 |
| 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament Chlorhexidine, Calcium Hydroxide - Apical Periodontitis | Phase 3 | Unknown | University of Southern California | 40 | 2023-05-30 | 2023-03-08 |
| Efficacy of Herbal Dentifrice for Management of Dentinal Hypersensitivity Toothpaste Preparation - Dentinal Hypersensitivity, Chronic Periodontitis | Phase 3 | Completed | Dr. D. Y. Patil Dental College & Hospital | 75 | 2023-05-15 | 2024-10-08 |
| Insulin Versus Hyaluronic Acid in Management of Periodontal Defects Insulin, Hyaluronic acid - Periodontal Diseases, Periodontal Pocket | Phase 3 | Unknown | October University for Modern Sciences and Arts | 30 | 2023-01-12 | 2023-02-28 |
| Effect of Probiotics on Periodontitis Stage III Grade C Molar-incisor Pattern Probiotic Formula, placebo formula - Periodontal Diseases | Phase 3 | Completed | Al-Azhar University | 65 | 2023-01-01 | 2024-02-12 |
| Evaluation of L-PRF as an Antibiotic Slow-release Biological Device in the Treatment of Moderate Periodontitis Subgingival application of L-PRF loaded with metronidazole, Subgingival application of L-PRF - Periodontitis | Phase 2 / Phase 3 | Completed | Yasmeen Khaled | 24 | 2022-06-01 | 2023-12-01 |
| Effect of Azithromycin on Failure Proportion of Severe Periodontitis Non-surgical Treatment Non-surgical periodontal treatment and azithromycin treatment, Non-surgical periodontal treatment and placebo treatment - Severe Chronic Periodontitis | Phase 3 | Terminated | University Hospital, Strasbourg, France | 6 | 2021-11-02 | 2024-08-20 |
Showing 20 of 94. Sign in to see all of them.
Chronic Periodontitis (41) · Periodontal Diseases (9) · Periapical Periodontitis (7) · Periodontal Pocket (6) · Aggressive Periodontitis (5) · Alveolar Bone Loss (4) · Diabetes Mellitus, Type 2 (4) · Gingivitis (4) · Periodontal Attachment Loss (3) · Diabetes Mellitus (2) · Inflammation (2) · Peri-Implantitis (2) · Periapical Abscess (2) · Premature Birth (2)
Mouth Diseases (94) · Stomatognathic Diseases (94) · Periodontal Diseases (85) · Pathological Conditions, Signs and Symptoms (49) · Pathologic Processes (48) · Chronic Disease (41) · Disease Attributes (41) · Jaw Diseases (10) · Periapical Diseases (10) · Metabolic Diseases (7) · Nutritional and Metabolic Diseases (7) · Glucose Metabolism Disorders (6) · Infections (6) · Bone Diseases (5)
Metronidazole (7) · Tooth Exfoliation (7) · Amoxicillin (6) · Root Planing (6) · Metformin (5) · Probiotics (5) · Chlorhexidine (4) · Rosuvastatin Calcium (4) · Atorvastatin (3) · Doxycycline (3) · Periodontal Debridement (3) · Alendronate (2) · Anti-Bacterial Agents (2) · Aspirin (2) · Calcium Hydroxide (2)
Government Dental College and Research Institute, Bangalore (21) · Dr. D. Y. Patil Dental College & Hospital (4) · Universidade Estadual Paulista Júlio de Mesquita Filho (4) · Al-Azhar University (3) · CD Pharma India Pvt. Ltd. (3) · Islamic Azad University, Sanandaj (3) · Ain Shams University (2) · Cairo University (2) · Colgate Palmolive (2) · KLE Society's Institute of Dental Sciences (2) · Kaken Pharmaceutical (2) · Next Gen Pharma India Pvt. Ltd. (2) · OraPharma (2) · SVS Institute of Dental Sciences (2) · University of Guarulhos (2)
India (20) · Egypt (11) · Brazil (10) · United States (10) · China (3) · Italy (3) · France (2) · Iran (2) · Japan (2) · Pakistan (2) · United Kingdom (2) · Canada (1) · Colombia (1) · Croatia (1) · Czechia (1)
Magda Feres, Professor (3) · Chikara Ieda (2) · Mauro Santamaria, Professor (2) · A R Pradeep, MDS (1) · Adolfo Contreras, DDS, MS, PhD (1) · Ahmed Y Gamal, PhD (1) · Aliaa G Aboulela, PhD (1) · Anne D Haffajee, BDS (1) · Anthony DiAngelis, DMD (1) · Anumala Naveen, MDS (1) · Arun Sadasivan, MDS (1) · Arya K.S., BDS (1) · Avani Pradeep, MDS (1) · Avani R Pradeep, MDS (1) · Bernal Stewart (1)
PMID 10477976, PMID 15016256, PMID 15316186, PMID 17079762, PMID 17668979, PMID 17716312, PMID 17716313, PMID 18596969, PMID 18672990, PMID 19711612, PMID 20151804, PMID 20348487, PMID 20354090, PMID 20831669, PMID 20937388, PMID 21269037, PMID 21324167, PMID 21357860, PMID 21422479, PMID 22028505, PMID 23016867, PMID 23055587, PMID 23071896, PMID 23205917, PMID 23649042, PMID 24024983, PMID 24080100, PMID 24310847, PMID 24346989, PMID 24495202, PMID 24685786, PMID 24992844, PMID 26427036, PMID 26478974, PMID 27108476, PMID 27715376, PMID 28303587, PMID 28452620, PMID 28731373, PMID 30328176, PMID 31257591, PMID 32794485, PMID 33197289, PMID 33858486, PMID 34087466, PMID 35003565, PMID 36635764, PMID 38395824, PMID 39709402, PMID 42474735
2008 (1), 4UH3DE031129-02 (1), R01DE012872 (1), R01HD119029 (1), U01DE018886 (1), U01DE018902 (1)