9 completed, 3 unknown, 2 not yet recruiting, 1 recruiting. 7 Not applicable, 3 Phase 2, 3 Phase 4, 2 Phase 3, 1 Early Phase 1.
Follow Periapical Abscess: new trials by email Literature Review of Periapical Abscess trials Research Report on Periapical Abscess
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial CTZ Paste, ZOE Pulpectomy - Pulp Disease, Dental, Pulp Necrosis | Early Phase 1 | Not yet recruiting | University of Sao Paulo | 110 | 2026-06-08 | 2026-05-12 |
| Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication - Intervention Studies, ASA Physical Status I | Phase 1 | Recruiting | Ain Shams University | 60 | 2026-06-01 | 2026-06-12 |
| Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth. - Chronic Apical Periodontitis, Necrosis of Pulp | Not applicable | Not yet recruiting | University of Medicine and Pharmacy at Ho Chi Minh City | 57 | 2025-09-15 | 2025-09-25 |
| Evaluation of Bone Healing After Obturation With Dia-Root Bio Sealer (Calcium Silicate-based Sealer CSBS) Using Three Obturation Techniques Dia-Root Bio Sealer, Single cone (SC) Obturation technique, Warm Vertical compaction (WVC) technique - Periapical Periodontitis, Chronic Periapical Periodontitis | Not applicable | Suspended | Ain Shams University | 63 | 2025-07-29 | 2026-07-07 |
| "Is Antibiotic Therapy Necessary for Patients Undergoing Extraction of Teeth With Abscess?" Amoxicillin 500mg - Periapical Abscess | Not applicable | Completed | Subbaiah Institute of Dental Sciences | 176 | 2025-03-20 | 2026-10-26 |
| Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion. Ethylene Diamine Tetra Acetic acid, smearOFF, Etidronic acid /sodium hypochlorite - Root Canal Infection, Periapical Abscess | Not applicable | Completed | Dow University of Health Sciences | 100 | 2021-11-16 | 2023-10-26 |
| C-reactive Protein Levels in Acute Apical Abscess Due to Root Canal Infection ROOT CANAL TREATMENT - Dentoalveolar Abscess | Not applicable | Unknown | CSI College of Dental Sciences and Research, Madurai | 200 | 2020-11-01 | 2020-12-24 |
| Comparison of Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide as a Root Canal Disinfectant root canal treatment and intracanal medicament - Periapical Abscess | Phase 2 / Phase 3 | Unknown | Dr. D. Y. Patil Dental College & Hospital | 40 | 2018-12-03 | 2020-03-24 |
| Systemic and Local Antimicrobials in the Management of Dental Abscess in Children Odontopaste®, Pulpdent, Amoxicillin - Dentoalveolar Abscess | Phase 2 | Completed | University of Malaya | 55 | 2018-09-18 | 2020-05-12 |
| Clinical Applicability of PBSCIMMO as a Single Material in Endodontic Obturations Gutta Percha and AHPLUS cement (group A), PBS CIMMO cement (group B) - Root Canal Therapy | Not applicable | Unknown | Universidade do Vale do Sapucai | 70 | 2017-11-09 | 2018-06-06 |
| Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy Neem leaf extract, Chlorhexidine gluconate - Periapical Abscess | Phase 2 / Phase 3 | Completed | Cairo University | 40 | 2016-12-01 | 2019-07-31 |
| Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. Canal Disinfection Triple Antibiotic Paste (TAP), Ciprofloxacin + Propolis Paste, Ciprofloxacin + Metronidazole Paste - Dental Pulp Necrosis, Periapical Abscess | Phase 4 | Completed | Tariq Yehia | 40 | 2015-01-16 | 2018-05-30 |
| Prospective Clinical Trial of Three Apical Sealing Materials EndoSequence, ProRoot MTA, Biodentine - Periapical Abscess | Phase 4 | Completed | University of the Pacific | 59 | 2014-11-02 | 2019-12-13 |
| Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days, Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days - Periapical Abscess | Not applicable | Completed | Federal University of Rio Grande do Sul | 27 | 2013-04-01 | 2016-04-25 |
| AUGMENTIN™ in Dental Infections Amoxicillin/clavulanate, Clindamycin - Focal Infection, Dental | Phase 4 | Completed | GlaxoSmithKline | 472 | 2013-03-21 | 2017-09-25 |
| Root Canal Treatment Outcome in Patients Under Bisphosphonate Therapy Root canal treatment - Root Canal Infection, Bisphosphonate-Associated Osteonecrosis | Completed | University of Bologna | 111 | 2009-01-07 | 2020-05-27 |
Dental Pulp Necrosis (4) · Periapical Periodontitis (2) · Agnosia (1) · Bacterial Infections (1) · Bisphosphonate-Associated Osteonecrosis of the Jaw (1) · Dental Caries (1) · Dental Pulp Diseases (1) · Fistula (1) · Focal Infection, Dental (1) · Infections (1) · Tooth, Nonvital (1)
Abscess (16) · Jaw Diseases (16) · Mouth Diseases (16) · Periapical Diseases (16) · Periodontal Diseases (16) · Periodontitis (16) · Stomatognathic Diseases (16) · Suppuration (16) · Infections (15) · Periapical Periodontitis (14) · Tooth Diseases (7) · Pathological Conditions, Signs and Symptoms (6) · Necrosis (5) · Pathologic Processes (5) · Dental Pulp Diseases (4)
Amoxicillin (2) · Amoxicillin-Potassium Clavulanate Combination (1) · Calcium Hydroxide (1) · Ciprofloxacin (1) · Clindamycin (1) · Edetic Acid (1) · EndoSequence root repair material (1) · Etidronic Acid (1) · Gutta-Percha (1) · Methods (1) · ProRoot MTA (1) · Prolactin-Releasing Hormone (1) · Propolis (1) · Pulpdent (1) · Root Canal Obturation (1)
Ain Shams University (2) · CSI College of Dental Sciences and Research, Madurai (1) · Cairo University (1) · Dow University of Health Sciences (1) · Dr. D. Y. Patil Dental College & Hospital (1) · Federal University of Rio Grande do Sul (1) · GlaxoSmithKline (1) · Subbaiah Institute of Dental Sciences (1) · Tariq Yehia (1) · Universidade do Vale do Sapucai (1) · University of Bologna (1) · University of Malaya (1) · University of Medicine and Pharmacy at Ho Chi Minh City (1) · University of Sao Paulo (1) · University of the Pacific (1)
Egypt (3) · India (3) · Malaysia (2) · Vietnam (2) · Brazil (1) · Pakistan (1) · Philippines (1) · Thailand (1)
Dalia M Moheb, Assoc Prof (1) · Daniela F Veiga, MD,PhD (1) · Lily Azura Shoaib Dr (1) · Mohammed M Nagy, Professor (1) · Norhan A El Dokky, Assoc Prof (1) · Piyush D Oswal, MDS (1) · Rubia Boczar (1) · Sara H Fahmy, Lecturer of Endodontics (1) · Sehrish Zubair (1) · Shani Ann Mani Dr (1) · Suchith S Shetty, Masters in Dental Surgery (1) · Syarida Hasnur Dr (1)