267 completed, 56 unknown, 11 recruiting, 9 terminated. 153 Not applicable, 61 Phase 2, 50 Phase 4, 41 Phase 3, 14 Phase 1.
Follow Chronic Periodontitis: new trials by email Literature Review of Chronic Periodontitis trials Research Report on Chronic Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Masticatory Performance in Patients With Periodontitis Periodontitis, Adult, Periodontitis | Recruiting | University Hospital, Clermont-Ferrand | 100 | 2026-10-09 | 2026-10-16 | |
| Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis. Periodontitis, Adult, Periodontitis | Not yet recruiting | University Hospital, Clermont-Ferrand | 100 | 2026-10-01 | 2026-10-09 | |
| Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial scaling and root planing - Periodontitis, Adult, Periodontal Diseases | Not applicable | Not yet recruiting | Zeyad Nazar | 21 | 2026-07-15 | 2026-05-19 |
| HbA1c Screening in Dental Care and Primary Care Referral in Patients With Advanced Periodontitis Point-of-care HbA1c screening, Conditional standardized primary care referral - Periodontitis, Adult, Prediabetes / Type 2 Diabetes | Not applicable | Recruiting | Region Skane | 600 | 2026-07-01 | 2026-07-07 |
| Clinical and Radiographic Evaluation of Doxycycline and Atorvastatin Loaded Chitosan Nanoparticles as an Adjunctive to Scaling and Root Planning in the Management of Chronic Periodontitis. A Randomized Controlled Clinical Trial. Doxycycline and Atorvastatin loaded Chitosan nanoparticles local drug - Chronic Periodontitis | Phase 4 | Not yet recruiting | Fayoum University | 80 | 2026-06-01 | 2026-06-08 |
| Vector® System vs Mini-Five Curettes in Non-Surgical Periodontal Therapy Vector® Ultrasonic System, Mini-Five Curettes - Periodontitis, Chronic Periodontitis | Not applicable | Recruiting | Hacettepe University | 36 | 2026-02-19 | 2026-03-05 |
| Metabolic Regeneration Registry for Periodontal Health (20-Patient Cohort). Nutraceutical Bio-Active Oral Repair Formula (Food-Grade), Nutraceutical Bio-Active Oral Repair Formula - Chronic Periodontitis, Chronic Periodontitis Wth Diabetes Mellitus | Completed | Amar h Zireg | 20 | 2026-01-03 | 2026-04-28 | |
| Clinical Efficacy of NST With Adjunctive Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis. full mouth non-surgical scaling - Periodontitis, Adult | Not applicable | Completed | Cairo University | 60 | 2025-11-02 | 2026-07-06 |
| Salivary Mitofusin-1 Levels in Periodontitis: Associations With Disease Severity, Smoking, and Treatment Response Non-surgical Periodontal Therapy (Scaling and Root Planing), Saliva Collection - Periodontal Disease, Chronic Periodontitis (Disorder) | Not applicable | Completed | Ömer Faruk Okumuş | 104 | 2025-11-01 | 2026-10-08 |
| Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis Arm 1 Scaling and Root Planing (SRP), Arm 2 Metformin Gel 1% (locally delivered), Arm 3 Chlorhexidine Gel 0.2% (locally delivered) - Stage II, Grade B Periodontitis, Chronic Periodontitis | Not applicable | Not yet recruiting | Kafrelsheikh University | 60 | 2025-10-06 | 2025-10-10 |
| The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness Enamel Matrix Derivative - Dental Implantation, Missing Teeth | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 32 | 2025-08-31 | 2025-11-12 |
| Impact of Periodontal Inflammation on Allostatic Load Sub-gingival instrumentation - Allostatic Load, Periodontitis, Chronic | Not applicable | Recruiting | Postgraduate Institute of Dental Sciences Rohtak | 112 | 2025-06-10 | 2026-05-26 |
| Full Mouth Ultrasonic Debridement Carried Out With Either Piezoelectric or Magnetostrictive Device Full-mouth ultrasonic debridement with piezoelectric device (EMS, mini piezon), Full-mouth ultrasonic debridement with magnetostrictive device (Cavitron Select, Dentsply) - Periodontitis, Adult | Not applicable | Recruiting | University of Siena | 52 | 2025-03-31 | 2025-09-10 |
| Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis Platelet rich fibrin, Metformin hydrochloride powder, alendronate sodium powder - Alveolar Bone Loss Associated Chronic Periodontitis | Phase 4 | Active not recruiting | Bahria University | 120 | 2025-01-22 | 2025-03-04 |
| Role of NLRP6 in Chronic Periodontitis Evaluation of serum NLRP6 levels - Chronic Periodontitis | Completed | Babol University of Medical Sciences | 50 | 2024-12-13 | 2025-11-24 | |
| Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CHD Scaling and root planing - Periodontitis, Chronic Periodontitis (Disorder) | Not applicable | Active not recruiting | Meenakshi Ammal Dental College and Hospital | 84 | 2024-11-20 | 2026-01-22 |
| A Chitosan Brush and Enamel Matrix Derivative for Non-surgical Treatment of Furcations Emdogain® FL, Labrida BioClean® - Periodontitis, Adult, Furcation Defects | Not applicable | Recruiting | Riga Stradins University | 40 | 2024-11-15 | 2025-09-08 |
| Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy Non-surgical periodontal therapy (NSPT) and supportive periodontal therapy (SPT), Probiotic lozenge (Limosilactobacillus reuteri; GUM® PerioBalance®), Vitamin B12 drops (natural elements) - Periodontitis, Adult, Periodontitis (Stage 3) | Not applicable | Recruiting | University Hospital Heidelberg | 60 | 2024-10-25 | 2026-03-02 |
| Analysis of the Impact of Contemporary Subgingival Debridement Techniques on Immunological Biomarkers in Gingival Crevicular Fluid Peridontal Disease, Periodontal Inflammation | Completed | Selcen Ozcan Bulut | 80 | 2024-10-15 | 2025-11-21 | |
| Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal Disease Clinical Measurements and Saliva Sample Collection - Periodontitis, Adult, Smoking | Unknown | Necmettin Erbakan University | 100 | 2024-08-01 | 2024-07-30 |
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Periodontitis (80) · Periodontal Diseases (43) · Diabetes Mellitus, Type 2 (16) · Aggressive Periodontitis (15) · Diabetes Mellitus (15) · Smoking (12) · Periodontal Pocket (10) · Inflammation (8) · Alveolar Bone Loss (6) · Gingivitis (5) · Arthritis, Rheumatoid (3) · Cardiovascular Diseases (3) · Cigarette Smoking (3) · Dysbiosis (3)
Chronic Disease (356) · Disease Attributes (356) · Pathologic Processes (356) · Pathological Conditions, Signs and Symptoms (356) · Stomatognathic Diseases (356) · Mouth Diseases (354) · Periodontal Diseases (313) · Periodontitis (276) · Metabolic Diseases (31) · Nutritional and Metabolic Diseases (31) · Endocrine System Diseases (29) · Glucose Metabolism Disorders (28) · Behavior (13) · Diabetes Mellitus (12) · Musculoskeletal Diseases (12)
Root Planing (50) · Tooth Exfoliation (46) · Photochemotherapy (11) · Metronidazole (10) · Amoxicillin (9) · Probiotics (6) · Atorvastatin (5) · Rosuvastatin Calcium (5) · Azithromycin (4) · Doxycycline (4) · Lasers, Solid-State (4) · Metformin (4) · Minocycline (4) · Periodontal Index (4) · Alendronate (3)
Government Dental College and Research Institute, Bangalore (21) · Cairo University (16) · Meenakshi Ammal Dental College and Hospital (11) · Tatyasaheb Kore Dental College (9) · University of Sao Paulo (8) · Ataturk University (6) · Postgraduate Institute of Dental Sciences Rohtak (6) · Damascus University (5) · Tanta University (5) · University of Campinas, Brazil (5) · Baskent University (4) · Bulent Ecevit University (4) · Dr. D. Y. Patil Dental College & Hospital (4) · King Saud University (4) · Kırıkkale University (4)
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Jaideep Mahendra, MDS,PhD (4) · Magda Feres, Professor (3) · A R Pradeep, MDS (2) · Ahmed A. Al-Kubaisi, PhD (2) · Bahar Kuru, Prof. Dr. (2) · Dilip Khambete, MDS (2) · Dr Subhash Garg, MDS (2) · Gihane G Madkour, Ass Prof (2) · Girish D Deore, BDS (2) · Mauro P Santamaria, PhD (2) · Noha Ghallab, M.D. (2) · Rampalli V Chandra, MDS;DNB (2)
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