41 completed, 11 unknown, 3 recruiting, 1 terminated. 21 Not applicable, 7 Phase 2, 7 Phase 4, 5 Phase 3, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 21 | Completed 14, Unknown 6, Terminated 1 |
| Phase 2 | 7 | Completed 6, Unknown 1 |
| Phase 4 | 7 | Completed 6, Unknown 1 |
| Phase 3 | 5 | Completed 4, Recruiting 1 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
Follow Aggressive Periodontitis: new trials by email Literature Review of Aggressive Periodontitis trials Research Report on Aggressive Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features Periodontis, Aggressive Periodontitis | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 9 | 2025-12-26 | 2026-03-23 | |
| A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar Pustulosis Bimekizumab, Placebo - Palmoplantar Pustulosis | Phase 3 | Recruiting | UCB Biopharma SRL | 320 | 2025-11-14 | 2026-08-27 |
| The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis L-PRF with antimicrobial photodynamic therapy, antimicrobial photodynamic therapy without L-PRF - L-PRF, Photodynamic Therapy | Not applicable | Unknown | Kafrelsheikh University | 20 | 2021-11-22 | 2024-04-11 |
| Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients non surgical periodontal therapy - Aggressive Periodontitis | Completed | Future University in Egypt | 50 | 2021-03-27 | 2022-03-25 | |
| Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis non surgical periodontal therapy - Aggressive Periodontitis | Completed | Future University in Egypt | 50 | 2021-03-27 | 2022-04-07 | |
| Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis GTR, concentrated growth factor - Aggressive Periodontitis | Phase 1 / Phase 2 | Completed | Tanta University | 10 | 2020-07-01 | 2021-09-17 |
| is Generalized Aggressive Periodontitis an Endless Disease When Does it Stop panoramic radiograph - Aggressive Periodontitis, Generalized | Completed | Rasha Wagih | 92 | 2020-01-16 | 2025-05-14 | |
| Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods Periodontitis Group - Generalized Aggressive Periodontitis, Chronic Periodontitis | Unknown | Kocaeli University | 200 | 2019-09-01 | 2019-07-25 | |
| Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration Transplantation of allogeneic MSCs in periodontal disease - Chronic Periodontal Disease, Aggressive Periodontitis | Phase 1 / Phase 2 | Unknown | Instituto Venezolano de Investigaciones Cientificas | 30 | 2018-08-30 | 2023-08-04 |
| Efficacy of Sub-gingival Air-polishing With Erythritol in the Treatment of Periodontitis Perioflow and Erythritol powder and ultrasonic debridement, Airflow and Erythritol powder and ultrasonic debridement - Periodontitis, Adult, Periodontitis, Aggressive | Not applicable | Completed | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | 40 | 2018-02-28 | 2020-02-18 |
| Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis GTR + radiation-sterilize allogenic bone graft, GTR + xenogenic graft - Periodontitis, Aggressive | Not applicable | Unknown | Medical University of Warsaw | 20 | 2018-01-05 | 2017-11-13 |
| GCF HIF-1α, VEGF and TNF-α Levels in G-AgP Patients Before and After Periodontal Treatment. Non-surgically performed scaling and root planing - Aggressive Periodontitis, Generalized, Periodontal Health | Not applicable | Completed | Aydin Adnan Menderes University | 20 | 2017-12-01 | 2019-07-17 |
| Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis Experimentally induced plaque - Gingivitis, Mucositis | Not applicable | Completed | University of Campinas, Brazil | 20 | 2017-11-07 | 2018-10-19 |
| Chairside Mouthrinse Test and Cost Effectiveness aMMP-8 chairside test - Periodontitis, Juvenile | Not applicable | Unknown | University of Helsinki | 200 | 2017-09-01 | 2020-11-03 |
| Immediate Implant Placement in Aggressive Periodontitis implants in periodontitis - Periodontitis | Not applicable | Unknown | Cairo University | 20 | 2017-06-10 | 2017-07-18 |
| Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Omega-3 polyunsaturated fatty acids, Aspirin, Placebo - Aggressive Periodontitis | Phase 2 / Phase 3 | Completed | Universidade Estadual Paulista Júlio de Mesquita Filho | 38 | 2017-05-15 | 2021-12-28 |
| Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Open flap debridement, Placebo, Omega-3 polyunsaturated fatty acids - Residual Disease, Aggressive Periodontitis | Phase 2 / Phase 3 | Completed | Universidade Estadual Paulista Júlio de Mesquita Filho | 34 | 2017-05-15 | 2020-11-17 |
| Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis. full mouth ultrassonic debridement associated to Amoxicilin 500 + Metronidazole 400 mg - Periodontal Diseases, Aggressive Periodontitis | Not applicable | Unknown | University of Campinas, Brazil | 30 | 2017-03-01 | 2019-08-12 |
| Interaction Between Immune Cells and Bacteria Associated With Periodontitis In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs) - Periodontal Diseases, Periodontitis | Completed | University of Copenhagen | 90 | 2017-02-01 | 2020-03-24 | |
| Efficacy of GBT vs SRP+US, in the Treatment of Severe Generalized Periodontitis. Airflow, Perioflow and Erythritol powder and ultrasonic debridement, Ultrasonic debridement and curettes - Periodontitis, Aggressive, Periodontal Diseases | Not applicable | Completed | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | 32 | 2016-11-22 | 2021-11-08 |
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Chronic Periodontitis (15) · Periodontitis (8) · Periodontal Diseases (7) · Gingivitis (2) · Inflammation (2) · Periodontal Pocket (2) · Arthritis, Rheumatoid (1) · Dysbiosis (1) · Hypoxia (1) · Immune System Diseases (1) · Mucositis (1) · Neoplasm, Residual (1) · Peri-Implantitis (1) · Psoriasis (1)
Mouth Diseases (56) · Stomatognathic Diseases (56) · Periodontal Diseases (49) · Periodontitis (48) · Pathological Conditions, Signs and Symptoms (18) · Pathologic Processes (17) · Chronic Disease (15) · Disease Attributes (15) · Gingival Diseases (2) · Infections (2) · Skin and Connective Tissue Diseases (2) · Arthritis (1) · Autoimmune Diseases (1) · Behavior (1) · Connective Tissue Diseases (1)
Metronidazole (7) · Amoxicillin (6) · Periodontal Debridement (4) · Root Planing (4) · Clarithromycin (3) · Tooth Exfoliation (3) · Aspirin (2) · Docosahexaenoic Acids (2) · Fish Oils (2) · Moxifloxacin (2) · Photochemotherapy (2) · Anti-Bacterial Agents (1) · Doxycycline (1) · Drug Implants (1) · Flow Cytometry (1)
Universidade Estadual Paulista Júlio de Mesquita Filho (7) · University of Campinas, Brazil (6) · Abant Izzet Baysal University (2) · Aydin Adnan Menderes University (2) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (2) · Bulent Ecevit University (2) · Cairo University (2) · Centre Hospitalier Universitaire de Nice (2) · Damascus University (2) · Facultad Nacional de Salud Publica (2) · Future University in Egypt (2) · Kocaeli University (2) · Ain Shams University (1) · Goethe University (1) · Hacettepe University (1)
Brazil (8) · Egypt (6) · France (4) · Turkey (Türkiye) (4) · China (3) · Italy (3) · Colombia (2) · Denmark (2) · Germany (2) · Poland (2) · Syria (2) · United States (2) · Canada (1) · Czechia (1) · Finland (1)
Mauro P Santamaria, DDS, PhD (4) · Magda Mensi (2) · Mauro Santamaria, Professor (2) · Sarah M Elkot, Lecturer (2) · Abeer Alasadi, DDS (1) · Ahmet C Talmac, PhD (1) · Ali Abou Sulaiman, DDS MSc PhD (1) · Ali Abou Sulaiman, DDS MSc Phd (1) · Basak Dogan, Prof. Dr. (1) · Boris Gaspirc, Assoc.prof. (1) · Carlos M Ardila, Ph.D (1) · Claus Henrik Nielsen, PhD, MSc, MD (1)
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R01DE019456 (1)