1026 completed, 370 unknown, 300 recruiting, 149 terminated. 1068 Not applicable, 199 Phase 2, 97 Phase 3, 92 Phase 1, 65 Phase 4.
Follow Brain Injuries, Traumatic: new trials by email Literature Review of Brain Injuries, Traumatic trials Research Report on Brain Injuries, Traumatic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury | Phase 2 | Not yet recruiting | University of California, Los Angeles | 264 | 2028-01-10 | 2026-01-16 |
| Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury MUSE Stem Cell Therapy - Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients | Not yet recruiting | Healing Hope International | 10 | 2028-01-01 | 2026-03-10 | |
| Behavior Therapy vs Education for Persistent Headache After Mild TBI Headache reprocessing, Headache education - Post-Traumatic Headache | Not applicable | Not yet recruiting | VA Office of Research and Development | 60 | 2027-10-01 | 2025-12-26 |
| Self-Management Training Among Individuals With TBI Participants will be referred to a community based self-management training program - Traumatic Brain Injury | Not applicable | Not yet recruiting | Boston University Charles River Campus | 85 | 2027-09-01 | 2026-08-03 |
| Supplementary Neuromuscular Rehabilitation During Acute Concussion Recovery Exercise, Return to Activity Progression - Concussion (Diagnosis), Gait Abnormality | Early Phase 1 | Not yet recruiting | Northern Illinois University | 30 | 2027-08-02 | 2026-09-03 |
| Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2027-07-01 | 2026-10-23 | |
| Correlation and Rapid Analysis of Neurological Injury Using Markers Traumatic Brain Injury (TBI) Patients | Not yet recruiting | Università Vita-Salute San Raffaele | 200 | 2027-06-01 | 2026-04-29 | |
| Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury | Phase 2 | Not yet recruiting | Nova Scotia Health Authority | 45 | 2027-06-01 | 2026-10-09 |
| Concurrent Trials on Nature-Based Therapy for Inpatients in Dementia and Rehabilitation Medicine Wards Nature Immersion Therapy - Dementia, Acquired Brain Injury Including Stroke | Not applicable | Not yet recruiting | Changi General Hospital | 1600 | 2027-05-01 | 2026-03-23 |
| Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Not yet recruiting | Northwestern University | 432 | 2027-05-01 | 2026-08-13 |
| Cognitive Network Restoration Therapy for Moderate to Severe Traumatic Brain Injury: A Feasibility Study Deep brain stimulation - Chronic Traumatic Brain Injury, TBI (Traumatic Brain Injury) | Not applicable | Not yet recruiting | ReEmerge, Inc. | 40 | 2027-02-01 | 2026-07-28 |
| Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments Locomotion in a virtual reality setting - Traumatic Brain Injury | Not applicable | Recruiting | Pôle Saint Hélier | 40 | 2027-01-04 | 2026-09-17 |
| Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II Optimal cerebral perfusion pressure - Traumatic Brain Injury, Severe Traumatic Brain Injury | Not applicable | Not yet recruiting | Maastricht University Medical Center | 62 | 2027-01-01 | 2026-09-28 |
| Paired VNS For TBI Rehabilitation VNS for TBI group - Traumatic Brain Injury, TBI (Traumatic Brain Injury) | Not applicable | Not yet recruiting | Stony Brook University | 20 | 2027-01-01 | 2026-08-13 |
| hCG Treatment for Rehabilitation From a TBI Ovidrel, Placebo - Traumatic Brain Injury | Early Phase 1 | Not yet recruiting | VA Office of Research and Development | 50 | 2027-01-01 | 2026-10-19 |
| Sleep MAPP in the Polytrauma/TBI System of Care Sleep MAPP Care Pathway - Insomnia Disorder, Mild Traumatic Brain Injury | Not applicable | Not yet recruiting | VA Office of Research and Development | 900 | 2027-01-01 | 2026-10-21 |
| Carbon Dioxide Administration and Brain Waste Clearance Hypercapnia task performed during fMRI - Traumatic Brain Injury, Aging Disorder | Not applicable | Recruiting | Andrew Mayer | 200 | 2026-12-01 | 2026-10-06 |
| Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury Crisis Response Planning - Mild Traumatic Brain Injury, Suicide Prevention | Not applicable | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 120 | 2026-12-01 | 2026-01-08 |
| Transcutaneous Vagus Nerve Stimulation for Attention and Memory Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT - Traumatic Brain Injury (TBI) Patients | Not applicable | Not yet recruiting | Baylor College of Medicine | 30 | 2026-12-01 | 2026-10-05 |
| Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for TBI cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells - Traumatic Brain Injury | Phase 1 | Not yet recruiting | The Foundation for Orthopaedics and Regenerative Medicine | 20 | 2026-12-01 | 2026-10-16 |
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Brain Concussion (634) · Brain Injuries (257) · Stroke (166) · Stress Disorders, Post-Traumatic (113) · Craniocerebral Trauma (107) · Post-Concussion Syndrome (93) · Cognitive Dysfunction (64) · Subarachnoid Hemorrhage (62) · Wounds and Injuries (56) · Depression (54) · Cerebral Hemorrhage (44) · Spinal Cord Injuries (43) · Consciousness Disorders (37) · Intracranial Hypertension (37)
Central Nervous System Diseases (2167) · Brain Diseases (2161) · Trauma, Nervous System (2160) · Nervous System Diseases (2157) · Wounds and Injuries (2119) · Craniocerebral Trauma (2068) · Brain Injuries (1918) · Wounds, Nonpenetrating (669) · Head Injuries, Closed (641) · Pathological Conditions, Signs and Symptoms (529) · Mental Disorders (341) · Signs and Symptoms (320) · Cardiovascular Diseases (312) · Vascular Diseases (309)
Transcranial Direct Current Stimulation (30) · Exercise (29) · Sodium Chloride (22) · Rehabilitation (21) · Transcranial Magnetic Stimulation (21) · Blood Specimen Collection (19) · Magnetic Resonance Imaging (18) · Saline Solution (18) · Standard of Care (18) · Therapeutics (17) · Hyperbaric Oxygenation (16) · Cognitive Behavioral Therapy (13) · Cognitive Training (13) · Amantadine (12) · Magnetic Resonance Spectroscopy (12)
VA Office of Research and Development (77) · Kessler Foundation (43) · University of Washington (30) · Children's Hospital Medical Center, Cincinnati (29) · University of Pittsburgh (24) · University of British Columbia (17) · Craig Hospital (16) · Indiana University (16) · Massachusetts General Hospital (16) · University of Calgary (16) · University of California, San Francisco (16) · Assiut University (15) · The University of Texas Health Science Center, Houston (15) · University of Aarhus (15) · University of Michigan (15)
United States (1202) · Canada (138) · France (119) · China (63) · United Kingdom (50) · Italy (46) · Denmark (39) · Egypt (38) · Israel (38) · Germany (34) · Switzerland (33) · Spain (30) · Sweden (27) · Australia (22) · Taiwan (19)
Gregory D Myer, PhD (11) · Ramon Diaz-Arrastia, MD, PhD (10) · Eric M Wassermann, M.D. (9) · Flora Hammond, MD (7) · Leslie Prichep, Ph.D. (6) · Nieto Luis, Master (6) · Noah Silverberg, PhD (6) · Anthony P Kontos, PhD (5) · David R Howell, PhD (5) · Jeanne M Hoffman, PhD (5) · Jeffrey S Kreutzer, PhD (5) · Leighton Chan, M.D. (5) · Lisa A Brenner, PhD (5) · Uzma Samadani, MD, PhD (5) · Christina Master, MD (4)
PMID 30413559, PMID 31405391, PMID 32228157, PMID 21876461, PMID 22224835, PMID 22771222, PMID 25325609, PMID 26452709, PMID 26537996, PMID 27567470, PMID 28901969, PMID 29253420, PMID 29717652, PMID 30215286, PMID 31377190, PMID 33201041, PMID 34813082, PMID 34873185, PMID 35065038, PMID 35170571, PMID 36585608, PMID 39382077, PMID 40353282, PMID 40440029, PMID 41114449, PMID 10668696, PMID 10869046, PMID 11323136, PMID 11383749, PMID 11454660, PMID 12080869, PMID 12411660, PMID 1244564, PMID 12593613, PMID 12703651, PMID 12794404, PMID 12924684, PMID 12964174, PMID 14526234, PMID 1501986, PMID 15028145, PMID 15068659, PMID 15226070, PMID 15644669, PMID 15756405, PMID 15805957, PMID 15901745, PMID 16010055, PMID 16151035, PMID 16174954
2018 (5), UL1TR001412 (4), R61MH138612 (3), 2008 (2), 2017 (2), 2019 (2), 2025 (2), U01HL077863 (2), 1IK2RX001136-01A2 (1), 1IK2RX003073-01A2 (1), 1IK2RX003494-01A2 (1), 1UL1TR003098 (1), 2014 (1), 2016 (1), 2023 (1)