111 completed, 46 unknown, 30 recruiting, 16 active not recruiting. 130 Not applicable, 12 Phase 4, 4 Phase 3, 3 Phase 2, 1 Phase 1.
Follow Arthroplasty, Replacement, Knee: new trials by email Literature Review of Arthroplasty, Replacement, Knee trials Research Report on Arthroplasty, Replacement, Knee
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty Total knee arthroplasty - Knee Osteoarthritis | Not applicable | Not yet recruiting | Loyola University | 96 | 2027-01-01 | 2026-08-27 |
| Application of Perinatal Derivatives in Total Knee Arthroplasty Intraoperative application of CTM Flow and CTM Thick, Total knee arthroplasty (TKA) - Total Knee Arthroplasty, Knee Osteoarthristis | Not applicable | Not yet recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 48 | 2026-12-01 | 2026-11-02 |
| Daycase Hip and Knee Arthroplasty in Møre and Romsdal Trial Total Hip Arthroplasty, Total Knee Arthroplasty, Unicondylar knee artrhoplasty - Knee Osteoarthritis, Hip Osteoarthritis | Not yet recruiting | Helse Møre og Romsdal HF | 300 | 2026-10-01 | 2026-09-22 | |
| Evaluation of 5-year Survival and Clinical Outcomes in Patients Undergoing Total Knee Arthroplasty With a Polyethylene Tibial Component Total knee arthroplasty - Prosthesis Survival, Arthropathy of Knee | Not applicable | Recruiting | Istituto Ortopedico Rizzoli | 78 | 2026-05-13 | 2026-06-23 |
| Clinical Performance and Safety of the Unicompartmental Univation® XF Pro Implant univation® XF Pro - Gonarthritis, Degenerative Disease | Recruiting | Aesculap AG | 150 | 2026-04-02 | 2026-10-16 | |
| Persona SoluTion PPS Femur PMCF Total knee arthroplasty - Rhematoid Arthritis, Osteo Arthritis of the Knee | Enrolling by invitation | Zimmer Biomet | 200 | 2026-02-26 | 2026-11-05 | |
| Microbiota as Early Diagnostic and predictivE Factor for Osteoarthritic Degeneration and Microbial Contamination total knee replacement - Knee Prosthesis, Knee Prosthesis Infection | Not applicable | Not yet recruiting | Istituto Clinico Humanitas | 170 | 2026-02-01 | 2025-04-25 |
| Partial vs Total Knee Replacement for Medial Knee Osteoarthritis: a Prospective Randomized Controlled Study unicompartmental knee arthroplasty, total knee arthroplasty - Medial Knee Osteoarthritis | Not applicable | Not yet recruiting | Medical University of Graz | 102 | 2026-01-01 | 2025-12-02 |
| MultiCenter IDE Study of the PEEK-OPTIMA™ Femoral Component vs a CoCr Alloy TKA Femoral Component of Similar Design Total Knee Arthroplasty - Knee Osteoarthritis | Not applicable | Recruiting | Maxx Orthopedics Inc | 200 | 2026-01-01 | 2026-06-26 |
| Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty total knee arthroplasty - Knee Osteoarthristis, Knee Replacement Arthroplasty | Not applicable | Recruiting | Elsan | 170 | 2025-12-24 | 2026-03-04 |
| Prospective, In-Vivo, Post-Market Safety and Efficacy Surveillance Registry of the MAXX Orthopedics, Freedom Total Knee® System Total Knee Arthroplasty - Knee Osteoarthristis, Total Knee Anthroplasty | Recruiting | Maxx Orthopedics Inc | 300 | 2025-11-01 | 2026-06-26 | |
| Functional Impact at 12 Months Post-op of Posterior Cruciate Ligament Conservation During Robotic-assisted Surgery (MAKO) for Total Knee Replacement. Total knee arthroplasty - Knee Arthroplasty, Total | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nīmes | 300 | 2025-10-10 | 2026-03-27 |
| Changes in Physical Activity, Sleep and Knee Function After Same-Day Discharge Knee Arthroplasty Medial unicompartmental knee arthroplasty (UKA), Total knee arthroplasty (TKA) - Arthrosis | Recruiting | Turku University Hospital | 120 | 2025-08-01 | 2026-09-25 | |
| Pain Profile and Pain Medication Use After THA and TKA total hip arthroplasty, total knee arthroplasty - Pain, Postoperative | Withdrawn | Duke University | 2025-08-01 | 2025-06-15 | ||
| The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty Total knee arthroplasty (TKA), Cryoablation - Post-Operative Pain, Total Knee Arthroplasty | Not applicable | Recruiting | NYU Langone Health | 215 | 2025-06-13 | 2026-04-03 |
| Effects of Tourniquet Applied During Total Knee Replacement Surgery on Patient Hemodynamics and Blood Table Total knee replacement - Primary Gonarthrosis | Completed | Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital | 22 | 2025-06-04 | 2026-01-09 | |
| ROSA® Knee System V1.5 Pilot Study Total Knee Arthroplasty - Knee Arthroplasty, Total, Robotic Surgical Procedures | Not applicable | Completed | Zimmer Biomet | 40 | 2025-02-25 | 2026-02-27 |
| Comparison of Restricted Versus Unrestricted Kinematic Alignment in 1ry TKA Total knee arthroplasty - Osteoarthritis (OA) of the Knee, Total Knee Anthroplasty | Not applicable | Not yet recruiting | Assiut University | 80 | 2025-02-01 | 2024-12-19 |
| Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First? laparoscopic sleeve gastrectomy, total knee arthroplasty - Osteoarthritis of Knee, Arthroplasties, Knee Replacement | Not applicable | Not yet recruiting | Memorial University of Newfoundland | 142 | 2025-02-01 | 2025-01-30 |
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Osteoarthritis, Knee (82) · Osteoarthritis (60) · Arthritis, Rheumatoid (17) · Arthritis (15) · Pain, Postoperative (12) · Joint Diseases (10) · Osteonecrosis (6) · Osteoarthritis, Hip (4) · Arthritis, Juvenile (3) · Musculoskeletal Diseases (3) · Obesity (3) · Prosthesis Failure (3) · Genu Varum (2) · Infections (2) · Motor Activity (2)
Zimmer Biomet (10) · DePuy Orthopaedics (9) · Istituto Ortopedico Rizzoli (6) · Aesculap AG (4) · Assiut University (4) · Ewha Womans University (4) · Heekin Orthopedic Research Institute (4) · Medical University of Warsaw (4) · Smith & Nephew, Inc. (4) · University of Salford (4) · Corin (3) · Hospital for Special Surgery, New York (3) · Maxx Orthopedics Inc (3) · Northern Orthopaedic Division, Denmark (3) · Pamukkale University (3)
United States (62) · France (20) · United Kingdom (17) · Canada (16) · Turkey (Türkiye) (12) · Germany (10) · Italy (9) · Denmark (8) · Netherlands (8) · Austria (7) · Spain (7) · China (6) · Norway (6) · Belgium (5) · Poland (5)
Asit Shah, MD, PhD (2) · Donald Roberts, MD (2) · Frank R Noyes, MD (2) · Geoffrey Dervin, MD,MSc,FRCSC (2) · Giulio Maria Marcheggiani Muccioli, MD, PhD (2) · R. David Heekin, M.D. (2) · Satit Thiengwittayaporn, M.D. (2) · Tammy L O'Dell, EMT, CCRA (2) · Todd Borus, MD (2) · Aasis Unnanuntana, M.D. (1) · Adrija Sharma, Ph D (1)
PMID 19844772, PMID 25381418, PMID 15457426, PMID 16140800, PMID 16156464, PMID 16331023, PMID 17259414, PMID 19571079, PMID 20048101, PMID 21656315, PMID 22000572, PMID 22045067, PMID 22459101, PMID 22571284, PMID 23268822, PMID 24028414, PMID 24095836, PMID 24671469, PMID 24810539, PMID 24929659, PMID 25200513, PMID 26304646, PMID 26762299, PMID 26776100, PMID 27029553, PMID 28122388, PMID 28302462, PMID 28662692, PMID 28764691, PMID 28870873, PMID 29369450, PMID 29529622, PMID 29598886, PMID 29723634, PMID 30276435, PMID 30832636, PMID 30848244, PMID 30894146, PMID 31326135, PMID 31372679, PMID 31832694, PMID 31948990, PMID 32085760, PMID 32228074, PMID 32561964, PMID 32962591, PMID 33180187, PMID 33397330, PMID 33517740, PMID 34162649
2017 (1), R03AR054538 (1)