41 completed, 13 unknown, 7 not yet recruiting, 4 withdrawn. 29 Not applicable, 26 Phase 4, 6 Phase 2, 6 Phase 3, 4 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Corneal Endothelium Health Following Articaine Ophthalmic Solution Administration Articaine (CYKLX), Vehicle - Healthy Cornea | Phase 4 | Not yet recruiting | Laboratoires Thea | 165 | 2027-01-01 | 2026-09-24 |
| Cost-Effectiveness of Upfront Supplemental Anaesthesia in Symptomatic Irreversible Pulpitis Inferior Alveolar Nerve Block With 2% Lidocaine With 1:80,000 Adrenaline, Upfront Buccal Infiltration With 4% Articaine With 1:100,000 Adrenaline, Upfront Intraligamentary Injection With 2% Lidocaine With 1:80,000 Adrenaline - Irreversible Pulpitis, Anesthesia, Local | Phase 4 | Not yet recruiting | Jamia Millia Islamia | 234 | 2026-10-30 | 2026-10-30 |
| Anesthetic Effectiveness of Mental/Incisive Nerve Block Versus Inferior Nerve Block Using 4% Articaine and 2% Lidocaine in Mandibular First and Second Premolars With Symptomatic Irreversible Pulpitis. Group A : MINB with 2% Lidocaine HCL+ 1:1000,000 Epinephrine - 1.8 ml, Group B : MINB with 4% Articaine HCL + 1:1000,000 Epinephrine - 1.8 ml, Group C : IANB with 2% Lidocaine HCL + 1:1000,000 Epinephrine - 1.8 ml - Pain | Not applicable | Not yet recruiting | Foundation University Islamabad | 108 | 2026-10-01 | 2026-10-29 |
| Different Local Anesthesia Techniques for Mandibular Primary Molar Pulpectomy Computer-Controlled Local Anesthesia, Conventional Inferior Alveolar Nerve Block, Articaine hydrochloride with epinephrine 1:100,000 - Dental Anxiety, Pain | Not applicable | Not yet recruiting | Recep Tayyip Erdogan University Training and Research Hospital | 38 | 2026-08-12 | 2026-08-12 |
| Pre-emptive Local Anesthesia and Sevoflurane Consumption in Pediatric Dental Anesthesia Pre-emptive Local Anesthesia, Articaine With Epinephrine, Sevoflurane - Sevoflurane Consumption | Not applicable | Not yet recruiting | TC Erciyes University | 80 | 2026-08-01 | 2026-05-27 |
| Pre-emptive Local Anesthesia and Emergence Behavior After Pediatric Dental General Anesthesia Pre-emptive Local Anesthesia, Articaine Hydrochloride With Epinephrine - Emergence Delirium, Pediatric Dental General Anesthesia | Not applicable | Not yet recruiting | seher orbay yasli | 80 | 2026-06-01 | 2026-06-09 |
| Articaine Versus Lidocaine for Supplemental Buccal Infiltration in Lower First Molars With Irreversible Pulpitis Articaine 4% with epinephrine 1:100,000, Lidocaine 2% with Epinephrine 1:100,000 - Irreversible Pulpitis, Failed Inferior Alveolar Nerve Block | Phase 4 | Completed | Rehman Medical Institute - RMI | 50 | 2026-03-03 | 2026-10-09 |
| Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry lidocaine + epinephrine 1:100,000, Articaine 4% with epinephrine 1:100,000 - Dental Pain | Phase 4 | Not yet recruiting | Universidad Austral de Chile | 100 | 2025-12-20 | 2025-11-17 |
| COMT, MAOA, and SLC6A4 Polymorphisms and Inferior Alveolar Nerve Block Success Inferior Alveolar Nerve Block with 4% Articaine - Symptomatic Irreversible Pulpitis (SIP) | Not applicable | Completed | Marmara University | 95 | 2025-11-12 | 2026-07-14 |
| Effects of Local Ketamine in Orthognathic Procedures Ketamine, Articaine Hydrochloride + Epinephrine - Dentofacial Deformities, Analgesia | Not applicable | Active not recruiting | Bezmialem Vakif University | 40 | 2025-06-21 | 2026-03-27 |
| Pudendal Nerve Block With Articaine and Triamcinolone for Pudendal Neuralgia Articaine and triamcinolone, Placebo (0.9% sodium chloride) - Pudendal Neuralgia Pudendal Nerve Entrapment Chronic Pelvic Pain | Not applicable | Active not recruiting | Irkutsk State Medical University | 120 | 2025-01-15 | 2026-09-18 |
| Assessment of Anesthetic Efficacy and Hemodynamic Stability of Two LA Drugs for Hypertensive Patients 4% Articaine HCL With 1:100,000 Epinephrine, 3% plain mepivacaine HCL - Hypertension | Not applicable | Enrolling by invitation | Tanta University | 60 | 2025-01-10 | 2025-11-18 |
| Comparison of Postoperative Effects of Articaine and Lidocaine in Mucogingival Surgery Lidocaine hydrochloride 2% with epinephrine 1:100 000, Articaine 4% with epinephrine 1:100,000, Free gingival graft (FGG) - Local Analgesia Via Infiltration, Wound Heal | Not applicable | Completed | Pamukkale University | 43 | 2025-01-01 | 2025-08-28 |
| Buccal Infiltration of Different Volumes of Articaine for Extraction. 1.8 ml of 4% Articaine, 3.6 ml of 4% Articaine - Buccal Infiltration, Articaine | Not applicable | Recruiting | Qassim University | 114 | 2024-11-24 | 2025-05-29 |
| Pain and Microbial Reduction of Antimicrobial Corticosteroid Mixture Versus Cryotherapy in Necrotic Teeth Local anaesthetic injection of 4% articaine with 1:100000 epinephrine, Tooth isolation, Access cavity preparation - Dental Pulp Necrosis | Not applicable | Completed | Cairo University | 28 | 2024-07-01 | 2025-06-05 |
| Articaine Plus Dexmedetomidine in Supraclavicular Block Articaine, Dexmedetomidine - Post Operative Pain, Acute | Not applicable | Unknown | Benha University | 66 | 2024-02-01 | 2024-05-23 |
| Risk of Nerve Damage After Administration of Local Anesthesia 4% Articaine with 1:200,000 epinephrine, 2% lidocaine with 1:100,000 epinephrine - Inferior Alveolar Nerve Injuries | Phase 1 | Unknown | Cleveland Dental Institute | 80 | 2024-01-01 | 2024-08-26 |
| Combination of Buffered Anesthetic to Treat Mandibular Molars Sodium bicarbonate, Lidocaine w/ epi, Articaine w/ epi - Symptomatic Irreversible Pulpitis | Phase 4 | Terminated | Indiana University | 40 | 2023-12-05 | 2025-05-13 |
| Different Volumes of Articaine for Inferior Alveolar Nerve Block in Irreversible Pulpitis Articaine HCl 4 % / EPINEPHrine 1:100,000 in 1.8 mL Dental Cartridge - Drug Effect, Pulpitis - Irreversible | Phase 2 | Completed | Armed Forces Institute of Dentistry, Pakistan | 78 | 2023-12-01 | 2024-10-15 |
| Anesthetic Efficacy of 1.8 ml Versus 3.6 ml of 4% Articaine Buccal Infiltration 3.6 ml 4% Articaine hydrochloride, 1.8 ml 4% Articaine hydrochloride - Symptomatic Irreversible Pulpitis | Not applicable | Unknown | Cairo University | 70 | 2023-12-01 | 2023-11-07 |
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Pain (11) · Agnosia (4) · Dental Caries (4) · Pain, Postoperative (4) · Dental Pulp Diseases (3) · Periapical Periodontitis (3) · Toothache (3) · Pulpitis (2) · Tooth, Impacted (2) · Acute Kidney Injury (1) · Aortic Valve Disease (1) · Atrial myxoma, familial (1) · Behavior, Addictive (1) · Bicuspid Aortic Valve Disease (1) · Child Behavior (1)
Cairo University (8) · American Genomics, LLC (4) · Netherlands Institute for Pigment Disorders (4) · Virginia Commonwealth University (3) · Ain Shams University (2) · Helsinki University Central Hospital (2) · Marmara University (2) · Minia University (2) · University of Michigan (2) · 28 Military Dental Centre Lahore (1) · Ankara Yildirim Beyazıt University (1) · Aristotle University Of Thessaloniki (1) · Armed Forces Institute of Dentistry, Pakistan (1) · Benha University (1) · Bezmialem Vakif University (1)
United States (12) · Egypt (10) · Turkey (Türkiye) (8) · Brazil (4) · Pakistan (4) · Netherlands (3) · Saudi Arabia (3) · Finland (2) · Chile (1) · Colombia (1) · Germany (1) · Greece (1) · India (1) · Iran (1) · Malaysia (1)
Albert Wolkerstorfer, MD, PhD (4) · Martin Uram, MD (4) · Menno A. De Rie, MD, PhD (3) · Parthasarathy Madurantakam, DDS, PhD (3) · Abeer Salem, MD (1) · Ahmad Elheeny (1) · Ahmed A Hashem, PhD (1) · Albatool Baroom (1) · Andre Chen, Msc (1) · Asya A. Almansour, SBPD (1) · Atyaf A. Alhunti (1) · Aysan Lektemur Alpan, PhD DDS (1) · Branislav V Bajkin, DMD, PhD (1)
PMID 20006669, PMID 26868800, PMID 37192994, PMID 10028738, PMID 10832257, PMID 10916328, PMID 11733293, PMID 12366885, PMID 15051743, PMID 15793381, PMID 15966499, PMID 16320034, PMID 16554198, PMID 17082283, PMID 17138173, PMID 17670879, PMID 18155484, PMID 18436027, PMID 18762633, PMID 20831926, PMID 20921070, PMID 21772732, PMID 21881058, PMID 22915899, PMID 22924356, PMID 24455735, PMID 24702239, PMID 24862701, PMID 25885712, PMID 26202994, PMID 28186223, PMID 29043507, PMID 29257943, PMID 29397214, PMID 29573375, PMID 29742264, PMID 29980352, PMID 30734772, PMID 30883236, PMID 30887677, PMID 31028737, PMID 31365529, PMID 33029135, PMID 33384805, PMID 33487824, PMID 33990740, PMID 34195402, PMID 35162650, PMID 37313270, PMID 37865418
2009 (2)