70 completed, 43 unknown, 19 not yet recruiting, 12 recruiting. 107 Not applicable, 18 Phase 2, 11 Phase 4, 9 Early Phase 1, 9 Phase 3.
Follow Dental Pulp Necrosis: new trials by email Literature Review of Dental Pulp Necrosis trials Research Report on Dental Pulp Necrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Bitewing Radiography on Outcomes and Costs of Treating Caries in Permanent Teeth Visual-tactile caries examination, Visual-tactile caries examination and bilateral bitewing radiography - Dental Caries, Teeth Loss | Not applicable | Not yet recruiting | Jukka Leinonen | 250 | 2027-03-01 | 2026-10-20 |
| Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection Sodium hypochlorite 3%, Frankincense-based irrigant - Pulp Necrosis, Root Canal Infection | Early Phase 1 | Not yet recruiting | Oman Dental College | 30 | 2027-01-19 | 2026-09-22 |
| Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children Calcium Hydroxide, Iodoform, paste, modified triple antibiotic paste - Dental Pulp Necrosis, Periapical Diseases | Not applicable | Not yet recruiting | Cairo University | 50 | 2027-01-01 | 2026-08-19 |
| PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic Teeth PRP-Assisted Regenerative Endodontic Treatment, Conventional Root Canal Treatment - Pulp Necrosis, Apical Periodontitis | Not applicable | Not yet recruiting | TC Erciyes University | 10 | 2027-01-01 | 2026-11-05 |
| Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis. Conventional Root Canal Treatment, Regenerative Endodontic Treatment with i-PRF, Injectable Platelet-Rich Fibrin (i-PRF) - Chronic Apical Periodontitis, Pulp Necrosis | Not applicable | Not yet recruiting | Medipol University | 120 | 2026-11-15 | 2026-11-03 |
| Post-operative Pain and Clinical Outcome After Single-cone Obturation With a Calcium Silicate-based Versus Epoxy Resin Sealer A calcium silicate-based sealer, An epoxy resin- based sealer - Post Operative Pain, Acute, Irreversible Pulpitis (Toothache) | Not applicable | Not yet recruiting | University Ghent | 138 | 2026-11-01 | 2026-11-06 |
| Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process Intracanal medication - Immature Permanent Teeth With Open Apex, Pulp Necrosis | Not applicable | Recruiting | Mansoura University | 20 | 2026-10-01 | 2026-09-23 |
| Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5% - Pulp Necrosis, Apical Periodontitis | Not applicable | Recruiting | October 6 University | 60 | 2026-10-01 | 2026-10-27 |
| Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment. Sodium Hypochlorite 3% Solution, Emblica officinalis Solution - Pulp Necrosis, Apical Periodontitis | Not applicable | Not yet recruiting | Postgraduate Medical Institute, Lahore | 66 | 2026-09-17 | 2026-09-22 |
| Comparison of Post-operative Pain and Levels of MMP -9 Following Root Canal Irrigation With Sodium Hypochlorite Versus Cold Atmospheric Plasma in Patient With Necrotic Single Rooted Teeth: Randomized Clinical Trial Application of cold atmospheric plasma - Necrotic Pulp | Not applicable | Not yet recruiting | Ahmed Hesham Abdelmohaimen Rezk | 60 | 2026-08-01 | 2026-08-05 |
| Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial CTZ Paste, ZOE Pulpectomy - Pulp Disease, Dental, Pulp Necrosis | Early Phase 1 | Not yet recruiting | University of Sao Paulo | 110 | 2026-06-08 | 2026-05-12 |
| Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis Group A - LSTR Therapy (CTZ Paste), Group B - ZOE Pulpectomy - Pulp Necrosis | Phase 1 / Phase 2 | Not yet recruiting | University of Faisalabad | 180 | 2026-05-01 | 2026-03-19 |
| Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols Ultrasonic Irrigation Activation, Laser-Activated Irrigation, Mechanical Irrigation Activation - Dental Pulp Necrosis, Pulpitis | Not applicable | Not yet recruiting | Suez Canal University | 40 | 2026-04-30 | 2026-05-04 |
| Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar triton irrigation protocol, conventional irrigation group - Pulp Necrosis | Not applicable | Not yet recruiting | sara hosny mostafa | 36 | 2026-03-01 | 2026-02-27 |
| Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars Patency Group, Standard Root Canal Instrumentation - Periapical Periodontitis, Dental Pulp Necrosis | Not applicable | Not yet recruiting | College of Physicians and Surgeons Pakistan | 48 | 2026-02-10 | 2025-11-20 |
| This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated Wit Step down technique - Pulp Necrosis | Not applicable | Not yet recruiting | Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi | 110 | 2026-02-01 | 2025-12-18 |
| Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain Calcium Hydroxide (Ca(OH)2), chitosan nanoparticles gel - Pulp Necrosis | Phase 4 | Not yet recruiting | Ain Shams University | 52 | 2026-02-01 | 2026-02-05 |
| Calcium Hydroxide Versus Triple Antibiotic Paste for Pain After Root Canal Treatment Calcium Hydroxide (CH), Triple Antibiotic Paste - Apical Periodontitis, Pulp Necrosis | Phase 4 | Completed | Rehman Medical Institute - RMI | 138 | 2026-02-01 | 2026-11-06 |
| Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar. Root canal treatment with intracanal medication by calcium hydroxide for one week., Root canal treatment with intracanal medication by cocoa husk for one week, Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week. - Pulp Necrosis, Postoperative Pain | Not applicable | Active not recruiting | Future University in Egypt | 36 | 2026-01-06 | 2026-08-27 |
| The Effect of Different Intra-canal Medications on Postoperative Pain ibuprofen, Nitrofurantoin, Calcium Hydroxide - Pulp Necrosis, Apical Periodontitis | Early Phase 1 | Recruiting | Cairo University | 111 | 2025-12-15 | 2026-07-21 |
Showing 20 of 156. Sign in to see all of them.
Periapical Periodontitis (38) · Pain, Postoperative (26) · Dental Pulp Diseases (8) · Dental Caries (4) · Pain (4) · Periapical Abscess (4) · Periapical Diseases (4) · Tooth, Nonvital (3) · Infections (2) · Necrosis (2) · Pulpitis (2) · Acute Pain (1) · Anodontia (1) · Bicuspid Aortic Valve Disease (1)
Pathologic Processes (156) · Pathological Conditions, Signs and Symptoms (156) · Stomatognathic Diseases (156) · Tooth Diseases (156) · Necrosis (154) · Dental Pulp Diseases (148) · Jaw Diseases (43) · Periodontal Diseases (43) · Mouth Diseases (42) · Periodontitis (40) · Periapical Diseases (39) · Neurologic Manifestations (30) · Signs and Symptoms (30) · Pain (26) · Postoperative Complications (26)
Sodium Hypochlorite (13) · Calcium Hydroxide (12) · Pemetrexed (5) · mineral trioxide aggregate (5) · Apexification (3) · Ciprofloxacin (3) · Prolactin-Releasing Hormone (3) · Root Canal Obturation (3) · Therapeutic Irrigation (3) · Edetic Acid (2) · Endodontics (2) · Lasers (2) · Metapex (2) · Nitrofurantoin (2) · Ointments (2)
Cairo University (37) · Mansoura University (8) · Ain Shams University (5) · Future University in Egypt (4) · Minia University (3) · Suez Canal University (3) · The University of Texas Health Science Center at San Antonio (3) · Alexandria University (2) · Bulent Ecevit University (2) · Faculty of Dental Medicine for Girls (2) · Isparta Military Hospital (2) · Istanbul University (2) · Kahramanmaras Sutcu Imam University (2) · Nourhan M.Aly (2) · Pakistan Institute of Medical Sciences (2)
Egypt (43) · Turkey (Türkiye) (20) · United States (12) · Pakistan (7) · Brazil (6) · Jordan (4) · China (2) · France (2) · Spain (2) · Sweden (2) · Belgium (1) · Finland (1) · Greece (1) · India (1) · Indonesia (1)
Aliye Kamalak (2) · Nehal Amir, BDS (2) · Abhishek Parolia, PhD, MDS (1) · Ahmad Alhiyasat, PhD (1) · Ahmet D Uygun, Assoc. Prof. (1) · Alaina Tariq Mughal, BDS, FCPS (R) (1) · Alicia Caro, MSC, DDS (1) · Amany Bader, prof (1) · Amatallah HN Al-Rawhani, Master (1) · Antonio JL Cunha, doctor (1) · Ashraf M Zaazou, PhD (1) · Ashraf Y Alhsoainy, PhD (1) · Asma A Khan (1)
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