132 completed, 46 unknown, 17 recruiting, 11 not yet recruiting. 153 Not applicable, 20 Phase 2, 19 Phase 4, 12 Phase 1, 12 Phase 3.
Follow Tooth Exfoliation: new trials by email Literature Review of Tooth Exfoliation trials Research Report on Tooth Exfoliation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alb-PRF as an Adjunct to Nonsurgical Periodontal Therapy Nonsurgical Periodontal Therapy, Albumin Platelet-Rich Fibrin - Periodontitis | Not applicable | Not yet recruiting | Halil Ata BIÇAKÇIOĞLU | 24 | 2026-12-01 | 2026-08-31 |
| Stingless Bee Honey Mouth Rinse on Gingivitis mouth rinse, scaling, oral hygiene education and instruction - Gingivitis | Early Phase 1 | Not yet recruiting | Ministry of Higher Education, Malaysia | 60 | 2026-09-06 | 2026-08-19 |
| Photodynamic Therapy as an Adjunct in Periodontal Treatment Scaling and Root Planing, Antimicrobial Photodynamic Therapy - Periodontitis, Periodontal Disease | Not applicable | Enrolling by invitation | Universidad Catolica Santiago de Guayaquil | 30 | 2026-07-28 | 2026-09-25 |
| Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial scaling and root planing - Periodontitis, Adult, Periodontal Diseases | Not applicable | Not yet recruiting | Zeyad Nazar | 21 | 2026-07-15 | 2026-05-19 |
| Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Therapy in Smokers Scaling and Root Planing, Hyaluronic Acid (HYADENT BG) - Hyaluronic Acid, Periodontal Therapy | Not applicable | Recruiting | Marmara University | 23 | 2026-07-13 | 2026-08-18 |
| Adjunctive Hyaluronic Acid Gel in Non-Surgical Periodontal Treatment of Patients With Diabetes Mellitus Scaling and root planing, Hyaluronic Acid (HYADENT BG) - Periodontitis, Diabetes Mellitus | Not applicable | Not yet recruiting | Marmara University | 23 | 2026-06-01 | 2026-06-08 |
| Periodontal Inflammation and Epigenetics in Obese Individuals Non-surgical periodontal therapy will be administered - Obesity, Periodontitis | Not applicable | Not yet recruiting | Louisiana State University Health Sciences Center in New Orleans | 40 | 2026-05-25 | 2026-05-28 |
| This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis Patients Injectable Platelet-Rich Fibrin (I-PRF), Diode Laser Activation, Povidone-Iodine Irrigation (1%) - Periodontitis, Smokers | Phase 4 | Recruiting | Military Hospital of Tunis | 50 | 2026-05-25 | 2026-07-16 |
| Effect of Periodontal Therapy on Asprosin in Stable Angina Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning) - Stable Angina Pectoris, Periodontitis | Not applicable | Not yet recruiting | Ondokuz Mayıs University | 60 | 2026-05-20 | 2026-05-18 |
| Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitus Scaling and root planing, Photodynamic Therapy with Conventional Methylene Blue - Type 2 Diabetes, Halitosis | Not applicable | Recruiting | University of Sao Paulo | 32 | 2026-04-02 | 2026-03-16 |
| Effectiveness of Epigallocatechin-3-Gallate (Green Tea Extract) as Adjunctive Locally Delivered Nanotherapeutic in the Treatment of Stage II Periodontitis Ten patients with stage II periodontitis will receive epigallocatechin-3-gallate (EGCG)-loaded chitosan nanoparticulate gel injected into the periodontal pockets, chitosan nanoparticulate gel (CTN gel), scaling and root planing (SRP) only. - Peridontitis | Phase 1 | Recruiting | Mansoura University | 30 | 2026-03-16 | 2026-08-10 |
| Effects of Non-Surgical Periodontal Treatment on Inflammatory and Bone Markers in Periodontitis Patients Scaling and Root Planing (SRP) - Periodontitis (Stage 3) | Not applicable | Active not recruiting | Saglik Bilimleri Universitesi | 56 | 2026-03-15 | 2026-04-27 |
| Non-Surgical Periodontal Therapy and Cardiac Biomarkers in Stable Angina Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning) - Stable Angina, Periodontitis | Not applicable | Not yet recruiting | Ondokuz Mayıs University | 60 | 2026-02-20 | 2026-02-17 |
| Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics local antibiotic application of topical minocycline, Scaling and Root Planing - Periodontitis, Diabetes Mellitus Type 2 | Early Phase 1 | Recruiting | Case Western Reserve University | 42 | 2026-02-06 | 2026-02-19 |
| Injectable PRF in Non-Surgical Periodontal Treatment Injectable Platelet-Rich Fibrin (i-PRF)., Scaling and Root Planing (SRP). - Periodontitis, Periodontal Pocket | Not applicable | Completed | Al-Mustansiriyah University | 18 | 2026-01-29 | 2026-10-07 |
| Injectable Platelet-Rich Fibrin (i-PRF) and Oxygen-Releasing Gel in the Treatment of Stage II Periodontitis. Injectable Platelet-Rich Fibrin (i-PRF, Peroxoborate Oxygen-Releasing Oral Gel, Sterile 0.9% Saline Solution - Stage III Periodontitis | Phase 1 / Phase 2 | Completed | Assiut University | 24 | 2026-01-20 | 2026-10-05 |
| Effect of Morus Nigra Mouthwash on Gingivitis Treatment Scaling and Root Planing, Morus Nigra Mouthwash - Gingivitis | Not applicable | Recruiting | Inonu University | 30 | 2026-01-15 | 2026-04-13 |
| Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis Non-surgical periodontal therapy (Scaling and root planing) - Periodontitis, Smoking ( Cigarette) | Not applicable | Recruiting | Al-Mustansiriyah University | 44 | 2026-01-01 | 2026-04-23 |
| Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients Scaling and Root Planing, Diode Laser - Periodontitis, Kidney Transplant Recipients | Not applicable | Recruiting | Military Hospital 103 | 80 | 2025-12-09 | 2026-04-16 |
| Olfactory Function and Oral Malodor in Periodontitis Before and After Periodontal Therapy Scaling and Root Planing (SRP) - Periodontitis, Olfactory Dysfunction | Not applicable | Completed | Batman University | 101 | 2025-12-03 | 2026-10-20 |
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Periodontitis (117) · Periodontal Diseases (55) · Chronic Periodontitis (46) · Gingivitis (15) · Periodontal Pocket (11) · Diabetes Mellitus (9) · Diabetes Mellitus, Type 2 (9) · Smoking (9) · Inflammation (6) · Obesity (6) · Arthritis, Rheumatoid (4) · Cardiovascular Diseases (4) · Peri-Implantitis (4) · Periodontal Attachment Loss (4) · Aggressive Periodontitis (3)
Postgraduate Institute of Dental Sciences Rohtak (13) · University of Sao Paulo (10) · Cairo University (6) · Mansoura University (6) · Alexandria University (5) · Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre (5) · Ataturk University (4) · Meenakshi Ammal Dental College and Hospital (4) · Assiut University (3) · Belén Retamal-Valdes (3) · Federal University of Rio Grande do Sul (3) · Inonu University (3) · Ondokuz Mayıs University (3) · Tanta University (3) · Tatyasaheb Kore Dental College (3)
Egypt (34) · United States (26) · India (25) · Turkey (Türkiye) (25) · Brazil (21) · Spain (7) · Italy (5) · Canada (4) · Colombia (4) · Germany (3) · Pakistan (3) · Saudi Arabia (3) · Vietnam (3) · Chile (2) · France (2)
Magda Feres, Professor (3) · Dilip Khambete, MDS (2) · Gaetano Isola (2) · Maha R. Taalab, PhD (2) · Sena Altintas, DDS (2) · A R Pradeep, MDS (1) · Adriana P Sant'Ana, DDS PhD (1) · Ahmed Fattouh, Bachelor (1) · Ahmet C Talmac, PhD (1) · Ajay Mahajan, MDS (1) · Aliaa Gamaleldin Aboulela, PhD (1) · Alparslan Dilsiz, Professor (1) · Alpiste Illueca Francisco, Professor (1) · Amir Moeintaghavi, DDS.,Ms. (1)
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2008 (1), R01DE014242 (1), R21DE020916 (1)