141 completed, 39 unknown, 25 recruiting, 24 not yet recruiting. 177 Not applicable, 16 Phase 2, 11 Phase 4, 10 Phase 3, 7 Early Phase 1.
Follow Periapical Periodontitis: new trials by email Literature Review of Periapical Periodontitis trials Research Report on Periapical Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation - Apical Periodontitis | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 60 | 2027-07-01 | 2026-04-08 |
| Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection Sodium hypochlorite 3%, Frankincense-based irrigant - Pulp Necrosis, Root Canal Infection | Early Phase 1 | Not yet recruiting | Oman Dental College | 30 | 2027-01-19 | 2026-09-22 |
| Apical Periodontitis and Glycemic Control in Diabetic and Non-diabetic Egyptian Sub-population Apical Periodontitis | Not yet recruiting | Cairo University | 88 | 2026-10-05 | 2026-10-02 | |
| Endodontic Microsurgery Platelet rich fibrin - Apical Periodontitis | Phase 4 | Not yet recruiting | Mark Schachman | 20 | 2026-10-01 | 2026-07-29 |
| Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation sonically activated irrigation, laser activated irrigation, conventional needle irrigation - Apical Periodontitis, Post Operative Pain, Acute | Not applicable | Not yet recruiting | University Ghent | 183 | 2026-10-01 | 2026-10-20 |
| Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment. Sodium Hypochlorite 3% Solution, Emblica officinalis Solution - Pulp Necrosis, Apical Periodontitis | Not applicable | Not yet recruiting | Postgraduate Medical Institute, Lahore | 66 | 2026-09-17 | 2026-09-22 |
| Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial silver nanoparticles reinforced double antibiotic paste, Double Antibiotic Paste - Apical Periodontitis, Post Endodontic Pain | Not applicable | Not yet recruiting | All India Institute of Medical Sciences | 50 | 2026-08-30 | 2026-08-13 |
| Biomarkers in Apical Periodontitis laser activation, PUI, CSI - Apical Periodontitis, Retreatment | Not applicable | Completed | Kırıkkale University | 66 | 2026-08-30 | 2026-10-21 |
| Nanozymes in Endodontics Nanozyme treatment, Control (Standard treatment) - Apical Periodontitis, Endodontic Disease | Phase 4 | Enrolling by invitation | University of Pennsylvania | 72 | 2026-08-24 | 2026-10-13 |
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| Effect of Different Apical Motion Algorithms on Postoperative Pain After Root Canal Treatment Root Canal Treatment, Rotary Instrumentation, Reciprocating Instrumentation - Apical Periodontitis, Postoperative Pain After Endodontic Treatment | Not applicable | Not yet recruiting | Alanya Alaaddin Keykubat University | 120 | 2026-07-20 | 2026-07-20 |
| Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide. 3D-Printed Static Surgical Guide and Trephine Bur, Ultrasonic Retrograde Preparation and Bioceramic Retrograde Obturation - Periapical Periodontitis, Periradicular Lesion | Not applicable | Recruiting | University of Medicine and Pharmacy at Ho Chi Minh City | 11 | 2026-07-01 | 2026-07-29 |
| Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment Triple Antibiotic Paste, Calcium Hydroxide (Ca(OH)2) - Periapical Lesion, Periapical Periodontitis | Not applicable | Not yet recruiting | Faiz ur rahman | 62 | 2026-06-15 | 2026-03-18 |
| Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial CTZ Paste, ZOE Pulpectomy - Pulp Disease, Dental, Pulp Necrosis | Early Phase 1 | Not yet recruiting | University of Sao Paulo | 110 | 2026-06-08 | 2026-05-12 |
| Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication - Intervention Studies, ASA Physical Status I | Phase 1 | Recruiting | Ain Shams University | 60 | 2026-06-01 | 2026-06-12 |
| Effect of Intracanal Cryotherapy on Postoperative Endodontic Pain root canal treatment and cryotherapy - Periapical Periodontitis, Asymptomatic Irreversible Pulpitis | Not applicable | Completed | Recep Tayyip Erdogan University | 132 | 2026-05-11 | 2026-07-17 |
| Comparison of Root Canal Desinfection Protocols Desinfection device, Analytical microbiological methods - Periapical Periodontitis | Not applicable | Recruiting | State University of New York at Buffalo | 50 | 2026-04-01 | 2026-06-23 |
| Clinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic Retreatments Root canal treatment and non surgical endodontic retreatment - Periapical Periodontitis, Pulpitis | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 75 | 2026-03-15 | 2026-02-18 | |
| The Present Study Aims to Follow up on All Root Canal Treatments Performed During the Year 2023 Within the Public Dental Services of the Counties of Jönköping, Kalmar, and Östergötland, Sweden. The Study is Entirely Observational in Nature. Endodontic Treatment, Apical Periodontitis | Not yet recruiting | Region Jönköping County | 1500 | 2026-03-01 | 2025-12-16 | |
| Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis Apical Periodontitis | Not yet recruiting | Duygu Degirmencioglu | 45 | 2026-03-01 | 2026-01-20 |
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Pain, Postoperative (41) · Dental Pulp Necrosis (37) · Periapical Abscess (16) · Periapical Diseases (11) · Dental Pulp Diseases (10) · Pulpitis (8) · Tooth, Nonvital (8) · Dental Caries (7) · Pain (7) · Inflammation (6) · Periapical Granuloma (6) · Diabetes Mellitus (4) · Radicular Cyst (4) · Diabetes Mellitus, Type 2 (3)
Jaw Diseases (249) · Mouth Diseases (248) · Periodontal Diseases (248) · Stomatognathic Diseases (248) · Periodontitis (247) · Periapical Diseases (238) · Pathological Conditions, Signs and Symptoms (86) · Pathologic Processes (83) · Tooth Diseases (65) · Dental Pulp Diseases (47) · Neurologic Manifestations (47) · Signs and Symptoms (47) · Postoperative Complications (40) · Pain (39) · Necrosis (37)
Calcium Hydroxide (13) · Sodium Hypochlorite (8) · Endodontics (5) · Chlorhexidine (4) · Edetic Acid (4) · Therapeutic Irrigation (4) · Amoxicillin (3) · Carticaine (3) · Control Groups (3) · Diclofenac (3) · Lasers, Semiconductor (3) · Methods (3) · Oxymetazoline (3) · Pemetrexed (3) · Sodium Chloride (3)
Postgraduate Institute of Dental Sciences Rohtak (27) · Cairo University (16) · Istanbul Medipol University Hospital (9) · Ain Shams University (8) · University of Siena (7) · TC Erciyes University (6) · Recep Tayyip Erdogan University (5) · Seyda Ersahan, DDS, PhD (5) · Medipol University (4) · University of Pennsylvania (4) · Biruni University (3) · Future University in Egypt (3) · Isparta Military Hospital (3) · Kahramanmaras Sutcu Imam University (3) · Kırıkkale University (3)
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PMID 3457698, PMID 21238793, PMID 14651280, PMID 19345793, PMID 9477818, PMID 10371903, PMID 11199749, PMID 12196219, PMID 12701769, PMID 1298800, PMID 14342926, PMID 14503827, PMID 14655819, PMID 15209994, PMID 15910469, PMID 15917679, PMID 16554195, PMID 16911098, PMID 17889679, PMID 17931388, PMID 17931389, PMID 18166260, PMID 18437843, PMID 18771838, PMID 18928835, PMID 19452675, PMID 19703082, PMID 19875314, PMID 19932338, PMID 19961451, PMID 2084204, PMID 21329812, PMID 21924201, PMID 22117841, PMID 22403423, PMID 22595123, PMID 22733649, PMID 22892736, PMID 23385425, PMID 23617276, PMID 24139274, PMID 24332588, PMID 24651335, PMID 24908421, PMID 25307919, PMID 25354086, PMID 25627883, PMID 25892512, PMID 26241781, PMID 26300919
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