677 completed, 131 unknown, 69 terminated, 34 recruiting. 408 Not applicable, 213 Phase 2, 170 Phase 3, 135 Phase 4, 73 Phase 1.
Follow this drug Literature Review of Cholecalciferol trials Research Report on Cholecalciferol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sequential Treatment With Romosozumab Followed by Denosumab vs. Zoledronic Acid for Gains in HIP BMD Romosozumab, Zoledronic Acid 5 MG in 5 ML Injection, Calcium 500 mg and Vitamin D3 800 IU - Osteoporosis in Post-menopausal Women | Phase 4 | Not yet recruiting | Sahlgrenska University Hospital | 216 | 2027-01-11 | 2026-08-19 |
| The Effectiveness of a Weight-dependent Algorithm for Dosing Vitamin D. Vitamin D3, Calcium, and Vitamin C - Hypovitaminosis D | Not applicable | Not yet recruiting | Atlantic Health System | 200 | 2027-01-01 | 2026-10-20 |
| HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide Calcium-HMB Plus Vitamin D3, Matching placebo - Type 2 Diabetes Mellitus (T2DM), Sarcopenia | Phase 2 | Not yet recruiting | Vanderbilt University Medical Center | 90 | 2026-12-01 | 2026-08-28 |
| Multiple Adjunct Therapies to Improve Immunotherapy Treatment in Patients With Locally Advanced or Metastatic Melanoma or Advanced Hepatocellular Cancer Biospecimen Collection, Cholecalciferol, Computed Tomography - Advanced Hepatocellular Carcinoma, Advanced Melanoma | Phase 2 | Not yet recruiting | University of Southern California | 46 | 2026-11-01 | 2026-09-23 |
| Effect of Vitamin D3 Supplementation on Serum Sphingosine-1-Phosphate Levels and Dental Implant Osseointegration: A Prospective Study Vitamin D3 ( Colecalciferol) - Dental Implant | Not applicable | Not yet recruiting | Air Force Military Medical University, China | 60 | 2026-10-30 | 2026-10-20 |
| Evaluating the Impact of Vitamin D Supplementation on Healing Bed Sores in ICU. Enteral Vit-D 3 (cholecalciferol) - Bed Sores | Not applicable | Recruiting | Maha Salah | 50 | 2026-09-06 | 2026-09-24 |
| Supplementation Absorption Comparison Aquacelle® Omega 3, Comparator Omega 3, Plexosome® Vitamin D3 - Healthy Volunteer | Phase 4 | Recruiting | RDC Clinical Pty Ltd | 160 | 2026-08-31 | 2026-09-10 |
| Vitamin D and Type 2 Diabetes - Treat-To-Target Vitamin D (Cholecalciferol ), Placebo - Prediabetes, Type 2 Diabetes (T2DM) | Phase 3 | Recruiting | Tufts Medical Center | 100 | 2026-08-04 | 2026-08-18 |
| The Efficacy of Vitamin D Supplementation to Sustain Performance Outcomes Vitamin D3 (Cholecalciferol), Oral Placebo Tablet - Acute Stress Reaction | Not applicable | Recruiting | Walter Reed Army Institute of Research (WRAIR) | 52 | 2026-07-17 | 2026-09-10 |
| Vitamin D Supplementation Among Pregnant Women in Uganda for the Prevention of Hypertensive Disorders in Pregnancy, and Other Adverse Maternal and Foetal Outcomes oral 2.000 IU vitamin D3 (cholecalciferol) daily, in addition to routine ANC supplementations, Placebo - Preeclampsia, Eclampsia | Phase 4 | Not yet recruiting | St Mary's Hospital, Lacor | 1980 | 2026-06-01 | 2026-04-03 |
| Effects of Cofrogliptin on Beta-Cell Function in LADA Patients Cofrogliptin, Vitamin D3, Metformin - Latent Autoimmune Diabetes in Adults (LADA) | Not applicable | Not yet recruiting | Second Xiangya Hospital of Central South University | 84 | 2026-05-15 | 2026-05-08 |
| COMPARISON OF THE EFFICACY BETWEEN PREOPERATIVE CALCIUM & VITAMIN D3 VERSUS CALCIUM SUPPLEMENTATION ALONE TO PREVENT POST OPERATIVE SYMPTOMATIC HYPOCALCEMIA AFTER TOTAL THYROIDECTOMY IN EUTHYROID PATIENTS Calcium carbonate plus vitamin D3 (cholecalciferol) - Postoperative Symptomatic Hypocalcemia Following Total Thyroidectomy | Not applicable | Not yet recruiting | King Edward Medical University | 124 | 2026-05-10 | 2026-05-19 |
| Vitamin D Treat-to-Target Strategy for Children With Overactive Bladder-Wet urotherapy, Solifenacin Succinate, Vitamin D3 - Urinary Bladder, Overactive, Overactive Bladder | Not applicable | Recruiting | Children's Hospital of Chongqing Medical University | 180 | 2026-04-20 | 2026-04-17 |
| Comparing MOP, Prostaglandin E1, and Calcitriol to Accelerate Orthodontic Tooth Movement PGE₁ (pharmacological) • Agent: Prostaglandin E1, Calcitriol (1,25-(OH)₂D₃) local injection • Agent: Calcitriol (1,25-(OH)₂D₃) Vitamin D3, microosteoperforation MOP (surgical) - Accelerated Orthodontic Tooth Movement | Phase 2 | Recruiting | Ghufran Dhari Awad | 60 | 2026-04-16 | 2026-09-25 |
| Vitamin D3 for Moderate to Mild Traumatic Brain Injury: A Randomized Trial on Inflammation and Recovery (VIMOT) Vitamin D3 (Cholecalciferol) - Traumatic Brain Injury (TBI) Patients, Neuroinflammation | Phase 2 | Recruiting | Lagos State University | 240 | 2026-03-02 | 2026-05-13 |
| Effects of Laser Therapy and Vitamin D Pills on Braces Tooth Movement: A Random Controlled Study Cholecalciferol (Vit D3), Low-Level Laser Therapy, Fixed Orthodontic Appliance - Malocclusion of Anterior Teeth | Not applicable | Active not recruiting | Universiti Sains Malaysia | 50 | 2026-01-01 | 2026-04-28 |
| Effect of Isoflavone and Vitamin D Supplementation on Serum Vitamin D Levels, Body Composition, Inflammatory Markers, and Quality of Life in Patients With Inflammatory Bowel Disease Standard medical treatment, Tempeh Isoflavone, Vitamin D (Cholecalciferol ) - Ulcerative Colitis (UC), Crohn Disease (CD) | Not applicable | Completed | Universitas Indonesia | 50 | 2025-11-17 | 2026-06-18 |
| The Prospective Improved Vitamin D Study for Inflammatory Bowel Disease Patients Vitamin D3 (Cholecalciferol) - Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease) | Phase 1 | Active not recruiting | Terry Ponich | 150 | 2025-11-05 | 2026-10-05 |
| Effect of Vitamin D on Postoperative Pain in Symptomatic Irreversible Pulpitis Vitamin D3, Placebo - Pulpitis - Irreversible, Vitamin D Deficiency | Not applicable | Active not recruiting | Future University in Egypt | 54 | 2025-11-01 | 2026-05-12 |
| Vitamin k, D-chiro Inositol and α-lactalbumin in Bone Homeostasis Group 1: calcium carbonate/cholecalciferol, Group 2: Synostea® (calcium carbonate/cholecalciferol/vitamin K/α-lactalbumin/ d-chiro-inositol) - Osteoporosis Secondary, Breast Cancer Females | Recruiting | Regina Elena Cancer Institute | 134 | 2025-09-29 | 2025-12-01 |
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Vitamin D Deficiency (302) · Osteoporosis (57) · Obesity (43) · Insulin Resistance (37) · Diabetes Mellitus, Type 2 (34) · Diabetes Mellitus (28) · COVID-19 (27) · Bone Diseases, Metabolic (25) · Inflammation (24) · Renal Insufficiency, Chronic (24) · Breast Neoplasms (22) · Asthma (21) · Cardiovascular Diseases (19) · Crohn Disease (18) · Hypertension (18)
Brigham and Women's Hospital (21) · Medical University of South Carolina (13) · Creighton University (12) · Emory University (12) · Ain Shams University (10) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (10) · Massachusetts General Hospital (10) · Merck Sharp & Dohme LLC (10) · Columbia University (9) · Mayo Clinic (9) · University of Aarhus (9) · Roswell Park Cancer Institute (8) · Universitas Indonesia (8) · University of Tromso (8) · University of Wisconsin, Madison (8)
United States (365) · Canada (51) · Egypt (35) · United Kingdom (33) · China (25) · Denmark (23) · Mexico (23) · Bangladesh (20) · Pakistan (18) · South Korea (18) · France (17) · Indonesia (16) · Norway (16) · Austria (14) · India (14)
Rolf Jorde, Professor (6) · Muhammad M Hammami, MD, PhD (5) · Adrian R Martineau, MRCP (4) · Sebastiano Gattoni-Celli, MD (4) · An Pan, PHD (3) · Arturo Borzutzky, M.D. (3) · Daniel Roth, MD (3) · Francine M Ducharme, MD (3) · Jason Stubbs, MD (3) · Mahmoud S Abu-Samak, PhD (3) · Meryl S LeBoff, M.D. (3) · Michael F Holick, PhD, MD (3) · Neil Binkley, M.D. (3)
PMID 33305842, PMID 39077939, PMID 35018442, PMID 25777546, PMID 28506446, PMID 33513226, PMID 33757717, PMID 34853363, PMID 19125756, PMID 21706518, PMID 22586483, PMID 22805498, PMID 23527013, PMID 25988278, PMID 26151421, PMID 27194308, PMID 29445400, PMID 29526608, PMID 31699704, PMID 32492153, PMID 32749491, PMID 33184642, PMID 33724323, PMID 34849536, PMID 34932079, PMID 35082139, PMID 36285795, PMID 37212116, PMID 37267732, PMID 37454148, PMID 37952113, PMID 38272846, PMID 38772577, PMID 39351881, PMID 40139482, PMID 10826123, PMID 10990036, PMID 11146455, PMID 11158062, PMID 11176917, PMID 11181474, PMID 12605179, PMID 12791627, PMID 12795371, PMID 12840119, PMID 12865912, PMID 14717616, PMID 15175591, PMID 15468356, PMID 15470215
2009 (11), 2018 (3), 2008 (2), 2014 (2), 2019 (2), P30CA012197 (2), P30CA016056 (2), P50CA090440 (2), R01AG028739 (2), R01AR059775 (2), R01AR060574 (2), R01AT005531 (2), R01CA138962 (2), R01DK076092 (2), R01DK084986 (2)