920 completed, 190 unknown, 167 recruiting, 61 not yet recruiting. 313 Not applicable, 300 Phase 3, 280 Phase 2, 163 Phase 4, 121 Phase 1.
Follow Neuroinflammatory Diseases: new trials by email Literature Review of Neuroinflammatory Diseases trials Research Report on Neuroinflammatory Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| Optimizing Care for Cryptococcal Antigenemia: Evaluation of Short Course Fluconazole and ART Timing Among CrAg+ Persons With Low Titers Immediate ART Initiation, Delayed ART Initiation, 10-Week Fluconazole - Cryptococcal Antigenemia, HIV-1-infection | Phase 3 | Not yet recruiting | University of Minnesota | 505 | 2027-01-05 | 2026-09-03 |
| Immune-Mitochondrial Correction in Military Recruits Multivitamin/Mineral supplements, Sodium nucleinate combination - Respiratory Tract Infections (RTI), Meningitis | Not applicable | Not yet recruiting | MIPO Clinic | 200 | 2027-01-01 | 2026-06-29 |
| Aciclovir Versus Placebo for HSV-2 Meningitis Acyclovir 50 MG/ML, Placebo - Herpes Simplex 2, Meningitis, Viral | Phase 4 | Not yet recruiting | Jacob Bodilsen | 150 | 2027-01-01 | 2026-10-28 |
| CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 38 | 2026-12-01 | 2026-07-24 |
| Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care MS Boost, Standard of care - Multiple Sclerosis, Fatigue Syndrome, Chronic | Not applicable | Not yet recruiting | Ad scientiam | 208 | 2026-12-01 | 2025-10-03 |
| THiamine for Recovery In Vulnerable Early-life Infections thiamine hydrochloride 100 mg, Placebo - Meningitis, Bacteremia | Phase 2 | Not yet recruiting | Milton S. Hershey Medical Center | 240 | 2026-12-01 | 2026-10-09 |
| Minocycline In Neurocognitive Outcomes - Sickle Cell Disease Minocycline, Placebo - Sickle Cell Disease, Cognitive Impairment | Phase 1 | Not yet recruiting | University of Cincinnati | 30 | 2026-12-01 | 2026-11-03 |
| A Pivotal Safety and Immunogenicity GBS-NN/NN2 Vaccine Maternal Immunisation Trial GBS-NN/NN2 vaccine, Placebo - Streptococcus Agalactiae Infection, Neonatal Sepsis | Phase 2 / Phase 3 | Not yet recruiting | Minervax ApS | 6600 | 2026-11-30 | 2026-11-06 |
| Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic | Recruiting | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 225 | 2026-11-09 | 2026-11-12 | |
| Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy Transcutaneous Auricular Vagus Nerve Stimulation (AVNS) - HIV Associated Polyneuropathy | Not applicable | Recruiting | University of Miami | 70 | 2026-11-01 | 2026-10-06 |
| Low-Dose Naltrexone For ME/CFS: Dose-Finding Low-Dose Naltrexone, 1.5mg, Low-Dose Naltrexone, 3.0mg, Low-Dose Naltrexone, 4.5mg - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 75 | 2026-11-01 | 2026-10-08 |
| Neurogenetics and Multi-omics of Neuroinflammatory Diseases in Multiplex Families to Improve Patients Health Blood sampling and multi-omic profiling - Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder | Not applicable | Not yet recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 500 | 2026-11-01 | 2026-11-04 |
| Safety, Tolerability, and Pharmacodynamic Exploration of Orelabrutinib in Patients With Amyotrophic Lateral Sclerosis (ALS) Orelabrutinib - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 | Not yet recruiting | Liu Qing | 18 | 2026-11-01 | 2026-11-06 |
| Exploratory Study of Low-Dose Whole-Brain Radiation Therapy With HeLaXON 1X in Patients With Mild Alzheimer's Disease Dementia HeLaXON 1X Low-Dose Radiation Therapy, Sham HeLaXON 1X Procedure - Alzheimer Disease | Not applicable | Recruiting | ReadyCure Inc. | 30 | 2026-10-26 | 2026-10-07 |
| Study of BK1803 in Healthy Infants BK1803, GOBIK Aqueous Suspension Syringes, Bimmugen® Injection - Pertussis, Diphtheria | Phase 3 | Recruiting | Tanabe Pharma Corporation | 344 | 2026-10-21 | 2026-11-12 |
| Single-center, Open-label Study: Immunogenicity and Safety Observation After Vaccination With ACYW135 Meningococcal Polysaccharide Vaccine in Junior High School Students Aged 13-15 Years MPSV-ACYW - Meningococcal Disease; Meningococcal Meningitis | Phase 4 | Not yet recruiting | Zhejiang Provincial Center for Disease Control and Prevention | 200 | 2026-10-20 | 2026-10-21 |
| A Longitudinal Natural History Study of Immune Biomarkers in Neuropsychiatric Illness Neuropsychiatric Disorders, Neuroinflammatory Disorders | Recruiting | National Institute of Mental Health (NIMH) | 5000 | 2026-10-19 | 2026-11-03 | |
| A Phase I/II Clinical Trial of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine+Inactivated Poliomyelitis Vaccine Made From Sabin Strains - Diphtheria, Pertussis | Phase 1 / Phase 2 | Recruiting | Institute of Medical Biology, Chinese Academy of Medical Sciences | 380 | 2026-10-11 | 2026-10-23 |
| Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study Cryotherapy - ME/CFS, Fibromyalgia (FM) | Not applicable | Recruiting | Oxford Brookes University | 40 | 2026-10-05 | 2026-11-05 |
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Poliomyelitis (263) · Fatigue Syndrome, Chronic (262) · Meningitis (259) · Meningitis, Meningococcal (125) · Tetanus (123) · Diphtheria (121) · Encephalitis (116) · Meningococcal Infections (105) · Whooping Cough (90) · Haemophilus Infections (78) · Encephalitis, Japanese (72) · Hepatitis B (69) · Fatigue (62) · Meningitis, Cryptococcal (54)
Nervous System Diseases (1480) · Central Nervous System Diseases (1001) · Infections (996) · Central Nervous System Infections (815) · Virus Diseases (630) · RNA Virus Infections (594) · Pathological Conditions, Signs and Symptoms (576) · Neuromuscular Diseases (569) · Pathologic Processes (532) · Bacterial Infections and Mycoses (443) · Brain Diseases (418) · Bacterial Infections (376) · Spinal Cord Diseases (361) · Myelitis (336)
Meningococcal Vaccines (60) · Poliovirus Vaccine, Inactivated (29) · diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (29) · Fluconazole (28) · Blood Specimen Collection (24) · Amphotericin B (23) · Tetanus Toxoid (20) · Vaccines (19) · Heptavalent Pneumococcal Conjugate Vaccine (18) · 4CMenB vaccine (16) · Sodium Chloride (16) · Saline Solution (14) · Flucytosine (13) · 13-valent pneumococcal vaccine (12) · Diphtheria-Tetanus-acellular Pertussis Vaccines (12)
Sanofi Pasteur, a Sanofi Company (102) · GlaxoSmithKline (68) · Pfizer (43) · Novartis Vaccines (37) · National Institute of Allergy and Infectious Diseases (NIAID) (31) · Sanofi (24) · National Institute of Neurological Disorders and Stroke (NINDS) (22) · Sinovac Biotech Co., Ltd (19) · Valneva Austria GmbH (17) · Assistance Publique - Hôpitaux de Paris (15) · Centers for Disease Control and Prevention (15) · PATH (15) · Aga Khan University (13) · Novartis (13) · National Institute of Mental Health (NIMH) (11)
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Fred Friedberg, PhD (5) · Robert B Innis, M.D. (5) · Ingrid Kromann (4) · Irene CM Cortese, M.D. (4) · Yuemei Hu (4) · Astrid Kaltenboeck, Ph.D. (3) · Avindra Nath, M.D. (3)
PMID 35164991, PMID 25386668, PMID 26212172, PMID 26873055, PMID 32867698, PMID 39972326, PMID 20934459, PMID 21592984, PMID 22153001, PMID 22871021, PMID 23600892, PMID 26132314, PMID 28340322, PMID 28545923, PMID 29253560, PMID 29550195, PMID 29749279, PMID 30325463, PMID 32273184, PMID 32681472, PMID 32843994, PMID 33283229, PMID 33325757, PMID 33487470, PMID 33676197, PMID 34498507, PMID 36369456, PMID 36462524, PMID 38218668, PMID 39088987, PMID 40318674, PMID 41574175, PMID 10025486, PMID 10529146, PMID 10625901, PMID 11088089, PMID 11093451, PMID 11113214, PMID 11227314, PMID 11459743, PMID 11516765, PMID 12236201, PMID 12238249, PMID 12358329, PMID 12393404, PMID 12522449, PMID 12563281, PMID 12691631, PMID 15472843, PMID 15564716
2014 (9), 2017 (9), 2016 (7), 2019 (7), 2009 (5), 2008 (4), 2018 (4), 2023 (4), 2005 (2), 2015 (2), 2025 (2), 1UG3NS141843-01A1 (1), IK1RX004807-01A2 (1), K01AG047279 (1), K01DK075478 (1)