170 completed, 45 unknown, 29 recruiting, 28 not yet recruiting. 208 Not applicable, 20 Phase 2, 12 Phase 4, 10 Phase 3, 7 Early Phase 1.
Follow Periapical Diseases: new trials by email Literature Review of Periapical Diseases trials Research Report on Periapical Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation - Apical Periodontitis | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 60 | 2027-07-01 | 2026-04-08 |
| Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection Sodium hypochlorite 3%, Frankincense-based irrigant - Pulp Necrosis, Root Canal Infection | Early Phase 1 | Not yet recruiting | Oman Dental College | 30 | 2027-01-19 | 2026-09-22 |
| Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children Calcium Hydroxide, Iodoform, paste, modified triple antibiotic paste - Dental Pulp Necrosis, Periapical Diseases | Not applicable | Not yet recruiting | Cairo University | 50 | 2027-01-01 | 2026-08-19 |
| Laser-Activated Versus Passive Ultrasonic Irrigation in Endodontic Retreatment Photon-Induced Photoacoustic Streaming, Shock Wave Enhanced Emission Photoacoustic Streaming, Passive Ultrasonic Irrigation - Apical Periodontitis | Not applicable | Not yet recruiting | Inonu University | 90 | 2026-11-01 | 2026-10-29 |
| Apical Periodontitis and Glycemic Control in Diabetic and Non-diabetic Egyptian Sub-population Apical Periodontitis | Not yet recruiting | Cairo University | 88 | 2026-10-05 | 2026-10-02 | |
| Endodontic Microsurgery Platelet rich fibrin - Apical Periodontitis | Phase 4 | Not yet recruiting | Mark Schachman | 20 | 2026-10-01 | 2026-07-29 |
| Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5% - Pulp Necrosis, Apical Periodontitis | Not applicable | Recruiting | October 6 University | 60 | 2026-10-01 | 2026-10-27 |
| Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation sonically activated irrigation, laser activated irrigation, conventional needle irrigation - Apical Periodontitis, Post Operative Pain, Acute | Not applicable | Not yet recruiting | University Ghent | 183 | 2026-10-01 | 2026-10-29 |
| Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment. Sodium Hypochlorite 3% Solution, Emblica officinalis Solution - Pulp Necrosis, Apical Periodontitis | Not applicable | Not yet recruiting | Postgraduate Medical Institute, Lahore | 66 | 2026-09-17 | 2026-09-22 |
| Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial silver nanoparticles reinforced double antibiotic paste, Double Antibiotic Paste - Apical Periodontitis, Post Endodontic Pain | Not applicable | Not yet recruiting | All India Institute of Medical Sciences | 50 | 2026-08-30 | 2026-08-13 |
| Biomarkers in Apical Periodontitis laser activation, PUI, CSI - Apical Periodontitis, Retreatment | Not applicable | Completed | Kırıkkale University | 66 | 2026-08-30 | 2026-10-21 |
| Nanozymes in Endodontics Nanozyme treatment, Control (Standard treatment) - Apical Periodontitis, Endodontic Disease | Phase 4 | Enrolling by invitation | University of Pennsylvania | 72 | 2026-08-24 | 2026-10-13 |
| Effect of Different Apical Motion Algorithms on Postoperative Pain After Root Canal Treatment Root Canal Treatment, Rotary Instrumentation, Reciprocating Instrumentation - Apical Periodontitis, Postoperative Pain After Endodontic Treatment | Not applicable | Recruiting | Alanya Alaaddin Keykubat University | 120 | 2026-08-20 | 2026-10-27 |
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT Saline 0.9% (1.5-2.5°C) - Periapical Diseases | Not applicable | Not yet recruiting | Islamabad Medical and Dental College | 60 | 2026-07-10 | 2026-05-20 |
| Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide. 3D-Printed Static Surgical Guide and Trephine Bur, Ultrasonic Retrograde Preparation and Bioceramic Retrograde Obturation - Periapical Periodontitis, Periradicular Lesion | Not applicable | Recruiting | University of Medicine and Pharmacy at Ho Chi Minh City | 11 | 2026-07-01 | 2026-07-29 |
| Diagnostic Accuracy of Educated Large Language Models in Endodontic Diagnosis and Case Difficulty Assessment ChatGPT, Gemini, Calude - Pulpal and Periapical Diseases | Not yet recruiting | Cairo University | 349 | 2026-07-01 | 2026-07-16 | |
| Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment Triple Antibiotic Paste, Calcium Hydroxide (Ca(OH)2) - Periapical Lesion, Periapical Periodontitis | Not applicable | Not yet recruiting | Faiz ur rahman | 62 | 2026-06-15 | 2026-03-18 |
| Early Healing of Apical Periodontitis After Root Canal Treatment With Bioceramic and Calcium Hydroxide Medicaments: Evaluation Using PAI and ImageJ Bioceramic Intracanal Medicament, Calcium Hydroxide Intracanal Medication - Apical Periodontitis, Root Canal Treatment | Not applicable | Active not recruiting | Hasanuddin University | 24 | 2026-06-12 | 2026-11-03 |
| Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial CTZ Paste, ZOE Pulpectomy - Pulp Disease, Dental, Pulp Necrosis | Early Phase 1 | Not yet recruiting | University of Sao Paulo | 110 | 2026-06-08 | 2026-05-12 |
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Periapical Periodontitis (238) · Pain, Postoperative (46) · Dental Pulp Necrosis (40) · Periapical Abscess (17) · Dental Pulp Diseases (13) · Radicular Cyst (11) · Dental Caries (10) · Pulpitis (8) · Tooth, Nonvital (8) · Pain (7) · Inflammation (6) · Periapical Granuloma (6) · Diabetes Mellitus (5) · Cardiovascular Diseases (3)
Jaw Diseases (295) · Mouth Diseases (293) · Periodontal Diseases (293) · Stomatognathic Diseases (293) · Periodontitis (253) · Pathological Conditions, Signs and Symptoms (95) · Pathologic Processes (91) · Tooth Diseases (73) · Neurologic Manifestations (52) · Signs and Symptoms (52) · Dental Pulp Diseases (50) · Pain (44) · Postoperative Complications (44) · Necrosis (40)
Calcium Hydroxide (15) · Sodium Hypochlorite (8) · Control Groups (6) · Lasers, Semiconductor (6) · Endodontics (5) · Apicoectomy (4) · Chlorhexidine (4) · Edetic Acid (4) · Low-Level Light Therapy (4) · Sodium Chloride (4) · Therapeutic Irrigation (4) · mineral trioxide aggregate (4) · Amoxicillin (3) · Carticaine (3) · Ciprofloxacin (3)
Postgraduate Institute of Dental Sciences Rohtak (30) · Cairo University (18) · Ain Shams University (13) · Istanbul Medipol University Hospital (10) · TC Erciyes University (7) · University of Siena (7) · Medipol University (6) · Recep Tayyip Erdogan University (5) · Seyda Ersahan, DDS, PhD (5) · University of Bologna (4) · University of Pennsylvania (4) · Biruni University (3) · Future University in Egypt (3) · Isparta Military Hospital (3) · Kahramanmaras Sutcu Imam University (3)
Turkey (Türkiye) (79) · Egypt (37) · India (26) · United States (20) · Pakistan (11) · Italy (9) · Brazil (5) · Belgium (4) · China (4) · Greece (4) · Malaysia (4) · Vietnam (4) · Chile (3) · Croatia (3) · Denmark (3)
Seyda Ersahan, Assoc.Prof. (4) · Aliye Kamalak (3) · Ehab Hassanien, PhD (3) · Maram F Obeid, Professor (3) · Maram Obeid, PhD (3) · Parthasarathy Madurantakam, DDS, PhD (3) · Bekir Karabucak, DMD, MS (2) · Dr. Sanjay Tewari, MDS (2) · Seyda Ersahan, PhD (2) · Simone Grandini, PhD, DDS (2) · Abdulkadir Tiftik, DDS, DDS (1) · Abdurrahman Aksoy, PhD (1)
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