126 completed, 39 unknown, 25 terminated, 19 recruiting. 98 Phase 2, 90 Phase 3, 29 Phase 1, 26 Phase 4, 20 Not applicable.
Follow Immunoglobulins, Intravenous: new trials by email Literature Review of Immunoglobulins, Intravenous trials Research Report on Immunoglobulins, Intravenous
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Empasiprubart as Add-On Therapy to IVIg in Adult Participants With Guillain-Barré Syndrome Empasiprubart IV, Empasiprubart Placebo IV, Intravenous immunoglobulin (IVIg) - Guillain-Barré Syndrome (GBS) | Phase 2 | Not yet recruiting | argenx | 63 | 2026-12-01 | 2026-09-25 |
| Autoantibody Reduction Therapy for Progressive Idiopathic Pulmonary Fibrosis Therapeutic Plasma Exchange, Rituximab, Intravenous immunoglobulin - Idiopathic Pulmonary Fibrosis | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 52 | 2026-12-01 | 2026-10-20 |
| Efficacy of Short Course of Intravenous Dexamethasone and Intravenous Immunoglobulin Therapy in Infection-Related Secondary Hemophagocytic Lymphohistiocytosis (isHLH) Intravenous Immunoglobulin (IVIg) therapy, Intravenous Dexamethasone (IVD) therapy, Targeted antimicrobial therapy & standard care - Hemophagocytic Lymphohistiocytosis (HLH), Secondary Hemophagocytic Lymphohistiocytosis | Phase 3 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 116 | 2026-10-15 | 2026-10-06 |
| Stopping Strep Throat With Antibodies in Healthy Adults. Streptococcus pyogenes M1 challenge strain, Intravenous immunoglobulin (IVIG), Saline (NaCl 0,9 %) (placebo) - Streptococcal Pharyngitis | Phase 1 | Not yet recruiting | Murdoch Childrens Research Institute | 60 | 2026-10-01 | 2026-10-07 |
| Human Albumin Combined With Plasma Exchange for Frailty Intervention Plasma Exchange, 5% human albumin, Intravenous immunoglobulin (IVIG) - Frailty, Plasma Exchange | Not applicable | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 34 | 2026-09-24 | 2026-09-23 |
| IVIG Boya: Safety, Efficacy, and Pharmacokinetics Boya IVIG - Primary Immunodeficiency Disease | Phase 3 | Not yet recruiting | Azidus Brasil | 50 | 2026-09-01 | 2026-06-03 |
| Efficacy and Safety of Efgartigimod in the Treatment of Guillain-Barré Syndrome(GREAT) Intravenous immunoglobulin (IVIG), Efgartigimod Alfa-Fcab - Guillain-Barré Syndrome | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 110 | 2026-09-01 | 2026-09-18 |
| Efficacy and Safety of Immunoglobulin Plus Firsekibart in Patients With Kawasaki Disease IVIG, Aspirin, Firsekibart - Kawasaki Disease | Phase 2 / Phase 3 | Not yet recruiting | Children's Hospital of Fudan University | 90 | 2026-08-01 | 2026-07-27 |
| Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia methotrexate, rituximab, bortezomib - Hypophosphatasia | Phase 4 | Withdrawn | Alexion Pharmaceuticals, Inc. | 2026-07-29 | 2025-12-18 | |
| Dexamethasone, Intravenous Injection of Human Immunoglobulin, and Increased Infusion of Mononuclear Cells to Reduce Donor Specific Antibodies in Haploidentical Hematopoietic Stem Cell Transplantation Intravenous Immunoglobulin, Dexamethasone, Mononuclear Cells - Leukemia, Lymphoma | Phase 2 | Not yet recruiting | Hematology department of the 920th hospital | 60 | 2026-07-03 | 2026-07-14 |
| Acalabrutinib Maleate and Bortezomib for Patients With HLA Antibodies Acalabrutinib maleate, bortezomib, HLA-matched or crossmatched irradiated platelets - Hematological Malignancies, Platelet Transfusion Refractoriness (PTR) | Phase 3 | Not yet recruiting | The First Affiliated Hospital of Soochow University | 42 | 2026-06-01 | 2026-06-09 |
| Neonatal Outcomes on Direct Fetal Intravenous Immunoglobulin During Intrauterine Transfusion for Rhesus Isoimmunization Intrauterine Transfusion, Intravenous immunoglobulin (IVIG) - Hemolytic Disease of the Newborn, Fetal Anemia | Phase 2 | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 30 | 2026-05-25 | 2026-10-21 |
| Effects of IVIG for BPD in Preterm Infant Born at 28 Weeks and Below intravenous immunoglobulin - Bronchopulmonary Dysplasia | Phase 2 | Recruiting | International Peace Maternity and Child Health Hospital | 29 | 2026-04-23 | 2026-07-23 |
| Intravenous Immunoglobulin for the Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis Intravenous immunoglobulin (IVIG), Usual treatment - Idiopathic Pulmonary Fibrosis, Acute Exacerbation of Idiopathic Pulmonary Fibrosis | Phase 3 | Recruiting | Argyrios Tzouvelekis | 196 | 2026-01-25 | 2026-03-16 |
| Comparison of the Efficacy and Safety of Immunoadsorption and Intravenous Immunoglobulin for Guillain-Barre Syndrome immunosorbent column, intravenous immunoglobulin - Guillain-Barre Syndrome | Not applicable | Not yet recruiting | The First Affiliated Hospital of Zhengzhou University | 204 | 2026-01-01 | 2025-03-12 |
| An Open-label Study of Intravenous Immunoglobulin (5%) for the Treatment of Primary Immune Thrombocytopenia Human immunoglobulin (pH4) for intravenous injection - Primary Immune Thrombocytopenia (ITP) | Phase 3 | Recruiting | Grand Shuyang Life Sciences (Chengdu) Co., Ltd. | 36 | 2025-11-24 | 2026-04-08 |
| Telitacicept for Refractory Chronic Inflammatory Demyelinating Polyneuropathy Conventional Therapy, Telitacicept - Refractory Chronic Inflammatory Demyelinating Polyneuropathy | Not applicable | Active not recruiting | Sichuan Academy of Medical Sciences | 76 | 2025-09-26 | 2026-05-19 |
| A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP empasiprubart, IVIg, empasiprubart-placebo - Chronic Inflammatory Demyelinating Polyneuropathy, CIDP | Phase 3 | Recruiting | argenx | 218 | 2025-08-22 | 2026-10-16 |
| V-IMMUNE: A Novel Immunoglobulin Therapy for Immunodeficiency Intravenous immunoglobulin (IVIG) - Immunodeficiencies, Primary Immunodeficiencies (PID) | Phase 3 | Recruiting | On Pharma Importadora, Exportadora e Distribuidora de Medicamentos LTDA. | 50 | 2025-08-15 | 2026-01-20 |
| Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT) Intravenous immunoglobulin, Trimethoprim / Sulfamethoxazole, Amoxicillin clavulanic acid - Myeloma, Non-Hodgkin's Lymphoma | Phase 2 / Phase 3 | Recruiting | Monash University | 900 | 2025-05-06 | 2025-10-07 |
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Purpura, Thrombocytopenic, Idiopathic (18) · Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (14) · Mucocutaneous Lymph Node Syndrome (12) · Agammaglobulinemia (9) · Autoimmune Diseases (8) · COVID-19 (8) · Guillain-Barre Syndrome (8) · Autoimmune Diseases of the Nervous System (7) · Kidney Failure, Chronic (7) · Primary Immunodeficiency Diseases (7) · Common Variable Immunodeficiency (6) · Myasthenia Gravis (5) · IgG Deficiency (4) · Immunologic Deficiency Syndromes (4) · Infections (4)
CSL Behring (8) · Assistance Publique - Hôpitaux de Paris (7) · Grifols Therapeutics LLC (7) · Children's Hospital of Fudan University (5) · National Institute of Allergy and Infectious Diseases (NIAID) (4) · National Institute of Neurological Disorders and Stroke (NINDS) (4) · Nihon Pharmaceutical Co., Ltd (4) · NYU Langone Health (3) · Northwestern University (3) · Seoul National University Hospital (3) · argenx (3) · Annexon, Inc. (2) · Assiut University (2) · Azidus Brasil (2) · Benesis Corporation (2)
United States (105) · China (28) · Canada (24) · France (18) · Germany (15) · United Kingdom (13) · Japan (12) · Australia (11) · Netherlands (11) · Denmark (10) · Poland (10) · Italy (9) · Czechia (8) · Spain (8) · Israel (6)
Richard Burt, MD (4) · Cyndya Shibao, MD (2) · Fu Xuemei (2) · George Sakoulas, MD (2) · Luciana Ferrara (2) · Mehdi Yousefi, Immunologist (2) · Mohammad Nouri, Ph.D (2) · Pam Taub, MD (2) · Peter Novak, MD (2) · Stanley Jordan, MD (2) · Tae Chung, MD (2) · Theresa Zesiewicz, MD (2) · Zoe McQuilten, Professor (2) · Ajit Rayamajhi, MBBS, MD (1)
PMID 12765346, PMID 17166218, PMID 19710204, PMID 19819893, PMID 21095154, PMID 22889462, PMID 24628478, PMID 30116551, PMID 34887657, PMID 39352862, PMID 41720282, PMID 17091076, PMID 17175311, PMID 17479360, PMID 17666597, PMID 18163506, PMID 18178525, PMID 18635429, PMID 18645164, PMID 18814020, PMID 19148734, PMID 19236457, PMID 19260050, PMID 19365055, PMID 19496683, PMID 19635187, PMID 20217199, PMID 20386074, PMID 20391423, PMID 20457948, PMID 20634190, PMID 20647554, PMID 20837852, PMID 21670440, PMID 21745374, PMID 21868369, PMID 22882285, PMID 23046599, PMID 23116538, PMID 23235588, PMID 23375965, PMID 23450336, PMID 23781960, PMID 23910617, PMID 23956564, PMID 23979731, PMID 24088271, PMID 24235922, PMID 24892422, PMID 25090414
2018 (4), 2023 (4), 2014 (2), 2004 (1), 2009 (1), 2015 (1), 2017 (1), P01HL009011 (1), R01HL034545 (1), U01AI077867 (1), U01DK062456 (1), U01HD019897 (1), U10CA013539 (1), U10CA098543 (1), U10CA180886 (1)