1242 completed, 420 recruiting, 335 unknown, 324 terminated. 858 Phase 2, 691 Phase 1, 584 Not applicable, 168 Phase 3, 77 Early Phase 1.
Follow Brain Neoplasms: new trials by email Literature Review of Brain Neoplasms trials Research Report on Brain Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas RNS System Implantation - Glioma, Glioma Intracranial | Not applicable | Not yet recruiting | Medical College of Wisconsin | 3 | 2028-08-01 | 2026-10-13 |
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients Aminolevulinic acid hydrochloride - Pediatric Brain Tumor | Phase 2 | Not yet recruiting | Costas Hadjipanayis | 20 | 2027-08-01 | 2026-10-07 |
| H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-10-30 |
| Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements Non-Interventional Study - Brain Tumor, Recurrent Brain Tumor | Not yet recruiting | Mayo Clinic | 30 | 2027-06-01 | 2026-09-16 | |
| Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG Opdualag - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 12 | 2027-03-01 | 2026-09-09 |
| Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) Tovorafenib - High Grade Glioma (HGG) of the Brain With BRAF Aberration, High Grade Glioma (III or IV) | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 79 | 2027-02-01 | 2026-10-20 |
| IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade Astrocytomas IDH1-vac, IS-vac, Temozolomide (TMZ) - Astrocytoma, IDH-Mutant, Grade 3, Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Not yet recruiting | German Cancer Research Center | 216 | 2027-02-01 | 2026-10-22 |
| Blood Brain Barrier Dysfunction in Glioma and Epileptogenesis Epilepsy, Glioma | Not yet recruiting | University College, London | 56 | 2027-01-04 | 2026-11-02 | |
| Ceritinib Treatment for Recurrent Meningiomas Ceritinib - Recurrent Meningioma, Grade I and Grade II | Phase 2 | Not yet recruiting | Kevin Petrecca | 10 | 2027-01-01 | 2026-10-23 |
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| Listen Aphasia Pilot Study LISTEN (AI-based AAC smartphone app) - Aphasia, Malignant Brain Tumor | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 80 | 2027-01-01 | 2026-07-28 |
| ctDNA-Guided Intraventricular Therapy for CNS Malignancies CSF ctDNA-Guided Clinical Management - Leptomeningeal Disease, Glioblastoma | Not applicable | Not yet recruiting | Alireza Mansouri | 77 | 2027-01-01 | 2026-07-08 |
| DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) Dexmedetomidine, Normal Saline (0.9% NaCl) - Neurosurgery, Brain Cancer | Not applicable | Not yet recruiting | University of Malaya | 60 | 2027-01-01 | 2026-11-05 |
| rTMS for Postoperative Brain Tumor Patients Transcranial magnetic stimulation (TMS) - Brain Tumors, Transcranial Magnetic Stimulation | Not applicable | Recruiting | Brian J.Gill | 6 | 2027-01-01 | 2026-10-29 |
| IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells - High-grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 1 | Not yet recruiting | University of Florida | 24 | 2027-01-01 | 2026-10-30 |
| Immune Modulatory DC Vaccine Against Brain Tumor Immunomodulatory DC vaccine to target DIPG and GBM - Diffuse Intrinsic Pontine Glioma or Glioblastoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2026-12-31 | 2026-10-30 |
| Measuring Brain Changes Following Cognitive Intervention in Pediatric Patients With Brain Tumors Online computerized cognitive training intervention focused on processing speed. - Brain Tumor, Pediatric | Not applicable | Not yet recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 300 | 2026-12-30 | 2026-11-03 |
| Evaluating Biomarkers of Cognitive Dysfunction in Patients With Cancer Blood sample, Brain magnetic resonance imaging (MRI), Brain Health Assessment - Brain Tumor Adult, Brain Metastases From Solid Tumors | Not yet recruiting | University of California, San Francisco | 40 | 2026-12-15 | 2026-10-29 | |
| Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour Visual Stimulation, standard of care - Hemianopsia, Virtual Reality | Not applicable | Not yet recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 120 | 2026-12-01 | 2026-09-16 |
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Glioblastoma (632) · Glioma (547) · Astrocytoma (373) · Central Nervous System Neoplasms (342) · Gliosarcoma (285) · Oligodendroglioma (261) · Neoplasms (214) · Pituitary Neoplasms (192) · Breast Neoplasms (180) · Medulloblastoma (166) · Neoplasm Metastasis (160) · Carcinoma, Non-Small-Cell Lung (159) · Ependymoma (134) · Lung Neoplasms (131)
Neoplasms by Site (2750) · Nervous System Neoplasms (2750) · Nervous System Diseases (2749) · Central Nervous System Diseases (2746) · Brain Diseases (2742) · Neoplasms (2546) · Central Nervous System Neoplasms (2418) · Neoplasms by Histologic Type (1315) · Neoplasms, Nerve Tissue (1216) · Neuroectodermal Tumors (1185) · Neoplasms, Germ Cell and Embryonal (1171) · Neoplasms, Glandular and Epithelial (1137) · Neoplasms, Neuroepithelial (1053) · Glioma (489) · Pathological Conditions, Signs and Symptoms (430)
Temozolomide (193) · Radiosurgery (132) · Radiotherapy (124) · Bevacizumab (104) · Magnetic Resonance Spectroscopy (80) · Carboplatin (63) · Cyclophosphamide (44) · Etoposide (42) · Irinotecan (42) · Surgical Procedures, Operative (41) · Radiation (38) · Nivolumab (37) · Erlotinib Hydrochloride (35) · pembrolizumab (35) · Cisplatin (32)
National Cancer Institute (NCI) (158) · M.D. Anderson Cancer Center (93) · Duke University (68) · Memorial Sloan Kettering Cancer Center (53) · Children's Oncology Group (32) · Mayo Clinic (32) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (31) · St. Jude Children's Research Hospital (31) · Case Comprehensive Cancer Center (29) · Massachusetts General Hospital (23) · Novartis Pharmaceuticals (22) · National Institute of Neurological Disorders and Stroke (NINDS) (21) · University Health Network, Toronto (21) · City of Hope Medical Center (20) · Sun Yat-sen University (20)
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Henry S. Friedman, MD (15) · David A. Reardon, MD (11) · John Boockvar, MD (10) · Maryam Fouladi, MD (9) · David Peereboom, MD (7) · Katherine E Warren, M.D. (7) · Alexander Dmitriev, MD (6) · Annick Desjardins, MD, FRCPC (6) · Darell D. Bigner, MD, PhD (6) · Edward G. Shaw, MD (6) · Jeffrey J. Raizer, MD (6) · Stewart Goldman, MD (6)
PMID 34081125, PMID 19801201, PMID 16757720, PMID 23545055, PMID 25349290, PMID 27458945, PMID 16648043, PMID 19556464, PMID 21041710, PMID 21584645, PMID 21865400, PMID 23377664, PMID 23956241, PMID 25098701, PMID 25209242, PMID 25303679, PMID 25614945, PMID 25789053, PMID 26148750, PMID 27744512, PMID 28039367, PMID 28592387, PMID 29077941, PMID 29343557, PMID 29982805, PMID 30118397, PMID 30670498, PMID 31062234, PMID 31401903, PMID 31587882, PMID 31838007, PMID 32058845, PMID 32691060, PMID 33067126, PMID 34171339, PMID 35096584, PMID 35954244, PMID 37072349, PMID 39024777, PMID 40086048, PMID 41218853, PMID 10022400, PMID 10199767, PMID 10199774, PMID 10372687, PMID 10449559, PMID 10460438, PMID 10469005, PMID 10519716, PMID 10627774
2023 (13), P30CA033572 (12), 2015 (11), U01CA081457 (11), P30CA043703 (10), P30CA138292 (10), U01CA062399 (10), U01CA137443 (10), 2014 (9), U01CA062475 (8), UM1CA081457 (8), 2009 (7), P30CA014089 (7), P30CA016672 (7), U10CA021661 (7)