914 completed, 193 unknown, 165 recruiting, 65 not yet recruiting. 311 Not applicable, 299 Phase 3, 278 Phase 2, 162 Phase 4, 120 Phase 1.
Follow Neuroinflammatory Diseases: new trials by email Literature Review of Neuroinflammatory Diseases trials Research Report on Neuroinflammatory Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| Optimizing Care for Cryptococcal Antigenemia: Evaluation of Short Course Fluconazole and ART Timing Among CrAg+ Persons With Low Titers Immediate ART Initiation, Delayed ART Initiation, 10-Week Fluconazole - Cryptococcal Antigenemia, HIV-1-infection | Phase 3 | Not yet recruiting | University of Minnesota | 505 | 2027-01-05 | 2026-09-03 |
| Immune-Mitochondrial Correction in Military Recruits Multivitamin/Mineral supplements, Sodium nucleinate combination - Respiratory Tract Infections (RTI), Meningitis | Not applicable | Not yet recruiting | MIPO Clinic | 200 | 2027-01-01 | 2026-06-29 |
| CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 38 | 2026-12-01 | 2026-07-24 |
| Minocycline In Neurocognitive Outcomes - Sickle Cell Disease Minocycline, Placebo - Sickle Cell Disease, Cognitive Impairment | Phase 1 | Not yet recruiting | University of Cincinnati | 30 | 2026-12-01 | 2026-05-14 |
| Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care MS Boost, Standard of care - Multiple Sclerosis, Fatigue Syndrome, Chronic | Not applicable | Not yet recruiting | Ad scientiam | 208 | 2026-12-01 | 2025-10-03 |
| THiamine for Recovery In Vulnerable Early-life Infections thiamine hydrochloride 100 mg, Placebo - Meningitis, Bacteremia | Phase 2 | Not yet recruiting | Milton S. Hershey Medical Center | 240 | 2026-12-01 | 2026-10-09 |
| Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy Transcutaneous Auricular Vagus Nerve Stimulation (AVNS) - HIV Associated Polyneuropathy | Not applicable | Recruiting | University of Miami | 70 | 2026-11-01 | 2026-10-06 |
| Low-Dose Naltrexone For ME/CFS: Dose-Finding Low-Dose Naltrexone, 1.5mg, Low-Dose Naltrexone, 3.0mg, Low-Dose Naltrexone, 4.5mg - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 75 | 2026-11-01 | 2026-10-08 |
| Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic | Not yet recruiting | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 225 | 2026-10-27 | 2026-10-22 | |
| Exploratory Study of Low-Dose Whole-Brain Radiation Therapy With HeLaXON 1X in Patients With Mild Alzheimer's Disease Dementia HeLaXON 1X Low-Dose Radiation Therapy, Sham HeLaXON 1X Procedure - Alzheimer Disease | Not applicable | Recruiting | ReadyCure Inc. | 30 | 2026-10-26 | 2026-10-07 |
| Single-center, Open-label Study: Immunogenicity and Safety Observation After Vaccination With ACYW135 Meningococcal Polysaccharide Vaccine in Junior High School Students Aged 13-15 Years MPSV-ACYW - Meningococcal Disease; Meningococcal Meningitis | Phase 4 | Not yet recruiting | Zhejiang Provincial Center for Disease Control and Prevention | 200 | 2026-10-20 | 2026-10-21 |
| A Longitudinal Natural History Study of Immune Biomarkers in Neuropsychiatric Illness Neuropsychiatric Disorders, Neuroinflammatory Disorders | Recruiting | National Institute of Mental Health (NIMH) | 5000 | 2026-10-19 | 2026-10-22 | |
| Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study Cryotherapy - ME/CFS, Fibromyalgia (FM) | Not applicable | Not yet recruiting | Oxford Brookes University | 40 | 2026-10-01 | 2026-10-14 |
| Brain and Blood Vessel Health Following Endometriosis Treatment in People With Endometriosis Investigate how norethindrone acetate, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Orlissa, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Oriahnn, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health - Endometriosis, Endometriosis and Dysmenorrhea | Phase 4 | Not yet recruiting | Colorado State University | 45 | 2026-10-01 | 2026-09-02 |
| A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS) SUN-627, Placebo - Primary Progressive Multiple Sclerosis, Primary Progressive MS | Phase 2 | Recruiting | Sundance Biosciences, Inc. | 20 | 2026-10-01 | 2026-09-25 |
| [11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction [11C]PS13: [carbon-11]PS13; COX-1 PET radioligand, Sacubitril-Valsartan - Heart Failure With Reduced Ejection Fraction, Cognitive Impairment, Mild | Phase 1 | Not yet recruiting | Stony Brook University | 18 | 2026-10-01 | 2026-10-02 |
| Safety, Tolerability, and Pharmacodynamic Exploration of Orelabrutinib in Patients With Amyotrophic Lateral Sclerosis (ALS) Orelabrutinib - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 | Not yet recruiting | Liu Qing | 12 | 2026-10-01 | 2026-10-15 |
| Clinical Evaluation of a Novel DAB Chromogenic Tissue-Based Assay for Detecting Anti-GABABR Antibodies Autoimmune Encephalitis, Anti-NMDAR Encephalitis | Not yet recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 300 | 2026-10-01 | 2026-10-05 | |
| Study of BK1803 in Healthy Infants BK1803, GOBIK Aqueous Suspension Syringes, Bimmugen® Injection - Pertussis, Diphtheria | Phase 3 | Not yet recruiting | Tanabe Pharma Corporation | 344 | 2026-10-01 | 2026-08-28 |
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Poliomyelitis (262) · Fatigue Syndrome, Chronic (260) · Meningitis (258) · Meningitis, Meningococcal (125) · Tetanus (122) · Diphtheria (120) · Encephalitis (116) · Meningococcal Infections (105) · Whooping Cough (89) · Haemophilus Infections (78) · Encephalitis, Japanese (72) · Hepatitis B (69) · Fatigue (62) · Meningitis, Cryptococcal (54)
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Meningococcal Vaccines (60) · Poliovirus Vaccine, Inactivated (29) · diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (29) · Fluconazole (28) · Amphotericin B (23) · Blood Specimen Collection (23) · Tetanus Toxoid (19) · Vaccines (19) · Heptavalent Pneumococcal Conjugate Vaccine (18) · 4CMenB vaccine (16) · Sodium Chloride (16) · Saline Solution (14) · Flucytosine (13) · 13-valent pneumococcal vaccine (12) · Diphtheria-Tetanus-acellular Pertussis Vaccines (12)
Sanofi Pasteur, a Sanofi Company (102) · GlaxoSmithKline (68) · Pfizer (43) · Novartis Vaccines (37) · National Institute of Allergy and Infectious Diseases (NIAID) (31) · Sanofi (24) · National Institute of Neurological Disorders and Stroke (NINDS) (22) · Sinovac Biotech Co., Ltd (19) · Valneva Austria GmbH (17) · Assistance Publique - Hôpitaux de Paris (15) · Centers for Disease Control and Prevention (15) · PATH (15) · Aga Khan University (13) · Novartis (13) · National Institute of Mental Health (NIMH) (11)
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2014 (9), 2017 (9), 2016 (7), 2019 (7), 2009 (5), 2008 (4), 2018 (4), 2023 (4), 2005 (2), 2015 (2), 2025 (2), 1UG3NS141843-01A1 (1), IK1RX004807-01A2 (1), K01AG047279 (1), K01DK075478 (1)