116 completed. 116 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 116 | Completed 116 |
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Role of NaV1.8 in Human Pain Models Suzetrigine, Lidocaine (drug), Control Solution - Pain, Acute Pain | Early Phase 1 | Completed | Medical University of Vienna | 67 | 2026-04-21 | 2026-06-24 |
| Pain Management in Teeth With Reversible Pulpitis Ibuprofen 10 mg/kg - Reversible Pulpitis, Ibuprofen | Early Phase 1 | Completed | Inonu University | 46 | 2025-08-02 | 2025-09-24 |
| Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model Synthetic interstitial fluid (SIF) / SIF neutral pH, Synthetic interstitial fluid (SIF) / SIF acidic pH, Synthetic interstitial fluid (SIF) / SIF acidic pH + BCTC 1 µM - Pain | Early Phase 1 | Completed | Stefan Heber | 42 | 2025-06-17 | 2025-07-29 |
| Peripheral KV7 Activation for Pain Relief Capsaicin only (7.6 ng), Capsaicin + Flupirtine 0.5 µg, Capsaicin + Flupirtine 1.2 µg - Pain | Early Phase 1 | Completed | Stefan Heber | 32 | 2025-05-08 | 2025-06-10 |
| Nitrous Oxide Neuroimaging Nitrous oxide, Peripheral Nerve Stimulation - Anesthesia, Pain | Early Phase 1 | Completed | Keith M Vogt | 34 | 2025-01-13 | 2026-08-19 |
| Effect of Unilateral Erector Spinae Plane Block Versus Intrathecal Morphine on Early Mobilization After Hip Replacement erector spinae plane block, Morphine - Pain, Postoperative | Early Phase 1 | Completed | Cairo University | 70 | 2024-09-23 | 2025-12-02 |
| Ultrasound Guided Serratus Anterior Plane Block in ED Patients With Rib Fractures Serratus Anterior Plane Block, Ropivacaine injection - Rib Fractures, Pain Acute | Early Phase 1 | Completed | Rhode Island Hospital | 40 | 2024-07-01 | 2026-02-18 |
| Sevoflurane's Effect on Neurocognition Study Sevoflurane, Peripheral Nerve Stimulation - Anesthesia, Pain | Early Phase 1 | Completed | Keith M Vogt | 42 | 2024-01-17 | 2026-04-15 |
| Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 Room temperature, Cold temperature, Lidocain - Pain | Early Phase 1 | Completed | Medical University of Vienna | 36 | 2023-07-07 | 2024-03-15 |
| Evaluate the TetraLens, a Tetracaine Releasing Therapeutic Bandage Contact Lens in Patients Undergoing PRK Procedure TetraLens bandage contact lens, Control Acuvue Oasys Bandage contact Lens - Ocular Pain | Early Phase 1 | Completed | Vance Thompson Vision | 10 | 2023-06-26 | 2025-09-17 |
| Effects of Riboflavin in Mitigating Muscle Soreness in Ultra-marathon Athletes Riboflavin, Placebo - Muscle Soreness | Early Phase 1 | Completed | Steven Moore | 150 | 2023-06-23 | 2025-04-03 |
| Medrol Dose Packs for Post-Operative Pain Control Placebo, Medrol - Pain | Early Phase 1 | Completed | University of Utah | 57 | 2023-01-13 | 2025-01-07 |
| Effect of Oral Analgesics on Post-op Pain Novafen, Tramadol, Naproxen - Post Operative Pain | Early Phase 1 | Completed | Armed Forces Institute of Dentistry, Pakistan | 100 | 2023-01-01 | 2025-10-02 |
| Dilution of Verapamil During Intraarterial Administration Verapamil, Nicardipine - Vasospasm;Peripheral, Burning | Early Phase 1 | Completed | University of Illinois at Chicago | 55 | 2022-12-13 | 2024-11-27 |
| Effect of Gabapentin on Post-Operative Pain in Minimally Invasive Sacrocolpopexy Gabapentin, Placebo - Post Operative Pain | Early Phase 1 | Completed | University of Oklahoma | 40 | 2022-11-29 | 2024-12-06 |
| Endocannabinoids, Stress, Craving And Pain Effects Study Palmitoylethanolamide, Placebo - Opioid Use Disorder | Early Phase 1 | Completed | Brigham and Women's Hospital | 12 | 2022-11-01 | 2025-10-20 |
| Comparison of Post-Operative Pain After Use of Calcium Hydroxide and Bio Ceramic Sealer for Root Canal Treatment. Endosequence Bio ceramic Sealer, Sealapex Calcium hydroxide Based Sealer - Postoperative Pain | Early Phase 1 | Completed | Dow University of Health Sciences | 80 | 2022-10-25 | 2023-04-18 |
| A Single Preoperative Dose of Gabapentin to Decreases Postoperative Pain in Ambulatory Anal Surgeries Gabapentin - Pain, Postoperative | Early Phase 1 | Completed | Minia University | 50 | 2022-09-01 | 2023-03-16 |
| Effectiveness of Cannabidiol vs. Narcotics for Post Operative Pain Control in Elective Shoulder Arthroscopic Surgery Cannabidiol Oil - Post-operative Pain | Early Phase 1 | Completed | Foundation for Orthopaedic Research and Education | 40 | 2022-07-01 | 2025-03-17 |
| Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 TRPA1-inhibitor, TRPV1-inhibitor, TRPM3-inhibitor - Pain | Early Phase 1 | Completed | Medical University of Vienna | 51 | 2022-06-13 | 2023-03-17 |
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Pain, Postoperative (28) · Chronic Pain (16) · Acute Pain (9) · Agnosia (6) · Opioid-Related Disorders (5) · Low Back Pain (4) · Anxiety Disorders (3) · Shoulder Pain (3) · Amnesia (2) · Back Pain (2) · Depression (2) · Dysmenorrhea (2) · Emergence Delirium (2) · Hyperalgesia (2)
Neurologic Manifestations (116) · Pathological Conditions, Signs and Symptoms (116) · Signs and Symptoms (116) · Pathologic Processes (35) · Postoperative Complications (31) · Nervous System Diseases (24) · Mental Disorders (14) · Neurobehavioral Manifestations (12) · Musculoskeletal Diseases (9) · Perceptual Disorders (8) · Chemically-Induced Disorders (7) · Joint Diseases (6) · Neuromuscular Diseases (6) · Substance-Related Disorders (6)
Bupivacaine (8) · Lidocaine (7) · Morphine (5) · Cannabidiol (4) · Gabapentin (4) · Ketorolac (4) · Ropivacaine (4) · Sodium Chloride (4) · Acetaminophen (3) · Dronabinol (3) · Ibuprofen (3) · Naloxone (3) · Saline Solution (3) · Aspirin (2) · Capsaicin (2)
Ain Shams University (4) · University of Utah (4) · Medical University of Vienna (3) · Yale University (3) · Aydin Adnan Menderes University (2) · Brigham and Women's Hospital (2) · Cairo University (2) · Keith M Vogt (2) · Medical University of South Carolina (2) · Minia University (2) · National University of Natural Medicine (2) · Oregon Health and Science University (2) · Stanford University (2) · Stefan Heber (2) · United States Naval Medical Center, San Diego (2)
United States (65) · Egypt (10) · Austria (5) · Canada (3) · Israel (3) · Pakistan (3) · Spain (3) · Turkey (Türkiye) (3) · Brazil (2) · China (2) · Denmark (2) · Iran (2) · Taiwan (2) · United Kingdom (2) · Belgium (1)
Fadel Zeidan, PhD (2) · Patrick T Morrell, DMD (2) · Ryan Bradley, ND, MPH (2) · Admir Hadzic, MD,PhD,Prof (1) · Akiva Mintz, MD, PhD (1) · Alparslan Turan, Associate Prof (1) · Alparslan Turan, Associate Professor (1) · Alphonsa Thomas, DO (1) · Andrew N Sawka, MD, FRCPC (1) · Angela Bianco, M.D. (1) · Anuj Bhatia, MD, FRCPC (1) · Aykut Soyder, Assistant Professor (1) · Ayse Ilksen Egilmez, Specialist Doctor (1) · Beth D Darnall, PhD (1) · Betul Kozanhan, Specialist Doctor (1)
PMID 10191237, PMID 10709302, PMID 11057075, PMID 15060237, PMID 1550287, PMID 16023915, PMID 16416713, PMID 17154138, PMID 1729516, PMID 18215746, PMID 18299127, PMID 18350746, PMID 19462133, PMID 19729492, PMID 20562702, PMID 20702514, PMID 21102963, PMID 21267039, PMID 21270403, PMID 22265386, PMID 22341813, PMID 22828681, PMID 22888399, PMID 23053464, PMID 23142441, PMID 23337558, PMID 23582727, PMID 23651076, PMID 24119776, PMID 24257398, PMID 24686526, PMID 24726923, PMID 24886572, PMID 24899360, PMID 25250055, PMID 25607427, PMID 26352946, PMID 27334885, PMID 27420164, PMID 27837343, PMID 28062311, PMID 29026354, PMID 30782041, PMID 30983457, PMID 32107360, PMID 33087142, PMID 33370510, PMID 33548580, PMID 33863932, PMID 34293819
R35GM146822 (2), 2017 (1), K23DA052682 (1), K23GM110540 (1), P30CA015083 (1), R01DK083609 (1), R21AT010352 (1), R21DA044503 (1)