9 completed, 4 not yet recruiting, 4 recruiting, 3 unknown. 6 Not applicable, 5 Phase 2, 2 Phase 1, 2 Phase 4.
Follow Neuroinflammation: new trials by email Literature Review of Neuroinflammation trials Research Report on Neuroinflammation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| [11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction [11C]PS13: [carbon-11]PS13; COX-1 PET radioligand, Sacubitril-Valsartan - Heart Failure With Reduced Ejection Fraction, Cognitive Impairment, Mild | Phase 1 | Not yet recruiting | Stony Brook University | 18 | 2026-10-01 | 2026-10-02 |
| Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP/NPY and POMC Pathways in Mexican Population With Obesity Ascorbic acid (Vitamin C), tocopherol alpha, Ascorbic acid + tocopherol alpha - Obesity (BMI>30), Neuroinflammation | Not applicable | Not yet recruiting | Autonomous University of Morelos | 192 | 2026-08-10 | 2026-08-24 |
| Tinnitus and Treatment With umPEA-LUT PEA-LUT 2 sachet day, Placebo, umPEALUT + Rutin + 5 hTp - Tinnitus, Neuroinflammation | Not applicable | Not yet recruiting | University of Campania Luigi Vanvitelli | 100 | 2026-04-20 | 2026-02-06 |
| Vitamin D3 for Moderate to Mild Traumatic Brain Injury: A Randomized Trial on Inflammation and Recovery (VIMOT) Vitamin D3 (Cholecalciferol) - Traumatic Brain Injury (TBI) Patients, Neuroinflammation | Phase 2 | Recruiting | Lagos State University | 240 | 2026-03-02 | 2026-05-13 |
| Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study Anesthesia, Neuroinflammation | Not yet recruiting | University of Health Sciences Balikesir Hospital Eduation and Research | 160 | 2026-01-25 | 2026-02-04 | |
| Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling. - Chronic Low Back Pain (CLBP), Chronic Insomnia | Recruiting | Vrije Universiteit Brussel | 80 | 2025-10-03 | 2025-12-15 | |
| Effectiveness of Ashwagandha in Schizophrenia Patients on Risperidone Risperidone 4mg/day, Ashwagandha, Placebo - Schizophrenia Patients, Neuroinflammation | Phase 2 | Completed | Hasanuddin University | 80 | 2025-10-01 | 2026-05-12 |
| Preemptive IV Ibuprofen for Neurocognitive Recovery and Analgesic Needs After Inguinal Hernia Surgery Ibuprofen (400 mg x 4), Placebo (NaCl 0.9 % solution) - Inguinal Hernia Unilateral, Delayed Neurocognitive Recovery | Phase 4 | Completed | Mehmet Çiğdem | 76 | 2025-09-27 | 2026-03-03 |
| A Pilot Study of Adjunctive Structured Supportive Psychotherapy in Schizophrenia Structured supportive psychotherapy, Risperidone, Unstructured Supportive Conversation - Schizophrenia, Cognitive and Executive Dysfunction | Not applicable | Completed | Hasanuddin University | 44 | 2025-03-01 | 2026-06-30 |
| Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent RVP-001 - Central Nervous System (CNS) Lesions, Brain Metastases | Phase 2 | Completed | Reveal Pharmaceuticals Inc. | 18 | 2024-08-15 | 2025-12-26 |
| Neuroinflammation/Oxidative Stress/Cardiac Surgery extracorporeal circulation - Neuroinflammation | Unknown | EPC Education s.r.o. | 60 | 2024-04-30 | 2024-04-30 | |
| The Effect of Oral Use of Lyophilised Royal Jelly on Cognitive Functions and Immune System in Elderly Individuals Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 500 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1000 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1500 mg/day - Cognitive Change, Cytokine Levels | Not applicable | Completed | Medipol University | 120 | 2024-01-15 | 2026-10-26 |
| Imaging - Clinical Evaluation of Altered Nervous System Drainage Magnetic resonance imaging - Neuroinflammation, Autism Spectrum Disorder | Unknown | IRCCS Eugenio Medea | 100 | 2023-10-01 | 2024-05-29 | |
| Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 IV normal saline, IV immunoglobulin - Systemic Inflammation, Neuroinflammation | Phase 2 | Enrolling by invitation | National Institute of Neurological Disorders and Stroke (NINDS) | 45 | 2023-07-10 | 2026-11-10 |
| Imaging Lymphatic/Cerebrospinal Fluid (CSF) Drainage From the Head and Neck in Persons With Traumatic Brain Injury: Demonstration of Feasibility and Evaluation of Manual Therapy to Improve Drainage and Facilitate Cognitive Recovery Manual Lymphatic Drainage (MLD) - Trauma, Brain, Neuroinflammation | Not applicable | Terminated | The University of Texas Health Science Center, Houston | 2 | 2022-05-18 | 2026-03-10 |
| Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and Psoriasis Sociodemographic variables - Psoriasis, Neuroinflammation | Withdrawn | Germans Trias i Pujol Hospital | 2021-02-01 | 2022-01-28 | ||
| The Influence of [18F]PMPBB3 and [18F]THK5351 PET Distribution Patterns on Post-stroke Cognitive Impairment PMPBB3, THK5351 - Post-stroke Cognitive Impairment, Neuroinflammation | Phase 2 | Unknown | Chang Gung Memorial Hospital | 80 | 2020-11-01 | 2023-05-01 |
| Translocator Protein PET/CT in Various TSPO-Related Disease 18F-DPA714/FDPA - Neuroinflammation, Stroke | Recruiting | Tianjin Medical University | 200 | 2018-11-01 | 2026-09-08 | |
| The Effect of Celecoxib on Neuroinflammation in MDD Celecoxib 400 mg - Major Depressive Disorder, Neuroinflammation | Phase 4 | Completed | Stony Brook University | 41 | 2018-08-01 | 2026-04-24 |
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Neuroinflammatory Diseases (23) · Cognitive Dysfunction (3) · Brain Injuries, Traumatic (2) · Depressive Disorder, Major (2) · Inflammation (2) · Pain, Postoperative (2) · Schizophrenia (2) · Alzheimer Disease (1) · Anxiety Disorders (1) · Autism Spectrum Disorder (1) · Brain Neoplasms (1) · COVID-19 (1) · Central Nervous System Neoplasms (1) · Chronic Pain (1) · Dementia (1)
Nervous System Diseases (23) · Pathologic Processes (23) · Pathological Conditions, Signs and Symptoms (23) · Inflammation (21) · Mental Disorders (11) · Brain Diseases (8) · Central Nervous System Diseases (8) · Signs and Symptoms (6) · Neurologic Manifestations (5) · Neurocognitive Disorders (4) · Cognition Disorders (3) · Postoperative Complications (3) · Brain Injuries (2) · Cardiovascular Diseases (2) · Craniocerebral Trauma (2)
Blood Specimen Collection (2) · Ibuprofen (2) · Risperidone (2) · 11C-PS13 (1) · 5-Hydroxytryptophan (1) · Arthroplasty, Replacement, Hip (1) · Arthroplasty, Replacement, Knee (1) · Ascorbic Acid (1) · Ashwagandha (1) · Celecoxib (1) · Cholecalciferol (1) · Dietary Supplements (1) · Extracorporeal Circulation (1) · Gabapentin (1) · Immunoglobulins, Intravenous (1)
Hasanuddin University (2) · Stony Brook University (2) · Autonomous University of Morelos (1) · Chang Gung Memorial Hospital (1) · EPC Education s.r.o. (1) · Germans Trias i Pujol Hospital (1) · IRCCS Eugenio Medea (1) · Karolinska University Hospital (1) · Lagos State University (1) · Medipol University (1) · Mehmet Çiğdem (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Pfizer (1) · Plovdiv Medical University (1) · Reveal Pharmaceuticals Inc. (1)
United States (6) · Indonesia (2) · Italy (2) · Sweden (2) · Turkey (Türkiye) (2) · Belgium (1) · Bulgaria (1) · China (1) · Mexico (1) · Nigeria (1) · Slovakia (1) · Spain (1) · Taiwan (1)
Agus Durman, MD (1) · Arianna Di Stadio, MD, PhD, MSc (1) · Avindra Nath, M.D. (1) · Christine DeLorenzo, PhD (1) · Deyan Neychev, MD, PhD (1) · Eva Sevick, PhD (1) · Indrawaty Suhuyanli, MD (1) · Lars I Eriksson (1) · Masnaeni Awaliah, MD (1)
PMID 12238249, PMID 17416295, PMID 17956787, PMID 19561730, PMID 22931904, PMID 25190255, PMID 25862619, PMID 25997584, PMID 26547700, PMID 28885581, PMID 30015600, PMID 30058696, PMID 30261653, PMID 30469326, PMID 30538616, PMID 31042571, PMID 31842394, PMID 32471239, PMID 34282564, PMID 34768526, PMID 41393743, PMID 5642369, PMID 6743061
R21AG102953 (1), R44CA261240 (1)