Doxycycline: Clinical Trials

203 completed, 53 unknown, 28 recruiting, 27 terminated. 103 Phase 2, 90 Phase 4, 66 Not applicable, 61 Phase 3, 34 Phase 1.

By phase and status

Phase	Trials	Status
Phase 2	103	Completed 55, Terminated 14, Unknown 13, Recruiting 10, Active not recruiting 5, Not yet recruiting 4, Withdrawn 2
Phase 4	90	Completed 55, Unknown 13, Recruiting 6, Terminated 6, Not yet recruiting 5, Active not recruiting 2, Withdrawn 2, Enrolling by invitation 1
Not applicable	66	Completed 31, Unknown 13, Recruiting 8, Not yet recruiting 5, Withdrawn 5, Terminated 4
Phase 3	61	Completed 39, Unknown 11, Not yet recruiting 3, Recruiting 3, Withdrawn 3, Terminated 2
Phase 1	34	Completed 23, Terminated 4, Active not recruiting 3, Unknown 3, Recruiting 1
Early Phase 1	7	Active not recruiting 2, Unknown 2, Completed 1, Recruiting 1, Terminated 1

Follow Doxycycline: new trials by email Literature Review of Doxycycline trials Research Report on Doxycycline

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Ceftriaxone for Injection, Amoxicillin - Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection	Phase 2	Not yet recruiting	The University of Queensland	300	2027-04-01	2026-03-20
Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System	Phase 4	Not yet recruiting	Radboud University Medical Center	50	2027-03-01	2026-08-27
A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United States Doxycycline, Standard of Care (SOC) - Chlamydia Females, Gonorrhea Female	Phase 4	Not yet recruiting	Tulane University	519	2027-01-01	2026-07-15
A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African Women Doxycycline hyclate, Standard of Care for STI prevention - Sexually Transmitted Infection (STI), Gonorrhea	Phase 3	Not yet recruiting	National Institute of Allergy and Infectious Diseases (NIAID)	580	2026-11-30	2026-10-20
These Studies That Evaluated the Efficacy of Antibiotics for Leptospirosis Treatment. Doxycycline, Placebo - Leptospirosis, Chemoprophylaxis	Phase 4	Not yet recruiting	Chulalongkorn University	1000	2026-11-01	2026-10-08
All-Oral Fluoroquinolone-Based Triple Therapies for Adults With Imaging-Confirmed Osteoarticular Brucellosis Doxycycline + Rifampicin + Ceftriaxone (intravenous therapy for 4 weeks), Triple oral regimen (Doxycycline + Rifampicin + Levofloxacin), Triple oral regimen (Doxycycline + Rifampicin + Moxifloxacin) - Brucellosis, Osteoarticular Brucellosis	Not applicable	Not yet recruiting	The First Affiliated Hospital of Shihezi University	150	2026-11-01	2026-10-21
Fluoroquinolone-Doxycycline Oral Treatments for Adults With Uncomplicated Brucellosis Doxycycline + Rifampicin, Doxycycline + Levofloxacin, Doxycycline + Moxifloxacin - Brucellosis	Not applicable	Not yet recruiting	The First Affiliated Hospital of Shihezi University	200	2026-11-01	2026-10-21
AUTOP 2: Screen-and-treat Strategy for Vaginal Flora Abnormalities by Molecular Biology in Pregnant Women at High Risk of Preterm Birth Vaginal flora abnormalities screening and quantification using molecular biology technique, Azithromycin, Ceftriaxone - Bacterial Vaginosis, Vaginal Dysbiosis	Phase 3	Not yet recruiting	Assistance Publique Hopitaux De Marseille	1794	2026-10-01	2026-08-27
Efficacy & Safety of Fluoroquinolone-Based Brucellosis Regimens (BRUCE) Doxycycline + Rifampicin, Doxycycline + Levofloxacin, Doxycycline + Moxifloxacin - Brucellosis, Osteoarthritis	Not applicable	Withdrawn	The First Affiliated Hospital of Shihezi University		2026-10-01	2026-10-27
Isotretinoin vs. Doxycycline for Acneiform Rash in Patients Receiving Drugs That Target the MAPK Pathway Isotretinoin, Doxycycline, Blood specimen collection - Acneiform Drug Eruption, Acneiform Eruptions	Phase 2	Not yet recruiting	University of California, San Francisco	50	2026-08-30	2026-06-05
Genicular Embolization Using Doxycycline Sclerotherapy Doxycycline Injection - Chronic Knee Pain, Osteoarthritis	Phase 2	Withdrawn	Campbell Clinic		2026-06-01	2026-02-27
Clinical and Radiographic Evaluation of Doxycycline and Atorvastatin Loaded Chitosan Nanoparticles as an Adjunctive to Scaling and Root Planning in the Management of Chronic Periodontitis. A Randomized Controlled Clinical Trial. Doxycycline and Atorvastatin loaded Chitosan nanoparticles local drug - Chronic Periodontitis	Phase 4	Not yet recruiting	Fayoum University	80	2026-06-01	2026-06-08
Doxycycline Use in Post-Operative Seromas Doxycycline - Seroma	Phase 2	Recruiting	University of Miami	10	2026-05-31	2026-07-09
Sexual Health Access at Retail Pharmacies: Advancing Pharmacy-based Delivery of Primary STI and HIV Prevention for Cisgender Women doxy-PEP, Serial STI testing, HIV PEP/PrEP - Sexually Transmitted Infections (Not HIV or Hepatitis), HIV Infections	Not applicable	Not yet recruiting	University of Washington	720	2026-05-01	2026-01-28
Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne. Sarecycline, Doxycycline - Acne Vulgaris	Phase 4	Recruiting	Integrative Skin Science and Research	30	2026-04-20	2026-04-22
Doxycycline vs. Macrolide for MRMP (DOMINO) Doxycycline, Azithromycin - Mycoplasma Pneumoniae, Mycoplasma Pneumoniae Pneumonia	Phase 4	Not yet recruiting	Young June Choe	208	2026-03-01	2025-12-29
The Efficacy and Safety of Anti-inflammation Treatment (Hirudoid Introduction Followed by Yellow Light Therapy) Combined With Tofacitinib and Doxycycline in Chinese Adult Patients With Mild to Moderate Erythematous Telangiectatic Rosacea Doxycycline, Hydroxychloroquine, Tofacitinib - Erythematotelangiectatic Rosacea	Not applicable	Recruiting	The Fourth Affiliated Hospital of Zhejiang University School of Medicine	186	2026-02-01	2026-03-24
Injection Sclerotherapy With Bleomycin VS Doxycycline in Patients With Lymphatic Malformations Bleomycin, doxycycline (tetracycline) - Lymphatic Abnormality	Phase 2	Not yet recruiting	Basharat Hussain	92	2026-01-26	2026-01-06
Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro Doxycycline - Sexually Transmitted Diseases, Syphilis	Not applicable	Recruiting	Oswaldo Cruz Foundation	200	2025-10-28	2026-03-30
Got Doxy- 'Flipping the Script' on STI PEP Doxycycline monohydrate 200 mg, Observation - Sexually Transmitted Infections (STI)	Phase 4	Recruiting	Emory University	200	2025-10-13	2026-04-30

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Conditions studied

Acne Vulgaris (23)  ·  Rosacea (18)  ·  Sexually Transmitted Diseases (15)  ·  COVID-19 (11)  ·  Syphilis (11)  ·  Chlamydia Infections (9)  ·  Lyme Disease (9)  ·  Gonorrhea (8)  ·  Glossitis, Benign Migratory (7)  ·  Infections (7)  ·  Inflammation (7)  ·  Pulmonary Disease, Chronic Obstructive (7)  ·  Lyme Neuroborreliosis (6)  ·  Periodontitis (6)  ·  Colitis, Ulcerative (5)

Sponsors

Galderma R&D (11)  ·  University Medical Centre Ljubljana (11)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (9)  ·  University of California, San Francisco (6)  ·  University of Washington (6)  ·  Emory University (5)  ·  Par Pharmaceutical, Inc. (5)  ·  M.D. Anderson Cancer Center (4)  ·  National Taiwan University Hospital (4)  ·  Radboud University Medical Center (4)  ·  Sun Yat-sen University (4)  ·  Assiut University (3)  ·  CollaGenex Pharmaceuticals (3)  ·  Fondazione IRCCS Policlinico San Matteo di Pavia (3)  ·  Johns Hopkins University (3)

Countries

United States (143)  ·  Canada (25)  ·  China (18)  ·  Egypt (11)  ·  France (11)  ·  Slovenia (10)  ·  Netherlands (9)  ·  United Kingdom (9)  ·  Germany (8)  ·  South Korea (8)  ·  Israel (7)  ·  Italy (6)  ·  Taiwan (6)  ·  Bangladesh (5)  ·  Brazil (5)

Top investigators

Colleen Kelley, MD, MPH (4)  ·  Dan Liang, MD (3)  ·  Dorian Williams, M.D. (3)  ·  Eric Masson, Pharm.D. (3)  ·  Eric Ottesen, MD (3)  ·  Franc Strle, MD (3)  ·  Ronald W Gottschalk, MD (3)  ·  Troy Grennan, MD (3)  ·  Angelo Secci, MD (2)  ·  Franc Strle, MD PhD (2)  ·  Heidi H Kong, M.D. (2)  ·  Jennifer Johnson, MD, PhD (2)  ·  Marouf M Alhalabi, MD (2)

Results publications

PMID 11873261, PMID 22610930, PMID 30075748, PMID 32228663, PMID 41701614, PMID 10656038, PMID 38118022, PMID 40042869, PMID 42852919, PMID 10738419, PMID 11296335, PMID 11383749, PMID 11438138, PMID 11762933, PMID 12050508, PMID 12242525, PMID 14986270, PMID 15201781, PMID 15232785, PMID 15276398, PMID 15329363, PMID 15365071, PMID 15840453, PMID 15917525, PMID 15986343, PMID 16979286, PMID 16982292, PMID 17029130, PMID 17321157, PMID 17430750, PMID 17668979, PMID 17716312, PMID 17716313, PMID 18052736, PMID 18071030, PMID 18165398, PMID 18212521, PMID 18567539, PMID 18632241, PMID 18672990, PMID 18818959, PMID 19588358, PMID 19812401, PMID 19875685, PMID 19884021, PMID 20110457, PMID 20151804, PMID 20155838, PMID 20176900, PMID 20348487

NIH funding

2017 (2), 2023 (2), R01AI145971 (2), 2008 (1), 2009 (1), 2015 (1), 2019 (1), 2025 (1), 5UM1AI148684-03 (1), K23HL141445 (1), KL2TR001438 (1), M01RR000827 (1), P20RR017696 (1), P30CA015083 (1), P30DK063491 (1)