9 completed, 3 recruiting, 1 active not recruiting, 1 not yet recruiting. 7 Not applicable, 7 Phase 2, 2 Phase 4, 1 Phase 3.
Follow 5-Hydroxytryptophan: new trials by email Literature Review of 5-Hydroxytryptophan trials Research Report on 5-Hydroxytryptophan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tinnitus and Treatment With umPEA-LUT PEA-LUT 2 sachet day, Placebo, umPEALUT + Rutin + 5 hTp - Tinnitus, Neuroinflammation | Not applicable | Not yet recruiting | University of Campania Luigi Vanvitelli | 100 | 2026-04-20 | 2026-02-06 |
| The Effect of 5-hydroxytryptophan on ADHD Traits and Eye Movements 5-hydroxytryptophan (food supplement) 200mg, 5-hydroxytryptophan (food supplement) 300mg, Placebo - Attention Deficit and Hyperactivity Disorder (ADHD), Attention Deficit Hyperactivity Disorder in Adults | Not applicable | Recruiting | University of Sheffield | 150 | 2025-11-25 | 2026-08-20 |
| 5-HTP and Creatine for Depression R33 Phase Low Dose 5-hydroxytryptophan, High Dose 5-hydroxytryptophan, Low Dose Creatine Monohydrate - Major Depressive Disorder | Phase 2 | Recruiting | University of Utah | 106 | 2023-09-28 | 2026-08-27 |
| ERG/5-HTP in Fragile X Syndrome (FXS) 5-Hydroxytryptophan, Ergoloid Mesylates, Matching placebo for Ergoloid mesylates - Fragile X Syndrome | Phase 2 | Completed | Elizabeth Berry-Kravis | 15 | 2021-10-07 | 2024-09-19 |
| 5-HTP and Creatine for Depression 5-Hydroxytryptophan 100 MG, Creatine monohydrate, placebo matched to 5-HTP - Major Depressive Disorder | Phase 2 | Completed | University of Utah | 43 | 2021-03-01 | 2024-07-23 |
| 5HTP Regulation Of Asthma In Children 5-Hydroxytryptophan, Placebo - Mild or Moderate Asthma With Allergic Sensitization | Phase 2 | Recruiting | Indiana University | 20 | 2021-02-11 | 2026-10-01 |
| Effects of Daily Supplementation of 5-HTP on Body Composition 5-HTP, Placebo - Body Composition | Not applicable | Completed | Nova Southeastern University | 65 | 2021-01-01 | 2025-02-12 |
| Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults 5-HTP, Without 5-HTP - Sleep, Gut Microbiome | Not applicable | Completed | National University of Singapore | 33 | 2020-07-04 | 2021-09-08 |
| Effects of 5HTP on the Injured Human Spinal Cord 5-Hydroxytryptophan 100 MG, 5-Hydroxytryptophan, Carbidopa - Spinal Cord Injuries | Phase 2 / Phase 3 | Active not recruiting | University of Alberta | 6 | 2020-07-01 | 2026-09-16 |
| 5-HTP in Patients With IBD in Clinical and Biologic Remission:Effect on Fatigue Scores 5-HTP, Placebo oral capsule - Crohn Disease, Ulcerative Colitis | Phase 2 | Completed | University Hospital, Ghent | 175 | 2018-12-06 | 2021-05-18 |
| Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females 5-hydroxytryptophan and Creatine, Placebo control - Major Depressive Disorder | Phase 4 | Terminated | Brent Michael Kious, MD, PhD | 32 | 2016-11-01 | 2022-05-31 |
| 5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females 5-hydroxytryptophan and Creatine monohydrate - Major Depressive Disorder | Phase 4 | Completed | Perry Renshaw | 15 | 2015-04-01 | 2018-01-29 |
| Effects of Exercise and 5-HTP on Cortisol Levels 5-HTP, Placebo - Plasma Cortisol | Not applicable | Unknown | Benedictine University | 12 | 2014-06-01 | 2014-07-11 |
| Sub-chronic Effects of 5-hydroxytryptophan on Mood and Emotional Processing in Healthy Volunteers 5-Hydroxytryptophan, Pharmaceutical grade silica - Mood | Not applicable | Completed | Northumbria University | 33 | 2011-05-01 | 2012-01-23 |
| The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and Irritable Bowel Syndrome (IBS) Patients Oxitriptan, Acute tryptophan depletion, Amino acid drink with tryptophan - Irritable Bowel Syndrome | Not applicable | Completed | Maastricht University Medical Center | 60 | 2009-04-01 | 2014-11-13 |
| The Effect of 5-Hydroxytryptophan (5-HTP) on Satiety 5-hydroxytryptophan (food supplement) - Obesity | Phase 2 | Completed | TNO | 24 | 2006-03-01 | 2007-01-09 |
Depressive Disorder, Major (4) · Attention Deficit Disorder with Hyperactivity (1) · Colitis, Ulcerative (1) · Consciousness Disorders (1) · Crohn Disease (1) · Fatigue (1) · Fragile X Syndrome (1) · Irritable Bowel Syndrome (1) · Lymphoma, Follicular (1) · Neuroinflammatory Diseases (1) · Obesity (1) · Sleep Initiation and Maintenance Disorders (1) · Spinal Cord Injuries (1) · Tinnitus (1)
University of Utah (2) · Benedictine University (1) · Brent Michael Kious, MD, PhD (1) · Elizabeth Berry-Kravis (1) · Indiana University (1) · Maastricht University Medical Center (1) · National University of Singapore (1) · Northumbria University (1) · Nova Southeastern University (1) · Perry Renshaw (1) · TNO (1) · University Hospital, Ghent (1) · University of Alberta (1) · University of Campania Luigi Vanvitelli (1) · University of Sheffield (1)
United States (9) · Netherlands (2) · United Kingdom (2) · Belgium (1) · Canada (1) · Italy (1) · Singapore (1)
A AM Masclee, Prof. Dr. (1) · Arianna Di Stadio, MD, PhD, MSc (1) · Elizabeth Berry-Kravis, MD, PhD (1) · F Troost, PhD (1) · Jessica D'Amico, PhD (1) · Jose Antonio, PhD (1) · Kim J Eun, PhD (1) · Kirsten Kloepfer, MD (1) · Martine De Vos, MD, PhD (1) · Pedro Del Corral, PhD-MD (1) · Perry F. Renshaw, MD, PhD, MBA (1) · Wilrike Pasman, PhD (1)
PMID 12238249, PMID 17416295, PMID 17956787, PMID 19561730, PMID 22301931, PMID 22931904, PMID 23731747, PMID 24943480, PMID 25190255, PMID 25862619, PMID 25997584, PMID 26547700, PMID 28885581, PMID 29031742, PMID 30015600, PMID 30058696, PMID 30261653, PMID 30469326, PMID 30538616, PMID 31042571, PMID 31842394, PMID 32471239, PMID 34282564, PMID 34768526, PMID 35940251, PMID 38309227, PMID 5642369, PMID 6743061
2017 (1)