153 completed, 41 unknown, 9 recruiting, 8 terminated. 108 Not applicable, 46 Phase 4, 35 Phase 2, 31 Phase 3, 8 Phase 1.
Follow Chlorhexidine: new trials by email Literature Review of Chlorhexidine trials Research Report on Chlorhexidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reduction of Complications Associated With Extraluminal PICC Management. G2:PIVC fixed with SecurAcath, with care performed by heparinization with push-stop-push technique and positive pressure + fibrillin and semitransparent dressing change with chlorhexidine 15 days, G3: PIVC fixed with SecurAcath, with care performed by heparinization with push-stop-push technique and positive pressure + fibrillin and semitransparent dressing change without chlorhexidine 15 days - Treatment (ProudMe), Vascular Access | Not applicable | Not yet recruiting | Fundacion Miguel Servet | 240 | 2027-01-01 | 2026-09-03 |
| Effect of Curcumin Topical Spray on Wound Healing After Tooth Extraction Curcumin Topical Spray, Chlorhexidine Topical Spray - Wound Healing, Alveolitis of Jaw | Not applicable | Recruiting | Istanbul University | 54 | 2026-09-29 | 2026-10-15 |
| Comparative Efficacy of Amoxicillin, Metronidazole, and Chlorhexidine in Preventing Alveolar Osteitis Amoxicillin, Metronidazole, Chlorhexidine - Alveolar Osteitis | Not applicable | Not yet recruiting | Khyber Medical University Peshawar | 240 | 2026-09-25 | 2026-10-14 |
| Effect of FB301 on Vaginal Bacterial Profile in Women With Asymptomatic Vaginal Dysbiosis Undergoing a Mock Frozen Embryo Transfer Cycle FB-301, Placebo, Chlorhexidine (0.5%) Vaginal Cleanse - Vaginal Dysbiosis | Phase 2 | Recruiting | Freya Biosciences ApS | 30 | 2026-07-22 | 2026-10-15 |
| ORAL-PROTECT I: Oral Asepsis Preventing Transmission During Intubation Preoperative oral decontamination with chlorhexidine - Bacterial Transmission, Intubation Intratracheal | Not applicable | Not yet recruiting | University Hospital Ulm | 60 | 2026-06-20 | 2026-06-25 |
| Effects of Three Oral Hygiene Protocols on Oral Bacteria in Intensive Care Patients Mechanical Oral Hygiene, Chlorhexidine, Hexetidine - Oral Bacterial Colonization, Oral Hygiene | Not applicable | Enrolling by invitation | University of Zagreb | 86 | 2026-06-01 | 2026-10-09 |
| Effect of a Bioactive Mineral-Ionic Mouthrinse on Periodontal Soft Tissue Healing Normal Saline, chlorhexidine (CHX), Theravex Bioactive Solutions (Tissue Care Plus and Oral) - Tooth Extraction Site Healing | Not applicable | Completed | Biointelligent Technology Systems SL | 94 | 2026-04-28 | 2026-05-29 |
| Frankincense and Herbal Extracts for Plaque-Induced Gingivitis: A Double-Blind RCT Frankinscence and coconut Oil based mouthwash, Frankinscence and Thyme essence/ water based mouthwash, Chlorhexidine (0.2%) - Gingivitis | Not applicable | Completed | Oman Dental College | 99 | 2026-04-19 | 2026-09-02 |
| Topical Chlorhexidine Spray for the Prevention of Acute Radiation Dermatitis in Patients With Nasopharyngeal Carcinoma: 2% chlorhexidine, Sterile Water as control - Nasopharangeal Cancer | Phase 3 | Recruiting | Jiangxi Provincial Cancer Hospital | 148 | 2026-04-01 | 2026-04-30 |
| Evaluation of the Anti-plaque Effect of a Bioflavonoid-based Antiseptic Mouthwash Bioflavonoid mouthwash, Chlorhexidine 0.12% mouthwash - Gingival Inflammation, Dental Plaque Accumulation | Phase 4 | Completed | University of Barcelona | 24 | 2026-03-02 | 2026-09-17 |
| Comparison Between the Effect of Triclosan Toothpaste and Chlorhexidine Mouthwash on Gingival Health in a Group of Fixed Orthodontic Patients: A Randomized Controlled Clinical Trial Triclosan 0.3% toothpaste, sodium fluoride 0.24% toothpaste, Chlorhexidine 0.2% mouthwash - Gingival Inflammation | Phase 4 | Completed | University of Science and Technology, Yemen | 60 | 2026-02-14 | 2026-09-11 |
| PMPR and Chlorhexidine on Periodontal Disease and Vascular Function Chlorhexidine (0.2%) mouthwash, Placebo mouthwash - Periodontal Disease (PD), Cardio Vascular Disease | Not applicable | Recruiting | Mahdi Mutahar | 30 | 2026-01-23 | 2026-03-25 |
| Comparative Effects of Two Oral Antiseptics Used as an Adjuvant in the Treatment of Periodontitis Experimental (chlorhexidine), Control (chlorhexidine with cetylpyridinium chloride) - Periodontitis, Periodontitis Stage II | Not applicable | Recruiting | The University of Hong Kong | 60 | 2025-11-20 | 2026-06-23 |
| Sore Throat After Open Neck Elective Surgery Hydrocortisone Acetate 1% Ointment, Lidocaine hydrochloride 0,05% with chlorhexidine - Postoperative Sore Throat, Cough, Hoarseness, Thyroid and Parathyroid Surgery | Phase 4 | Recruiting | Saint Petersburg State University, Russia | 764 | 2025-09-15 | 2026-04-13 |
| MicroRepair® ABX vs Chlorhexidine 0.12% in Gingivitis Patients MicroRepair ABX mouthwash, Chlorhexidine 0.12% mouthwash - Gingivitis, Dental Plaque | Not applicable | Completed | University of Pavia | 40 | 2025-08-30 | 2026-04-23 |
| 0.2% Chlorhexidine vs MicroRepair ABX in Gingivitis MicroRepair ABX mouthwash, Chlorhexidine 0.2% mouthwash - Gingivitis and Periodontal Diseases, Dental Plaque | Not applicable | Completed | University of Pavia | 40 | 2025-08-30 | 2026-04-29 |
| Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer Metronidazole, Chlorhexidine - Oral Squamous Cell Carcinoma, Oral Cancer | Phase 2 | Recruiting | Case Comprehensive Cancer Center | 30 | 2025-07-22 | 2026-08-06 |
| Mouthwashes for Gingivitis: Comparing a Hydrogen Peroxide-Hyaluronic Acid Mix, Hyaluronic Acid, and Chlorhexidine, A Triple-Blind Clinical Trial 1-Hydrogen peroxide and hyaluronic acid, 2- Hyaluronic acid, Chlorhexidine - Plaque Induced Gingival Disease | Not applicable | Completed | Ramziyah Hayder Bakr | 80 | 2025-07-01 | 2026-09-30 |
| Treatment of Periodontitis by Tulsi Gel Tulsi gel, Chlorhexidine gel - Advanced Periodontitis, Stage III Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Al-Azhar University | 24 | 2025-07-01 | 2025-07-01 |
| Chlorhexidine and Zinc in Non-Surgical Periodontal Therapy Chlorhexidine and zinc application, Scaling and root planing with distilled water - Periodontitis, Periodontitis Stage I | Not applicable | Completed | Ataturk University | 44 | 2025-06-16 | 2026-04-22 |
Showing 20 of 228. Sign in to see all of them.
Gingivitis (22) · Periodontitis (22) · Periodontal Diseases (18) · Dental Plaque (14) · Surgical Wound Infection (14) · Peri-Implantitis (13) · Pneumonia, Ventilator-Associated (10) · Infections (9) · Pain, Postoperative (7) · Staphylococcal Infections (7) · Dental Caries (6) · Periapical Periodontitis (5) · Communicable Diseases (4) · Dry Socket (4) · Gingival Hemorrhage (4)
Cairo University (10) · Dexcel Pharma Technologies Ltd. (5) · Ain Shams University (4) · Johns Hopkins Bloomberg School of Public Health (4) · University of Pavia (4) · University of Santiago de Compostela (4) · Università Vita-Salute San Raffaele (4) · Assiut University (3) · Dr Meru S (3) · Government College of Dentistry, Indore (3) · University of Oslo (3) · Aga Khan University (2) · All India Institute of Medical Sciences (2) · Ataturk University (2) · Cukurova University (2)
United States (47) · Egypt (18) · Italy (15) · Spain (13) · Turkey (Türkiye) (12) · Brazil (11) · India (8) · Israel (7) · Pakistan (7) · Canada (5) · Mexico (5) · United Kingdom (5) · Germany (4) · China (3) · France (3)
Massimo De Sanctis (3) · Meru S, MDS (3) · Andrea Scribante, Associate Professor (2) · Bruno CV Gurgel, Doctor (2) · Inmaculada Tomas (2) · Luke C Mullany, PhD (2) · Mary-Claire Roghmann, MD (2) · Aaron Milstone, MD, MHS (1) · Ahmed R. Ahmed, MD (1) · Alejandro E Macias, MD (1) · Alejandro E. Macias, M. D. (1) · Alparslan Dilsiz, Professor (1)
PMID 32580252, PMID 11737510, PMID 12660125, PMID 12666710, PMID 14296927, PMID 14489483, PMID 15459950, PMID 15496868, PMID 15677372, PMID 15766375, PMID 16223755, PMID 16460251, PMID 16464960, PMID 16546539, PMID 16822220, PMID 16885929, PMID 16922026, PMID 17065275, PMID 1706728, PMID 17079556, PMID 17210728, PMID 17492050, PMID 18245686, PMID 18269662, PMID 18287373, PMID 18450880, PMID 18450881, PMID 18539298, PMID 18606930, PMID 18622483, PMID 18762599, PMID 18990201, PMID 19034065, PMID 19248648, PMID 19431006, PMID 19846212, PMID 20048245, PMID 20054046, PMID 20603466, PMID 20615216, PMID 20618550, PMID 21458812, PMID 21621212, PMID 21705765, PMID 21949140, PMID 21972580, PMID 22322126, PMID 22385260, PMID 22565291, PMID 22566109
R01HD044004 (2), 2015 (1), 2018 (1), 2023 (1), R01CI000373 (1), R01HD097692 (1), R01NR007652 (1)